• Journal of Korean Medicine for Obesity Research
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• v.22 no.1
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• pp.30-37
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• 2022

Objectives: Adipogenesis is the process by which pre-adipocytes are differentiated into adipocytes. It also plays an important role in adipocyte formation and lipid accumulation. Ranunculus sceleratus (R. sceleratus) extracts are used for the treatment of various diseases such as hepatitis, jaundice, and tuberous lymphadenitis in oriental medicine. However, its effect on adipogenesis has not yet been studied. In this study, we investigated the effects of R. sceleratus on adipogenesis in 3T3-L1 cells. Methods: Cells were treated with 50, 100, and 200 ㎍/ml of R. sceleratus and cell viability was evaluated. To differentiate the 3T3-L1 preadipocytes, a 3-isobutyl-1-methylxanthine, dexamethasone, and insulin (MDI) solution were used. The accumulation of lipid droplets was determined by Oil Red O staining. The expression levels of adipogenesis-related proteins were also determined. Results: MDI solution differentiated the preadipocytes into adipocytes and accumulation of lipids was observed in the differentiated 3T3-L1 cells. Interestingly, the amount of lipid droplets was reduced after R. sceleratus treatment. In addition, the expression levels of key adipogenic transcription factors, such as CCAAT/enhancer-binding proteins-𝛼 (C/EBP-𝛼) and peroxisome proliferator-activated receptors-𝛾 (PPAR-𝛾) were also reduced after R. sceleratus treatment. Furthermore, R. sceleratus increased AMP-activated kinase (AMPK) phosphorylation and decreased sterol regulatory element-binding protein-1 expression. Conclusions: Our results showed that R. sceleratus reduced preadipocyte differentiation by inhibiting C/EBP-𝛼 and PPAR-𝛾 levels via the AMPK pathway. Therefore, we suggest that R. sceleratus may be potentially used as an anti-adipogenic agent.

• The Inventors News
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• no.54
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• pp.1-16
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• 2007

한국여성경제단체연합, 여성경제계 위해 공식 출범/발행인 칼럼/'마드리드 출원제도' 적극 활용 상표 침해 줄여라/일본 특허출원 심사기간 단축된다/기업.연구소 신입사원75%, 특허 관련 지식 전무/'주몽'이계인 씨 산자부 홍보대사 위촉/특허등록세, 신청 다음날 내도 된다/특허청, 6시그마 공공부문 혁신 주도/아듀 2006 한국여성발명협회 결산/자문위원 칼럼/로봇시장에도 브랜드 선점 열풍/농산물도 발명특허 상표 등록 시대/도소매업도 서비스업으로 출원 가능/기름대신 물 사용한 자동차, 항공기 현실화/반도체 배선 기술 특허 출원 상승세/자동차는 모바일 엔터네이너/'적외선 감지기술' 우리 생활속으로/서울반도체.바론테크, 일본 특허분쟁 승소/하나TV, 특허권 침해 피소/삼성전자, 분쟁.경쟁 대응위해 특허조직 통합/신한다이아몬드 일본 MDI 특허분쟁 승소/미니인터뷰/나노기술 응용한 디스플레이 특허출원 급증/미국의 두 배인 '휴면 특허', 대책 마련 시급/특허법원 "사용횟수 적다고 상표취소 못해"/종자번식 유전자 변형식물도 특허출원 가능/변리사 1차 시험 합격자 대폭 축소/역사 속의 발명품/하루 10분 발명교실/특허Q&A/신년인터뷰/화장하는 방법도 특허 받는다/'취업에서 결혼까지' 올인원 시스템 화제/아이디어 착상 및 발명 기법/아줌마의 힘이 발휘될 때까지 발명 또 발명/버뱅크의 식물 품종 개량/미국 청년, 몸짱 선탠용 티셔츠 발명/스위스, 국가경쟁력 1위의 비밀/저지방식,'유방암' 제발 위험 감소/서울대, 세계최초 암캐 복제 성공/국가 R&D 특허조사, 전체 R&D 부처로 확대/전국 초.중생 발명 글짓기.만화현상 공모전/특허청, 공공부문 성과주의 대통령상/한국여성발명협회 회원사 발명품 가이드

• Textile Coloration and Finishing
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• v.30 no.2
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• pp.90-97
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• 2018

