• YAKHAK HOEJI
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• v.52 no.2
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• pp.137-146
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• 2008

Even though driving under the influence of drug (DUID) is a worldwide problem, we, Korea has no regulation system yet except for alcohol, and there are little cases reported related to DUID. In order to investigate the type of abused drugs for drivers in Korea, we tried to analyze controlled and non-controlled drugs in alcohol-positive blood samples. 275 whole bloods, which were positive for alcohol on the roadside test, were collected from the police for two months ($Nov.{\sim}Dec.$ 2006). The analytical strategy was constituted of three steps: First, alcohol in blood samples were confirmed and quantified by gas chromatography. Second, controlled drugs were screened by $Evidence_{investigator}\;^{TM}$ (Randox, U.K.) as preliminary test. It was based on immunoassay by biochip array analyzer. Nine groups of drug abuse were screened: amphetamines, methamphetamines, cannabis, cocaine, opiates, barbiturates, methadone, benzodiazepines I (oxazepam) & II (lorazepam). Finally, confirmation of these drugs was performed by GC-MS. Blood samples were extracted by solid-phase extraction by $RapidTrace^{TM}$ (Zymark, U.S.A.). After trimethylsilyl (TMS) derivatization, eluates were analyzed to GC-MS. Total 49 drugs were investigated in this study including controlled drugs, antidepressants, 1st generation antihistamines, dextromethorphan, nalbuphine, ketamine, etc. For rapid detection, we developed the automated identification system. It was made up a new software, "DrugMan", modified Chemstation data analysis menu and newly developed macro modules. A series of peak selection, identification and reporting of the results were performed automatically by this system. Concentrations of alcohol in 275 blood samples were ranged from 0.011 to 0.249% (average, 0.119%). Among 149 blood samples, just six samples (4.0%) were showed positive results to the immunoassay: one methamphetamine and five benzodiazepines group I. By GC-MS confirmation, only benzodiazepines were detected and methamphetamine was not detected from immunoassay positive blood sample. Besides these drugs, 5 chlorpheniramines, dextromethorphan, diazepam, doxylamine, ibuprofen, lidocaine and topiramate were also detected in whole bloods by GC-MS. Conclusively, the frequency of drug abuse for Korean drivers was relatively low. There was none case which illegal drug was detected. However these results were limited to alcohol positive blood samples, so it is necessary to analyze more samples including alcohol negative blood.

• Molecules and Cells
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• v.40 no.4
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• pp.271-279
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• 2017

Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the role of RanBP9 in retinal development is largely unknown. Here, we present the novel and regulatory roles of RanBP9 in retinal development of a vertebrate animal model, zebrafish. Zebrafish embryos exhibited abundant expression of ranbp9 in developing brain tissues as well as in the developing retina. Yeast two-hybrid screening demonstrated the interaction of RanBP9 with Mind bomb, a component of Notch signaling involved in both neurogenesis and neural disease autism. The interaction is further substantiated by co-localization studies in cultured cells. Knockdown of ranbp9 resulted in retinal dysplasia with defective proliferation of retinal cells, downregulation of neuronal differentiation marker huC, elevation of neural proliferation marker her4, and alteration of cell cycle marker p57kip2. Expression of the $M{\ddot{u}}ller$ glial cell marker glutamine synthase was also affected in knockdown morphants. Our results suggest that Mind bomb-binding partner RanBP9 plays a role during retinal cell development of zebrafish embryogenesis.

• Journal of Environmental Science International
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• v.14 no.6
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• pp.583-596
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• 2005

Samples of water, soil, and sediment were taken from 10 streams of Andong city in Gyeongbuk province in October 2004. To assess the degree of environmental pollution for each stream site, the chemical analyses of pollutants such as T-N, T-P, COD, heavy metal, organophosphorous and organochlorine pesticides, and dioxin-like PCB congeners were implemented using the standard process tests or the U. S. EPA methods. In addition, biological assessment using insect immune biomarkers was conducted on the same environmental samples to complement the chemical assessment. Except Waya stream (T-N; 2.91 mg/L, T-P; 0.16 mg/L, COD; 14.0 mg/L) with above the environmental quality standards, the T-P and COD concentrations of 9 sites are relatively low. The contents of Pb and Cd in samples taken from each stream were much lower than environmental quality standards. However, in comparison with soil samples of other streams, several times higher concentrations of Pb and Cd were found in locations at Mi, Gilan, Yeonha, and Waya stream sites. Dementon-S-methyl, diazinon, parathion, and phenthoate compounds among organophosphorous pesticides were detected as concentrations of ppb levels, respectively, from soil samples collected in the vicinity of Gilan, Mi, Norim, and Waya stream. On the other hand, 16 organochlorine pesticides and 12 dioxin-like PCB congeners selected in this study were not found in all samples. In particular, considering significant disrupting effects of Waya stream's samples on insect immune capacity, this stream seems to be contaminated with investigated and/or univestigated pollutants in this study.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.261-261
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• 2010

