• KEPCO Journal on Electric Power and Energy
• /
• v.2 no.3
• /
• pp.461-467
• /
• 2016

In order to install the floating transport type wind-turbine foundation, water pumping is used to sink the foundation. During this process, its mass and center of gravity, and buoyancy center become continuously changed so that the dynamic stability of the floating foundation become unstable. Dynamic stability analysis of the floating foundation is a complex problem since it should take into account not only the environmental wave, wind, and current loads but also its weight change effect simultaneously considering six-degree-of-freedom motion. In this study, advanced numerical method based on the coupled computational fluid dynamics (CFD) and multi-body dynamics (MBD) approach has been applied to the dynamic stability analysis of the floating foundation. The sloshing effect of foundation internal water is also considered and the floating dynamic characteristics are numerically investigated in detail.

• The Korean Journal of Physiology and Pharmacology
• /
• v.24 no.3
• /
• pp.277-286
• /
• 2020

Polycystic kidney disease 2-like-1 (PKD2L1), also known as polycystin-L or TRPP3, is a non-selective cation channel that regulates intracellular calcium concentration. Calmodulin (CaM) is a calcium binding protein, consisting of N-lobe and C-lobe with two calcium binding EF-hands in each lobe. In previous study, we confirmed that CaM is associated with desensitization of PKD2L1 and that CaM N-lobe and PKD2L1 EF-hand specifically are involved. However, the CaM-binding domain (CaMBD) and its inhibitory mechanism of PKD2L1 have not been identified. In order to identify CaM-binding anchor residue of PKD2L1, single mutants of putative CaMBD and EF-hand deletion mutants were generated. The current changes of the mutants were recorded with whole-cell patch clamp. The calmidazolium (CMZ), a calmodulin inhibitor, was used under different concentrations of intracellular. Among the mutants that showed similar or higher basal currents with that of the PKD2L1 wild type, L593A showed little change in current induced by CMZ. Co-expression of L593A with CaM attenuated the inhibitory effect of PKD2L1 by CaM. In the previous study it was inferred that CaM C-lobe inhibits channels by binding to PKD2L1 at 16 nM calcium concentration and CaM N-lobe at 100 nM. Based on the results at 16 nM calcium concentration condition, this study suggests that CaM C-lobe binds to Leu-593, which can be a CaM C-lobe anchor residue, to regulate channel activity. Taken together, our results provide a model for the regulation of PKD2L1 channel activity by CaM.

• Korean Journal of Clinical Pharmacy
• /
• v.26 no.2
• /
• pp.97-106
• /
• 2016

Background: Sevelamer is associated with reduced complications of chronic kidney disease-mineral bone disorder (CKD-MBD) resulted from hyperphosphatemia, which may contribute mortality, in CKD patients with dialysis. So far clinical outcomes of sevelamer on mortality and risk of cardiovascular mortality related to CKD-MBD are debating. Purpose of this study was to evaluate the effectiveness of sevelamer HCl on mortality of secondary hyperparathyroidism (SHPT), risk of cardiovascular mortality and, frequency of osteopathy in end stage renal disease (ESRD) patients with dialysis. Methods: We retrospectively reviewed the electronic medical records of 536 patients with ESRD, who were admitted for moderate to severe SHPT, for 36 months. 75 patients who met inclusion criteria were evaluated for the efficacy of sevelamer (mean serum iPTH = 487.5 pg/mL). Results: Sevelamer intervention was not associated with increased three-year survival time compared with non-sevelamers group [average survival month: 30.4 months in sevelamer group, 26.8 months in non-sevelamer group, p = 0.463]. Sevelamer intervention was not associated with significant mortality benefit and cardiovascular mortality benefit as compared to non-sevelamer group [sevelamer group: non-sevelamer group, all-cause mortality (iPTH > 600 pg/mL): 14.3% (1/34): 20% (1/41) p = 0.962, OR = 0.935, 95% CI, 0.058-14.98, heart disease mortality: 6.67% (2/30): 0% (0/32) p = 0.138]. Sevelamer was not associated with significantly lower cumulative incidence of osteopathy compared to non-sevelamer group (sevelamer group: non-sevelamer group, 5.9% (2/34):9.8% (4/41); p = 0.538; OR = 0.578; 95% CI, 0.099-3.367). Conclusion: Sevelamer was not associated with decreased all-cause mortality and risk of cardiovascular mortality compared to non-sevelamer group in ESRD patients with SHPT.

