• Title/Summary/Keyword: MC model

Search Result 702, Processing Time 0.028 seconds

Mechanism of Differential Ag-specific Immune Induction by Different Tumor Cell Lysate Pulsed DC (종양 세포 용해액에 따른 수지상세포 유도 항원 특이 면역반응 차이의 기전 연구)

  • Lee, Kang-Eun;Shon, Hye-Jin;Kim, Myung-Joo;Baek, So-Young;Lee, Hyun-Ah
    • IMMUNE NETWORK
    • /
    • v.6 no.3
    • /
    • pp.145-153
    • /
    • 2006
  • Background: Tumor cell lysate has been considered as a preferential antigen source for the therapeutic dendritic cell pulsing. Our experiences with in vivo study with animal tumor model indicate the tumor cell lysate dependent differential effect of DC therapy. Our previous data show that MC38 lysate pulsed-DC induced stronger ag-specific immunity than CT26 lysate pulsed-DC in vitro. In this study we tried to reveal the mechanism for differential induction of ag-specific immunity of different colon cancer cell lysate pulsed-DCs. Methods: MC38 and CT26 cell lines were prepared as lysate by freezing-thawing procedure. Tumor cell antigenicity was confirmed by detecting the surface expression of MHC I/II & B7.1/2 molecules. IL-10, IL-12 and TGF-beta in the tumor cell lysate were detected by ELISA and the presence of heat shock proteins were analysed by western blotting. Results: The secretion of IL-10, a immune-inhibitory cytokine was about 470% higher in CT26 lysate than in MC38. Hsp 70 was detected only in the MC38 lysate but not in the CT26. On the other hand, Hsp 60 and 90 expression were not different in two colon cancer cell lysates. Conclusion: In two different colon cancer cell lysate, immune inhibitory IL-10 (higher in CT26) and Hsp70 (MC38 superiority) were differentially expressed. These data indicate that higher agspecific immunity induction by MC38 lysate pulsed-DC may due to the expression of hsp70 and lower secretion of IL-10, a immune-inhibitory cytokine than CT26 lysate. The significance of other cytokine and the surface marker expression will be discussed.

Development and verification of a Monte Carlo two-step method for lead-based fast reactor neutronics analysis

  • Yiwei Wu;Qufei Song;Ruixiang Wang;Yao Xiao;Hanyang Gu;Hui Guo
    • Nuclear Engineering and Technology
    • /
    • v.55 no.6
    • /
    • pp.2112-2124
    • /
    • 2023
  • With the rise of economic and safety standards for nuclear reactors, new concepts of Gen-IV reactors and modular reactors showed more complex designs that challenge current tools for reactor physics analysis. A Monte Carlo (MC) two-step method was proposed in this work. This calculation scheme uses the continuous-energy MC method to generate multi-group cross-sections from heterogeneous models. The multi-group MC method, which can adapt locally-heterogeneous models, is used in the core calculation step. This calculation scheme is verified using a Gen-IV modular lead-based fast reactor (LFR) benchmark case. The influence of homogenized patterns, scatter approximations, flux separable approximation, and local heterogeneity in core calculation on simulation results are investigated. Results showed that the cross-sections generated using the 3D assembly model with a locally heterogeneous representation of control rods lead to an accurate estimation with less than 270 pcm bias in core reactivity, 0.5% bias in control rod worth, and 1.5% bias on power distribution. The study verified the applicability of multi-group cross-sections generated with the MC method for LFR analysis. The study also proved the feasibility of multi-group MC in core calculation with local heterogeneity, which saves 85% time compared to the continuous-energy MC.

Structural Strength Analysis of Automotive Suspension (자동차 현가장치의 구조 강도 해석)

  • Cho, Jae-Ung;Kwon, Oh-Beom;Han, Moon-Sik
    • Journal of the Korean Society of Manufacturing Technology Engineers
    • /
    • v.19 no.1
    • /
    • pp.89-93
    • /
    • 2010
  • This paper describes the analysis of state when load applies to McPherson strut assembly. Strut assembly except knuckle-arm are created with 3 dimensional modeling program. Stress and structural strength on this model are analyzed by analysis program as load applies on the lower part of assembly modeling. When McPherson suspension is applied with 3000N at Z direction, maximum stress at spring becomes 433MPa and the cycle of minimum life is 4321. The designed modeling suspension at this study has no possibility with resonance.

The Feasibility Study on the Monte Carlo Based RTP Commissioning

  • Kang, Sei-Kwon;Cho, Byung-Chul;Park, Suk-Won;Oh, Do-Hoon;Park, Hee-Chul;Bae, Hoon-Sik
    • Proceedings of the Korean Society of Medical Physics Conference
    • /
    • 2004.11a
    • /
    • pp.43-46
    • /
    • 2004
  • The commissioning of a treatment planning system of model-based dose calculation algorithm requires a lot of parameters to be selected to fit measured data, in which process physical insights for the parameters are often forgotten. We present the photon beam commissioning of Pinnacle$^3$ with the help of Monte Carlo (MC) simulation and evaluate the parameters Pinnacle$^3$ demands. Even though the MC calculation produces reasonable values for the commissioning, the thorough physical basis of the Pinnacles$^3$'s commissioning process is needed to use the MC derived parameters directly.

