Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence

  • Choi, Jeong-Hwa (School of Environmental and Life Sciences, University of Newcastle) ;
  • Yates, Zoe (Biomedical Sciences and Pharmacy, University of Newcastle) ;
  • Martin, Charlotte (School of Environmental and Life Sciences, University of Newcastle) ;
  • Boyd, Lyndell (School of Environmental and Life Sciences, University of Newcastle) ;
  • Ng, Xiaowei (School of Environmental and Life Sciences, University of Newcastle) ;
  • Skinner, Virginia (Teaching & Research Unit, Central Coast Local Health District) ;
  • Wai, Ron (Teaching & Research Unit, Central Coast Local Health District) ;
  • Kim, Jeongseon (Molecular Epidemiology Branch, National Cancer Center) ;
  • Woo, Hae Dong (Molecular Epidemiology Branch, National Cancer Center) ;
  • Veysey, Martin (Teaching & Research Unit, Central Coast Local Health District) ;
  • Lucock, Mark (School of Environmental and Life Sciences, University of Newcastle)
  • Published : 2015.06.03
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Abstract

Background: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. However, little is known on C1561T-GCPII as a risk factor for colorectal cancer. Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Materials and Methods: 164 controls and 38 adenomatous polyp cases were analysed to determine blood folate and plasma homocysteine (Hcy) level, dietary intake of natural methylfolate, synthetic pteroylglutamic acid (PteGlu), vitamin C and C1561T-GCPII genotype. Results: In controls and cases, 7.3 and 18.4 percent of subjects respectively, were found to have the CT genotype, increasing the risk for adenomatous polyp occurrence 2.86 times (95% CI:1.37-8.0, p=0.035). Total dietary folate, methylfolate and PteGlu intake and the level of erythrocyte folate and plasma Hcy did not predict the occurrence of an adenomatous polyp. However, dietary natural vitamin C intake was associated with adenomatous polyp risk within C1561T-GCPII CT genotype subjects (p=0.037). Conclusions: The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.

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References

  1. Araki A, Sako Y (1987). Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr, 422, 43-52. https://doi.org/10.1016/0378-4347(87)80438-3
  2. Chandler CJ, Wang TT, Halsted CH (1986). Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J Biol Chem, 261, 928-33.
  3. Clapin HF, Fritschi L, Iacopetta B, et al (2012). Dietary and supplemental folate and the risk of left- and right-sided colorectal cancer. Nutr Cancer, 64, 937-45. https://doi.org/10.1080/01635581.2012.715718
  4. Cole BF, Baron JA, Sandler RS, et al (2007). Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA, 297, 2351-9. https://doi.org/10.1001/jama.297.21.2351
  5. Devlin AM, Ling EH, Peerson JM, et al (2000). Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Hum Mol Genet, 9, 2837-44. https://doi.org/10.1093/hmg/9.19.2837
  6. Divyya S, Naushad SM, Addlagatta A, et al (2012). Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility. Gene, 497, 273-9. https://doi.org/10.1016/j.gene.2012.01.055
  7. Gao S, Ding LH, Wang JW, et al (2013). Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer. Asian Pac J Cancer Prev, 14, 299-302. https://doi.org/10.7314/APJCP.2013.14.1.299
  8. Jing C, Huang Z, Duan Y, et al (2012). Folate intake, methylenetetrahydrofolate reductase polymorphisms in association with the prognosis of esophageal squamous cell carcinoma. Asian Pac J Cancer Prev, 13, 647-51. https://doi.org/10.7314/APJCP.2012.13.2.647
  9. Kim J, Cho YA, Kim DH, et al (2012). Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. Am J Clin Nutr, 95, 405-12. https://doi.org/10.3945/ajcn.111.020255
  10. Liu AY, Scherer D, Poole E, et al (2013). Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. Mol Nutr Food Res, 57, 721-34. https://doi.org/10.1002/mnfr.201200180
  11. Liu YX, Wang B, Wan MH, et al (2011). Meta-analysis of the relationship between the metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. Asian Pac J Cancer Prev, 12, 247-52.
  12. Lucock M (2000). Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab, 71, 121-38. https://doi.org/10.1006/mgme.2000.3027
  13. Lucock M, Yates Z, Boyd L, et al (2013). Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status. Eur J Nutr, 52, 569-82. https://doi.org/10.1007/s00394-012-0359-8
  14. Mesters JR, Barinka C, Li W, et al (2006). Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer. EMBO J, 25, 1375-84. https://doi.org/10.1038/sj.emboj.7600969
  15. Ng X, Lucock M, Veysey M (2008). Physicochemical effect of pH and antioxidants on mono-and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability. Food Chemistry, 106, 200-10. https://doi.org/10.1016/j.foodchem.2007.05.057
  16. Potten CS, Allen TD (1977). Ultrastructure of cell loss in intestinal mucosa. J Ultrastruct Res, 60, 272-7. https://doi.org/10.1016/S0022-5320(77)80071-3
  17. Roswall N, Olsen A, Christensen J, et al (2010). Micronutrient intake and risk of colon and rectal cancer in a Danish cohort. Cancer Epidemiol, 34, 40-6. https://doi.org/10.1016/j.canep.2009.12.012
  18. Vijaya Lakshmi SV, Naushad SM, Seshagiri Rao D, et al (2013). Oxidative stress is associated with genetic polymorphisms in one-carbon metabolism in coronary artery disease. Cell Biochem Biophys, 67, 353-61. https://doi.org/10.1007/s12013-011-9322-1