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The Changes of Cerebral Metabolic Parameters, Serum Levels of Neuron-Specific Enolase and S-100$\beta$ Protein During Retrograde Cerebral Perfusion Under Profound Hypothermic Total Circulatory Arrest (초저체온하 완전순환정지 시에 이용되는 역행성 뇌관류의 시간에 따른 뇌대사 지표, 혈청 내 neuron-specific enolase, 및 S-100 베타단백의 변화)

  • 김경환
    • Journal of Chest Surgery
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    • v.34 no.9
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    • pp.653-661
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    • 2001
  • Background: Retrograde cerebral perfusion(RCP) is one of the methods used for brain protection during aortic arch surgery. The author previously published the data, however, for the safety of it, there still remains many controversies. The author performed RCP and checked various parameters to clarify the possibility of early detection of cerebral injury. Material and Method: The author used pigs(Landrace species) weighing 25 to 30kg and performed RCP for 120 minutes. After weaning of cardiopulmonary bypass, we observed pigs for another 120 minutes. Rectal temperature, jugular venous oxygen saturation, central venous pressure were continuously monitored, and the hemodynamic values, histological changes, and serum levels of neuron-specific enolose(NSE) and S100$\beta$ protein were checked. Central venous pressure during RCP was maintained in the range of 20 to 25 mmHg. Result: Flow rates(ml/min) during RCP were 224.3$\pm$87.5(20min), 227.1$\pm$111.0(40min), 221.4$\pm$119.5(60min), 230.0$\pm$136.5(80min), 234.3$\pm$146.1(100min), and 184.3$\pm$50.5(120min). Serum levels of NSE did not increase after retrograde cerebral perfusion. Serum levels of S100$\beta$ protein(ng/ml) were 0.12$\pm$0.07(induction of anesthesia), 0.12$\pm$0.07(soon after CPB), 0.19$\pm$0.12(20min after CPB), 0.25$\pm$0.06(RCP 20min), 0.29$\pm$0.08(RCP 40min), 0.41$\pm$0.05(60min), 0.49$\pm$0.03(RCP 80min), 0.51$\pm$0.10(RCP 100min), 0.46$\pm$0.11(RCP 120min), 0.52$\pm$0.15(CPBoff 60min), 0.62$\pm$0.15(60min after rewarming), 0.76$\pm$0.17(CPBoff 30min), 0.81$\pm$0.20(CPBoff 60min), 0.84$\pm$0.23(CPBoff 90min) and 0.94$\pm$0.33(CPBoff 120min). The levels of S100$\beta$ after RCP were significantly higher than thosebefore RCP(p<0.05). The author could observe the mitochondrial swellings using transmission electron microscopy in neocortex, basal ganglia and hippocampus(CA1 region). Conclusion: The author observed the increase of serum S100$\beta$ after 120 minutes of RCP. The correlation between its level and brain injury is still unclear. The results should be reevaluated with longterm survival model also considering the confounding factors like cardiopulmonary bypass.

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Effect of Hot-water Dipping on Inhibiting Red Discoloration of Basal Part in Chicon (열수 침지 처리가 치콘 절단면의 적변 억제에 미치는 영향)

