• Title/Summary/Keyword: MCR

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The Effect of Antioxidative Change in Cardiac Muscle of Obesity Rat by Treadmill Exercise with Intensity and Time (운동강도와 지속시간에 따른 트레드밀 운동이 비만 쥐의 심장근 내 항산화에 미치는 영향)

  • Kim, Myung-Hee;Kim, Young-Eok;Yoon, Chang-Lyuk;Ryu, Ji-Won;Ahn, Jong-Mo
    • Journal of Oral Medicine and Pain
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    • v.38 no.1
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    • pp.35-51
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    • 2013
  • The aims of this study was to observed an effect of antioxidative in cardiac muscle of high fat diet induced obesity rat by treadmill exercise with intensity and time. Thirty-two Sprauge-Dawley rats which were divided into four group. Normal, Control(high fat diet induced obesity rat), Experimental I(high intensity intermittent exercise in high fat diet induced obesity rat), Experimental II(moderate intensity endurance exercise in high fat diet induced obesity rat). The results of this study were as follows: 1. In change of body weight, the outcome of each group significantly difference compared with control. Also, 1 to 3 weeks significantly different compared with pre valu experimental I and II(p<0.001). 2. In change of lipid profile, the outcome of each group significantly difference compared with control(p<0.001). Difference between experimental I and II is not significantly. 3. In change of antioxidative enzymes(SOD, CAT, GPx) in myocardium, there are significant difference between control and experimental II, and also between control and experimental I(p<0.001). 4. In change of antioxidative protein MCR-1, the outcome of each group significantly difference compared with control(p<0.01). Experimental II was most significantly difference than the other group(p<0.001). The above results suggest that treadmill exercise effectively reduced in fat. It would be considered that moderate intensity endurance exercise has an effects on improved antioxidative enzyme in cardiac muscle of high fat diet induced obesity rat.

On-Line Determination Steady State in Simulation Output (시뮬레이션 출력의 안정상태 온라인 결정에 관한 연구)

