• Title/Summary/Keyword: MARK3

Search Result 802, Processing Time 0.026 seconds

A Study on the Architectural Characteristics of Rice Mill in the Rural Village in the Chungbuk Area - Focused on Eomjeong Myeon Chungju City - (충북지역 농촌마을 정미소의 건축적 특성 - 충주시 엄정면을 중심으로 -)

  • Park, Heon-Choon;Kim, Seong-Keun;Han, Kyu-Young
    • Journal of the Korean Institute of Rural Architecture
    • /
    • v.8 no.1
    • /
    • pp.33-42
    • /
    • 2006
  • The rice mill occurred from modernization process of the farming village. It comes to follow in intention of the architect and is not the position building. By the user of the building it comes to follow necessary and it is a position thing. The like this rice mill was the community center of the village. Also the material which is unique and form quality were land mark of the village. The object of research is the rice mill where it takes charge of a like this role. And the scope of research is 8 rice mills of Eomjeong Myeon Chungju City which is located in the northern Chungbuk area. The progress of research the documentary survey, actual measurement, question, field work it analyzed the construction quality which the rice mill keeps with base and it arranges. The results of study are follows; 1. conditions of location : The rice mill the entrance of the village, the crossroads system is formed most the place is doing in the place which well. 2. The inside composition of a space : In order to compose the work space and the store space efficiently the plane surface is doing a rectangular form. 3. Form of roof : The roof raises the efficient characteristic of the work where is not the design which is intended to be naturally formed from the space composition for. 4. Selection of material : Most it was a natural enemy and an utility, it selected the scientific material and it used.

  • PDF

The Effect of Female Adolescent Body-Related Variables, Self-Esteem and Internal Control on Eating Disorder Behavior (여자청소년의 신체관련변인, 자존감, 내적통제력이 섭식장애행동에 미치는 영향)

  • Kim, Gab-Sook;Kang, Yeon-Jeong
    • Journal of Families and Better Life
    • /
    • v.25 no.3 s.87
    • /
    • pp.77-87
    • /
    • 2007
  • This study purports to understand the direct and indirect effects between eating disorder behavior of female adolescents and their body-related variables(concerning the degree of diet regime, weight control, body satisfaction, and obesity), self-esteem and internal control, by checking three sub-categorized behavior of eating disorders of diet behavior, bulimia behavior, and eating control behavior. The sample group used for the study consisted of 190 female high school students and 292 female university students; measurement devices used for the study were those of body-related variables, self esteem and internal control, and eating disorder behavior; and data analysis was performed using ${\chi}2$, t-test, Pearson's correlation, regression analysis and path analysis. The results are as follows. First, there is a significant difference between university students and high school students regarding their body satisfaction, weight control experience, and self esteem. University students are more satisfied with their body, have higher self esteem, and control their weight better than high school students. Second, diet behavior shows a correlation with the degree of diet interest, weight control experience, and body satisfaction. Body satisfaction and internal control proved to be correlated with bulimia behavior, while weight control experience, obesity, and self esteem were correlated with eating control behavior. Third, the variables that showed a direct influence on diet behavior as an eating disorder are diet interest, weight control experience, body satisfaction and obesity, in that the explanatory power of the variables is 60.7% with the highest mark on obesity. The variables that showed effects on bulimia are body satisfaction and internal control with an explanatory power of 2.8%. Indirect variables effecting bulimia include objects, diet interest, body satisfaction, and self esteem. The variable with a direct influence on eating control behavior was self esteem with and explanatory power of 4%, whereas the variables of objects, diet interest, body satisfaction, weight control experience, and internal control were all indirectly correlated with eating control behavior.

THE CHANGES OF TELOMERASE ACTIVITY AND PROLIFERATING CELL NUCLEAR ANTIGEN(PCNA) EXPRESSION IN THE DEVELOPMENTAL STAGES OF RAT'S UPPER DIGESTIVE SYSTEM (백서 상부 소화기계의 발달 시기별 Telomerase 활성 및 PCNA(proliferating cell nuclear antigen)의 발현 변화)

