• Information and Communications Magazine
• /
• v.5 no.3
• /
• pp.321-328
• /
• 1988

• Information and Communications Magazine
• /
• v.8 no.8
• /
• pp.3-25
• /
• 1991

• Information and Communications Magazine
• /
• v.9 no.5
• /
• pp.60-65
• /
• 1992

• 건축구조
• /
• v.15 no.1
• /
• pp.55-65
• /
• 2008

• Information and Communications Magazine
• /
• v.8 no.5
• /
• pp.30-51
• /
• 1991

• TTA Journal
• /
• s.47
• /
• pp.42-49
• /
• 1996

• Animal cells and systems
• /
• v.1 no.1
• /
• pp.77-80
• /
• 1997

DOantrolene is a primary specific therapeutic drug for prevention and treatment of malignant hyperthermia symptoms. The mechanisms underlying the therapeutic effects of the drug are not well understood. The present study aimed at the characterization of the effects of azumolene, a water soluble dantrolene analogue, on ryanodine binding to sarcoplasmic reticulum (SR) from normal and malign::lnt hyperthermia susceptible (MHS) swine muscles. Characteristics of $[^3H]ryanodine$ binding were clearly different between the two types of SR. Kinetic analysis of eH]ryanodine binding to SR in the presence of $2{\mu}M$ $Ca^{2+}$ showed that association constant $(K_{ryanodine}_7$ is significantly higher in MHS than normal muscle SR $(2.83 vs. 1.32{\times}10^7 M^{-1}$, whereas the maximal ryanodine binding capacity $(B_{max})$ is similar between the two types of SR. Addition of azumolene $(e.g. 400{\mu}M)$ did not significantly alter both $K_{ryanodine}$ and $B_{max}$ of $[^3H]$ryanodine binding in both types of SR, indicating that the azumolene effect was not on the ryanodine binding sites. Addition of caffeine activated $[^3H]$ ryanodine binding in both types of SR, and caffeine sensitivity was significantly higher in MHS muscle SR than normal muscle SR $(K_{caffeine}:3.24 vs. 0.82 {\times} 10^2 M^{-l}). Addition of azumolene $(e.g.400{\mu}M)$ decreased Kcaffeine without significant change in $B_{max}$ in both types of SR suggesting that azumolene competes with caffeine binding site(s). These results suggest that malignant hyperthermia symptoms are caused at least in part by greater sensitivity of the MHS muscle SR to the $Ca^{2+}$ release drug(s), and that azumolene can reverse the symptoms by reducing the drug affinity to $Ca^{2+}$ release channels.

• International Journal of Highway Engineering
• /
• v.16 no.6
• /
• pp.115-120
• /
• 2014

PURPOSES : This research describes how to predict the life cycles of fatigue cracking based on NCHRP Report 704 as well as modified harmony search (MHS) algorithm. METHODS : The fatigue cracking regression model of NCHRP Report 704 was used in order to calculate the ESAL (Equivalent Single Axle Load) numbers up to pavement failure, based on using material parameters, composite modulus, and surface pavement thickness. Furthermore, the MHS algorithm was implemented to find appropriate material parameters and other structural conditions given the number of ESALs, which is related to pavement service life. RESULTS : The case studies show that the material and structural parameters can be obtained, resulting in satisfying the failure endurance of asphalt concrete structure, given the number of ESALs. For example, the required ESALs such as one or two millions are targeted to satisfy the service performance of asphalt concrete pavements in this study. CONCLUSIONS : According to the case studies, It can be concluded that the MHS algorithm provides a good tool of optimization problems in terms of minimizing the difference between the required service cycles, which is a given value, and the calculated service cycles, which is obtained from the fatigue cracking regression model.

• Journal of the East Asian Society of Dietary Life
• /
• v.19 no.3
• /
• pp.444-450
• /
• 2009

This study examined the preferred salinity levels of soups by different demographic groups in order to establish desirable serving conditions for soups with respect to customer satisfaction and health. The salinity levels were measured in August and November to determine seasonal variations using a digital salinity measuring device. Four demographic groups totaling 1,723 individuals were surveyed from institutional foodservice establishments (IFEs) in elementary schools (ES: male 202/female 194), middle-high schools (MHS: 268/216), universities (UNIV: 208/238), and companies (COM: 182/215) in Seoul. Various thin or thick soups typically offered in foodservice establishments were served salty (1.2%) and less salty (0.4%) at $55{\pm}2^{\circ}C$ in a 50 mL portion. The preferred salinities of the soups were found to be 0.71%, 0.79%, 0.76%, and 0.74% for ES, MHS, UNIV, and COM, respectively. Men had 0.02~0.08% higher preferences than women in ES, MHS and UNIV. The customers also preferred higher salinity levels in November than in August, and in thick soups than in thin soups. The salinities preferred by school children were significantly (p<0.01) lower than those of soups by the IFEs. A similar observation was made for MHS, in which each IFE served the soups with significantly (p<0.01) higher salinities than those preferred by the students. Again, at two COM IFEs, the salinities of the soups served were significantly higher than those preferred by the customers. However, for one of UNIV, the salinity of the served soup was significantly (p<0.05) higher than that preferred by the students, while in the two other UNIV no significant differences were noted between the salinity of the served soup and the level preferred by customers. The surveys showed that 9 out of 12 IFEs served soups having salinities that were significantly higher than those preferred by customers. In particular, regardless of preference, the MHS group was served soups with higher salinity levels than the other demographic groups. The salinities of the soups provided by the IFEs were unnecessarily high for the levels preferred by the customers. Therefore, IFEs should make an effort to serve soups that are less salty soups to enhance public health.

• Proceedings of the Korean Institute of Communication Sciences Conference
• /
• 1995.10a
• /
• pp.453-456
• /
• 1995