Hydrophilic reactive hot-melt polyurethane adhesive(HRHA) using a hydrophilic polyol having different molecular weight and NCO index was synthesized. This HRHA was synthesized using Polyethylene glycol(PEG) as a hydrophilic polyol, Polypropylene glycol(PPG) and Polycaprolactone diol(PCL) as hydrophobic polyols, and Methylene diphenyl diisocyanate(MDI) as an isocyanate. The changes in IR spectrum, viscosity and thermal properties of HRHA with different PEG molecular weights and NCO index were investigated, and the tensile strength and elongation of the HRHA casting film and the peel strength, moisture permeability and water pressure of the HRHA coated fabric were confirmed. In this experiment, as the molecular weight of PEG and NCO index increased, the adhesive strength, tensile strength, elongation and moisture permeability was increased but viscosity and Tg was decreased.

• Journal of Astronomy and Space Sciences
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• v.26 no.3
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• pp.287-294
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• 2009

In helioseismology it is normally assumed that p-mode oscillations are excited in a statistically independent fashion. Unfortunately, however, this issue is not clearly settled down in that two experiments exist, which apparently look in discrepancy. That is, Appourchaux et al. (2000) looked at bin-to-bin correlation and found no evidence that the assumption is invalid. On the other hand, Roth (2001) reported that p-mode pairs with nearby frequencies tend to be anti-correlated, possibly by a mode-coupling effect. This work is motivated by an idea that one may test if there exists an excess of anticorrelated power variations of pairs of solar p-modes. We have analyzed a 72-day MDI spherical-harmonic time series to examine temporal variations of p-mode power and their correlation. The power variation is computed by a running-window method after the previous study by Roth (2001), and then distribution function of power correlation between mode pairs is produced. We have confirmed Roth's result that there is an excess of anti-correlated p-mode pairs with nearby frequencies. On the other hand, the amount of excess was somewhat smaller than the previous study. Moreover, the distribution function does not exhibit significant change when we paired modes with non-nearby frequencies, implying that the excess is not due to mode coupling. We conclude that the origin of this excess of anticorrelations may not be a solar physical process, by pointing out the possibility of statistical bias playing the central role in producing the excess.

• Journal of Astronomy and Space Sciences
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• v.34 no.2
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• pp.99-103
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• 2017

The sun is not equally bright over the whole sphere, but rather is darkened toward the limb. This effect is well-known as limb darkening. The limb darkening coefficient is defined by the ratio of the center intensity to limb intensity. In this study, we calculate the limb darkening coefficient using the photospheric intensity estimated from solar images taken by solar and helispheric observatory (SOHO) and solar dynamics observatory (SDO). The photospheric intensity data cover almost two solar cycles from May 1996 to December 2016. The limb darkening coefficient for a size of 0.9 diameter is about 0.69 and this value is consistent with solar limb darkening. The limb darkening coefficient estimated from SOHO shows a temporal increase at solar maximum and a gradual increase since the solar minimum of 2008. The limb darkening coefficient estimated from SDO shows a constant value of about 0.65 and a decreasing trend since 2014. The increase in the coefficient reflects the effect of weakened solar activity. However, the decrease since 2014 is caused by the aging effect.

• Journal of the Korean Wood Science and Technology
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• v.44 no.2
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• pp.274-282
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• 2016

This aims of this study were to investigate the relationship between non-destructive evaluation (NDE) and actual bending properties of particleboard, and to predict the bending properties of three-layer particleboard. Three kinds of raw materials, i.e. Hinoki (Chamaecyparis obtusa Endl.) strand, knife-milled Douglas-fir (Pseudotsuga manziesii (Mirb) Franco), and hammer-milled matoa (Pometia spp.) obtained from wooden industry, were utilized as furnish for experimental panel with methylene diphenyl diisocyanate (MDI) resin as binder. The NDE test was conducted by hit sounds using an FFT analyzer according to the spectrum peak of wave frequency, while the static bending test was conducted according to JIS A-5908. The results reveal that the dynamic Young's modulus as an NDE test has a potential for being used to predict the elastic bending of particleboards by a specific equation for adjusting its proper values. The values of NDE and static test are significantly different with a deviation range at 3-20%. The bending stiffness of three-layer particleboards manufactured from different wood species is predictable by observing the bending stiffness of two elements based on the thickness of its layers. The predicted values of bending stiffness and static test are significantly different with a deviation range at 5-24%.

