• Physical Therapy Korea
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• v.10 no.4
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• pp.1-15
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• 2003

본 연구는 슬관전 신전 직전에 수행된 선행 슬관절 굴곡이 슬관절 신전근의 최대 근력발생 및 근육 활성도(activation)에 미치는 영향을 알아보기 위하여 실시되었다. 16명의 정상인이 Cybex II 등속운동기구에서 3가지 다른 운동 속도($100^{\circ}/s$, $200^{\circ}/s$, $300^{\circ}/s$)와 2가지 다른 근육 활성 조건(선행부하가 없는 조건과 선행부하 조건)에서 슬관절의 최대 신전을 수행하였다. 연구대상자들에게 선행부하 없는 조건에서는 $90^{\circ}$ 슬관절 굴곡 상태에서 $0^{\circ}$까지 최대 신전을 수행하도록 하였고, 선행부하 조건에서는 구심성 슬와부 근육의 구심성 수축으로 $0^{\circ}$에서 $110^{\circ}$까지 굴곡한 후, 다시 $0^{\circ}$까지 최대 신전을 하도록 요구하였다. 종속변인으로는 내측광근과 외측광근의 최대 근전도와 최대 신전근력을 측정하였다. 실험 결과 최대 근전도와 최대 근력 모두 선행부하 조건에서 높게 나타났으며, 운동 속도가 증가함에 따라 최대 근력은 감소하는 전형적인 최대 근력-운동속도 상관법칙이 본 실험에서도 나타났다. 또한 운동속도와 전환속도 간의 간섭이 없는 것으로 나타나, 슬관절 신전근에 선행부하(preloading)를 가하는 것이 최대 근력-운동속도 상관법칙(force-velocity relation)에 영향을 미치지 못하는 것으로 해석되었다. 선행부하로 인해 증가된 최대 근력 및 근 활성도의 증가는 주로 신경촉진에 의한 것으로 해석된다.

• Molecular & Cellular Toxicology
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• v.2 no.2
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• pp.81-88
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• 2006

Sphingolipid metabolites regulate many aspects of cell proliferation, differentiation, and apoptosis. In the present study, we have assessed the effects of the novel phytosphingosine derivative, N-acetylphytospingosine (NAPS), on the depigmentation of murine B16F10 melanoma cells, and have also attempted to identify the possible signaling pathway involved, in comparison with $C_{2}-ceramide$. NAPS and $C_{2}-ceramide$ both inhibited the growth of the B16F10 cells in a dose-dependent manner. Melanin content and tyrosinase activity were significantly reduced in response to treatment with NAPS and $C_{2}-ceramide$ at concentrations in a range between $1-5\;{\mu}M$. However, the levels of tyrosinase mRNA, as well as the levels of tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2) genes and the level of tyrosinase protein remained unaffected by treatment with either NAPS or $C_{2}-ceramide$. We also attempted to determine the signaling pathway exploited by NAPS and $C_{2}-ceramide$. Interestingly, the phosphorylation of Akt/PKB at serine 473 by NAPS was reduced at the 5 minute mark, whereas $C_{2}-ceramide$ induced the phosphorylation of Akt/PKB at serine 473. Finally, Akt/PKB activity in the NAPS-treated cells was elevated in comparison with the untreated cells. LY294002, a specific PI3-K inhibitor which is located upstream of Akt/PKB, inhibited the phosphorylation of Akt/PKB, but induced an increase in melanin synthesis. These results suggest that the activation of Akt/PKB at serine 473 is related with the suppression of melanin production in the B16F10 mouse melanoma cells. Therefore, the mechanisms exploited by NAPS and $C_{2}-ceramide$ responsible for the depigmentation of B16F10 cells were concluded to involve the inhibition of melanosomal tyrosinase activity.

• Archives of Plastic Surgery
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• v.44 no.2
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• pp.124-135
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• 2017

