• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.2
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• pp.210-219
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• 2002

Background and Objectives The diagnosis of allergic rhinitis includes detailed clinical history, physical examination and the use of either in vivo or vitro tests for relevant allergens. Skin test has been used the most commonly. Recently MAST CLA is used for determination of serum spcecific IgE, This study attempted to find out the distribution of Sasang Constitution and to compare the MAST CLA with skin tests in allergic rhinitis patients. Methods Skin tests, MAST CLA and Sasang Constitution study were performed for 35 allergic rhinitis patients who visited Kyunghee Oriental Medical Center from Sept. 2001 to Nov. 2001. Results 1. The ratio between male and female was 1:1.5. the peak age was the thirties(42.9$\%$) 2. 45.7$\%$ of patients had family history of allergic diseases and allergic rhinitis was the most common. 3. 51.4$\%$ of patients lived in A.P.T. and in preference of cool and warm, 54.3$\%$ of patients prefered both of cool and warm. 4. Among 24 cases who were consulted to dept. of Sasang, 45.8$\%$ was Taeumin. 5. 65.7$\%$ of patients reacted positive to skin test and the common offending allergen was D. pteronyssinus(82.6$\%$). 6. 25.7$\%$ of patients reacted positive to MAST CLA and the common offending allergen was D. farinae(88.9$\%$). 7. Among 22 cases who was performed skin test and MAST CLA the sensivity and specificity of MAST CLA was 27.4$\%$ and 94.9$\%$. There was significant correlations between MAST CLA and skin test(p=0.005, r=0.574, 1, spearman correlation coefficienct).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.3
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• pp.220-229
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• 2003

Background and Objectives : The diagnosis of allergic diseases in current oriental medicine is in the state of depending mainly on two factors: some distinctive symptoms and scientific 'opinions', MAST CLA test is also believed to be helpful in Oriental Medicine on making definite diagnosis of allergic diseases and identifying causative antigen. This study will address the clinical importance of MAST CLA test, the residential type of allergic patients and its distribution status, etc. Methods : From March of 2000 through September of 2003, tests were made in Oriental Medicine Hospital of Semyung University on sex, age, types of residence, allergic diseases and MAST CLA system for the patients who showed allergic symptoms and had been diagnosed so in other hospitals. Results : 1. Sex: Among 91 subjects, 38 of them were men, 53 of them were women. 2. Age group : 15.3% of them were in their 40s; 31.8% in 30s; 15.3% in 20s; 17.5% in 10s. 3. Residental type : A.P.T(51 of them, 56%), plain type of house(33 of them, 36.2%) and villa(7 of them, 7.6%). 4. Discases : Among the diseases, allergic dermatitis was most common(69 of them. 75.8%); allergic rhinitis(17 of them, 18.6%); and chronic and acute urticaria(4 of them, 4.3%) in order. 5. Among 91 subjects, 39 of them showed positive reaction to more than one type of antigens in MAST CLA test: 23 of them were men(60.5%); 16 of them. women(30.1%). 6. Among 91 subjects. 53 of them(58.2%) showed positive reaction to antibodies in MAST CLA test: 22 of them were men; 31 of them, women. 7. Antigen distribution order among 39 subjects who showed positive reaction in MAST CLA test: Mite-farinae, Mite-pterony, Housedust in men and women subjects alike.

• Parasites, Hosts and Diseases
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• v.45 no.3
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• pp.239-243
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• 2007

Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MAST-CLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and k-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.

• Parasites, Hosts and Diseases
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• v.39 no.2
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• pp.197-199
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• 2001

Arthropod antigens are main causative agents which induce allergic reponses in humans. However. little information is known about the prevalence of specific arthropod allergens in Koreans with allergic diseases. The current study was designed to determine the positive rates of arthropod antibodies by the Korean inhalant panel of MAST-CLA. One hundred sixty patients, who were diagnosed with allergic rhinitis from an out-patient center at the Soonchunhyang University Chunan Hospital, were studied between August 1998 to July 2000. The overall positive rate, at least more than one specific antibody of arthropods such as Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), and cockroach mix (Cm) , was 46.9%. Each positive rate of Df, Dp, and Cm was 45.0%, 43.1%, and 8.8%, respectively. A significant agreement among arthropod allergens was observed (Df and Dp: 95.6%, Kappa : 0.911, P < 0.001). Our data supported the fact that arthropods were the most common allergens in Korean patients with allergic rhinitis; however, the MAST-CLA should be modified to increase specificity of arthropod allergens .

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.1
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• pp.172-182
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• 2005

Objective : The purpose of this study was to know the clinical effect of Hydrotherapy based Ultasonic spa on Atopic Dermatitis and Allergic Rhinitis. Methods : Allery Test(MAST CLA Allergy system, inhalant panel), DITI, Bio Chemistry, Hematology were investigated in 20 patients(Atopic Dermatitis 10, Allergic Rhinitis 10) who visited Department of Ophthalmology & Otolaryngology & Dermatology, Semyung Oriental medicine hospital from November 2004 to January 2005. Results : 1. In atopic dermatitis patients, there was good in 7 cases(70%), excellent in 3 cases(30%). 2. In allergic rhinitis patients there was improved in 5 eases(50%), good in 2 cases(20%), unimproved in 3cases(30%). 3. In conclusion, there was good(doctor and patients ail) in 6(60%), unimproved in 3(30%) Conclusion : Hydrotherapy based Utasonic spa showed useful effect on Atopic Dermatitis and Allergic Rhinitis.

• Korean Journal of Clinical Laboratory Science
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• v.39 no.2
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• pp.104-112
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• 2007

The purpose of this study was to evaluate the general features of allergic patients in northwestern Chungcheongnamdo who visited Soonchunhyang University Cheonan Hospital. The subjects in this study were 1692 suspected allergic patients. After their allergic symptoms were checked and a MAST-CLA test was conducted, the following results were obtained: 1. The mean age of the subjects was 23.1 years old. The male patients represented 56.2% and the female patients accounted for 43.8%. 1387 (82.0%) patients of those investigated suffered from allergic disease. 2. Among the 1387 patients, 1022 (73.7%) patients showed an increased total IgE level. The positive rate of those who were in their 40s (87.0%) was the highest, but their age made no difference to their positive rate of total IgE. 3. Concerning the positive rate for allergen specific antibody by age, those who were in their teens (73.5%) topped the list and similar in all age group except in their 40s. By gender, the positive rate of the male and female were 56.3% and 43.9% respectively. Regarding the positive rates by allergic disease, those who suffered from allergic rhinitis (60.4%) were most vulnerable, followed by the patients with allergic dermatitis (47.4%), with bronchial asthma (47.2%) and with urticaria (39.4%). 4. As for seasonal positive rates, they were most susceptible in April (77.2%) and May (71.1%). We discovered a significant difference according to seasons; Spring (60.1%), Winter (45.4%) and Summer (39.2%). 5. In case of Korean inhalent panel, the most dominant allergen-specific antibodies were "Cockroach mix" (31.1%), followed by "D. pteronyssius" (23.8%) and "Dog" (14.3%). In the event of food panel, the most popular allergen-specific antibodies were "D. farinae" (25.0%), followed by "D. pteronyssinus" (19.8%) and "Hose dust" (12.0%). 6. The residential type made no difference to the positive rates of "House dust", "Cockroach mix" and "Dog" as major antigen but compared with others, positive rates for "Tick" were somewhat higher in apartment buildings.