  • PDF

Control of an underwater biomimetic vehicle using Floquet theory

  • Plamondon, Nicolas;Nahon, Meyer
    • Ocean Systems Engineering
    • /
    • v.4 no.3
    • /
    • pp.243-261
    • /
    • 2014
  • Aqua is an underwater biomimetic vehicle designed and built at McGill University that uses six paddles to produce control and propulsion forces. It has the particularity of having time-periodic thrust due to its oscillating paddles. Using an existing model of the vehicle, two types of controller were developed: a PD controller and a Floquet controller. The Floquet controller has the advantage of explicitly addressing the time-periodicity of the system. The performance of the controllers was assessed through simulation and experimentally in the Caribbean Sea. We find that the vehicle was able to follow the prescribed trajectories with relative accuracy using both controllers, though, the Floquet controller slightly outperforms the PD controller. Furthermore, a key advantage of the Floquet controller is that it requires no tuning while the PD controller had to be tuned by trial and error.

OLED Power Driving Simulation Using Impedance Spectroscopy

  • Kong, Ung-Gul;Hyun, Seok-Hoon;Yoon, Chul-Oh
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2003.07a
    • /
    • pp.32-35
    • /
    • 2003
  • Nonlinear parameterization of OLED device from measurements of bias dependence of impedance spectra and parameter extraction using Levenberg-Marquardt complex nonlinear least square regression algorithm based on resistor-capacitor equivalent circuit model enables computer simulation of OLED power driving characteristics in forms of square-wave or sinusoidal output signal at arbitrary conditions. We introduce developed OLED power driving simulation software and discuss transient responses in voltage-or current-controlled operations as well as nonlinear characteristics of OLED, by presenting both the simulation and experimental results. This OLED simulation technique using impedance spectroscopy is extremely useful in predicting performance of the nonlinear device, especially in time-domain analysis of device operation.

  • PDF

Effects of Nonlinearity on the Performance of Multi-Code CDMA Communication Systems (Multi-Code CDMA 시스템에서의 비선형 전력 증폭기의 영향분석)

  • 권진만;김상우
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.24 no.6A
    • /
    • pp.855-863
    • /
    • 1999
  • Recently a number of multi-rate CDMA systems have been proposed for the third generation mobile communication system. Multi-Code CDMA (MC-CDMA) offers the system construction advantage of being able to use a single-rate receiver. But MC-CDMA suffers from the distortion due to the nonlinearity of the power amplifier. In this paper, we analyze the effect of the nonlinearity on the bit error rate performance of MC-CDMA systems. A polynomial model is used to represent the amplifier amplitude nonlinearities.

  • PDF

Impedance spectroscopy for lifetime analysis of OLED

  • Yoon, Chul-Oh;Kim, Hyun-Chul;Yi, Seok-Kyung;Kong, Ung-Gul;Lee, Nam-Heon;Lee, Chang-Hee
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2002.08a
    • /
    • pp.137-140
    • /
    • 2002
  • The frequency response analysis of complex impedance spectra using small perturbation ac impedance spectroscopy is an informative method of OLED performance characterization and lifetime analysis. Using simple RC equivalent circuit mode,l macroscopic nonliniear transport properties of semiconductive emission/transport layers can be analyzed and parameterized. We present the bias voltage dependence and aging effect in impedance spectra measured from an ITO/CuPC/TPD/$Alq_3$/LiF/Al OLED device, and discuss possible failure mechanism based on impedance model parameters.

  • PDF

Computation of Super High-Resolution Global Ocean Model using Earth Simulator

  • Kim, Dong-Hoon;Norikazu Nakashiki;Yoshikatsu Yoshida;Takaki Tsubono;Frank O. Bryan;Richard D.Smith;Mathew E. Maltrud;Matthew W. Hecht;Julie L. McClean
    • Proceedings of the Korean Society of Coastal and Ocean Engineers Conference
    • /
    • 2003.08a
    • /
    • pp.164-169
    • /
    • 2003
  • The need fur higher grid resolution in climate models is often discussed (e.g. McAvaney et al.,2001) because a number of important oceanic processes are not resolved by the current generation of coupled models, e.g., boundary currents, mesoscale eddy fluxes, sill through flows. McClean et al., (1997) and Bryan and Smith (1998) have compared simulated mesoscale variability in simulations at several eddy-resolving resolutions to TOPEX/Poseidon and similar data. (omitted)

  • PDF

A comparison study of approximate and Monte Carlo radiative transfer methods for late type galaxy models

  • Lee, Dukhang;Baes, Maarten;Seon, Kwang-il
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.41 no.1
    • /
    • pp.49.3-50
    • /
    • 2016
  • Two major radiative transfer (RT) techniques have been developted to model late-type galaxies: approximate RT and Monte Carlo (MC) RT. In the approximate RT, first proposed by Kylafis & Bahcall, only two terms of unscattered (direct) and single-scattered intensities are computed and higher-order multiple scattering components are approximated, saving computing time and cost compared to MC RT. However, the approximate RT can yield errors in regions where multiple scattering effect is significant. In order to examine how significant the errors of the approximate RT are, we compare results of the approximate RT with those of SKIRT, a state-of-the-art MC RT code, which is basically free from the approximation errors by fully incorporating all the multiple scattered intensities. In this study, we present quantitative errors in the approximate RT for late type galaxy models with various optical depths and inclination angles. We report that the approximate RT is not reliable if the central face-on optical depth is intermediate or high (${\tau}_V$ > 3).

  • PDF