• 대한기관식도과학회지
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• 제4권1호
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• pp.73-78
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• 1998

The mutation of p53 is the most common genetic alteration found in human cancers and has oncogenic properties. mdm-2 is a recently discoverd that controls the p53 activity by binding of its protein, so negative feedback loop has been suggested in which p53 induces mdm-2 expression. The purpose of this study was to analyze the expression of p53 in leukoplakias, mdm-2 in squamous cell carcinomas, and relationship between p53 and mdm-2 expression in leukoplakias and squamous cell carcinomas. The results were as follows : 1) The p53 was expressed 33.4% in leukoplakias 2) The mdm-2 was expressed 8.3% in leukoplakias and 22.7% in squamous cell carcinomas. 3) The expression rate of p53 was higher in specimens negative for mdm-2 than in specimens positive for mdm-2, but there was not significant relationship between p53 and mdm-2 expression. In conclusion p53 was thought to participate in early phase of oncogenesis, and mdm-2 was thought to have a role as a oncogene in squamous cell carcinoma of head and neck. Though there was not significant relationship between p53 and mdm-2 expression, mdm-2 was thought to inhibit p53 activity.

• Journal of Information Technology Applications and Management
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• 제20권1호
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• pp.1-17
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• 2013

It has been found that users' characteristics are important variables that explain information systems adoption. These user groups, which are called COIs (Community Of Interests), might show different behaviors to each other to the same information system. We study differences in MDM (master data management) system adoption between military users and SI developers using TAM (Technology Acceptance Model). In case of military users, the perceived usefulness of an MDM system does not have impacts on intention to use an MDM system. Only the ease of use of an MDM system has impacts on intention to use an MDM system. However, in case of SI developers, both the perceived usefulness and the ease of use of an MDM system have impacts on intention to use an MDM system, which are similar to findings in previous studies. These results might be interpreted that users do not pay much attention to the usefulness in adopting a new information system in a centralized organization. They are obligated to use an information system whether it is useful or not. Thus the ease of use has more impacts on users than the usefulness.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3295-3300
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• 2016

Background: Different types of cancer exhibit abnormalities in cell cycle regulators. The murine double minute-2(MDM2) cell cycle regulator is a proto-oncogene that negatively regulates the P53 tumour suppressor gene. Surface epithelial tumours constitute approximately two thirds of ovarian neoplasms. Each histologic type can be classified as benign, borderline and malignant. This study aimed to examine immunohistochemical expression of the MDM2 protein in ovarian serous and mucinous epithelial tumours (benign, borderline and malignant). Materials and Methods: This study included forty five ovarian tumours, subdivided into fifteen cystadenomas (5 serous and 10 mucinous), fifteen borderline tumours (11 serous and 4 mucinous) and fifteen cystadenocarcinomas (9 serous and 6 mucinous). Paraffin sections were stained with haematoxylin and eosin for histopathologic study, and with mouse monoclonal anti-MDM2 antibody for immunohistochemistry. Results: MDM2 positivity was detected in 28.9% of the studied ovarian tumours. All benign tumours were negative and positivity was significantly higher in malignant than borderline tumours (P value of chi-square test =0.000). Significantly, all MDM2 positive mucinous tumours were malignant with no positive mucinous borderline tumours. Malignant tumours showed positive MDM2 expression in 83.3% of mucinous type and in 55.6% of serous type. Borderline serous tumours showed negative MDM2 in 72.7% of cases (P value of Z test =0.04). Conclusions: Alterations in the expression of the cell cycle regulator (MDM2) occur early in the process of tumourigenesis in serous and mucinous ovarian tumours. We suggest that MDM2 may be used in those tumours as a marker for risk stratification and identification of cases with cancer development and progression. We recommend further studies on MDM2 immunohistochemistry, in conjunction with adjuvant methods as DNA ploidy and FISH gene amplification, focusing on the mucinous tumours and differentiating between the three tumour categories, benign, borderline and malignant.

