• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4239-4243
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• 2014

Background: This study investigated the influence of curcumin on HOX transcript antisense RNA (HOTAIR)-mediated migration of cultured renal cell carcinoma (RCC) cells. Materials and Methods: Five RCC cell lines (769-P, 769-P-vector, 769-P-HOTAIR, 786-0, and Kert-3 ) were maintained in vitro. The expression of HOTAIR mRNA was determined by quantitative real-time PCR and cell migration was measured by transwell migration assay. The effects of different concentrations of curcumin (0 to $80{\mu}mol/L$) on cell proliferation was determined by the CCK-8 assay and influence of non-toxic levels (0 to $10{\mu}M$) on the migration of RCC cells was also determined. Results: Comparison of the 5 cell lines indicated a correlation between HOTAIR mRNA expression and cell migration. In particular, the migration of 769-P-HOTAIR cells was significantly higher than that of 769-P-vector cells. Curcumin at $2.5-10{\mu}M$ had no evident toxicity against RCC cells, but inhibited cell migration in a concentration-dependent manner. Conclusions: HOTAIR expression is correlated with the migration of RCC cells, and HOTAIR may be involved in the curcumin-induced inhibition of RCC metastasis.

• IMMUNE NETWORK
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• v.5 no.4
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• pp.247-251
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• 2005

Background: Natural killer (NK) cells are CD3 (-) CD14 (-) CD56 (+) lymphocytes. They play an important role in the body's innate immune response. They can induce spontaneous killing of cancer cells or virus-infected cells via the Fas/Fas ligand or the granzyme/perforin systems. The corticotropin-releasing hormone (CRH) is an important regulator for the body's stress response. It promotes proliferation and migration of various cancer cells through the CRH type 1 receptor under stress, and also inhibits NK or T cell activity. However, the relationship of CRH and NK cell migration to the target has not been confirmed. Herein, we study the effect of CRH on NK cell migration. Methods: We used the human NK cell line, NK-92MI, and tested the expression of CRH receptor type 1 on NK-92MI by RT-PCR. This was to examine the effect of CRH on tumor and NK cell migration, thus NK cells (NK-92MI) were incubated with or without CRH and then each CRH treated cell's migration ability compared to that of the CRH untreated group. Results: We confirmed that CRH receptor type 1 is expressed in NK-92MI. CRH can decrease NK cell migration in a time-/dose-dependent manner. Conclusion: These data suggest CRH can inhibit NK cell migration to target cells.

• The Korean Journal of Community Living Science
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• v.20 no.2
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• pp.193-204
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• 2009

Although the majority of elderly are residentially stable, many western studies have recently reported that there has been a gradual growth of retirement migration. However, little is known about that in Korea. Therefore, this study intended to examine the trend and nature of elderly migration. For this purpose, inter- and intra-province migration among the aged 65 and over were analyzed, using the migration data of the Korea National Statistical Office, compiled from the 2000 and 2006 resident registration records. The results were as follows. First, there was an increase of elderly migrants to 531 thousand persons in 2006 from 383 thousand persons in 2000. Secondly, the migration rate of elderly has steadily grown with a 11.7% in 2000 and 12% in 2006. Also, the move of female among old population was active but this trend tended to decrease in 2006. Thirdly, the number of provinces which showed a positive net inter-province migration of old population increased from 7 provinces in 2000 to 8 provinces in 2006. Fourthly, we found that the destinations of elderly migrants were mostly neighboring province except the Chungnam, Jeonbuk, and Jeju. These results suggested that elderly migration would be expected to increase gradually and be important in the future of Korea.

• Journal of the Korea Society of Computer and Information
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• v.25 no.5
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• pp.91-98
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• 2020

The mobile agent, which handles a given task while migrating between the sensor nodes, moves including the execution commands and task processing results. This increases the size of the mobile agent, causing the network to load, leading to the migration time delay and the loss of migration reliability. This paper presents the method of lightening the mobile agent using distributed object technology and the algorithm for exploring and providing the optimal migration path that is actively performed in the event of network traffic, and it proposes a method to ensure the reliability of the mobile agent migration by applying them. In addition, through the comparative analysis experiments based on agent size and network traffic for the migration time of mobile agent equipped with active rules in sensor network-based mobile agent middleware environment, applying the proposed methods proves to ensure the autonomy and migration reliability of the mobile agent.

• The Korean Journal of Community Living Science
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• v.28 no.4
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• pp.653-667
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• 2017

The purpose of this study were to investigate the socio-economic impacts of urban-to-rural migration on the rural community and to identify the factors influencing rural residents' recognition of the socio-economic impacts of urban-to-rural migration on the rural community. For the purpose, this study analyzed Korea Rural Economic Institute's rural residents survey(2016), using multiple regression model. The main finding of this study were as follows: Positive social impacts of urban-to-rural migration on rural community were (1) contributing to community sustainability through population growth, (2) contributing to securing agricultural human resources, and others. Negative social impacts of urban-to-rural migration on rural community were (1) increasing unnecessary complaints and deepening distrust, (2) weakening of community consciousness, and others. Positive economic impacts of urban-to-rural migration on rural community were (1) increasing the value of residents' property, (2) contributing to local finance through increased local tax revenue, and others. Negative economic impacts of urban-to-rural migration on rural community were (1) difficulty of scaling farmland due to small-scale farming, (2) land shortage caused by rising land prices, and (3) fierce competition to secure labor force. According to the multiple regression analysis, the major factors influencing rural residents' recognition of the socio-economic impacts of urban-to-rural migration were (1) villagers' general attitude toward urban-to-rural migrants, (2) urban-to-rural migrants' community participation, (3) age, and (4) fitness of village in urban-to-rural migration.

