• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.3
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• pp.288-293
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• 2008

In this study, we investigated the anticancer activity of Makgeoly (MG). MG was fractionated into four fractions by using solvent partition method, affording hexane (MGH), methanol (MGM), butanol (MGB) and aquous (MGA) soluble fractions. We determined the cytotoxicity of these four fractions in four kinds of cancer cell lines, such as HepG2, MCF-7, B16-F10 and HT29 by MTT assay. Among the various fractions, the MGM showed the strongest cytotoxic effects on all cancer cell lines. The morphological changes such as membrane shrinking and blebbing of cells were also observed by MGM treatment in HepG2 cell. In addition, we observed quinone reductase (QR) activity stimulating effects in all fraction layers of MG on HepG2 cells. QR activity increased approximately 2.6 and 2.1 times in MGM and MGH treated HepG2 cell at $100{\mu}g/mL$, respectively, compared to that in control value. Although further studies are needed, the present work could suggest that the fin of MG has a potential to be used as a chemopreventive agent against cancer.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 1995.12a
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• pp.9-21
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• 1995

A planning support system enhances our ability to use water capacity expansion as an urban growth management strategy. This paper reports the development of capacity expansion modeling of water supply as part of the continuing development of such a planning support system (PEGASUS: Planning Environment for Generation and Analysis of Spatial Urban Systems) to incorporate water supply, This system is designed from the understanding that land use and development drive the demand for infrastructure and infrastructure can have a significant influence on the ways in which land is developed and used. Capacity expansion Problems of water supply can be solved in two ways: 1) optimal control theory, and 2) mixed integer nonlinear programming (MINLP). Each method has its strengths and weaknesses. In this study the MINLP approach is used because of its strength of determining expansion sizing and timing simultaneously. A dynamic network optimization model and a water-distribution network analysis model can address the dynamic interdependence between water planning and land use planning. While the water-distribution network analysis model evaluates the performance of generated networks over time, the dynamic optimization model chooses alternatives to meet expanding water needs. In addition, the user and capacity expansion modeling-to-generate-alternatives (MGA) can generate alternatives. A cost benefit analysis module using a normalization technique helps in choosing the most economical among those alternatives. GIS provide a tool for estimating the volume of demanded water and showing results of the capacity expansion model.

• International Journal of Advanced Culture Technology
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• v.9 no.4
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• pp.18-28
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• 2021

This study surveyed how retirees' evaluation of starting food service business affects the effectiveness their new business and quality of life, based on personal factors such as entrepreneurship and business-starting capability and environmental factors by using questionnaires. Bootstrapping was carried out in order to find out factors affecting rapidly changing new business environments and retirees' initial intent to start a business so as to verify basic hypothesis about relation between retirees' evaluation of starting food service business (social, economic, and psychological effects) and the effectiveness of their new business and quality of life and confirm whether the effectiveness of the new business acts as a medium between the evaluation of starting food service business and quality of life. In addition, PLS-MGA was performed in order to verify whether the correlations among test factors can be varied according to the kind of job the target retirees had. Having examined the basic thesis, it was found that social and economic factors had significant positive effect on the effectiveness of the new business, and social and psychological factors had significant positive effect on the quality of life. Having analyzed whether the effectiveness of new business acted as a media between evaluation of starting food service business and quality of life, there was no significant effect as a medium. Having studied whether the kind of job of the retirees controlled or affected the relations among evaluation of starting food service business, effectiveness of new business and quality of life, the results were as follows: in the office job retiree group, the greater economic factor led to increase of effectiveness of new business, while social and psychological factors influenced the quality of life; In the physical labor group, the higher social factor resulted in higher effectiveness of new business, which showed significant positive effect on the quality of life. Having researched about which element is considered to be most important in starting food service business, the most important element was found to be dish/menu, followed by staff management, accounting management, business management, and service education. Having analyzed relation between accomplishment and important consideration for starting food service business, "managers with entrepreneurship," "appropriate distribution of time to prepare for starting business," and "operation of practical field education programs" showed higher importance compared to the degree of satisfaction, so it is needed to more concentrate on the above matters. This study intends to raise retirees' awareness of starting business and help them live better life based on the analysis results, and further suggest detailed mechanism and specific operations of factors affecting retirees' decision making on starting business, such that they can use the information as basic materials to make better choices that can lead to successful business.

• The Journal of the Korea Contents Association
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• v.22 no.10
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• pp.703-722
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• 2022

The concentration of local businesses in the capital region promotes a decrease in the local population and polarization between the capital region and non-capital regions. It affects the competitiveness of local industries and creates a vicious cycle throughout the local economy, society and culture. Therefore, this study classified the companies in the capital region and non-capital regions by group and examined the effect of the innovation capability factors of companies on the creation of business performance. We analyzed the effects of R&D capabilities, which are elements of innovation capability, and open innovation and convergence capabilities on business performance. Smart PLS 3.0 was used for analysis including direct and indirect mediating and moderating effects, multi-group analysis, and structural equation model analysis. As a result, R&D capability did not have a significant effect on business performance, but it has a positive influence towards business performance through convergence capability and open innovation. However, the effectiveness of open innovation in non-capital regions and convergence capabilities in capital region were not statistically significant. In particular, in terms of open innovation, as the difference between groups is statistically clear, follow-up measures are suggested especially in non-capital regions.