  • 이영해;정창식;경규형
    • Proceedings of the Korea Society for Simulation Conference
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    • 1996.05a
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    • pp.1-3
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    • 1996
  • 시뮬레이션 기법을 이용한 시스템의 분석에 있어서 실험의 자동화는 현재 많은 연구와 개발이 진행 중인 분야이다. 컴퓨터와 정보통신 시스템에 대한 시뮬레이션의 예를 들어 보면, 수많은 모델을 대한 시뮬레이션을 수행할 경우 자동화된 실험의 제어가 요구되고 있다. 시뮬레이션 수행회수, 수행길이, 데이터 수집방법 등과 관련하여 시뮬레이션 실험방법이 자동화가 되지 않으면, 시뮬레이션 실험에 필요한 시간과 인적 자원이 상당히 커지게 되며 출력데이터에 대한 분석에 있어서도 어려움이 따르게 된다. 시뮬레이션 실험방법을 자동화하면서 효율적인 시뮬레이션 출력분석을 위해서는 시뮬레이션을 수행하는 경우에 항상 발생하는 초기편의 (initial bias)를 제거하는 문제가 선결되어야 한다. 시뮬레이션 출력분석에 사용되는 데이터들이 초기편의를 반영하지 않는 안정상태에서 수집된 것이어야만 실제 시스템에 대한 올바른 해석이 가능하다. 실제로 시뮬레이션 출력분석과 관련하여 가장 중요하면서도 어려운 문제는 시뮬레이션의 출력데이터가 이루는 추계적 과정 (stochastic process)의 안정상태 평균과 이 평균에 대한 신뢰구간(confidence interval: c. i.)을 구하는 것이다. 한 신뢰구간에 포함되어 있는 정보는 의사결정자에게 얼마나 정확하게 평균을 추정할 구 있는지 알려 준다. 그러나, 신뢰구간을 구성하는 일은 하나의 시뮬레이션으로부터 얻어진 출력데이터가 일반적으로 비정체상태(nonstationary)이고 자동상관(autocorrelated)되어 있기 때문에, 전통적인 통계적인 기법을 직접적으로 이용할 수 없다. 이러한 문제를 해결하기 위해 시뮬레이션 출력데이터 분석기법이 사용된다.본 논문에서는 초기편의를 제거하기 위해서 필요한 출력데이터의 제거시점을 찾는 새로운 기법으로, 유클리드 거리(Euclidean distance: ED)를 이용한 방법과 현재 패턴 분류(pattern classification) 문제에 널리 사용 중인 역전파 신경망(backpropagation neural networks: BNN) 알고리듬을 이용하는 방법을 제시한다. 이 기법들은 대다수의 기존의 기법과는 달리 시험수행(pilot run)이 필요 없으며, 시뮬레이션의 단일수행(single run) 중에 제거시점을 결정할 수 있다. 제거시점과 관련된 기존 연구는 다음과 같다. 콘웨이방법은 현재의 데이터가 이후 데이터의 최대값이나 최소값이 아니면 이 데이터를 제거시점으로 결정하는데, 알고기듬 구조상 온라인으로 제거시점 결정이 불가능하다. 콘웨이방법이 알고리듬의 성격상 온라인이 불가능한 반면, 수정콘웨이방법 (Modified Conway Rule: MCR)은 현재의 데이터가 이전 데이터와 비교했을 때 최대값이나 최소값이 아닌 경우 현재의 데이터를 제거시점으로 결정하기 때문에 온라인이 가능하다. 평균교차방법(Crossings-of-the-Mean Rule: CMR)은 누적평균을 이용하면서 이 평균을 중심으로 관측치가 위에서 아래로, 또는 아래서 위로 교차하는 회수로 결정한다. 이 기법을 사용하려면 교차회수를 결정해야 하는데, 일반적으로 결정된 교차회수가 시스템에 상관없이 일반적으로 적용가능하지 않다는 문제점이 있다. 누적평균방법(Cumulative-Mean Rule: CMR2)은 여러 번의 시험수행을 통해서 얻어진 출력데이터에 대한 총누적평균(grand cumulative mean)을 그래프로 그린 다음, 안정상태인 점을 육안으로 결정한다. 이 방법은 여러 번의 시뮬레이션을 수행에서 얻어진 데이터들의 평균들에 대한 누적평균을 사용하기 매문에 온라인 제거시점 결정이 불가능하며, 작업자가 그래프를 보고 임의로 결정해야 하는 단점이 있다. Welch방법(Welch's Method: WM)은 브라운 브리지(Brownian bridge) 통계량()을 사용하는데, n이 무한에 가까워질 때, 이 브라운 브리지 분포(Brownian bridge distribution)에 수렴하는 성질을 이용한다. 시뮬레이션 출력데이터를 가지고 배치를 구성한 후 하나의 배치를 표본으로 사용한다. 이 기법은 알고리듬이 복잡하고, 값을 추정해야 하는 단점이 있다. Law-Kelton방법(Law-Kelton's Method: LKM)은 회귀 (regression)이론에 기초하는데, 시뮬레이션이 종료된 후 누적평균데이터에 대해서 회귀직선을 적합(fitting)시킨다. 회귀직선의 기울기가 0이라는 귀무가설이 채택되면 그 시점을 제거시점으로 결정한다. 일단 시뮬레이션이 종료된 다음, 데이터가 모아진 순서의 반대 순서로 데이터를 이용하기 때문에 온라인이 불가능하다. Welch절차(Welch's Procedure: WP)는 5회이상의 시뮬레이션수행을 통해 수집한 데이터의 이동평균을 이용해서 시각적으로 제거시점을 결정해야 하며, 반복제거방법을 사용해야 하기 때문에 온라인 제거시점의 결정이 불가능하다. 또한, 한번에 이동할 데이터의 크기(window size)를 결정해야 한다. 지금까지 알아 본 것처럼, 기존의 방법들은 시뮬레이션의 단일 수행 중의 온라인 제거시점 결정의 관점에서는 미약한 면이 있다. 또한, 현재의 시뮬레이션 상용소프트웨어는 작업자로 하여금 제거시점을 임의로 결정하도록 하기 때문에, 실험중인 시스템에 대해서 정확하고도 정량적으로 제거시점을 결정할 수 없게 되어 있다. 사용자가 임의로 제거시점을 결정하게 되면, 초기편의 문제를 효과적으로 해결하기 어려울 뿐만 아니라, 필요 이상으로 너무 많은 양을 제거하거나 초기편의를 해결하지 못할 만큼 너무 적은 양을 제거할 가능성이 커지게 된다. 또한, 기존의 방법들의 대부분은 제거시점을 찾기 위해서 시험수행이 필요하다. 즉, 안정상태 시점만을 찾기 위한 시뮬레이션 수행이 필요하며, 이렇게 사용된 시뮬레이션은 출력분석에 사용되지 않기 때문에 시간적인 손실이 크게 된다.

