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Important Role of Glutathione in Protecting Against Menadione-Induced Cytotoxicity in Rat Platelets

  • Cho, Youn-Sook;Seung, Sang-Ae;Kim, Mee-Jeong;Lee, Joo-Young;Chung, Jin-Ho-Chung
    • Archives of Pharmacal Research
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    • v.19 no.1
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    • pp.12-17
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    • 1996
  • Our previous studies demonstrate that menadione (MEN) is cytotoxic to platelets of rats by depleting glutathione (GSH). In order to clarify whether GSH has a role in protecting against menadione-induced cytotoxicity, the effect of GSH depletors as well as GSH precusors on menadione-induced cytotoxicity was investigated. Cysteine and dithiothreitol (DTT) prevent MEN-induced cytotoxicity in a dose-dependent manner, as determined by LDH leakage and change in turbidity. When platelets were treated with 1-chloro-2,4-dinitrobenzene (CDNB) and diethylmaleate (DEM), both of which deplete intracellular GSH, MEN-induced cytotoxicity was potentiated in the CDNB-treated paltelets, but not in the DEM-treated platelets. These data suggest that the GSH in platelets plays an important role in protecting against cytotoxicity induced by menadione.

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Care-Oriented Morality : Relationships to Gender and Sex Role Identity (보살핌 지향의 도덕성에 관한 연구 - 성별 및 성역할 정체감과의 관계를 중심으로 -)

  • Kwag, Kyung Hwa;Chung, Ock Boon
    • Korean Journal of Child Studies
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    • v.21 no.2
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    • pp.213-232
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    • 2000
  • This Study investigated the relationships of care-oriented morality to gender and sex role identity in young adults. Care-oriented morality was assessed by the Ethic of Care Interview(ECI) while sex role identity was assessed by the Korean Sex Role Inventory(KSRI) with a sample of 48 men and 42 women between 20 and 35 years of age. The level of care-oriented morality of most of the subjects was Level 2. There was a significant difference between men and women in level of care-oriented morality by both x2 and ANOVA. That is, women averaged and levels 2.5 and 3 while men averaged levels 1 and 1.5. The ANOVA reveled difference in sex role identity types by levels of care-oriented morality on the ANOVA test.

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The Multidimensional Masculinity in Nguyễn Huy Thiệp's Short Stories

  • Van Thuan Nguyen;Anh Dan Nguyen;Van Luan Nguyen
    • SUVANNABHUMI
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    • v.16 no.1
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    • pp.147-173
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    • 2024
  • Nguyễn Huy Thiệp is a pillar in Vietnamese cultural life after the Second Indochina War, and the fates of men and women at the beginning of Đổi mới (Renovation) is one of the prominent themes in his short stories. To show off sexual power, seek glory, and maintain his dominant position, Thiệp's heroes engage in a game of oppressing the weak, hunting animals, and harassing women. However, due to the complex changes in social life, moral values, and gender inequality, men in the postwar period quickly experienced the feeling of humiliation, impotence, and failure. In turn, the sophisticated aspects of masculinity demonstrate the cultural and ethical concerns of contemporary Vietnamese society. By exploring the multidimensional nature of masculinity expressed in Thiệp's stories, this study aims to resolve misconceptions about gender and the relationship between men and women in his work.

Low Systolic Blood Pressure and Mortality From All Causes and Vascular Diseases Among Older Middle-aged Men: Korean Veterans Health Study

  • Yi, Sang-Wook;Ohrr, Heechoul
    • Journal of Preventive Medicine and Public Health
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    • v.48 no.2
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    • pp.105-110
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    • 2015
  • Objectives: Recently, low systolic blood pressure (SBP) was found to be associated with an increased risk of death from vascular diseases in a rural elderly population in Korea. However, evidence on the association between low SBP and vascular diseases is scarce. The aim of this study was to prospectively examine the association between low SBP and mortality from all causes and vascular diseases in older middle-aged Korean men. Methods: From 2004 to 2010, 94 085 Korean Vietnam War veterans were followed-up for deaths. The adjusted hazard ratios (aHR) were calculated using the Cox proportional hazard model. A stratified analysis was conducted by age at enrollment. SBP was self-reported by a postal survey in 2004. Results: Among the participants aged 60 and older, the lowest SBP (<90 mmHg) category had an elevated aHR for mortality from all causes (aHR, 1.9; 95% confidence interval [CI], 1.2 to 3.1) and vascular diseases (International Classification of Disease, 10th revision, I00-I99; aHR, 3.2; 95% CI, 1.2 to 8.4) compared to those with an SBP of 100 to 119 mmHg. Those with an SBP below 80 mmHg (aHR, 4.5; 95% CI, 1.1 to 18.8) and those with an SBP of 80 to 89 mmHg (aHR, 3.1; 95% CI, 0.9 to 10.2) also had an increased risk of vascular mortality, compared to those with an SBP of 90 to 119 mmHg. This association was sustained when excluding the first two years of follow-up or preexisting vascular diseases. In men younger than 60 years, the association of low SBP was weaker than that in those aged 60 years or older. Conclusions: Our findings suggest that low SBP (<90 mmHg) may increase vascular mortality in Korean men aged 60 years or older.