• Childhood Kidney Diseases
• /
• v.8 no.1
• /
• pp.33-42
• /
• 2004

Purpose : Children with nephrotic syndrome(NS) are under high risk for metabolic bone disease(MBD) as a complication of long-term glucocorticoid therapy. We prospectively evaluated the effect of oral bisphosphonate(alendronate) therapy in children with NS, which has proven efficacy in adult patients with glucocorticoid induced MBD. Methods : Among 58 children with NS, aged 5 to 8 years and haying a disease duration of more than 2 years, 30(51.7%) were enrolled to meet the selection criteria, less than -1.0 Z-scores of lumbar spine bone mineral density(BMD) by dual energy X-ray absorptiometry (DEXA). These 30 children were divided into three groups and each were assigned to receive alendronate, calcitriol, and no-medication, respectively for one year. Lumbar spine BMD was followed up every 6 months and the biochemical indexes were measured before and 1 year after the treatment. There were no significant difference among groups with respect to the average age, the initial BMD, and the cumulative steroid doses. Analysis of the treatment efficacy was done by the % change of BMD and by the changes in Z-scores of lumbar spine BMD. Results : Mean age and disease duration of patients at the initial lumbar spine BMD evaluation was $7.4{\pm}1.7$ years and $2.2{\pm}1.2$ years, respectively. Twenty-three of 30 children(76%) had osteopenia, and seven(23%) had osteoporosis. There was no difference in the biochemical values among the groups, before and 1 year after the treatment(P<0.05). Twenty two children(73.3%) with frequent relapsing or steroid dependant NS had more frequent MBD, compared to the 8 children(26.6%) with infrequent relapsing NS. The one year % changes of BMD were 8.56 in alendronate group, 5.79 in calcitriol group, and 1.9 in no-medication group. The changes in Z-score of lumbar spine BMD increased in the alendronate group and the calcitriol group, but not in the no-medication group. One year % changes of BMD were different among groups(P=0.0002). Significant differences were found between the alendronate and the no-medication group, and between the calcitriol and the no-medication group(P<0.05). There was no difference between the alendronate and the calcitriol group. No serious adverse effect was observed in the alendronate group. Conclusion : Children with NS receiving high dose steroids are under the high risk of BMD and should undergo regular BMD evaluation. Z-score of lumbar spine BMD was a useful parameter in diagnosing low bone mass in children. Alendronate weekly oral therapy was effective and relatively safe in increasing the lumbar spine BMD in children with NS having steroid induced MBD.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.41 no.11
• /
• pp.1085-1089
• /
• 2017

Juryeonggu is a cuboctahedral die that was used during the Silla period in ancient Korea. This cuboctahedral die consists of two different penal servitudes of 14 sides; however, its equal probability distribution enables it to be used as a die. In this paper, a precise cuboctahedral die, Juryeonggu, was manufactured, and its probability was measured through experiments. Next, the probability was verified through Multibody-dynamics (MBD) modeling and analysis, and the effect of the coefficient of friction on the probability distribution was studied.

• Biodesign
• /
• v.6 no.4
• /
• pp.79-83
• /
• 2018

Mitogen-activated protein kinases (MAPKs) are one of the most important enzymes in various cellular activities, and the MAPK signaling pathway is implicated in many disorders. MAPK phosphatases (MKPs) are regulators that contain a MAPK-binding domain (MBD) for MAPK recognition, and a catalytic domain (CD), for dephosphorylation and inactivation of MAPKs. Due to their crucial role in regulating the MAPK pathway, MKPs are regarded as a potential drug target in various diseases. Attempts have also been made to regulate the MAPK pathway by reducing the MKP activity. For drug development, it is important to understand the key features of MAPK-MKP complex formation. This review summarizes the studies on MAPK-MKP complexes, mainly focusing on their selective recognition and catalytic activation.