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Studies on the Meat Production and Woolskin Processing of Sheep and Korean Native Goats for Increasing Farm Income as a Family Subsidiary Work (농가부업(農家副業)의 소득향상(所得向上)을 위한 양육생산(羊肉生産) 및 모피가공(毛皮加工)에 관(關)한 연구(硏究))

  • Kwon, Soon-Ki;Kim, Jong-Woo;Han, Sung-Wook;Lee, Kyu Seung
    • Korean Journal of Agricultural Science
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    • v.5 no.2
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    • pp.93-114
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    • 1978
  • The purpose of the study was to find out possible ways for increasing farm income through the sheep and Korean native goats farming, and to investigate meat productivity, wool productivity; woolskin utility, physiological characteristics and correlation between economical college animal farm of the Chungnam National University and sample farms in the suburbs of Dae jeon City were selected for feeding 20 heads of Corriedale wethers and another 20 heads Korean native kids as research materials for the periods of 5th May-26th November, 1977. The data such as growth rate, carcass, viscera weight, blood picture and plamsa components, hebage intake and economic traits were obtained and analysed. The result of the study are summarized as follows: 1. Meat production and quality 1) After 196days of feeding, the body weight of sheep and Korean native goats was increased by two times of those at the beginning of the trial, i.e. 20kg and 8kg respectively. 2) There was no significance of growth rates of sheep in housing and grazing. 3) The growth rate of Korean native goats were excellent at the mountainous areas of Gong ju-Gun where infectious diseases were not found 4) Accroding to the body measurements of 18-month-old sheep, percentages of hip height, body length, rump length, chest depth, chest width, hip width, chest girth and forearm circumference to the withers height were 103,%, 104%, 33%, 44%, 31%, 23%, 135% and 15% respectively, and those of hip height, body length, chest depth and chest girth of 8-month-old native goats to the withers height were 106%, 109%, 46% and 122,% respecitively. As a result, it was found that the percentage of hip height, body length and chest depth of Korean native goats were higher than those of sheep while that of the chest girth of goats was lower. 5) In the carcass data, 47, $52{\pm}2.27%$ of carcass percentage, $34.61{\pm}1.62%$ of lean meat, $26.07{\pm}2.51%$ of viscera, $9.75{\pm}1.4%$ of bone, and $20.95%{\pm}2.14%$ of woolskin for sheep, and $45.58{\pm}5.63%$ of carcass percentage, $27.62{\p}3.81%$ of meat, $34.86{\pm}4.16%$ of viscera, $11.66{\pm}1.83%$ of bone, $3.63{\pm}1.61%$ of skull and $9.26{\pm}2.41%$ of woolskin for native goats were obtained. 6) The contents of moisture, crude protein, crude fat and crude ash in native goat meat were much similar in both plots of housing and grazing. It was, however, known that the contents of moisture and protein were higher in grazinrg than in housing, while fat content was lower in grazing plots. 7) The weights of visceral organs shown similar tendency for both of sheep and native goats. For the weights of liver, heart, kidney and spleen, significance was not reconized among the treatments. Those of rumen, reticulum, small and large intestine were heavier in grazing than in housing, while the amount of visceral fat was heavier in housing. 2. Wool productivity and woolskin 1) The wool production of sheep for 7 months was $3.88{\pm}1.02kg$, and wool percentage, staple length, straighten length, wool growth per day and number of crimps were $9.27{\pm}1.48%$, 8. $47{\pm}1.00cm$, $10.63{\pm}0.99cm$, $0.40{\pm}0.04cm$ and $2.78{\pm}0.40$ respecitively. 2) The tensile strength and tear strength of woolskin treated by alum tanning were highest on the skin obtained from rump, i.e. $1,351kg/mm^2$ and $2,252kg/mm^2$ respectively, and they are in order of loin and shoulder. 3. Utilization and improvement of pasture. 