  • Sung, Iel-Yong;Kim, Jong-Ryoul
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
    • /
    • v.30 no.2
    • /
    • pp.85-99
    • /
    • 2004
  • Purpose: This study observed the changes in the telomerase activity, it's developmental regulation, PCNA expression, and their correlation in rat's upper digestive organs during growth and aging. Materials and Methods: Upper digestive organs(buccal mucosa, gingiva, palate, submandibular and parotid glands, and tongue) were aseptically removed from Sprague-Dawley rats of fetal(gestational 20 days), growing(1, 2, 3, 5, and 7 weeks after birth) and adult(12 week old). Samples for telomerase activity were frozen on liquid nitrogen immediately after sacrifice, and stored until the use at $-75^{\circ}C$ in order to measure it. Telomerase activity was measured by a PCR-based telomeric repeat amplication protoco(TRAP) assay and quantitated with Photometric Telo TAGGG Telomerase PCR ELISA plus(Roche Diagnostics GmbH. Mannheim. Germany). PCNA expression were measured immunohistochemistry with anti PCNA Ab-1, Clone PC10(NeoMark. California. USA). Results: 1. Telomerase activities in buccal mucosa, palate and gingiva were the highest in fetus and decreased gradually or rapidly after birth and then diminished, but In salivary gland and tongue were the highest in fetus and also high at 1 week and then decreased rapidly. 2. PCNA expression in buccal mucosa, gingiva, Tongue and salivary gland was the highest in fetus and decreased gradually and then diminished. but only in palate decreased rapidly after birth and then diminished. Conclusion: The highest telomerase activity of embryonic stage decreased rapidly after birth in rat's upper digestive organs. There may be a developmental regulation of telomerase activity, but not a tissue-specific. This telomerase activity seems correlated closely with PCNA expression in rat's upper digestive system.

The Utilization of Physical Therapies in the Korean Medicine Clinics : A Survey for National Health Insurance Planning (한의원의 한방물리요법 이용 현황과 건강보험 급여화에 대한 인식)

  • Shin, Mi-Sook;Shin, Byung-Cheul;Lee, Myeong-Jong;Kim, Ho-Jun;Song, Yoon-Kyung;Song, Mi-Yeon;Shin, Seung-Woo;Lim, Byungmook
    • Journal of Korean Medicine Rehabilitation
    • /
    • v.19 no.3
    • /
    • pp.101-109
    • /
    • 2009
  • Objectives : This study aimed to investigate the present status of physical therapies provided in the Korean medicine clinics, and to find out the priorities among and the estimated fees of physical therapies for the National Health Insurance plan. Methods : We administered nationwide survey to Korean medicine doctors using the on-line survey system. 16 physical therapies were listed in the Web-based questionnaires, and responders were asked to mark the therapies they used for their patients, and, for each therapy they marked, to fill in the form including the frequencies of service, service fees, target diseases, and priorities for health insurance coverage, etc. Results : Of 488 respondents, 93.7% provide more than one physical therapy for their patients, and each responder uses 5.9 physical therapies on average. 60-90% of physical therapies are being given to patients for free because they are not covered by the National Health Insurance. There is little evidence that the specialties of Korean medicine doctors are related with the use of physical therapies, but, in some therapies, the doctors with longer career years use the physical therapy more frequently. Most physical therapies are applied to the patients with musculoskeletal diseases, cardiovascular diseases, and nervous diseases, etc. Conclusions : Physical therapies are widely used among Korean medicine doctors without proper compensation. This could be the one of the main factors distorting the profit structure of Korean medicine clinics, and it encourages the National Health Insurance to cover physical therapies provided in the Korean medicine clinics.

Facilitation of Quadriceps Activation Following a Concentric Knee Flexion During Reciprocal Knee Movement: The Influence of Muscle Preloading (교차적 슬관절 굴곡-신전 시 슬관절 굴곡근의 구심성 수축에 의한 선행부하가 대퇴사두근의 활성화에 미치는 영향)

  • Jeon, Hye-Seon;Trimble, Mark H.;Brunt, Denis
    • Physical Therapy Korea
    • /
    • v.10 no.4
    • /
    • pp.1-15
    • /
    • 2003
  • 본 연구는 슬관전 신전 직전에 수행된 선행 슬관절 굴곡이 슬관절 신전근의 최대 근력발생 및 근육 활성도(activation)에 미치는 영향을 알아보기 위하여 실시되었다. 16명의 정상인이 Cybex II 등속운동기구에서 3가지 다른 운동 속도($100^{\circ}/s$, $200^{\circ}/s$, $300^{\circ}/s$)와 2가지 다른 근육 활성 조건(선행부하가 없는 조건과 선행부하 조건)에서 슬관절의 최대 신전을 수행하였다. 연구대상자들에게 선행부하 없는 조건에서는 $90^{\circ}$ 슬관절 굴곡 상태에서 $0^{\circ}$까지 최대 신전을 수행하도록 하였고, 선행부하 조건에서는 구심성 슬와부 근육의 구심성 수축으로 $0^{\circ}$에서 $110^{\circ}$까지 굴곡한 후, 다시 $0^{\circ}$까지 최대 신전을 하도록 요구하였다. 종속변인으로는 내측광근과 외측광근의 최대 근전도와 최대 신전근력을 측정하였다. 실험 결과 최대 근전도와 최대 근력 모두 선행부하 조건에서 높게 나타났으며, 운동 속도가 증가함에 따라 최대 근력은 감소하는 전형적인 최대 근력-운동속도 상관법칙이 본 실험에서도 나타났다. 또한 운동속도와 전환속도 간의 간섭이 없는 것으로 나타나, 슬관절 신전근에 선행부하(preloading)를 가하는 것이 최대 근력-운동속도 상관법칙(force-velocity relation)에 영향을 미치지 못하는 것으로 해석되었다. 선행부하로 인해 증가된 최대 근력 및 근 활성도의 증가는 주로 신경촉진에 의한 것으로 해석된다.