• Geophysics and Geophysical Exploration
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• v.6 no.3
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• pp.153-159
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• 2003

Using reciprocity theorem, one direction aperture of seismogram can be extended to full aperture seismogram. Modified seismogram is applied to reverse time migration only to acquire improved migration image. In this paper, we tested reverse time migration with the Marmousi velocity data to examine efficiency of modified seismogram. And linearly increasing velocity model is selected and examined for a case where velocity data is insufficient. When true velocity is applied, using modified seismogram enhances the reverse time migration image more than using original seismogram. In the case of using linearly increasing velocity model, migration image is distorted. So low frequency source is brought in migration process. Reverse time migration image with low frequency source and linearly increasing velocity model is improved when modified seismogram is used. From the result of study, seismogram modification by reciprocity theorem is useful and migration image can be enhanced.

• Geophysics and Geophysical Exploration
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• v.10 no.2
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• pp.111-123
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• 2007

Unlike the conventional reverse time migration method which is implemented by simply extrapolating wavefield in reverse time, this paper presents a derivation of another reverse time migration operator as the exact adjoint of the presumed forward wavefield extrapolation operator. The adjoint operator is obtained by formulating the forward time extrapolation operator in an explicit matrix equation form and then taking the adjoint to this matrix equation followed by determining the corresponding operator. The reverse time migration operator as the exact adjoint to the implied forward operator can be used not only as a migration algorithm but also as an adjoint operator which is required in the imaging through an inversion such as least-squares migration.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.342-347
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• 2011

Background: Glial cells are involved in immune and inflammatory responses in the central nervous system (CNS). Glial cells such as microglia and astrocytes also provide structural and functional support for neurons. Migration and morphological changes of CNS cells are associated with their physiological as well as pathological functions. The secreted protein lipocalin-2 (LCN2) has been previously implicated in regulation of diverse cellular processes of glia and neurons, including cell migration and morphology. Methods: Here, we employed a zebrafish model to analyze the role of LCN2 in CNS cell migration and morphology in vivo. In the first part of this study, we examined the indirect effect of LCN2 on cell migration and morphology of microglia, astrocytes, and neurons cultured in vitro. Results: Conditioned media collected from LCN2-treated astrocytes augmented migration of glia and neurons in the Boyden chamber assay. The conditioned media also increased the number of neuronal processes. Next, in order to further understand the role of LCN2 in the CNS in vivo, LCN2 was ectopically expressed in the zebrafish spinal cord. Expression of exogenous LCN2 modulated neuronal cell migration in the spinal cord of zebrafish embryos, supporting the role of LCN2 as a cell migration regulator in the CNS. Conclusion: Thus, LCN2 proteins secreted under diverse conditions may play an important role in CNS immune and inflammatory responses by controlling cell migration and morphology.

• Journal of the Korean association of regional geographers
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• v.15 no.5
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• pp.572-589
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• 2009

To grasp the migration characteristics of the Busan metropolitan area(BMA), this study analyzed the change of population and households, and the migration at the intra-regional and inter-regional scales. The major findings of the study are as follows: First, the ratio of population and households of the BMA to the whole country has continuously decreased, especially those 25 to 39 years of age greatly decreased. Second, the ratio of intra-regional migration is relatively high, and the ratio of inter-regional migration is relatively low in the BMA compared to the Seoul metropolitan area. Thus, Busan seems to be less integrated with the urban fringe. Third, the out-migration towards the Seoul metropolitan area from Busan has increased, so that Seoul metropolitan area becomes to have more considerable influence upon the population decrease in Busan.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.6
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• pp.1056-1062
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• 2004

Migration of low molecular weight components from expanded polystyrene (ESP) to distilled water was measured at different temperature conditions. Overall migration and specific monomer migration were measured. Diffusion model based on Fick's law was used to determine the apparent diffusion coefficients at various experimental conditions. The overall and specific migration levels were estimated to give some practical implications for regulatory guideline development and safe package design. Diffusion coefficients for overall migration in KMnO$_4$ oxidizable extractives and specific migration of styrene monomer from ESP at 6$0^{\circ}C$ were 0.030 and 6.8${\times}$10$^{-5}$ $\textrm{mm}^2$/h, respectively. Their temperature dependence could be explained by Arrhenius equation with respective activation energies of 80.5 and 98.6 kJ/㏖. Experimental conditions ensuring desired migration level were suggested for reliable examination of migration from the packaging material. Some explanatory estimations of migrations were given for some typical conditions of potential usages.