본 연구에서는 PBMS (Particle Beam Mass Spectrometer)와 ISPM (In-Situ Particle Monitor)을 연계하여 BPSG (Borophosphosilicate Glass) 및 PSG (Phosphosilicate Glass) 박막 증착을 위한 CVD (chemical vapor deposition) 공정 중 발생하는 오염입자 발생특성에 대해 비교 평가하였다. 소스는 TEB (Triethylborate), TEPO (Triethylphosphate) 및 TEOS (Tetraethoxysilane)를 사용하였고, 운반가스 및 반응가스로 He과 $O_2$ 및 $O_3$를 사용하였다. 증착온도와 압력은 각각 $450^{\circ}C$, 200 Torr 이었다. 반응기의 배기라인에 PBMS와 ISPM을 설치하고 500 nm 이하의 입자에 대해 공정단계별 시간에 따른 모니터링 결과 전 공정에 걸쳐 동일한 패턴의 입자발생분포를 보였으며, 특히 PBMS의 경우 ISPM의 입자측정한계인 260 nm 이하의 입자크기도 측정할 수 있었다. 입자발생이 안정적으로 일어나는 증착공정 중 PBMS를 통하여 입자크기를 측정한 결과 BPSG의 경우 약 110 nm, PSG의 경우 약 80 nm의 분포를 나타내었다. 이를 통해 TEB 소스가 배제된 PSG의 경우 BPSG의 경우보다 입자의 성장이 지체됨을 확인하였다. 측정에 대한 신뢰성을 확보하기 위해 PBMS 내의 TEM (Transmission Electron Microscopy) grid를 이용하여 입자를 샘플링 하였고, TEM 분석을 실시한 결과 PBMS 측정결과와 잘 일치하였다. 또한 EDS (Energy Dispersive Spectroscopy) 분석을 통하여 입자성분에 대해 검증하였다.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.3
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• pp.440-447
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• 2009

This study was performed to compare the wear resistance of sealant and flowable resins for analyzing the effect of flowable resin as a sealant in preventive resin restorations. Specimens were made and Vicker's hardness number and surface roughness were measured. SEM observations of the polished and abraded surfaces were established. Kruskal-Wallis rank test and Mann-Whitney U test at the significant level of ${\alpha}$=0.05 were used. The following results were obtained: 1. The microhardness was decreased among groups in following order: Z350 (3M ESPE, U.S.A), Estelite (Tokuyama Dental, Japan) and Ultraseal (Ultradent, U.S.A). There were significant differences in all groups (p<0.0001). 2. The surface roughness was decreased among groups in following order: Ultraseal XT plus, Palfique Estelite LV and Filtek Z350 flowable. However, there is no statistically significant differences in roughness among Estellite, Z350 and Ultraseal at the significance level of ${\alpha}$=0.05, with p=0.116 3. SEM observation of the unworn and worn surfaces revealed the qualitative differences in the wear appearance among groups. The results in this study indicate that flowable resin is better than sealant in aspect of physical properties.

• Investigative Magnetic Resonance Imaging
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• v.15 no.2
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• pp.123-129
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• 2011

Purpose : To compare lumbar disc changes between initial lumbar spine (L-spine) MRI and follow-up (f/u) MRI that were performed due to recurred backaches. Materials and Methods : A total 50 patients who had undergone f/u L-spine MRI were retrospectively reviewed. Five discs (L1-S1) were surveyed in each f/u MRI. Lumbar disc changes were defined as no change, aggravations, or improvements compared to initial disc states. These states were defined on the basis of morphologic status and disc levels. Results : In a total of 250 discs in 50 patients, 31 discs (12.4%) showed morphologic changes of disc lesions, whereas 219 discs (87.6 %) showed no changes. Among the 31 disc lesions, 24 were aggravated and 7 were partially improved. And on the basis of disc status, initially abnormal discs revealed any morphologic changes of the degree of disc herniation. A total of 33.3% of the morphologic changes are noted in initially extruded discs. Fifteen morphologic changes of disc lesions were located at the L4-5 level. Conclusion : Our results suggest that correlations between lumbar disc herniations and back pain symptoms are limited, and that evaluations of extra disc lesions are required.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.244-254
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• 2020

The purpose of this study was to analyze the differences in dating violence perception of dating violence perception of university students. As a research tool, CTS2 was used as a measure of dating violence, a measure developed by Kim(1999) was used, and a measure of dating violence by Jeong(2013) was used. Data analysis was performed using independent sample t-test and multi-variate analyses. The results are summarized as follows. First, female students showed higher differences in total violence against violence and psychological violence than boys, while boys showed higher physical violence than girls. Health majors were significantly higher in total dating violence and psychological violence than students in humanities and social sciences. There was no significant difference in dating violence offenses with or without sexual experience. Only psychological violence showed an interaction effect between gender and sex experience. Second, female students were significantly higher than male students with significant differences in recognition and sub-factors. Health majors were significantly higher in both date violence perception and lower factors than humanities and social sciences. Students without sexual experience perceived overall dating violence more than students with sexual, physical and cyber violence being significantly higher.

