• Tuberculosis and Respiratory Diseases
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• v.45 no.1
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• pp.128-139
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• 1998

Background: It is well known that various cytokines and growth factors secreted mainly from alveolar macrophages do the key role in the pathogenesis of IPF. But recently it has been known that structural cells like fibroblast can also release cytokines. So the phenotypic changes in fibroblasts of IPF may do a role in continuous progression of fibrosis. The aim of this study is to find out whether there is a change in the biologic properties of the lung fibroblasts of IPF. Subjects and Method: The study was done on 13 patients with IPF diagnosed by open or thoracoscopic lung biopsy and 7 control patients who underwent resectional surgery for lung cancer. Lung fibroblast cell lines (FB) were established by explant culture technique from the biopsy or resected specimen Result: Basal proliferation of the fibroblast of IPF(IFB) measured by BrdU uptake tended to be highter than control fibroblast(NFB) (0.212 0.107 vs $0.319{\pm}0.143$, p=0.0922), also there was no significant difference in proliferation after the stimulation with PDGF or 10% serum. On the contrary, the degree of inhibition in proliferation by PGE2 was significantly lower($33.0{\pm}13.1%$) in IFB than control($46.7{\pm}10.0%$, p=0.0429). The IFB secreted significantly higher amount of MCP-l($l574{\pm}1283$ pg/ml) spontaneously than NFB($243{\pm}100$ pg/ml) and also after the stimulation with TGF-$\beta$($3.23{\pm}1.31$ ng/ml vs $0.552{\pm}0.236$ ng/ml, p=0.0012). Similarly IL-8 and IL-6 seretion of IFB was significantly higher than NFB at basal state and with TGF-$beta$ stimulation. But after the maximal stimulation with IL-1,8, no significant difference in cytokine secretion was found between IFB and NFB. Conclusion : Above data suggest that the fibroblasts of IPF were phenotypically changed and these change may do a role in the pathogenesis of IPF.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.50 no.10
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• pp.483-493
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• 2001

The 3-phase induction is used for the MCP(main coolant pump) and the pure water is used for lubrication of bearing because of the difficulty of repair. Therefore the type of motor is the canned-motor that is welded by sealed can to prevent the stator and rotor from the lubricating water. A lot of Eddy currents are produced in the can because of the conductivity of material. And these eddy currents in the can are the most important cause that decrease the efficiency of induction motor. Therefore we have to find the method to decrease these eddy currents in the can for the improvement of efficiency of motor. In this paper, we proposed the method of design and analysis of canned-motor using equivalent circuit with consideration of can loss for the improvement of efficiency of motor.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.4
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• pp.201-212
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• 2016

A Wind resource assessment and optimal micrositing of wind turbines were implemented for the development of an onshore wind farm of 30 MW capacity on Gadeok Island in Busan, Republic of Korea. The wind data measured by the automatic weather system (AWS) that was installed and operated in the candidate area were used, and a reliability investigation was conducted through a data quality check. The AWS data were measured for one year, and were corrected for the long term of 30 years by using the modern era retrospective analysis for research and application (MERRA) reanalysis data and a measure- correlate-predict (MCP) technique; the corrected data were used for the optimal micrositing of the wind turbines. The micrositing of the 3 MW wind turbines was conducted under 25 conditions, then the best-optimized layout was analyzed with a various wake model. When the optimization was complete, the estimated park efficiency and capacity factor were from 97.6 to 98.7 and from 37.9 to 38.3, respectively. Furthermore, the annual energy production (AEP), including wake losses, was estimated to be from 99,598.4 MWh to 100,732.9 MWh, and the area was confirmed as a highly economical location for development of a wind farm.