  • Jung, Hyun Jin;Kang, Ho-Min
    • Horticultural Science & Technology
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    • v.32 no.3
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    • pp.353-358
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    • 2014
  • Hot water dipping test was conducted for chicon to restrict red discoloration of its basal part which impairs the product value during sales. Hot water dipping treatment was given to chicon for 4 min and for 8 min at $38^{\circ}C$ and for 2 min and 4 min at $42^{\circ}C$, and for 1 min and 2 min at $45^{\circ}C$, along with control (for one min at $20^{\circ}C$). The red discoloration indices of basal part of chicon during sensory evaluation on the sixth day of storage under the storage temperature at $10^{\circ}C$ was lower at $42^{\circ}C$ for 2 min, $42^{\circ}C$ for 4 min and $45^{\circ}C$ for 1 min treatments. The color change value of the basal part in chicon measured by colorimeter showed that the lowest ${\Delta}a^*$ and ${\Delta}h$ were maintained in the basal part of chicon treated at $42^{\circ}C$ for 2 min. Whereas, color changes in $42^{\circ}C$ for 2 min and $45^{\circ}C$ for 1 min treatments were significantly low as compared with that of control. The contents of total phenolic compounds which are the substances that cause red discoloration of basal part in chicon were lowest at $42^{\circ}C$ for 2 min, $42^{\circ}C$ for 4 min and $45^{\circ}C$ for 1 min treatments. The activity of phenylalanine ammonia lyase (PAL) resposible for in the synthesis of phenolic substances was the least in $42^{\circ}C$ for 2 min treatment. Whereas, PAL activity of the chicons treated a t $42^{\circ}C$ for 2 min and at $45^{\circ}C$ for 1 min were significantly lower than that of control. However, red discoloration was progressed as similar level with that of control in the basal part of chicon at $45^{\circ}C$ for 2 min. The contents of total phenolic compounds and PAL activity in this treatment were not significantly different from those in control. The polyphenol oxidase (PPO) activity which causes red discoloration of cut tissues was low in all the treatments including $42^{\circ}C$ and $45^{\circ}C$ treatment at which no inhibition effects of the red discoloration of basal part of chicon were observed. When the correlation coefficient between each investigated index was tested, most of them showed high correlation except the PPO activity and particularly and the red discoloration index and sensory evaluation ${\Delta}h$ values, and PAL activity and total phenolic compounds content were $r=0.927^{**}$, and $r=0.942^{**}$, respectively.

Evaluation of In-Vitro Efficacy of Active Ingredients in Dentifrice Used for Different Treatment Times (치약용 약효제의 적용시간에 따른 실험실적 효능 연구)

  • Ahn, Jae-Hyun;Kim, Ji-Hye;Kim, Ji-Young
    • Journal of dental hygiene science
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    • v.16 no.2
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    • pp.176-182
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    • 2016
  • The purpose of this study was to evaluate the in-vitro efficacy of the active ingredients of dentifrice following treatment time. The whitening effect was evaluated by a change in lightness value relative to the contact time of hydrogen peroxide, by using artificially stained hydroxyapatite discs. The anti-calculus effect was assessed based on the amount of calcium eluted from the human dental calculus by sodium pyrophosphate. Remineralization was evaluated by the Vickers hardness test following the application of sodium fluoride to bovine enamel. In order to view dentinal tubules occlusion, the formation of insoluble calcium salts by bovine dentin specimens was observed using scanning electron microscopy. Change in lightness value (${\Delta}L$) was $5.50{\pm}1.51$ after 1 min of treatment, $5.73{\pm}0.43$ after 3 min, $8.64{\pm}0.24$ after 10 min, $18.93{\pm}0.76$ after 30 min, and $27.35{\pm}0.54$ after 60 min. The amount of calcium eluted from the human dental calculus was $4.23{\pm}0.14ppm$ after 1 min of treatment, $4.51{\pm}0.04ppm$ after 3 min, $12.12{\pm}0.16ppm$ after 10 min, $17.85{\pm}0.81ppm$ after 30 min, and $25.15{\pm}0.32ppm$ after 60 min. The Vickers hardness change value (${\Delta}VHN$) was $1.96{\pm}1.44$ after 1 min, $1.52{\pm}1.06$ after 3 min, $9.06{\pm}0.15$ after 10 min, $10.83{\pm}5.13$ after 30 min, and $12.55{\pm}2.09$ after 60 min. Partial dentinal tubules occlusion was observed at 10 min and complete occlusion was evident at 60 min. In summary, the use of patch type dentifrices for 10, 30, or 60 min were 1.57 to 8.26 times more effective than using the paste type dentifrices for 1 to 3 min. Based on these findings, it is reasonable to expect that the use of patch type dentifrices for 10 min would lead to remineralization, anti-calculus and dentinal tubules occlusion effects, and that use for 30 min would result in a whitening effect.