• Korean Journal of Plant Taxonomy
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• v.47 no.4
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• pp.297-303
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• 2017

In central and southern Korea, the two small insectivorous, terrestrial herbs, Utricularia bifida and U. caerulea, often co-occur at wet locations (or in wetlands). The Korean Peninsula (with central China and northern Japan) constitutes the northern edge of their distribution, as their main range is subtropical and tropical Asia. The Korean populations of both species are very likely of post-glacial origin, given that warm-temperate vegetation was absent from the Korean Peninsula during the Last Glacial Maximum. Two hypotheses of the post-glacial colonization of the peninsula can be formulated; first, if current populations were founded by propagules coming from a single ancestral population (i.e., a single refugium), we would expect low levels of genetic diversity. Alternatively, if contemporary Korean populations originated from multiple sources (multiple refugia), we would expect high levels of genetic variation. To test which is more likely, we surveyed the degree of allozyme variation at 20 loci in ten populations for each of the two species from southern Korea. We found no allozyme variation within each species. However, their aquatic congener U. australis exhibited allozyme polymorphism across Japan (four polymorphic loci at three enzyme systems). We suggest that southern Korean populations of Utricularia bifida and U. caerulea were established by a single introduction event from a genetically depauperate ancestral population.

• Journal of the Korean Society of Clothing and Textiles
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• v.27 no.3_4
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• pp.407-417
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• 2003

The purpose of this study is to develop designs and patterns of a functional brassiere. For this purpose, women who have protruding and drooping breasts with 75B for their brassiere size were sampled. The fitting test for the fitness and function of test brassiere and control brassiere were carried out twice and compared the results from the both in terms of front, rear and side looks. The results of this study can be summarized as follows; 1. The results from measuring the level of sag and spread, and volume and protrusion of breasts shows that there are some distinctive differences in the measurements before and after wearing the test brassiere and the test brassiere is proved to be very effective in correcting breasts' shapes. 2. Front look: Since the two front cutting lines of the test brassiere served to have the curved main part pressing against the breasts, it could support breasts to more than satisfactory level. In addition, upperline panel and side panels of the test brassiere were found to have the upperline of the upper cup pressed against the breasts and at the same time it pressed and gathered the flab around upper part of the breasts and armpits that helped to rearrange the shape of the breasts. It is also proved that the two-pieced test brassier was found to be more functional in supporting the lower cup of the breasts. 3. Rear look: The test brassier was made up of two wide U-shaped wings with 2.5cm tape on its lower sides. Each wing has 4 lines and 3 hems (5.5cm). For this reason, the test brassiere was tighter and better fitted on its back. 4. Side look and entire look: The wings of the test brassiere might look wider than that of the control brassier which has conventional straight-shaped wings, but it was analyzed that the test brassiere held the upper and lower sides of the wings more effectively to be more pressed against the breast. Therefore, the test brassiere scored higher in terms of adjusting to body movements, while the control brassiere looked better in overall terms. 5. The functional brassier fur protruding and drooping breasts developed from the experiments of this study is a full side stretch brassiere which covers the entire breasts satisfactorily. The pattern drafting methods are suggested in to .

• Korean Journal of Food Science and Technology
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• v.46 no.3
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• pp.309-314
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• 2014

To improve the standardized quality of gochujang produced by major companies, the quality characteristics of 29 gochujang samples produced by regional small- and medium-scale manufacturers were determined. The average moisture content, crude protein content, pH, acidity, and salinity of gochujang from regional manufacturers were found to be 34.32-45.53%, 5.07-5.68%, 4.61-4.92, 3.30-3.72%, and 9.93-16.14%, respectively. The contents of reducing sugar, amino type N, and capsaicinoids were found to be 16.81-29.81%, 191.72-660.55 mg%, and 32.49-79.58 mg/kg, respectively, and the ${\alpha}$- and ${\beta}$-amylase activity were 2.52-4.15 and 26.36-36.47 U/g, respectively. These values varied significantly across regional manufacturers. In addition, overall, gochujang had a range of 23.93-55.64% moisture content, 4.01-7.30% crude protein content, 105.47-1092.00 mg% amino type N content, and 8.74-181.50 mg/kg capsaicinoid content. These results indicate that the quality characteristics of gochujang showed a wide distribution but met the Korean Industrial Standards. Therefore, these data can be used for quality control of gochujang.