• Toxicological Research
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• v.24 no.1
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• pp.45-49
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• 2008

Formaldehyde has been identified as the most prevalent cause of sick building syndrome (SBS), which has become a major social problem, especially in developing urban areas. However, studies on the molecular mechanisms associated with formaldehyde toxicity have been limited, probably because it is difficult to relate the experimental results obtained from in vitro studies to human exposure in vivo. Using polymerase chain reaction-based suppression subtractive hybridization, we recently identified 27 different formaldehyde-inducible genes including platelet-derived growth factor receptor alpha gene (PDGFRA) and mouse double minute 2 (MDM2) gene which were increased significantly in both formaldehyde-exposed human trachea cells, 680.Tr, and rat tracheas. To establish a possible relationship between induction of these formaldehyde-inducible genes and symptoms of SBS, we examined expression levels of these genes in peripheral lymphocytes of residents of new apartments. Here, we report that the expression of PDGFRA and MDM2 transcripts was significantly higher in peripheral blood lymphocytes obtained from 15 residents in new buildings than in seven control individuals. Our results suggest that the elevated levels of PDGFRA and MDM2 may be associated with the formaldehyde-induced pathophysiology that is closely related with SBS, and that they deserve evaluation as potential biomarkers for formaldehyde intoxication.

• Journal of Digital Convergence
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• v.8 no.4
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• pp.73-82
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• 2010

Auto-industry is very difficult to standardize item code generation rule, because it has more than 20,000 parts in this industry. As finished good companies have already used the ERP system such as SAP, they have a good Master Data Management(MDM) system. However, since many supplier companies have poor MDM system, they have a lot of barriers on system implementation like ERP, MES. PDM systems. This study surveys various benchmarking sites and investigates the standardization of item code of the auto-parts manufacturing companies. Finally, this study proposes the implementation guide (IMG) of auto-industry MDM standardization.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.888-890
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• 2015

많은 개발자가 참여하는 대형 소프트웨어 시스템 개발의 효율성 증대를 위해서는 컴포넌트 간 인터페이스의 효과적인 관리가 필수적이다. MDMS는 컴포넌트간의 인터페이스 정의 및 변경 이력 관리, 인터페이스 기술서 자동 생성, 소스 코드 자동 생성 등의 기능을 제공하는 도구이다. 한화탈레스는 1998년 MDMS를 처음 개발하여 적용한 이후 다양한 국방 소프트웨어 시스템 개발에 적용하여 소프트웨어 개발 생산성 향상에 효과를 보았다. 하지만, MDMS를 다양한 프로젝트에 적용하는 과정에서 최초 개발시 고려하지 못했던 여러 문제점 및 한계를 발견하였다. 이러한 문제점 및 한계는 다양한 프로젝트의 특성 지원 미흡, 형상관리 및 유지보수 문제, 프로젝트 간 메시지 재사용 미지원, 취약한 보안 등 이다. 본 논문에서는 이를 해결하기 위하여 네가지 개선방안을 제시한다. 첫 번째, 다양한 프로젝트에 적용이 가능한 유연한 SW 구조로 개선해야 한다. 두 번째, 통일되고 일관된 형상관리와 함께 전담 개발 및 유지보수 조직이 필요하다. 세 번째, 프로젝트간 메시지의 재사용 지원을 위한 방안으로 프로젝트 별 MDMS 운용이 아닌 통합된 MDMS의 운용이 필요하며, 그를 통하여 다른 프로젝트의 인터페이스 정의를 상호 참조할 수 있는 구조를 적용해야 한다. 마지막으로, 외부 협력업체와의 협업을 위한 보안 대책을 수립하고, 관련 보안 기능을 지원하여 사외의 협력업체의 개발자가 직접 MDMS에 접속하여 개발할 수 있도록 개선해야 한다.