Cut-down the Express and Required Time in Harvesting of Onion (Allium cepa L.) (양파 수확의 소요시간과 비용절감)

  • 권병선
    • Korean Journal of Plant Resources
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    • v.9 no.1
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    • pp.63-69
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    • 1996
  • The experiment was conducted to reduce the labor and production cost with the labor save of harvest in cultivating the onion using the machine and the results are as follows. On labor saving effect in transparent vinyl mulching, digging working hours per 10a in the case of using tractor are 55 min., fixing + turning time is 11 min.,the time of harvest is 66 min, digging working hours using cultivator are 90 min. and fixing + turning time is 9 min., but the time of hand harvesting is 693 min and 41 sec. and in digging labor saving effect, tractor shows 90% in the harvesting period and harvest by cultivator 86%. On nonmulching cases, the harvest by tractor takes 44 min. and that by cultivator does 75 min, and digging labor saving effect shows 93.6% in the tractor harvest and 89% in the cultivator harvest. Therefore, on the operation efficiency per hour, in the case of tractor with digger vinyl mulching and nonmulching show $0.091\sim0.136ha$ and in the case of cultivator with digger-both show $0.061\sim0.08ha$, but in the case of hand harvest, vinyl mulching and nonmulching are $0.008\sim0.009ha$, so in the mechanized harvest of onion, the harvest by tractor with digger is the best. On the cost and labor save for harvesting the onion with labor saving effect, tractor shows 19 hours and 26min./10a in vinyl mulching and 18 hours and 54min./10a in nonmulching, so it shows the short hours for harvesting. And labor saving effect shows 37% in comparison with 29 hours and 49 min. $\sim30$ hours and 38 min.($110,587\sim113,925won$) of the hand harvest, so the cost was reduced to $69,525\sim72,225won$. On the cultivator with diggers, vinyl mulching takes 19 hours and 49 min and nonmulching 20 hours and 2 min., so the labor saving effect and cost were reduced to $32\sim36%$($73,087\sim75,075$ won) in comparison with the hand harvest.

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What is the Appropriate Infusion Rate during Whitaker Test in Children? (소아 Whitaker 검사시에 적절한 관류속도는?)

  • Chung, Ky-Hyun;Lee, Gyeong-Ik
    • Childhood Kidney Diseases
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    • v.2 no.2
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    • pp.178-182
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    • 1998
  • Purpose : The conventional Whitaker test assesses the renal pelvic pressure response to a constant infusion rate of 10 mL/min in adult and 5 mL/min in children. We evaluated whether the infusion rate,5 mL/min is appropriate during Whitaker test in children. Materials and Methods : The study included 3 children with unilateral hydronephrosis, whose diuretic renography results were equivocal to define the presence of urinary obstruction. The kidneys were perfused at increasing flow rates from lmL/min. Results : There were intrapelvic pressure increases $26\;cmH_2O$ at 3 mL/min, $50\;cmH_2O$ at 2 mL/min and $80\;cmH_2O$ at 3 mL/min infusion rate, respectively. There was no need to increase the infusion rate over 4 mL/min to get a positive Whitaker test. Conclusion : Our experience with Whitaker test at variable low flow rates (1-5 mL/min) confirmed its usefulness in differentiating obstructive from nonobstructive uropathy. We recommend the increasing infusion rate from 1 mL/min during Whitaker test in children.