  • PDF

Activation of Akt/PKB at Serine 473 by N-acetylphytosphingosine (NAPS) and $C_{2}-ceramide$ Reduces Melanin Synthesis in B16F10 Mouse Melanoma Cells

  • Yi, Seh-Yoon;Han, Seon-Kyu;Park, Mee-Kyung;Yoo, Young-Sook
    • Molecular & Cellular Toxicology
    • /
    • v.2 no.2
    • /
    • pp.81-88
    • /
    • 2006
  • Sphingolipid metabolites regulate many aspects of cell proliferation, differentiation, and apoptosis. In the present study, we have assessed the effects of the novel phytosphingosine derivative, N-acetylphytospingosine (NAPS), on the depigmentation of murine B16F10 melanoma cells, and have also attempted to identify the possible signaling pathway involved, in comparison with $C_{2}-ceramide$. NAPS and $C_{2}-ceramide$ both inhibited the growth of the B16F10 cells in a dose-dependent manner. Melanin content and tyrosinase activity were significantly reduced in response to treatment with NAPS and $C_{2}-ceramide$ at concentrations in a range between $1-5\;{\mu}M$. However, the levels of tyrosinase mRNA, as well as the levels of tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2) genes and the level of tyrosinase protein remained unaffected by treatment with either NAPS or $C_{2}-ceramide$. We also attempted to determine the signaling pathway exploited by NAPS and $C_{2}-ceramide$. Interestingly, the phosphorylation of Akt/PKB at serine 473 by NAPS was reduced at the 5 minute mark, whereas $C_{2}-ceramide$ induced the phosphorylation of Akt/PKB at serine 473. Finally, Akt/PKB activity in the NAPS-treated cells was elevated in comparison with the untreated cells. LY294002, a specific PI3-K inhibitor which is located upstream of Akt/PKB, inhibited the phosphorylation of Akt/PKB, but induced an increase in melanin synthesis. These results suggest that the activation of Akt/PKB at serine 473 is related with the suppression of melanin production in the B16F10 mouse melanoma cells. Therefore, the mechanisms exploited by NAPS and $C_{2}-ceramide$ responsible for the depigmentation of B16F10 cells were concluded to involve the inhibition of melanosomal tyrosinase activity.

Systematic Review and Comparative Meta-Analysis of Outcomes Following Pedicled Muscle versus Fasciocutaneous Flap Coverage for Complex Periprosthetic Wounds in Patients with Total Knee Arthroplasty

  • Economides, James M.;DeFazio, Michael V.;Golshani, Kayvon;Cinque, Mark;Anghel, Ersilia L.;Attinger, Christopher E.;Evans, Karen Kim
    • Archives of Plastic Surgery
    • /
    • v.44 no.2
    • /
    • pp.124-135
    • /
    • 2017
  • Background In cases of total knee arthroplasty (TKA) threatened by potential hardware exposure, flap-based reconstruction is indicated to provide durable coverage. Historically, muscle flaps were favored as they provide vascular tissue to an infected wound bed. However, data comparing the performance of muscle versus fasciocutaneous flaps are limited and reflect a lack of consensus regarding the optimal management of these wounds. The aim of this study was to compare the outcomes of muscle versus fasciocutaneous flaps following the salvage of compromised TKA. Methods A systematic search and meta-analysis were performed to identify patients with TKA who underwent either pedicled muscle or fasciocutaneous flap coverage of periprosthetic knee defects. Studies evaluating implant/limb salvage rates, ambulatory function, complications, and donor-site morbidity were included in the comparative analysis. Results A total of 18 articles, corresponding to 172 flaps (119 muscle flaps and 53 fasciocutaneous flaps) were reviewed. Rates of implant salvage (88.8% vs. 90.1%, P=0.05) and limb salvage (89.8% vs. 100%, P=0.14) were comparable in each cohort. While overall complication rates were similar (47.3% vs. 44%, P=0.78), the rates of persistent infection (16.4% vs. 0%, P=0.14) and recurrent infection (9.1% vs. 4%, P=0.94) tended to be higher in the muscle flap cohort. Notably, functional outcomes and ambulation rates were sparingly reported. Conclusions Rates of limb and prosthetic salvage were comparable following muscle or fasciocutaneous flap coverage of compromised TKA. The functional morbidity associated with muscle flap harvest, however, may support the use of fasciocutaneous flaps for coverage of these defects, particularly in young patients and/or high-performance athletes.

