• Title/Summary/Keyword: MI2U

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MicroRNA-802 Promotes Osteosarcoma Cell Proliferation by Targeting p27

  • Cao, Zhong-Qing;Shen, Zan;Huang, Wei-Yi
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7081-7084
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    • 2013

  • MicroRNAs have been demonstrated to regulate proliferation and apoptosis in many types of cancers, but biological functions in osteosarcomas remain relatively unknown. Here, we found expression of miR-802 to be up-regulated in osteosarcoma tissues in comparison with adjacent normal tissues. Enforced expression of miR-802 was able to promote cell proliferation in U2OS and MG63 cells, while miR-802 antisense oligonucleotides (antisense miR-802) inhibited cell proliferation. At the molecular level, our results further revealed that expression of p27, a negative cell-cycle regulator, was negatively regulated by miR-802. Therefore, the data reported here indicate that miR-802 is an important regulator in osteosarcoma, our findings contributing to a better understanding of important mis-regulated miRNAs in this tumour type.

  • https://doi.org/10.7314/APJCP.2013.14.12.7081 인용 PDF KSCI

A Study on Strategy Direction for Promoting the U-City Industry Through its Characteristics (산업 특성을 통한 U-City산업 발전 정책 방향성에 대한 연구 -서울특별시 사례를 중심으로-)

  • Lim, Si-Yeong;Shin, Dong-Bin;Ahn, Jong-Wook;Yi, Mi-Sook
    • Journal of Korean Society for Geospatial Information Science
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    • v.19 no.1
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    • pp.37-43
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    • 2011

  • In this study, we dealt with the U-City industry in Seoul as a case study for deriving the characteristics of it. Using the interindustry analysis, we made sure that U-City industry has a great forward linkage effect. It means that development of U-City industry have a good effect on the entire industry likewise the infrastructure. In this sense it is important that we have to promote it first. Based on this result, we suggested the strategy direction as follows: 1) Solving the emerging problem, 2) Identifying the roles of public and private sector, 3) Drawing up the plan for supporting.

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Isolation and Elucidation of Specific RNAs by Treatment of Rhus verniciflua Stokes Extract to U937 Cell (옻추출물 처리에 의한 U937 세포에서의 특정 RNA 발현 양상)

  • Jeong, Mi-Young;Oh, Se-Wook
    • Korean Journal of Food Science and Technology
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    • v.40 no.5
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    • pp.593-598
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    • 2008

  • Differential display RT-PCR was used for screening the differentially expressed specific genes by Rhus verniciflua extract treatment to U937 cell, human leukemic monocyte. As a result, 19 clones differentially expressed were detected. Among the detected clones, one clone was confirmed to be over-expressed by R. verniciflua extract treatment in Northern blot analysis. Nucleotide sequence of the clone showed 100% homology with H2A histone family member Z gene. Therefore, it is concluded that the treatment of R. verniciflua extract to U937 cell specifically induces the expression of H2A.Z gene but its role should be elucidated by future works.

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