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Mechanization for Labor Saving in Harvesting of Potatoes (Solamum Tuberosum L.) (감자 수확의 성력 기계화)

  • 정동희
    • Korean Journal of Plant Resources
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    • v.8 no.3
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    • pp.297-302
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    • 1995
  • The experiment is conducted to reduce the labor and production cost with the labor save of harvest if cultivating the potatoes using the machine and the results are as follows. On labor saving effect in transparent vinyl mulching, digging working hours per 10a in the case of using tractor are 60 min., fixing + turning time is 5 min. and 30sec., the time of harvest is 65 min and 30sec., digging working hours using cultivator are 99 min. and fixing +turning time is 5 min. and 30sec., but the time of hand harvesting is 990 min. and in digging labor saving effect, tractor shows 94% in the harvesting period and harvest by cultivator 90%. On non mulching cases, the harvest by tractor takes 49 min. and 30 sec. and that by cultivator does 87 min. and 30 sec., and digging labor saving effect shows 94% in the tractor harvest and 90% in the cultivator harvest. Therefore, on the operation efficiency per hour, in the case of tractor with digger vinyl mulching and non mulching show, $0.091\sim0.121ha$ and in the case of cultivator with digger both show $0.057\sim0.069ha$, so in the mechanized harvest of potatoes, the harvest by tractor with digger is the best. On the cost and labor save for harvesting the potatoes with labor saving effect, tractor shows 19 hours and 20 min./10a in vinyl mulching and 19 hours. and 54 min./10a in non mulching, so it shows the short hours for harvesting. And labor saving effect shows $42\sim45%$ in comparison with 35 hours and 21 min. $\sim35$ hours and 23 min.($123,113\sim130,613$ won) of the hand harvest, so the cost was reduced to $71,250\sim72,225$ won. On the cultivator with diggers, vinyl mulching takes 19 hours and 55 min. and non mulching 19 hours and 38 min., so the labor saving effect and cost were reduced to $14\sim44%$ ($72,675\sim73,313$ won) in comparison with the hand harvest.

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Selection of Transition Point through Calculation of Cumulative Toxic Load -Focused on Incheon Area- (누적독성부하 산정을 통한 주민소산 전환시점 선정에 관한 연구 -인천지역을 중심으로-)

  • Lee, Eun Ji;Han, Man Hyeong;Chon, Young Woo;Lee, Ik Mo;Hwang, Yong Woo
    • Journal of the Korean Society of Safety
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    • v.35 no.6
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    • pp.15-24
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    • 2020
  • With the development of the chemical industry, the chemical accident is increasing every year, thereby increasing the risk of accidents caused by chemicals. The Ministry of Environment provides the criteria for determining shelter-in-place or outdoor evacuation by material, duration of accident, and distance from the toxic substance leak. However, it is hard to say that the criteria for determining the transition point are not clear. Transition point mean the time that evacuation method is switched from shelter-in-place to outdoor evacuation. So, the purpose of this study was to calculate appropriate transition point by comparing the cumulative toxic load. Namdong-gu in Incheon Metropolitan City was finally selected as the target area, considering the current status of the population of Incheon Metropolitan City in 2016 and the statistical survey of chemicals in 2016. The target materials were HCl, HF, and NH3. Modeling was simulated by ALOHA and performed assuming that the entire amount would be leaked for 10 min. Residents' evacuation scenarios were assumed to be shelter-in-place, immediate outdoor evacuation, and outdoor evacuation at an appropriate time after shelter-in-place. Based on the above method, the appropriate transition point from residents located in A(800 m away), B(1,200 m away), C(1,400 m away) and D(2,200 m away) was identified. In HCl, appropriate transition point was after 15 min, after 16 min, after 17 min, after 20 min in order by A, B, C and D. In HF, appropriate transition point was before 1 min or after 16 min, before 4 min or after 19 min, before 5 min or after 20 min, before 14 min or after 26 min in order by A, B, C and D. In NH3, appropriate transition point at A was before 4 min or after 16. Others are not in chemical cloud. This study confirmed the transition point to minimize the cumulative toxic load can be obtained by quantitative method. Through this, it might be possible to select evacuation method quantitatively that cumulative toxic load are minimal. In addition, if the shelter-in-place is maintained without transition to outdoor evacuation, the cumulative toxic load will increase more than outdoor evacuation. Therefore, it was confirmed that actions to reduce the concentration of chemicals in the room were necessary, such as conducting ventilation after the chemical cloud passed through the site.