• Radiation Oncology Journal
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• v.25 no.4
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• pp.193-200
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• 2007

Purpose: This study evaluated the pretreatment expression patterns of MDM2, p53, and pRb proteins to determine if the expression patterns could predict the outcome of concurrent chemoradiotherapy (CCRT) for esophageal squamous cell carcinoma and aid in the decisions for the selection of treatment modalities. Materials and Methods: Fifty-one patients that were treated with definitive chemoradiotherapy for stage $I{\sim}IVa$ esophageal squamous cell carcinoma were selected for this study. Radiotherapy was administered with daily $1.8{\sim}2\;Gy$ fractions up to a median dose of 54 Gy for primary tumors, and with four cycles of cisplatin/5-fluorouracil chemotherapy that was administered every 4 weeks, the first two cycles of which were administered concurrently with radiotherapy. Expression of MDM2, p53, and pRb was investigated by immunohistochemical analysis using pretreatment biopsy specimens. Results: MDM2, p53, and pRb were detected with high immunoreactivity in 19.6%, 27.5%, and 66.7% of the patients, respectively. However, there was no significant correlation between expression of these factors and clinical outcome. By the use of multivariate analysis with nine covariates-age, tumor location, tumor length, stage, pathological response, clinical response, MDM2 expression, p53 expression, and pRb expression, only pathological response and stage were significant factors for cause-specific survival. Conclusion: Expression of MDM2, p53, and pRb was not found to be clinically significant for predicting outcomes after CCRT in this study. Further studies with a larger patient population and longer follow-up periods are needed to re-evaluate the expression pattern and to identify new predictors for CCRT response.

• Journal of the Korean Institute of Telematics and Electronics
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• v.22 no.3
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• pp.16-22
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• 1985

In this paper a new algorithm named modified delta modulation (MDM) for encoding filter coefficients is proposed. And this paper presents the designing method of multiplier less FIR filters rosin영 Proposed MDM a19orithm. In the delta modulation (DM) system the quantiaation levels consist of two levels $\pm$1, but in newly proposed MDM algorithm quantization levels are extended to many levels 0, $\pm$2$^n$, n=0, 1, 2... It is recognized by the result of computer simulations that frequency response of multi-plierless FIR filters designed by MDM algorithm is relatively good. And comparing with con-ventional FIR filters on the number of hardware devices, this filter needs a little increased memory, but regardless of filter order it needs only one multiplier which is used for signal scaling.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4327-4330
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• 2012

The mouse double minute 2 (MDM2) gene plays a key role in the p53 pathway, and the SNP 309T/G single-nucleotide polymorphism in the promoter region of MDM2 has been shown to be associated with increased risk of cancer. However, no consistent results were found concerning the relationships between the polymorphism and prostate cancer risk. This meta-analysis, covering 4 independent case-control studies, was conducted to better understand the association between MDM2-SNP T309G and prostate cancer risk focusing on overall and subgroup aspects. The analysis revealed, no matter what kind of genetic model was used, no significant association between MDM2-SNP T309G and prostate cancer risk in overall analysis (GT/TT: OR = 0.84, 95%CI = 0.60-1.19; GG/TT: OR = 0.69, 95%CI = 0.43-1.11; dominant model: OR = 0.81, 95%CI= 0.58-1.13; recessive model: OR = 1.23, 95%CI = 0.95-1.59). In subgroup analysis, the polymorphism seemed more likely to be a protective factor in Europeans (GG/TT: OR = 0.52, 95%CI = 0.31-0.87; recessive model: OR = 0.58, 95%CI = 0.36-0.95) than in Asian populations, and a protective effect of the polymorphism was also seen in hospital-based studies in all models (GT/TT: OR = 0.74, 95%CI = 0.57-0.97; GG/TT: OR = 0.55, 95%CI = 0.38-0.79; dominant model: OR = 0.69, 95%CI = 0.54-0.89; recessive model: OR = 0.70, 95%CI = 0.51-0.97). However, more primary studies with a larger number of samples are required to confirm our findings.

• Genomics & Informatics
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• v.18 no.1
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• pp.9.1-9.5
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• 2020