The Influence of Acupuncture from Chosun Dynasty on Japanese Acupuncture Bronze Men in Edo Period - Recently Acquired Dongin K-1, Dongin K-2, and Dongin K-3 are at the Core - (에도시대 동인에 나타난 조선 침구학의 영향 -최근 입수한 동인 K-1과 동인 K-2, 동인 K-3를 중심으로-)

  • Ahn, Sangwoo;Park, Yunghwan
    • Korean Journal of Acupuncture
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    • v.35 no.4
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    • pp.210-225
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    • 2018
  • Objective : This research is aimed to compare the three sets of Dongin(K-1, K-2, K-3) to Chosun and Chinese acupuncture bronze men, and through literature review of acupuncture points and meridians to see how acupuncture of Chosun affected the Japan's acupuncture bronze men. Methods : Using 3D scanning, we compared the location of acupoints by the proportional bone measurement method of the three sets of Dongin to those of Chosun and China. We also compared the meridians and acupuncture points of the three sets of Dongin to Doningyosodo. Results : Dongin K-1 and K-2 have all the unique characteristics of ChimGuemDongIn. Their heads were made about 30% larger than the location of points by the proportional bone measurement method and their necks were shortened to get the right proportion. Their gender was not specified. Their hands were sticking forward, and knees were slightly bent, and the arms and legs were carefully crafted to record acupuncture points. Dongin K-1 and K-2 marked the meridians and acupuncture points according to Doningyosodo. In particular, BL39 in Dongin K-1 and K-2 has been marked as in ChimGeumDongIn, which is considered to have come from DongUiBoGam. These characteristics do not exist in Chinese acupuncture bronze men. The location of points by the proportional bone measurement method was marked on the right side of the Dongin K-3, while the eight extra meridians were marked on the left side. Conclusions : In summary, Dongin K-1 and K-2 indicate the Japanese history of acupuncture which may have influenced from Chosun.

A Study on Traditional Costume of China's Minorities(II) - Centering Around Yunnan Province Minorities - (중국소수민족(中國少數民族)의 민족복식(民族服飾)에 관(關)한 연구(硏究)(II) - 운남성(雲南省)의 소수민족(少數民族)을 중심(中心)으로 -)

  • Kim, Young-Sin;Hong, Jung-Min
    • Journal of Fashion Business
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    • v.3 no.1
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    • pp.65-80
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    • 1999
  • In this study, the researcher studied the historical background and the traditional culture about dress and ornament of Yunnan Province of China. The Results of the study are as follows. 1. In the Past, Derung's dress was very simple due to the influence of various factors, such as geography and history. Men wore shorts and covered diagonally a piece of cloth from left shoulders to right armpits and tied up the two ends on chests. Women covered crisscross two pieces of cloth from both shoulders to knee. 2. Achang people's dress and adornment has its own unique characteristic. Generally, men wear Jackets with buttons down the front and black trousers. Unmarried men like to wear white turbans, while most of married men usually wear dark blue ones. Women usually wear tight-sleeve blouses with buttons down the front and skirts. Unmarried women wear the hair in braids coil them on the top of their heads. They wear short blouses and trousers. Married women wear their hair Into buns and like to entwine black or blue cloth into high trubans. They wear short blouses and knee-length straight skirts. Achang knife enjoys high reputation and has a long history and an exquisite workmanship. All the men like to wear it. 3. The dress and adornment of the Lahu nationality has both the characteristic of farming culture and the style of nomadic culture of early times. Men usually wear short shirts with round necks and buttons down the front, loose-legged trousers, turbans or dark blue cloth caps Women's dress and adornment can be categorized into two styles. One is black cloth gown with buttons diagonally on the right front and waist-length slits on both sides. The edges of fronts and cuffs are edged with Silver ornaments and lace. They also wear trousers. The other is short blouse with round neck and short opening on th right front, straight skirt and colourful leggings with embroidered patterns. 4. The Hani people, men and women, old and young, like black colour and are fond of wearing black clothes. Men usually wear shirts with buttons down the front and trousers, entwining their heads with black or white cloth. The elderly people wear calottes. Women wear cloth blouses, skirts and trousers or shorts. Slight differences exist in the clothing and adornments according to region, branch and age 5. Blang people's dyeing technique with an exquisite method has a long history. Men wear dark blue long sleeve shirts with round necks and buttons down the front or arranged diagonally on the front and loose-legged trousers. Elderly men wear big turbans wdress and adornment varies greatly in different regions. 6. The Lisu people culture of dress and adornment has some unique characteristics. The styles and colours of their dress and adornment differ slightly from place to place. In the Nujiang area, Women wear black velvet Jackets over blouses with buttons arranged diagonally on the right front and long pleated ramie skirts. Men usually wear wraparound ramie gowns, with center vent, made of fabrics alternated with white and black cross stripes. They also wear cloth waistbands and trohile youngsters keep their hair short. Women's users. In the Lushui area, the dress and adornment is similar to that in the Nujing region, but women wear aprons and trousers instead of skirts. 7. The Nu people dress and adornment is simple but elegant Women are proficient in ramie-weaving. Men usually wear gowns With overlapping necks, knee-length trousers and leggings. They like to wear their hair long and entwine dark blue or white turbans. Women wear black and red vests over blouses with buttons arranged diagonally on the right front and ankle-length skirts. They also wear their hair long, make it into braids, and entwine dark blue or colourful cloth turbans. 8. Pumi men usually wear ramie shirts With buttons arranged diagonally on the right front, loose trousers and white sheepskin vests. Some also wear overcoats made of "pulu". Women's dress and adornment varies in different areas. In the Lanping and Weixi regions, women wear white short blouses with buttons arranged diagonally on the front and dark brown embroidered vests. They also wear trousers and blue or black cloth turbans. In the Ninglang and Yongsheng regions, women wear hemmed blouses With buttons arranged diagonally on the right front and drape sheepskin capes. They also wear white pleated skirts and use broad colourful cloth as their waistbands.