• 디지털융복합연구
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• 제9권6호
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• pp.355-368
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• 2011

네트워크중심전(NCW: Network Centric Warfare) 환경 하에서 효과적인 전쟁수행을 위해서는 각종 시스템 간 데이터 공유가 필수적이며, 이를 위해서는 국방아키텍처(MND-EA) 고도화 및 국방 통합정보관리소 구축 등과 연계한 데이터 공동 활용을 위한 표준화와 통합관리 등이 필요하다. 본 연구의 목적은 현재 각 기관에서 주요 이슈로 등장하고 있는 데이터 공동 활용을 위한 마스터 데이터관리(Master Data Management: MDM)를 국방 분야에 도입하기 위해 기술수용모델을 활용하여 사용자의 이용의도에 영향을 미치는 요인들을 분석하고자 하였다. 또한 현재 총괄적인 기업 형태에 따라 보편적으로 적용되고 있는 가트너사(社)의 MDM 구현아키텍처를 대상으로 국방 업무환경과 특성을 고려한 선호아키텍처를 선정하고 이용의도에 미치는 영향을 분석함으로서 효과적인 국방 MDM(MND-MDM) 구축 방안을 제안하고자 한다. 자료조사는 국방정보화 시스템의 개발 및 유지보수와 자료를 관리하는 정 보화분야 담당자들과 국방정보시스템 개발 사업경험을 가진 주요 SI업체의 국방사업팀 담당자들을 대상으로 2011년 9월 19부터 10월 7일까지 3주간에 걸쳐 실시하였다.

• 한국인터넷방송통신학회논문지
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• 제23권6호
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• pp.171-177
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• 2023

중앙 통제 서버 없이 앱만으로 MDM 서비스를 구성하는 경우, 보안 통제가 필요한 직장의 위치 정보를 MDM 앱에 내장하여 배포함으로써 직장의 보안 영역과 충분히 떨어진 지역에서는 GPS 신호를 기반으로 보안 통제를 해제할 수 있도록 하는 방식이 일반적으로 적용되고 있다. 본 연구에서는 직장 등 특정 구역의 위치 정보를 MDM 앱에 내장하여 배포하지 않고 배포된 앱에서 각 개인이 자신에게 필요한 보안 통제구역의 위치 정보를 직접 입력하여 설정 정보로써 유지하는 방식을 제안하였다. 본 연구에서 제안한 방법을 통해 MDM 서비스의 보편성과 호환성을 향상하여 구축 비용을 최소화할 수 있으며, 추가적인 기능 구현을 통해 보안 통제 수준 또한 향상할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2707-2712
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• 2015

Background: The human homologue of the mouse double minute 2 (MDM2) gene is a negative regulator of Tp53. MDM2-309T>G a functional promoter polymorphism was found to be associated with overexpression thereby attenuation of Tp53 stress response and increased cancer susceptibility. We have planned to evaluate the possible role of MDM2-309T>G polymorphism with risk and response to chemotherapy in AML. Materials and Methods: A total of 223 de novo AML cases and 304 age and sex matched healthy controls were genotyped for the MDM2-309T>G polymorphism through the tetra-primer amplification refractory mutation system (ARMS)-PCR method. In order to assess the functional relationship of -309T>G SNP with MDM2 expression level, we quantified MDM2 mRNA in 30 primary AML blood samples through quantitative RT-PCR. Both the (-309T>G) genotypes and the MDM2 expression were correlated with disease free survival (DFS) rates among patients who have achieved complete remission (CR) after first induction chemotherapy. Results: MDM2-309T>G polymorphism was significantly associated with AML development (p<0.0001). The presence of either GG genotype or G allele at MDM2-309 confered 1.79 (95% CI: 1.12-2.86; p<0.001) and 1.46 fold (95%CI: 1.14-1.86; p= 0.003) increased AML risk. Survival analysis revealed that CR+ve cases with GG genotype had significantly increased DFS rates (16months, p=0.05) compared to CR+ve TT (11 months) and TG (9 months) genotype groups. Further, MDM2 expression was also found to be significantly elevated in GG genotype patients (p=0.0039) and among CR+ve cases (p=0.0036). Conclusions: The MDM2-309T>G polymorphism might be involved in AML development and also serve as a good prognostic indicator.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1057-1060
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• 2016

Background: The tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of 53. Therefore, this study aimed to determine the role of the Mdm2 SNIP 309 polymorphism in the gastric mucosal morphological patterns in patients with Helicobacter pylori associated gastritis. Materials and Methods: A prospective cross-sectional study was carried out from November 2014 through November 2015. Biopsy specimens were obtained from patients and infection was proven by positive histology. Gastric mucosa specimens were sent to the Molecular Genetics Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 polymorphism using the real-time PCR hybridization probe method. The results were analyzed and correlated with gastric mucosal morphological patterns by using C-NBI endoscopy. Results: A total of 300 infected patients were enrolled and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygosity correlated with type 1 to type 3 gastric mucosal morphological patterns (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with type 4 and type 5 (P<0.01). Conclusions: Our study finds the frequency of Mdm2 SNIP309 G/G in a Thai population is very low, and suggests that this can explain ae Thailand enigma. Types 1 to type 3 are the most common gastric mucosal morphological patterns according to the unique genetic polymorphism of MDM2 SNIP 309 in the Thai population.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7781-7784
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• 2015