Ulcerative colitis is a form of inflammatory bowel disease characterized by chronic inflammation of the colon and rectum. The abnormal lesions in the digestive system caused by ulcerative colitis and intermittent colitis are of major clinical importance. MDM2 is a phospho-protein that functions as a ubiquitin ligase for p53. Recently, a T>G substitution in the promoter of the MDM2 gene (rs309) has been identified. In this case-control study, 174 ulcerative colitis biopsy samples and 82 control samples were collected from colonoscopy centers, hospitals, and clinics in Mazandaran and Gilan Provinces in Iran from October 2014 to May 2015. This MDM2 polymorphism was investigated in DNA samples (extracted from biopsy samples) by amplification-refractory mutation system polymerase chain reaction. The mean age of patients with ulcerative colitis was 46.5 years (range, 28 to 69 years) and that of control individuals was 45.3 years (range, 26 to 71 years). Seventy-eight patients (44.82%) were men and 96 (55.18%) were women. The distribution of the TT, TG, and GG genotypes was 17.93%, 27.59%, and 34.48%, respectively, in the ulcerative colitis patients and 31.70%, 24.40%, and 43.90%, respectively, in the control individuals (odds ratio of GG for ulcerative colitis, 7.142; 95% confidence interval, 2.400 to 9.542; p = 0.001). It was found that a single-nucleotide polymorphism at rs309 in the MDM2 gene was associated with ulcerative colitis. A direct relationship was found between age and ulcerative colitis, while no relationship was found with sex. This finding is of note because the occurrence of intestinal inflammation and subsequent ulcers can precede the development of cancer.

• The Journal of the Korea Contents Association
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• v.16 no.2
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• pp.243-250
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• 2016

Recently, with the rise of the mobile device, from mobile devices the user who owns the security, speed up the implementation of the guarantee management environment as businesses and individual equipment for the effcient management of the existing system, but the introduction of the MDM MDM App management features administrators to register the App until you can't prvent the security threat. Therefore, this paper addresses these issues in order to improve the security of your application for the control system. The proposed system is a function of the MDM authentication technology to design analysis, and system architecture to help prevent information disclosure within the design and implementation of Mobile-based application control system. Implementation of the control system to assess the security of the international common criteria security evaluation complete the test scenarios on the basis of the test items. An average of 40% of the test results to verify the results of this enhanced security.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2841-2846
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• 2012

Background: Many studies have investigated the association between the MDM2 promoter SNP309 T/G polymorphism and liver cancer risk, but inconsistencies make drawwing definitive conclusions difficult. Methods: We therefore searched main databases for articles relating MDM2 SNP309 T/G polymorphism to risk of liver cancer in humans and estimated summary odds ratio (OR) with 95% confidence intervals (95% CI) to assess the possible association in a meta-analysis. Results: The main analysis revealed no significant heterogeneity, and the pooled ORs of fixed-effects were all significant (for G versus T, OR = 1.59, 95% CI 1.42-1.78; for GG versus TT, OR = 2.45, 95% CI 1.93-3.12; for GT versus TT, OR = 1.70, 95% CI 1.38-2.09; for GG versus GT, OR = 1.49, 95% CI 1.24-1.79; for GG and GT versus TT, OR = 1.95, 95% CI 1.61-2.38; for GG versus TT and GT, OR = 1.73, 95% CI 1.46-2.07). Subgroup analyses by ethnicity and sensitivity analyses both showed associations to remain significant. Conclusion: The present meta-analysis of available data showed a significant association between the MDM2 SNP309 T/G polymorphism and liver cancer risk, the MDM2 SNP309 G allele contributing to increased risk in both Asians and Caucasians in a graded, dose-dependent fashion.

• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.396-403
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• 2017

Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic cell death is triggered. Inhibiting the ubiquitination of p53 under conditions where DNA damage has occurred is therefore crucial for preventing the development of cancer, because if cells with severely damaged genomes are not removed from the population, uncontrolled growth can result. However, questions remain about the cellular mechanisms underlying the regulation of p53 stability. In this study, we show that p53-inducible gene 3 (PIG3), which is a transcriptional target of p53, regulates p53 stability. Overexpression of PIG3 stabilized both endogenous and transfected wild-type p53, whereas a knockdown of PIG3 lead to a reduction in both endogenous and UV-induced p53 levels in p53-proficient human cancer cells. Using both in vivo and in vitro ubiquitination assays, we found that PIG3 suppressed both ubiquitination- and MDM2-dependent proteasomal degradation of p53. Notably, we demonstrate that PIG3 interacts directly with MDM2 and promoted MDM2 ubiquitination. Moreover, elimination of endogenous PIG3 in p53-proficient HCT116 cells decreased p53 phosphorylation in response to UV irradiation. These results suggest an important role for PIG3 in regulating intracellular p53 levels through the inhibition of p53 ubiquitination.