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The Knowledge and Attitude of Unmarried Young Men on AIDS (젊은 미혼 남성에서의 에이즈에 대한 지식과 태도)

  • Yeom, Chang-Hwan;Lee, Hye-Ree;Choi, Youn-Seon
    • Journal of Hospice and Palliative Care
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    • v.4 no.1
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    • pp.4-13
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    • 2001
  • Purpose : Since the acquired immune deficiency syndrome (AIDS) was first recognized in the United States in the summer of 1981, the number of these patients has been increasing in the world. But do not find out a cure and a vaccine for ARS (5). And so, the best treatment for AIDS is the prevention. People can find out accurate knowledge about AIDS, and they can prevent themselves from AIDS approximately 100%. In this study, we investigate with AIDS knowledge and attitudes in unmarried young men (<24 age) and suggest accurate preventive education for AIDS and good sexual behaviors. Methods : Un-married young soldiers and college students who were not diagnosed as AIDS until June 30, 2000 were included in the study. The study included a total of 923 men. A self evaluation questionnaire, included questions on 36 items(the part of demographic data - 9; the part of knowledge - 20; the part of attitudes - 8), was drawn up by three physicians. The demographic data, AIDS knowledge and attitudes were analyzed by chi-square analysis, and the total score of AIDS knowledge - comparison according to demographic factors and attitudewere analyzed by one-way ANOVA test. Results : In demographic characteristics, as for the first recognized time of AIDS, most of men knew it when they were in their middle school, as for sources of information on AIDS, most of them knew it through the TV-media, and as for the educational need about AIDS, most of them agreed with it. In AIDS knowledge, mean scores were $14.0{\pm}1.8$ (70.3%). Items of the misconceptions concerning AIDS, reported as less than 50% correct answers, were 6 among 20 items (30%). In AIDS attitudes, as for the item about that if I will be an AIDS patient, I will have an AIDS treatment, it showed that the number of men agreed with 759 (82.2%), and as for the item about that I will help for AIDS patient even though I don't know him, it showed that the number of them agreed with 412 (45.8%). In correlation of AIDS knowledge and demographic factors, the mean scores of knowledge of men with higher than college degree were higher than them of others. The mean scores of knowledge of men with total income of family with more than US$1667 were higher than them of others. The mean scores of knowledge of men with sources of information on AIDS through the TV-media were higher than them of others. And the mean scores of knowledge of men with past medical history of STD(sexually transmitted disease) were higher than them of others. Conclusions : The higher the knowledge he has, the lower the possibility of risk and the more positive the attitude he has. And then we think that the education program for AIDS will be included as a regular part of the curriculum in high school, and young men must be effectively educated by it.