Background: The commonly held view of the tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of p 53. Therefore, this study aimed to determine the correlation between the patterns of Mdm2 SNIP 309 and the inflammation grading of Helicobacter pylori associated gastritis in a Thai population. Materials and Methods: A cross-sectional study was carried out from November 2014 through June 2015. Biopsy specimens were obtained from infected patients and infection was proved by positive histology. The gastric mucosa specimens were sent to the Molecular Genetic Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 using the real-time PCR hybridization probe method. The results were analyzed and compared with the Updated Sydney classification. Results: A total of 100 infected patients were interviewed and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous correlated with mild to moderate inflammation (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with severe inflammation (P<0.01). Conclusions: Our study found the frequency of Mdm2 SNP309 G/G in our Thai population to be very low, and suggests that this can explain to some extent the low incidence of severe inflammation and gastric cancer changes in the Thai population. Mild to moderate inflammation are the most common pathologic gradings due to the unique genetic polymorphism of Mdm2 SNIP 309 in the Thai population.

• 한국식품과학회지
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• 제13권3호
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• pp.176-180
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• 1981

국내의 산란노계와 브로일러로부터 생산(生産)된 수동발골육(HDM) 및 기계발골육(MDM)을 여러가지 비율(比率)로 배합(配合)하여 제조(製造)한 치큰 패티와 프랑크푸르트 소시지의 특성(特性), 보존성(保存性), 기호성(嗜好性)을 평가(評價)하였던 바 다음과 같은 결과(結果)를 얻었다. 1. HDM을 사용한 치큰 패티의 TBA시험에 의한 지방산패도는 냉동저장중 계속 증가하였으나 8주(週)까지는 보존성이 양호(良好)였다. 2. 치큰 패티의 색(色)과 기호성(嗜好性)에 있어 MDM을 50%까지 첨가한 것이 가장 우수하였고 50%까지도 양호(良好)하였으나 70%이상 첨가는 권장할 수 없었다. 3.프랑크푸르트 소시지의 제조에 있어 MDM을 50%까지 첨가한 것의 기호성이나 조직적 특성은 HDM으로만 만든 제품과 비등하게 양호(良好)하였으나 70% 이상 첨가한 것은 불량(不良)하였다. 4. MDM을 함유(含有)한 프랑크푸르트 소시지의 보존성(保存性)은 $4^{\circ}C$에서 4주까지 무난하였으며 저장 기간에 따른 TBA 값의 변화는 거의 없었다. 5. 결론적으로 치큰 패티나 프랑크푸르트 소시지등의 육제품(肉製品) 제조에 있어서 MDM을 총원료육의 $30{\sim}35%$까지 첨가하여도 조직이나 기호성이 우수한 제품을 생산(生産)할 수 있었다.

• 산업경영시스템학회지
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• 제32권4호
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• pp.38-44
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• 2009

본 연구는 BPR(Business Process Reengineering)을 이루기 위한 가장 근본적이고 중요한 정보의 통합관리로써 MDM(Master Data Management)이라는 기준정보 관리 체계를 제시하였으며, 효과를 산출하기 위하여 국내의 글로벌 A 기업이 수행한 MDM 시스템을 분석하였다. 인사 및 고객 정보 위주로만 사용되었던 MDM을 제품 생산에 직접적으로 연관된 장비와 자재 부문까지 확장시켜 전사적으로 기업을 관리할 수 있는 정보 관리 체계의 효과를 분석하는 것이 본 연구의 목적이다. MDM은 전사의 가치 있는 기준정보를 명확히 정의하고 이를 하나의 데이터 시스템에서 관리하여 정보의 품질과 객관성을 유지시키는 동시에 기업환경에 맞춰 생성 및 수정을 하여 현실성을 유지시킨다. 또한 중앙 분산식 데이터 시스템을 사용함으로써 기준정보를 만들어 내거나 또는 사용하는 모든 정보시스템은 MDM을 거친 정보를 제공받음으로써 데이터의 적합성과 신뢰성을 보장받는다.