• The Korean Journal of Ecology
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• v.28 no.6
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• pp.395-404
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• 2005

A project has recently begun to reintroduce endangered Asiatic black bears to the Jirisan National Park. However, information on home range that is necessary to maintain the Minimum Viable Population (MVP) of those bears does not exist. Based on point data of two bears that were released for trial in Jirisan in 2001, we identified the movement pattern of bears and estimated their home ranges with two different methods Finally, the possibility of conserving the MVP of bears was evaluated by comparing the location and size of the home range with habitats which have been found to be suitable for bears. The frequency of bears' appearance reduced drastically as road densities of both paved roads and legal trails increased. The midpoint of home ranges of the two bears was 376.85 $km^2$ and 50.76 $km^2$ based on 100% MCP (Minimum Convex Polygon) and 95% AK (Adaptive Kernel Home Range Method), respectively, with an overlapped area of 126.0 $km^2$ and 3.99 $km^2$ each. The core areas of their home ranges are located not in the no-entry zone, where major trails were open to the public - despite being designated as no -entry zone - but in areas where most trails were closed to the public. A discrepancy between core areas of home ranges and potentially suitable habitats suggests the effects of vehicles and tracking people through roads within the park. Thus, for the success of in situ conservation of endangered bears, well-planned management of habitats is needed to protect bears and to ensure the home ranges to support the MVP.

• Journal of agriculture & life science
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• v.45 no.5
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• pp.41-47
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• 2011

This study was carried out to provide basic information for assessment conditions as habitat to conserve and restore asiatic black bear released in Jirisan National Park. The field investigation at Piagol, Bitjeom, Jangdanggol, Baemsagol, Chilseon valley, and Hanshin valley which checked for habitat of released asiatic black bear were conducted from 2008 to 2010. There were no obvious differences in home range size of asiatic black bear by study year. The seasonal home ranges were analyzed $25.64km^2$ for males and $17.57km^2$ for female in spring, $73.02km^2$ for males and $27.45km^2$ for females in summer, $41.58km^2$ for males and $13.26km^2$ for females in fall, and $6.11km^2$ for males and $2.89km^2$ for females in winter based on 95% Minimum Convex Polygon (MCP) method, respectively. In average elevation by gender of asiatic black bear, the male was higher than the female. respectively. Average elevation by season were $894{\pm}33m$ in spring, $852{\pm}20m$ in summer, $985{\pm}67m$ in fall, and $996{\pm}26m$ in winter, respectively.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.1
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• pp.63-71
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• 2019

Objective: The aim of the study was to investigate the effect of zinc-bearing palygorskite (Zn-Pal) on rumen fermentation by in vitro gas-production system. Methods: In trial, 90 incubators were evenly divided into five groups: control (0% Zn-Pal), treatment I (0.2% Zn-Pal), treatment II (0.4% Zn-Pal), treatment III (0.6% Zn-Pal), and treatment IV (0.8% Zn-Pal). The contents of zinc for treatments were 0, 49, 98, 147, 196 mg/kg, respectively. The main chemical composition and microstructure of Zn-Pal was investigated by X-ray diffraction. The physicochemical features were evaluated by Zeta potential analysis, cation-exchange capacity, ethylene blue absorption and specific surface area (the Brunauer-Emmett-Teller method). In vitro gas production (GP) was recorded at 3, 6, 9, 12, 18, 24, 36, 48, 60, and 72 h incubation. Incubation was stopped at 0, 6, 12, 24, 48, and 72 h and the inoculants were tested for pH, microbial protein yield (MCP), $NH_3-N$, volatile fatty acids (VFAs), lipopolysaccharide (LPS). Results: The results showed that the GP in the treatment groups was not significantly different from the control groups (p>0.05). Compared to the control group, pH was higher at 24 h, 48 h (p<0.05), and 72 h (p<0.01) (range 6 to 7). The concentration of $NH_3-N$ in the three treatment groups was higher than in the control group at 24 h (p<0.01), meanwhile, it was lower at 48 h and 72 h (p<0.01), except in the treatment IV. The concentration of MCP in treatment I group was higher than in the control at 48 h (p<0.01). Compared with control, the LPS concentration in treatment III became lower at 12 h (p<0.05). Total VFAs in treatments were higher than in the control at 24 h, 48 h (p<0.05). Conclusion: These results suggest that the addition of Zn-Pal can improve the rumen fermentation, especially when adding 0.2% Zn-Pal.