1) The difference of herbage intake of native goats was not recognized between grazing and tethering, but the intake in the afternoon was s lightly higher than that in the morning. However the hervage intake of sheep was superior in grazing and in the afternoon. 2) The cultivation effect was lower in the native goat plots due to their cultivation abilities, in other words, the establishment rates of pasture by hoof cultivation were 60.25% in the goat plots and 77.35% in the sheep plots. 4. Correlation among economical traits. 1) The correlation between live weight of sheep and daily gain was higher. On the other hand, the correlation between other traits was not significant except that live weight, daily gain and lean meat percentage to the length of thoracic vertebrae. The live weight of native goats and meat production were highly correlated, and high correlation was also found between weights of carcass and meat. However, negative correlation was shown between viscera weight and live weight as well as daily gain. 2) The correlatoin between fleece weight of sheep and other traits such as live weight, daily gain and fleece percentage is very high at the 1% siginficant level, and this means that rapid-growth individuals can produce much fleece. 3) The correlation between the factors such as weights of live body, lean meat and viscera of sheep and body measurements, i. e. chest girth and body length was highest, and weights, of carcass and lean meat was highly correlated to chest width and depth. It will be therefore reasonable that the meat productivity estimates will have to be made on the basis of chest girth and body length. The meat production traits of native goats were highly correlated to the most of body measurement data, and the correlation coefficient between chest girth and weights of live body, carcass, lean meat and bone percentage was very high, i. e. 0.992-0.974 in particular. The correlations of meat production traits to chest depth, forearm circumference, body length were 0.759-0.911, 0.759-0.909 and 0.708-0.872 respectively. Therefore, the meat production of native goats will have to be estimated on the basis of chest data. 5. Blood picture and plasma components. 1) The number of erythrocyte and MCHC of native goats were $12.93{\times}10^6/mm^3$ and 36.14%, and those of sheep were $10.68{\times}10^6/mm^3$ and 36.26 respectively. The values of native goats were significantly higher than those of sheep. 2) The hemoglobin concentration, PVC, MCV and MCR of native goats were 10.92 g/100ml, $23.40{\mu}^3$ and 10.94 pg, and those of sheep were 11.73 g/100ml, 36.25 ml/100ml, $33.97{\mu}^3$ and 30.2 ml/100ml 8.43 pg respectively. The values of native goats were significantly lower those of sheep. 3) The number of leukocytes of native goats was significantly higher than that of sheep, that is, $11.64{\times}10^3/mm^3$ in native goats and $9.32{\times}10^3/mm^3$ in sheep. 4) In differential count of leukocyte, neutrophil was significantly high in native goats while lympocyte in sheep. On the other hand, the basophil, eosinophil and monocyte were not significant between native goats and sheep. 5) The amounts of total protein and glucose in the plasma of native goats were 6.2g/100ml and 53.6mg/100ml, and those of sheep were 5.6g/100ml and 45.7mg/100ml, which means that the values of native goats were significantly higher that those of sheep. The amount of total-lipid of native goats(127.6mg/100ml) was significantly than that of sheep(149.6mg/100ml). 6) The amount of non-protein nitrogen, cholesterol, Ca, P, K, Na and Cl were not different between native goats and sheep. 6. Economic analysis. 1) The gross revenue of a farm which fed native goats and sheep was 4,000won per head and the optimum size for feeding them in a farm as a subsidiary work is 5-10 heads. 2) Since there was no difference between housing and grazing, they can be fed in group for farm's subsidiary work. 3) They can be also fed by youths and house wives in the suburbs of cities, because labour requirement is estimated as only two hours per days for feeding 5 heads of native goats and sheep.

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