Background In cases of total knee arthroplasty (TKA) threatened by potential hardware exposure, flap-based reconstruction is indicated to provide durable coverage. Historically, muscle flaps were favored as they provide vascular tissue to an infected wound bed. However, data comparing the performance of muscle versus fasciocutaneous flaps are limited and reflect a lack of consensus regarding the optimal management of these wounds. The aim of this study was to compare the outcomes of muscle versus fasciocutaneous flaps following the salvage of compromised TKA. Methods A systematic search and meta-analysis were performed to identify patients with TKA who underwent either pedicled muscle or fasciocutaneous flap coverage of periprosthetic knee defects. Studies evaluating implant/limb salvage rates, ambulatory function, complications, and donor-site morbidity were included in the comparative analysis. Results A total of 18 articles, corresponding to 172 flaps (119 muscle flaps and 53 fasciocutaneous flaps) were reviewed. Rates of implant salvage (88.8% vs. 90.1%, P=0.05) and limb salvage (89.8% vs. 100%, P=0.14) were comparable in each cohort. While overall complication rates were similar (47.3% vs. 44%, P=0.78), the rates of persistent infection (16.4% vs. 0%, P=0.14) and recurrent infection (9.1% vs. 4%, P=0.94) tended to be higher in the muscle flap cohort. Notably, functional outcomes and ambulation rates were sparingly reported. Conclusions Rates of limb and prosthetic salvage were comparable following muscle or fasciocutaneous flap coverage of compromised TKA. The functional morbidity associated with muscle flap harvest, however, may support the use of fasciocutaneous flaps for coverage of these defects, particularly in young patients and/or high-performance athletes.

• The Journal of the Acoustical Society of Korea
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• v.20 no.3
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• pp.63-69
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• 2001

A corpus-based lip sync algorithm for synthesizing natural face animation is proposed in this paper. To get the lip parameters, some marks were attached some marks to the speaker's face, and the marks' positions were extracted with some Image processing methods. Also, the spoken utterances were labeled with HTK and prosodic information (duration, pitch and intensity) were analyzed. An audio-visual corpus was constructed by combining the speech and image information. The basic unit used in our approach is syllable unit. Based on this Audio-visual corpus, lip information represented by mark's positions was synthesized. That is. the best syllable units are selected from the audio-visual corpus and each visual information of selected syllable units are concatenated. There are two processes to obtain the best units. One is to select the N-best candidates for each syllable. The other is to select the best smooth unit sequences, which is done by Viterbi decoding algorithm. For these process, the two distance proposed between syllable units. They are a phonetic environment distance measure and a prosody distance measure. Computer simulation results showed that our proposed algorithm had good performances. Especially, it was shown that pitch and intensity information is also important as like duration information in lip sync.

• Journal of the Korean Society of Clothing and Textiles
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• v.8 no.3
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• pp.19-30
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• 1984

There is a symbolic term which has realized custom of an era and has eome into fashion since the middle of 1920's. That is Garconne. This paper studied the image and costume of Garconne expressed in literary works, the form of art made it to come into being, and costume of a group of women played a role of pioneers of Garconne. Garconne attempted simple, casual, and mannish costume instead of usual elegance. It was the boiysh style($\`{a}$, la Garconne) which did not stress on the bust and waist like chanel suits used wool jersey by a designer, Chanel ana short skirts of low waist line. They got short haircut and wore low heel shoes. Garconne meant women who were free of convention, were familiar with love a d profession, and lived for themselves in the same manner of young men. They yieled new mode of 1920's. Though their lives were only a period, they manifested the symbol of the period though their figure and designation was not disappeared at the age but was settled as a mark of fixed image. There were several reasons why the Garconne was born. Rapid changes in politics, economics, and society in Europe were occurred from the First World War to 1920 and the trend of custom and art was a turning point. Especially, the entry of women into the society and the mode of Art Deco influenced it directly. The role of a pioneer of Garconne was appeared from the French Revolution. As Merveilleuse, Lionne, and Bloomers wore peculiar clothings ana had life style being irrelevant to tradition, they were talked about. They informed in advance the appearance of new women who were different from romantic ladies and were more modern and active. The pioneer design of Paul Poiret which were over whelming throughout a period and functional design of Chanel were increasingly accelerated.

• Journal of Internet Computing and Services
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• v.8 no.3
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• pp.131-143
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• 2007

The current trends in information technology and intelligent systems use data mining techniques to discover patterns and extract rules from distributed databases. In distributed environment, the extracted rules from data mining techniques can be used in dynamic replications, adaptive load balancing and other schemes. However, transmission of large data through the system can cause errors and unreliable results. This paper proposes the intelligent distributed platform based on dynamic group binding using mobile agents which addresses the use of intelligence in distributed environment. The proposed grouping service implements classification scheme of objects. Data compressor agent and data miner agent extracts rules and compresses data, respectively, from the service node databases. The proposed algorithm performs preprocessing where it merges the less frequent dataset using neuro-fuzzy classifier before sending the data. Object group classification, data mining the service node database, data compression method, and rule extraction were simulated. Result of experiments in efficient data compression and reliable rule extraction shows that the proposed algorithm has better performance compared to other methods.