• PNF and Movement
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• v.21 no.2
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• pp.171-183
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• 2023

Purpose: The purpose of this study was to compare universal goniometry (UG), which is commonly used in clinical practice to measure the range of motion (ROM) of finger joints with a wearable soft sensor glove, and to analyze the reliability to determine its usefulness. Methods: Ten healthy adults (6 males, 4 females) participated in this study. The metacarpophalangeal joint (MCP), interphalangeal joint (IP), and proximal interphalangeal joint (PIP) of both hands were measured using UG and Mollisen HAND soft sensor gloves during active flexion, according to the American Society for Hand Therapists' measurement criteria. Measurements were taken in triplicate and averaged. The mean and standard deviation of the two methods were calculated, and the 95% limits of agreement (LOA) of the measurements were calculated using the intraclass correlation coefficient (ICC) and Bland-Altman plot to examine the reliability and discrepancies between the measurements. Results: The results of the mean values of the flexion angles for the active range of motion (AROM) of the finger joints showed large angular differences in the finger joints, except for the MCP of the thumb. In the inter-rater reliability analysis according to the measurement method, the ICC (2, 1) value showed a low level close to 0, and the mean difference by the Bland-Altman plot showed a value greater than 0, showing a pattern of discrepancy. The 95% LOA had a wide range of differences. Conclusion: This study is a preliminary study investigating the usefulness of the soft sensor glove, and the reliability analysis showed a low level of reliability and inconsistency. However, if future studies can overcome the limitations of this study and the technical problems of the soft sensor glove in the development stage, it is suggested that the measurement instrument can show more accurate measurement and higher reliability when measuring ROM with UG.

• The Korea Journal of Herbology
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• v.25 no.3
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• pp.19-25
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• 2010

Objective : The aim of this study was to investigate anti-inflammatory activity of SD-01 methanol extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods : Cytotoxic activity of SD-01 methanol extract on RAW 264.7 cells was measured using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. The nitric oxide (NO) production was measured by Griess reagent system. And proinflammatory cytokines and $PGE_2$ were measured by ELISA method. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), $I{\kappa}$-B-alpha and nuclear NF-${\kappa}$ B p65 expression were detected by western blot. Results : Our results indicated that methanol extract of SD-01 significantly inhibited the LPS-induced NO, $PGE_2$ production and iNOS, COX-2 expression accompanied by an attenuation of TNF-$\alpha$, IL-$1\beta$, IL-6 and MCP-1 production in RAW 264.7 cells. Moreover, methanol extract of SD-01 treatment also blocked LPS-induced NF-kB activation. Conclusion : These findings indicate that methanol extract of SD-01 inhibits the production of pro-inflammatory mediators and cytokines via suppression of NF-${\kappa}$ B activation. Take together, these results indicate that methanol extract of SD-01 has the potential for use as an agent of anti-chronic inflammatory diseases.

• The Journal of the Acoustical Society of Korea
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• v.15 no.5
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• pp.13-20
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• 1996

Recently, for implementation of neural networks extensive studies have been done especially VLSI technology has been regarded as the one of the most attractive means to implement neural networks. The main drawbacks of digital VLSI implementations are their large area and slow processing speed. In this paper to solve the speed and size problems we designed the efficient architecture using the binary convolution method for basic operation of neural cell, multiplication and addition. When it is used for implementing 3-layer network with 16 neural cell per layer that used neural cell based on binary convolution, clock of 50MHz and 26MCPS on 0.8${\mu}$ standard cell library has been achieved.

• Biomedical Science Letters
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• v.17 no.1
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• pp.39-45
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• 2011

In the present study, we investigated whether volatile organic compounds induce inflammatory response in human T lymphocytes by evaluating the alteration of inflammatory cytokines. Volatile organic compounds such as formaldehyde, o-xylene, benzene, and hydroquinone have no cytotoxic effects on Jurkat T cells at a high concentration of 50 ${\mu}M$ for 48 h. IL-2, IL-4, IL-13, TNF-${\alpha}$ and IFN-${\gamma}$ were increased after the treatment with volatile organic compounds, although alteration of cytokines is different among volatile organic compounds. LPS as a positive control increased the secretion of IL-2, IL-4, IL-13, TNF-${\alpha}$ and IFN-${\gamma}$. MCP-1 and CCL17 (thymus and activation-regulated chemokine, TARC) were weakly increased after the treatment with volatile organic compounds but the amount of the increased cytokine was below 20 pg/ml. These results suggest that the measurement of cytokine in Jurkat T cells may be used as a useful method for evaluating the toxicity of volatile organic compounds in immune response.