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The Bone Density Level of Korean Men Aged 60 Years and Over, and Its Relevant Factors (60세 이상 노년 한국 남성들의 골밀도 수준 및 관련요인)

  • Kim, Young-Ran;Nam, Hae-Sung;Lee, Tae-Yong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.3
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    • pp.1180-1190
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    • 2013
  • This study is to analyze femoral necks and lumbar spine bone mineral density in Korean men aged 60 or older 2,736 people, as well as to research in its relation to anthropometry, life style, diet, fracture history, family history of osteoporosis and medical history using data from Korea National Health and Nutrition Examination Survey (KNHANES)(the 2nd(2008) and 3rd(2009) year at the 1st survey, and the 1st(2010) year at the 5th survey). To express the strength of the associations, percent differences were calculated from multiple linear regression models using the formula ${\beta}{\times}$(unit/mesnBMD). Unit for continuous variables were chosen to approximate 1 standard deviation(SD). Prevalence of osteoporosis for 60-69, 70-79 and >80 old men were 6.7%, 15.8% and 31.4% respectively. The proportion of osteoporosis calculated for each age group in the femoral neck group was: 60-69 years old, 2.6%, 70-79years old, 8.2%, >80years old, 24.8%. For the lumbar spine group, the values were: 60-69 years old, 5.5%, 70-79years old, 11.3%, >80years old, 15.4%. In men aged 60 or older, lean mass greatly influenced bone density in the femoral neck and lumbar spine. Thus, to increase the lean mass would be an effective way to prevent osteoporosis in elderly men.

A Development of Awareness Scale of Korean Men and Women on Singleness (한국 성인 남녀의 미혼에 대한 인식: 척도개발을 중심으로)

  • Taeyun Jung;Hyejin Jung;Hwari Eun
    • Korean Journal of Culture and Social Issue
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    • v.18 no.1
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    • pp.79-96
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    • 2012
  • The main studying problem of this study is to develop the scale which examines awareness of singleness for Korean men and women. So, firstly, study 1 fulfilled open survey related to condition for solitary life, its strengths and weaknesses and factors disturbing it for 490 unmarried and married people (244 men and 246 women) who are living in Seoul and capital area. And then, content analysis and category analysis were analyzed for their responses. As the result, each questionnaire was divided into economic aspect, relative aspect, characteristic aspect, eco related aspect, family aspect and social system aspect. Study 2 organized questionnaires for condition for solitary life, its strengths and weaknesses based on the material obtained in study 1 and then, exploratory factor analysis was conducted for total 800 adults (400 men and 400 women) who are living in Seoul, capital area, Incheon and Chungnam. As the result, the condition for solitary life extracted 5 factors including ego-maturity factor (24 questionnaires, total explanation quantity: 61.7%), strengths of solitary life extracted 6 factors including self-growth factor(29 questionnaires, total explanation quantity: 61.4 %) and weaknesses of solitary life extracted 6 factors including solitary factor(31questionnaires, total explanation quantity: 64.75 %). For verifying the suitability of the factor structure, as the result of conducting confirmatory factor analysis for 400 people (200 men and 200 women), the suitability of awareness scale model of men and women on singleness was verified. Those results were discussed from the aspect of variables and phenomenon related to singleness and marriage of Korean society.

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Effects of Methadone Maintenance Therapy on Thyroid Function of Adult Men

  • Bozchelou, Shahrzad;Delirrad, Mohammad
    • Toxicological Research
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    • v.35 no.1
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    • pp.9-12
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    • 2019
  • One of the major challenges in methadone maintenance therapy (MMT) for drug dependence is the physiological side effects on endocrine hormones. Because of the key role of the thyroid gland in the normal functioning of the human body and brain, this study examined the effect of MMT on thyroid function. Thyroid hormones (T3, T4, and thyroid-stimulating hormone (TSH)) were evaluated in normal and user treated with MMT who were referred to the Province Clinical & Pathology Center of Urmia, Iran. The study was conducted for three months using the Case Series method. A total of 270 samples were collected, 215 were from individuals who were not treated, whereas 55 were from men treated with methadone. Average levels of T3 and T4 in non-treated sample of men are $1.34{\pm}0.02ng/mL$ and $90.96{\pm}1.38ng/mL$ while the corresponding values for patients treated with methadone are $1.39{\pm}0.04ng/mL$ for T3 and $94.57{\pm}2.72ng/mL$ for T4. Mean TSH levels of the non-treated group and the methadone consuming group were $1.75{\pm}0.08{\mu}IU/mL$ and $3.17{\pm}0.45{\mu}IU/mL$, respectively. These results indicate that although men treated with methadone had higher levels of T3, T4, and TSH than normal individuals, only the difference in TSH level was significant. The importance of this difference among individuals on methadone maintenance programs should be investigated in larger samples over long periods of time. Additionally, the effects of methadone treatment on women should be examined.