• International Journal of Highway Engineering
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• v.14 no.6
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• pp.85-92
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• 2012

PURPOSES : Since expressways in South Korea are toll roads, many trumpet type interchanges exist, resulting in the installation of loop ramps very frequently. While the travel speed of the main lane is designed to be 100-110 km/h, the structure of a loop ramp is different and is designed for a minimum speed of 40 km/h. In fact, most of the actual travel speeds measured on the ramp exceed the designated speed, which has been a major problem in traffic safety. In this research, a type of pavement marking speed-reduction treatment called the "Peripheral Transverse Line" is installed on expressway loop ramps in order to study the change of driving speeds after the installation. METHODS : To verify statistically the change, this speed-reduction treatment has been installed on the Chungju interchange and the Yeoju junction. The driving speeds before the installation were compared with driving speeds both one month and five monthsafter the installation. RESULTS : As a result, the reductions of the average driving speeds after the treatment were statistically significant. More specifically, the average driving speeds of the Chungju interchange were reduced by 7.1-7.7 % for its tangent road section, and the speeds decreased by 8.5-9.5 % for its curve section. Similarly, in the Yeoju junction, an average speed reduction of 2.9-4.8 % for its tangent section was measured, along with 3.9% long-term speed reduction for its curve section. CONCLUSIONS : Since the pavement marking speed-reduction treatment has been partially proven to be effective from this research, we expect to expand this treatment and re-confirm the effect from a long-term perspective in the future.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.66.1-66.1
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• 2018

Turbulence is a phenomenon which largely determines the density and velocity fields in molecular clouds. Turbulence can produce density fluctuation which triggers a gravitational collapse, and it can also produce a non-thermal pressure against gravity. Therefore, turbulence controls the mode and tempo of star formation. However, despite many years of study, the properties of turbulence remain poorly understood. As part of the Taeduk Radio Astronomy Observatory (TRAO) Key Science Program (KSP), "apping Turbulent properties In star-forming MolEcular clouds down to the Sonic scale (TIMES; PI: Jeong-Eun Lee)", we have mapped two star-forming clouds, the Orion A and the ${\rho}$ Ophiuchus molecular clouds, in 3 sets of lines (13CO 1-0/C18O 1-0, HCN 1-0/HCO+ 1-0, and CS 2-1/N2H+ 1-0) using the TRAO 14-m telescope. We aim to map entire clouds with a high-velocity resolution (~0.05 km/s) to compare turbulent properties between two different star-forming environments. We will present the preliminary results using a statistical method, Principal Component Analysis (PCA), that is a useful tool to represent turbulent power spectrum.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4383-4386
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• 2015

Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. However, little is known on C1561T-GCPII as a risk factor for colorectal cancer. Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Materials and Methods: 164 controls and 38 adenomatous polyp cases were analysed to determine blood folate and plasma homocysteine (Hcy) level, dietary intake of natural methylfolate, synthetic pteroylglutamic acid (PteGlu), vitamin C and C1561T-GCPII genotype. Results: In controls and cases, 7.3 and 18.4 percent of subjects respectively, were found to have the CT genotype, increasing the risk for adenomatous polyp occurrence 2.86 times (95% CI:1.37-8.0, p=0.035). Total dietary folate, methylfolate and PteGlu intake and the level of erythrocyte folate and plasma Hcy did not predict the occurrence of an adenomatous polyp. However, dietary natural vitamin C intake was associated with adenomatous polyp risk within C1561T-GCPII CT genotype subjects (p=0.037). Conclusions: The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.

• Journal of Korea Multimedia Society
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• v.3 no.4
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• pp.356-364
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• 2000

Block based fast motion estimation algorithm use the fixed search pattern to reduce the search point, and are based on the assumption that the error in the mean absolute error space monotonically decreases to the global minimum. Therefore, in case of many local minima in a search region we are likely to find local minima instead of the global minimum and highly rely on the initial search points. This situation is evident in the motion boundary. In this paper we define the candidate regions within the search region using the motion information of the neighbor blocks and we propose the multiple local search method (MLSM) which search for the solution throughout the candidate regions to reduce the possibilities of isolation to the local minima. In the MLSM we mark the candidate region in the search point map and we avoid to search the candidate regions already visited to reduce the calculation. In the simulation results the proposed method shows more excellent results than that of other gradient based method especially in the search of motion boundary. Especially, in PSNR the proposed method obtains similar estimate accuracy with the significant reduction of search points to that of full search.