• 한국임상수의학회지
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• 제29권1호
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• pp.63-67
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• 2012

Mosquitoes are the vectors of a number of viral diseases in cattle, such as Akabane disease, bovine ephemeral fever, Ainovirus infection, Chuzan virus infection, and Ibaraki disease. These diseases are transmitted from an infected animal to a non-infected host via the blood feeding of the vector. In Korea, the National Veterinary Research and Quarantine Services, Ministry for Food, Agriculture, Forestry and Fisheries is responsible for planning, implementation, laboratory investigations and reporting the results of the national surveillance program for mosquito-borne bovine diseases (MBD). The surveillance program, which was started in 1993, focused to determine the seroprevalence of each disease in cattle herds in space and time. From the epidemiological point of view, more important component of the surveillance program is to monitor infection rates in vectors for specific pathogens because this information is essential for a more precise understanding the dynamics of these diseases in a given environment and for determining risk of transmission. The aim of this study was to describe and compare methods for estimation of vector infection rates using maximum likelihood (MLE) and minimum infection rate in pooled samples. Factors affecting MLE such as number of pools, pooling size and diagnostic test performance are also discussed, assuming some hypothetical sampling scenarios for MBD.

• 응용통계연구
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• 제5권2호
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• pp.229-242
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• 1992

Bradley & Stewart(1991)에서 인용하고 있는 예에 대해서 행간, 열간 정보를 회복하여 이것을 이용하고 블록내 분석결과와 결합하는 방법을 생각해 볼 수 있다. 이것은 행효과와 열효과를 다같이 확률효과(random effects)로 간주하여 일반화 최소제곱법(Generalized least squares method)에 의해서 해를 구하는 것과 동일한 것이다. 이것이 Paik(1986)에서 논의되고 있다. 이 방법은 어떤 행-열 계획(Row-column design)에도 적용된다. 따라서 격자방격(格子方格, Lattice square)에도 그대로 적용된다. 그런데 이와 같은 방법은 보통 불완비 블록계획(incomplete block designs)에서의 방법을 확대 적용하여 얻을 수 있다. 이러한 블록실험에 대한 SAS/IML을 이용한 분석법은 백운봉(1990a,1990b)에 의해서 제안된 바 있다. 그러나 이것이 개선될 필요가 있었고, 이 개선된 방법을 확대 적용한 것이 본 논문이다. 블록실험에 대한 개선된 방법은 본 논문 말미에 부록으로 제공 되어 있다.

• 전기전자학회논문지
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• 제26권2호
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• pp.280-286
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• 2022

본 논문에서는 Digital Signal Processor(DSP)와 PLECS 소프트웨어를 사용하여 영구자석동기전동기(Permanent Magnet Synchronous Machine, PMSM)를 위한 Rapid Control Prototyping (RCP)를 구현하였다. PLECS의 Auto-code generation(ACG) 기능을 활용하여 제어 프로세서를 DSP로 사용하는 PMSM 구동 시스템에 대한 현재 벡터 제어 알고리즘을 보다 상대적으로 간단하고 효율적으로 개발할 수 있다. 본 논문에서는 모델 기반 설계(Model Based Design, MBD)와 real time control(실시간 제어) 배경을 살펴본다. 또한, DSP 보드와 호환되는 상용 RCP 제품 및 실험을 통한 PMSM 드라이브 제어를 구현하였다.

• 한국임상약학회지
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• 제26권4호
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• pp.318-323
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• 2016

Background: Multidisciplinary team care (MTC) is a collaborative approach to treatment plan and ongoing care. We aimed to evaluate the clinical effect of MTC on the regulation of chronic kidney disease-mineral and bone disorder (CKD-MBD) complications in dialysis patients. Methods: This retrospective observational study was approved by the institutional review board. Among patients who have undergone dialysis at admission, the patients admitted to the nephrology ward were allocated to MTC group, and the others to usual care (UC) group. The MTC group had collaborative care by nephrologists, nurses, pharmacists, and nutritionists. The endpoints were the regulation of corrected calcium (cCa) and phosphate (P), the percent of patients in target level of cCa-P product ($cCa{\times}P$), and the prescription rate of non-calcium based P-binders. Results: A total of 163 patients were included from January to December 2009. A significant difference was shown in the percentage of patients in target $cCa{\times}P$ level at admission (MTC vs. UC, 81.40% vs. 91.67%; P = 0.038), but there was no significant difference at discharge. During admission, the cCa and P levels of patients in only UC group were significantly changed. In addition, compared with UC group, patients in MTC group were more likely prescribed appropriate P-binders, when they had higher $cCa{\times}P$ levels than $55mg^2/dL^2$ (P <0.001). Conclusion: It was found that MTC had beneficial effect on improving the regulation of CKD-MBD and the appropriate phosphate binder uses. Therefore, application of the MTC is anticipated to enhance quality of clinical care in chronic diseases.

