• Korean Journal of Clinical Pharmacy
• /
• v.1 no.1
• /
• pp.15-21
• /
• 1991

This study was attempted to investigate the dissolution rate and bioavailability of commercially available furosemide preparations. A. B. and C. The dissolution test was conducted in an artificial gastric juice using the basket method. and furosemide (40 mg) was administered orally to 8 normal volunteers by cross-over design. The results were as follows: the AUC and dissolution rate in 100 min ($D_{100\;min}$) were higher in order of preparations. A > C > B. But the peak concentration. time to reach peak concentration $(T_{max})$, and mean dissolution time (MDT) were in order of preparations. C > A > B. There were significantly linear correlations between the AUC and the $D_{100\;min}$, and between the $T_{max}$ and the MDT. From the results of this experiment. it can be concluded that commercially available preparations bioavailability of furosemide, which may be predicted from the dissolution rate.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.2 no.2
• /
• pp.39-43
• /
• 2001

This paper aims to manufacturing of connecting rod die using CAD/CAM systems. CAD/CAM systems are consist of CAD(MDT4.0), CAM(Z-MASTER) software and CNC milling machine. CAM software is purpose to G-code generation for CNC programming. Then CAM software and CNC milling machine are connect to RS-232-C cable for data network.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.05a
• /
• pp.78-78
• /
• 2002

Microsomal epoxide hydrolase (mEH), an epoxide detoxifying enzyme and putative cell surface autoantigen, is inducible by xenobiotics and by certain pathophysiological conditions. The present study was designed to determine mEH expression in H4IIE cells during cell death initiated by sulfur amino acid deprivation (SAAD) and to identify the signaling pathway for the enzyme induction.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.11b
• /
• pp.144-144
• /
• 2002

Ceramide, formed by sphingomyelinase, is involved in the expression of cyclooxygenase-2 (COX-2). This study examines the effect of C2-ceramide (C2), a cell-permeable ceramide analog, on the LPS-inducible COX-2 expression and signaling pathways.(omitted)

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.24 no.10
• /
• pp.1398-1401
• /
• 2020

We present the concept of a Medical Digital Twin (MDT) that can predict and analyze medical diseases using computer simulations and introduce a dynamic virtual body capture system to create it. The MDT is a technology that creates a 3D digital virtual human body by reflecting individual medical and biometric information. The virtual human body is composed of a static virtual human body that reflects an individual's internal and external information and a dynamic virtual human body that reflects his motion. Especially we describe an early version of the dynamic virtual body capture system that enables continuous simulation of musculoskeletal diseases.

• Journal of Korean Neurosurgical Society
• /
• v.40 no.3
• /
• pp.143-147
• /
• 2006

Objective : Brachial plexus injury can produce a intractable chronic neuropathic pain. This study was undertaken to assess the long term outcome of microsurgical dorsal root entry zonotomy[MDT]. Methods : Between October 1997 and December 2002, 21 patients received MDT because of a intractable pain resulting from brachial plexus injury. Of these, 19 patients were followed for more than 2 years. Fourteen of 19 patients were male and patient ages ranged from 22 to 69 years. Mean pain duration was 36.8 months and all patients had severe pain of $9{\sim}10$ visual analogue scale. To achieve complete destruction of abnormal dorsal horns, thermocoagulation of the posterolateral sulcus were performed and careful gluing was done to prevent postoperative adhesion and pain recurrence. Results : Of the 19 patients, 15 patients had excellent [>75% reduction in pain] and good [$51{\sim}75%$ pain relief] results in a average postoperative period of 4.1 years. One patient had a poor [less than 25% pain relief] result. Three patients were considered to have a fair result [$26{\sim}50%$ pain relief]. Postoperative complications were 2 transient ipsilateral ataxia and 1 CSF fistula that resolved without surgical revision. Conclusion : These results indicate that MDT provides excellent long-term pain relief in medically intractable chronic neuropathic pain following brachial plexus injury without significant complications.

• KIPS Transactions on Software and Data Engineering
• /
• v.9 no.1
• /
• pp.17-24
• /
• 2020

The traveling salesman problem is an algorithmic problem tasked with finding the shortest route that a salesman visits, visiting each city and returning to the started city. Due to the exponential time complexity of TSP, it's hard to implement on cases like amusement park or delivery. Also, TSP is hard to meet user's demand that is associated with multi-dimensional attributes like travel time, interests, waiting time because it uses only one attribute - distance between nodes. This paper proposed Top-n Skyline-Multi Dimension TSP to resolve formerly adverted problems. The proposed algorithm finds the shortest route faster than the existing method by decreasing the number of operations, selecting multi-dimensional nodes according to the dominance of skyline. In the simulation, we compared computation time of dynamic programming algorithm to the proposed a TS-MDT algorithm, and it showed that TS-MDT was faster than dynamic programming algorithm.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.14 no.4
• /
• pp.195-204
• /
• 2009

In order to estimate sea surface current fields in the East Sea, we examined characteristics of mean dynamic topography (MDT) fields (or mean surface current field, MSC) generated from three different methods. This preliminary investigation evaluates the accuracy of surface currents estimated from satellite-derived sea level anomaly (SLA) data and three MDT fields in the East Sea. AVISO (Archiving, Validation and Interpretation of Satellite Oceanographic data) provides a MDT field derived from satellite observation and numerical models with $0.25^{\circ}$ horizontal resolution. Steric height field relative to 500 dbar from temperature and salinity profiles in the East Sea supplies another MDT field. Trajectory data of surface drifters (ARGOS) in the East Sea for 14 years provide another MSC field. Absolute dynamic topography (ADT) field is calculated by adding SLA to each MDT. Application of geostrophic equation to three different ADT fields yields three surface geostrophic current fields. Comparisons were made between the estimated surface currents from the three different methods and in-situ current measurements from a ship-mounted ADCP (Acoustic Doppler Current Profiler) in the southwestern East Sea in 2005. For offshore areas more than 50 km away from the land, the correlation coefficients (R) between the estimated versus the measured currents range from 0.58 to 0.73, with 17.1 to $21.7\;cm\;s^{-1}$ root mean square deviation (RMSD). For coastal ocean within 50 km from the land, however, R ranges from 0.06 to 0.46 and RMSD ranges from 15.5 to $28.0\;cm\;s^{-1}$. Results from this study reveal that a new approach in producing MDT and SLA is required to improve the accuracy of surface current estimations for the shallow costal zones of the East Sea.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.9 no.4
• /
• pp.739-744
• /
• 2005

For the structure of AVLS is required to the GPS-MDT for realtime acquisition the position reporting of vehicle and traffic management S/W. It is necessary that the MODEM using VHF transceiver base on GPS and monitoring program for display base on GIS the traffic status by vehicles position report in management system. The other wise, vehicles among management system that is required the automatic communications protocol for GPS information and mobile's ID. In his paper have studied the VHF modem for transmission the voice and data at same time and S/W for management system using GIS-tool.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.13 no.5
• /
• pp.65-70
• /
• 2013

In this paper, we propose a multi-hop cooperative transmission protocol to obtain energy savings in static wireless networks. Each terminal in the network is equipped with a single antenna and each receiver uses equal gain combining technique (EGC) to combine received signals. We also propose a power allocation strategy which optimizes the total transmit power at each stage. Monte-Carlo simulations are presented to evaluate and compare performance of the proposed protocol with the multi-hop direct transmission (MDT) and the cooperative routing protocol proposed by Khadani [8], in terms of the average total transmit power and the average number of required stages.