• Journal of The Korean Astronomical Society
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• v.42 no.1
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• pp.9-15
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• 2009

A necessary condition for the formation of a filament is magnetic helicity. In the present paper we seek the origin of magnetic helicity of intermediate filaments. We observed the formation of a sinistral filament at the boundary of a decaying active region using full-disk $H_{\alpha}$ images obtained from Bi Bear Solar Observatory. We have measured the rate of helicity injection during the formation of the filament using full-disk 96 minute-cadence magnetograms taken by SOHO MDI. As a result we found that 1) no significant helicity was injected around the region (polarity inversion line; PIL) of filament formation and 2) negative helicity was injected in the decaying active region. The negative sign of the injected helicity was opposite to that of the filament helicity. On the other hand, at earlier times when the associated active region emerged and grew, positive helicity was intensively injected. Our results suggest that the magnetic helicity of the intermediate filament may have originated from the helicity accumulated during the period of the growth of its associated active region.

• Journal of The Korean Astronomical Society
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• v.41 no.6
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• pp.181-186
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• 2008

Recently, Choe & Cheng (2002) have demonstrated that multiple magnetic flux systems with closed configurations can have more magnetic energy than the corresponding open magnetic fields. In relation to this issue, we have addressed two questions: (1) how much fraction of eruptive solar active regions shows multiple flux system features, and (2) what winding angle could be an eruption threshold. For this investigation, we have taken a sample of 105 front-side halo CMEs, which occurred from 1996 to 2001, and whose source regions were located near the disk center, for which magnetic polarities in SOHO/MDI magnetograms are clearly discernible. Examining their soft X-ray images taken by Yohkoh SXT in pre-eruption stages, we have classified these events into two groups: multiple flux system events and single flux system events. It is found that 74% (78/105) of the sample events show multiple flux system features. Comparing the field configuration of an active region with a numerical model, we have also found that the winding angle of the eruptive flux system is slightly above $1.5{\pi}$.

• Journal of the Korean Wood Science and Technology
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• v.37 no.2
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• pp.121-127
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• 2009

Acacia wood (Acacia mangium Willd.) is the most popular fast growing tree species planted in timber estate in Indonesia and is considered to be very valuable raw materials for structural composite products. The objective of the research was to evaluate the properties of OSB prepared from A. Mangium wood with or without immersing the strands to hot water at $80^{\circ}C$ for 2 hours. MDI adhesive was used in 3 levels i.e., 3%, 5%, and 7%. The moisture content of strand was 7%. The results indicated that immersing strands in hot water for 2 hours at $80^{\circ}C$ prior to manufacture OSB improved significantly the mechanical peoperties (i.e., MOR and MOE) of OSB. The higher the adhesive content resulted in the better the dimensional stabilisation (i.e., water absorption and thickness swelling) and the mechanical properties (i.e., MOR, MOE and IB) of OSB. OSB prepared from hot-water immersed strands with 5% adhesive content has met all parameters requirement on the JIS A 5908 (2003) standard.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.29.1-29.1
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• 2010

We report three types of evolutions of EUV bright points (EBPs) which are characterized by their height variations. We analyzed three EBPs during their lifetimes observed by STEREO/SECCHI/EUVI and we obtained heights, sizes, and intensities. Moreover, we investigated their underlying magnetic bipoles observed by SOHO/MDI and we measured distances and fluxes of the two opposite fragments. We found three distinct changes in the heights of the EBPs: upward, downward, and flat. In the upward case, the EBP showed a small and dark structure first, and then changed to a large and bright loop. In the downward case, the EBP first appeared as a large and dark loop structure, and then evolved to a compact and bright loop system. Finally, in the flat case, the height and the size of the EBP didn't change significantly. We found that those EBPs were associated with three distinct contact types of their underlying magnetic fragments, emerging, cancelling, and shearing, respectively. In all cases, both flux emergences and flux cancellations were observed during the lifetimes of the BPs. The flux emergence was dominant in the initial phase and the flux cancellation was significant when the intensity reached its maximum. In addition, we found a remarkable correlation between the heights of the EBPs and the distance of the opposite magnetic fragments.