• 한국항공우주학회지
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• 제38권12호
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• pp.1217-1222
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• 2010

본 논문은 근접감시 무인항공기(KUS-9)의 비행제어 소프트웨어(S/W) 개발 과정과 모델기반 개발 기술 적용 결과를 다룬다. 대표적인 상용 모델기반 설계도구인 MATLAB $Simulink^{(R)}$를 활용하여 통합개발 환경을 구축하고 비행제어법칙, 운용로직, 비행 시뮬레이션 모델, HILS(Hardware-in-the-Loop Simulation) 시스템 모델을 설계하였다. 설계 과정에서 요구사항 충족을 위한 시뮬레이션 및 동료검토를 수행하고 DO-178B 검증 도구를 이용하여 모델을 검증한 후 S/W시험 도구를 통해 C코드의 무결성을 검증하였다. 탑재 소프트웨어는 두 기종의 하드웨어 및 실시간운용체제(${\mu}C$/OS-II, VxWorks)에 탑재하여 HILS시험과 비행시험을 수행하였다. 모델기반 개발 기법을 적용함으로써 S/W 재사용성과 확장성을 확보하고 자동코드생성 기술을 이용하여 고신뢰 비행제어 S/W를 단기간에 성공적으로 개발하였다.

• Experimental and Molecular Medicine
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• 제50권12호
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• pp.1.1-1.14
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• 2018

DNA methylation is a regulatory mechanism in epigenetics that is frequently altered during human carcinogenesis. To detect critical methylation events associated with gastric cancer (GC), we compared three DNA methylomes from gastric mucosa (GM), intestinal metaplasia (IM), and gastric tumor (GT) cells that were microscopically dissected from an intestinal-type early gastric cancer (EGC) using methylated DNA binding domain sequencing (MBD-seq) and reduced representation bisulfite sequencing (RRBS) analysis. In this study, we focused on differentially methylated promoters (DMPs) that could be directly associated with gene expression. We detected 2,761 and 677 DMPs between the GT and GM by MBD-seq and RRBS, respectively, and for a total of 3,035 DMPs. Then, 514 (17%) of all DMPs were detected in the IM genome, which is a precancer of GC, supporting that some DMPs might represent an early event in gastric carcinogenesis. A pathway analysis of all DMPs demonstrated that 59 G protein-coupled receptor (GPCR) genes linked to the hypermethylated DMPs were significantly enriched in a neuroactive ligand-receptor interaction pathway. Furthermore, among the 59 GPCRs, six GI hormone receptor genes (NPY1R, PPYR1, PTGDR, PTGER2, PTGER3, and SSTR2) that play an inhibitory role in the secretion of gastrin or gastric acid were selected and validated as potential biomarkers for the diagnosis or prognosis of GC patients in two cohorts. These data suggest that the loss of function of gastrointestinal (GI) hormone receptors by promoter methylation may lead to gastric carcinogenesis because gastrin and gastric acid have been known to play a role in cell differentiation and carcinogenesis in the GI tract.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 춘계학술대회 및 국제심포지움 초록집
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• pp.92-92
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• 2005

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 춘계학술대회 및 국제심포지움 초록집
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• pp.101-101
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• 2005

• The Journal of the Acoustical Society of Korea
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• 제25권4E호
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• pp.148-153
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• 2006

A new normalized MBD algorithm is presented for nonstationary convolutive mixtures and its properties/modifications are discussed in details. The proposed algorithm normalizes the signal spectrum in the frequency domain to provide faster stable convergence and improved separation without whitening effect. Modifications such as nonholonomic constraints and off-diagonal learning to the proposed algorithm are also discussed. Simulation results using a real-world recording confirm superior performanceof the proposed algorithm and its usefulness in real world applications.

• The Journal of the Acoustical Society of Korea
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• 제24권2E호
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• pp.54-60
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• 2005

A new multichannel blind deconvolution algorithm is proposed for speech mixtures. It employs unidirectional filters and normalization of gradient terms in the frequency domain. The proposed algorithm is shown to be approximately nonholonomic. Thus it provides improved convergence and separation performances without whitening effect for nonstationary sources such as speech and audio signals. Simulations using real world recordings confirm superior performances over existing algorithms and its usefulness for real applications.