• Radiation Oncology Journal
• /
• v.15 no.1
• /
• pp.57-64
• /
• 1997

Purpose : Before we report the results of curative radiotherapy in cervix cancer patients, we review the significance and safety of our dose specification methods in the brachytherapy system to have the insight of the potential Predictive value of doses at specified points. Matersials and Methods : We analyze the 리5 cases of cervix cancer patients treated with intracavitary brachytherapy in the lateral simulation film we draw the isodose curve and observe the absorbed dose rate of point A, the reference point of bladder(SBD) and rectum(SRD). In the sagittal view of Pelvic MRI film we demarcate the tumor volume(TV) and determine whether the prescription dose curve of point A covers the tumor volume adequately by drawing the isodose curve as correctly as possible. Also we estimate the maximum Point dose of bladder(MBD) and rectum(MRD) and calculate the inclusion area where the absorbed dose rate is higher than that of point A in the bladder(HBV) and rectum(HRV), respectively. Results : Of forty-five cases, the isodose curve of point A seems to cover tumor volume optimally in only 24(53%). The optimal tumor coverage seems to be associated not with the stage of the disease but with the tumor volume. There is no statistically significant association between SBD/SRD and MBD/MRD, respectively. SRD has statistically marginally significant association with HRV, while TV has statistically significant association with HBV and HRV. Conclusion : Our current treatment calculation methods seem to have the defect in the aspects of the nonoptimal coverage of the bulky tumor and the inappropriate estimation of bladder dose. We therefore need to modify the applicator geometry to optimize the dose distribution at the position of lower tandem source. Also it appears that the position of the bladder in relation to the applicators needs to be defined individually to define 'hot spots'.

• Journal of the Korean Society for Marine Environment & Energy
• /
• v.16 no.4
• /
• pp.239-247
• /
• 2013

Recently renewable energy such as offshore wind energy takes a higher interest due to the depletion of fossil fuel and the environmental pollution. This paper deals with multi-body dynamics (MBD) analysis technique for offshore wind turbine system considering aerodynamic loads and Thevenin equation used for determination of electric generator torque. Dynamic responses of 5MW offshore wind turbine system are evaluated via the MBD analysis, and the system is the horizontal axis wind turbine (HAWT) which generates electricity from the three blades horizontally installed at upwind direction. The aerodynamic loads acting on the blades are computed by AeroDyn code, which is capable of accommodating a generalized dynamic wake using blade element momentum (BEM) theory. In order that the characteristics of dynamic loads and torques on the main joint parts of offshore wind turbine system are simulated similarly such an actual system, flexible body modeling including the actual structural properties are applied for both blade and tower in the multi-body dynamics model.

• Journal of Advanced Navigation Technology
• /
• v.27 no.4
• /
• pp.382-390
• /
• 2023

The Korea market for LUAV (Light Unmanned Aerial Vehicle) weighing less than 150 kg is growing rapidly. As a result, the market for manufacturing and operating LUAV is expanding, and domestic development of parts and finished products is actively taking place. However, the flight control system and onboard software, which are key components of domestic LUAV, are largely dependent on overseas products due to the excessive cost and period required for development. This paper presented a domestic software development and certification procedure using DO-178C, a guideline for aircraft software development, and the Model-based Development method, and conducted a survey of those involved in the development, manufacturing, and certification of LUAV and analyzed the results. In addition, a case study was conducted to apply the software development plan to the helicopter FCC (Flight Control Computer).

• Transactions of the Korean Society of Automotive Engineers
• /
• v.21 no.3
• /
• pp.58-65
• /
• 2013

In this paper, we propose that a model based design for an electric motor cycle system using ASM (Automotive Simulation Models). Before prototyping a realistic electric motorcycle, a reliable simulation program is required to test the capacities of the power sources and optimize the parameters of an electric motorcycle. Because ASM is based on Simulink, we can design the drivetrain and powertrain of the vehicle model systems easily. To verify the electric motorcycle system analysis of design parameters such as max power, capacity, state of charge and slope angle is carried out by the simulation and experimental method. The predicted results by the development model were in good agreement with the experimentally obtained results. Therefore, the proposed electric motorcycle model can effectively reduce the expenses during the designing of an electric motorcycle system.