The Gettering Effect of Boron Doped n-type Monocrystalline Silicon Wafer by In-situ Wet and Dry Oxidation

  • Jo, Yeong-Jun;Yun, Ji-Su;Jang, Hyo-Sik
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.429-429
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    • 2012
  • To investigate the gettering effect of B-doped n-type monocrystalline silicon wafer, we made the p-n junction by diffusing boron into n-type monocrystalline Si substrate and then oxidized the boron doped n-type monocrystalline silicon wafer by in-situ wet and dry oxidation. After oxidation, the minority carrier lifetime was measured by using microwave photoconductance and the sheet resistance by 4-point probe, respectively. The junction depth was analyzed by Secondary Ion Mass Spectrometry (SIMS). Boron diffusion reduced the metal impurities in the bulk of silicon wafer and increased the minority carrier lifetime. In the case of wet oxidation, the sheet resistance value of ${\sim}46{\Omega}/{\Box}$ was obtained at $900^{\circ}C$, depostion time 50 min, and drive-in time 10 min. Uniformity was ~7% at $925^{\circ}C$, deposition time 30 min, and drive-in time 10 min. Finally, the minority carrier lifetime was shown to be increased from $3.3{\mu}s$ for bare wafer to $21.6{\mu}s$ for $900^{\circ}C$, deposition 40 min, and drive-in 10 min condition. In the case of dry oxidation, for the condition of 50 min deposition, 10 min drive-in, and O2 flow of 2000 SCCM, the minority carrier lifetime of 16.3us, the sheet resistance of ${\sim}48{\Omega}/{\Box}$, and uniformity of 2% were measured.

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New Time-Domain Decoder for Correcting both Errors and Erasures of Reed-Solomon Codes

  • Lu, Erl-Huei;Chen, Tso-Cho;Shih, Chih-Wen
    • ETRI Journal
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    • v.38 no.4
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    • pp.612-621
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    • 2016
  • A new time-domain decoder for Reed-Solomon (RS) codes is proposed. Because this decoder can correct both errors and erasures without computing the erasure locator, errata locator, or errata evaluator polynomials, the computational complexity can be substantially reduced. Herein, to demonstrate this benefit, complexity comparisons between the proposed decoder and the Truong-Jeng-Hung and Lin-Costello decoders are presented. These comparisons show that the proposed decoder consistently has lower computational requirements when correcting all combinations of ${\nu}$ errors and ${\mu}$ erasures than both of the related decoders under the condition of $2{\nu}+{\mu}{\leq}d_{\min}-1$, where $d_{min}$ denotes the minimum distance of the RS code. Finally, the (255, 223) and (63, 39) RS codes are used as examples for complexity comparisons under the upper bounded condition of min $2{\nu}+{\mu}=d_{\min}-1$. To decode the two RS codes, the new decoder can save about 40% additions and multiplications when min ${\mu}=d_{min}-1$ as compared with the two related decoders. Furthermore, it can also save 50% of the required inverses for min $0{\leq}{\mu}{\leq}d_{\min}-1$.

A Fault-Tolerant Multicasting Algorithm using Region Encoding Scheme in Multistage Interconnection Networks (다단계 상호연결망에서 영역 부호화 방식을 사용하는 고장 허용 멀티캐스팅 알고리즘)

  • Kim, Jin-Soo;Chang, Jung-Hwan
    • Journal of KIISE:Computer Systems and Theory
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    • v.29 no.3
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    • pp.117-124
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    • 2002
  • This paper proposes a fault-tolerant multicasting algorithm employing the region encoding scheme in multistage interconnection networks (MIN's) containing multiple faulty switching elements. After classifying all switching elements into two subsets with equal sizes in MIN, the proposed algorithm can tolerate the faulty pattern where every fault is contained in the same subset. In order to send a multicast message to its destinations detouring faults, the proposed algorithm uses the recursive scheme that recirculates it through MIN, We prove that this algorithm can route any multicast message in only two passes through the faulty MIN.