Development of a Lipsync Algorithm Based on Audio-visual Corpus (시청각 코퍼스 기반의 립싱크 알고리듬 개발)

  • 김진영;하영민;이화숙
    • The Journal of the Acoustical Society of Korea
    • /
    • v.20 no.3
    • /
    • pp.63-69
    • /
    • 2001
  • A corpus-based lip sync algorithm for synthesizing natural face animation is proposed in this paper. To get the lip parameters, some marks were attached some marks to the speaker's face, and the marks' positions were extracted with some Image processing methods. Also, the spoken utterances were labeled with HTK and prosodic information (duration, pitch and intensity) were analyzed. An audio-visual corpus was constructed by combining the speech and image information. The basic unit used in our approach is syllable unit. Based on this Audio-visual corpus, lip information represented by mark's positions was synthesized. That is. the best syllable units are selected from the audio-visual corpus and each visual information of selected syllable units are concatenated. There are two processes to obtain the best units. One is to select the N-best candidates for each syllable. The other is to select the best smooth unit sequences, which is done by Viterbi decoding algorithm. For these process, the two distance proposed between syllable units. They are a phonetic environment distance measure and a prosody distance measure. Computer simulation results showed that our proposed algorithm had good performances. Especially, it was shown that pitch and intensity information is also important as like duration information in lip sync.

  • PDF

The Emergence of $Gar\c{c}onne$ and it's Costume in 1920's (1920년대 가르손느의 출현과 그 복식)

  • Cho Kyu Hwa
    • Journal of the Korean Society of Clothing and Textiles
    • /
    • v.8 no.3
    • /
    • pp.19-30
    • /
    • 1984
  • There is a symbolic term which has realized custom of an era and has eome into fashion since the middle of 1920's. That is Garconne. This paper studied the image and costume of Garconne expressed in literary works, the form of art made it to come into being, and costume of a group of women played a role of pioneers of Garconne. Garconne attempted simple, casual, and mannish costume instead of usual elegance. It was the boiysh style($\`{a}$, la Garconne) which did not stress on the bust and waist like chanel suits used wool jersey by a designer, Chanel ana short skirts of low waist line. They got short haircut and wore low heel shoes. Garconne meant women who were free of convention, were familiar with love a d profession, and lived for themselves in the same manner of young men. They yieled new mode of 1920's. Though their lives were only a period, they manifested the symbol of the period though their figure and designation was not disappeared at the age but was settled as a mark of fixed image. There were several reasons why the Garconne was born. Rapid changes in politics, economics, and society in Europe were occurred from the First World War to 1920 and the trend of custom and art was a turning point. Especially, the entry of women into the society and the mode of Art Deco influenced it directly. The role of a pioneer of Garconne was appeared from the French Revolution. As Merveilleuse, Lionne, and Bloomers wore peculiar clothings ana had life style being irrelevant to tradition, they were talked about. They informed in advance the appearance of new women who were different from romantic ladies and were more modern and active. The pioneer design of Paul Poiret which were over whelming throughout a period and functional design of Chanel were increasingly accelerated.

  • PDF

Intelligent Distributed Platform using Mobile Agent based on Dynamic Group Binding (동적 그룹 바인딩 기반의 모바일 에이전트를 이용한 인텔리전트 분산 플랫폼)

  • Mateo, Romeo Mark A.;Lee, Jae-Wan
    • Journal of Internet Computing and Services
    • /
    • v.8 no.3
    • /
    • pp.131-143
    • /
    • 2007
  • The current trends in information technology and intelligent systems use data mining techniques to discover patterns and extract rules from distributed databases. In distributed environment, the extracted rules from data mining techniques can be used in dynamic replications, adaptive load balancing and other schemes. However, transmission of large data through the system can cause errors and unreliable results. This paper proposes the intelligent distributed platform based on dynamic group binding using mobile agents which addresses the use of intelligence in distributed environment. The proposed grouping service implements classification scheme of objects. Data compressor agent and data miner agent extracts rules and compresses data, respectively, from the service node databases. The proposed algorithm performs preprocessing where it merges the less frequent dataset using neuro-fuzzy classifier before sending the data. Object group classification, data mining the service node database, data compression method, and rule extraction were simulated. Result of experiments in efficient data compression and reliable rule extraction shows that the proposed algorithm has better performance compared to other methods.

  • PDF