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http://dx.doi.org/10.13048/jkm.21025

Inhibitory Effects of GGX on Lung Injury of Chronic Obstructive Lung Disease (COPD) Mice Model  

Kim, Tae Hyeon (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University)
Yang, Won Kyung (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University)
Lee, Su Won (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University)
Kim, Seung Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University)
Lyu, Yee Ran (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University)
Park, Yang Chun (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University)
Publication Information
The Journal of Korean Medicine / v.42, no.3, 2021 , pp. 56-71 More about this Journal
Abstract
Objectives: This study is aimed to evaluate the protective effects of GGX on lung injury of Chronic Obstructive Lung Disease (COPD) mice model. Materials and Methods: C57BL/6 mice were challenged with lipopolysaccharide (LPS) and cigarette smoke extract (CSE) and then treated with vehicle only (Control group), dexamethasone 3 mg/kg (Dexa group), gam-gil-tang 200 mg/kg (GGT group), GGX 100, 200, and 400 mg/kg (GGX group). After sacrifice, its bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed with cytospin, Enzyme-Linked Immunosorbent Assay (ELISA), real-time polymerase chain reaction (PCR) and hematoxylin & eosin (H&E), and Masson's trichrome staining. Results: In the COPD model, GGX significantly inhibited the increase of neutrophils, TNF-𝛼, IL-17A, CXCL-1, MIP2 in BALF and TNF-𝛼, IL-1𝛽, IL-10 mRNA expression in lung tissue. It also decreased the severity of histological lung injury. Conclusion: This study suggests the usability of GGX for COPD patients by controlling lung tissue injury.
Keywords
Chronic Obstructive Lung Disease; GGX; Herbal drug; Korean medicine;
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