• BMB Reports
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• v.47 no.2
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• pp.115-120
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• 2014

In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-${\alpha}$, and IL-$1{\beta}$) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized $CD4^+$ and $CD8^+$ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of $CD4^+$ and $CD8^+$ T cells.

• Journal of Environmental Science International
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• v.22 no.10
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• pp.1305-1316
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• 2013

A long-term wind resource map was made to provide the key design data for the 2.5 GW Korean West-South Offshore Wind Project, and its reliability was validated. A one-way dynamic downscaling of the MERRA reanalysis meteorological data of the Yeongwang-Gochang offshore was carried out using WindSim, a Computational Fluid Dynamics based wind resource mapping software, to establish a 33-year time series wind resource map of 100 m x 100 m spatial resolution and 1-hour interval temporal resolution from 1979 to 2012. The simulated wind resource map was validated by comparison with wind measurement data from the HeMOSU offshore meteorological tower, the Wangdeungdo Island meteorological tower, and the Gochang transmission tower on the nearby coastline, and the uncertainty due to long-term variability was analyzed. The long-term variability of the wind power was investigated in inter-annual, monthly, and daily units while the short-term variability was examined as the pattern of the coefficient of variation in hourly units. The results showed that the inter-annual variability had a maximum wind index variance of 22.3% while the short-term variability, i.e., the annual standard deviation of the hourly average wind power, was $0.041{\pm}0.001$, indicating steady variability.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.7
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• pp.1305-1310
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• 2007

ePosition is a technology that can provide the spacial position of the earth to the information of ePosition ID through the Internet. It is serving the information of land location based on the Internet using the ePosition technology now, but it needs the service technique which can supply the marine data and the information of maritime position. Moreover, to support the information service of marine position, it needs the ENC linked technique based on S-57 that is an IHO transfer standard for digital hydrographic data. In this paper, therefore, it develops a linkage method for applying and utilizing the ePosition technology to ENC data, and supplements the base technology for applying it to marine related fields. As study method, firstly, this paper analyses ENC data model and structure, and converses for processing ENC file to ePosition data. Lastly, it derives the interconnection method with ePosition database and shows the ePosition service application based on the linked data and its validity.

• Journal of Korean Society of Environmental Engineers
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• v.22 no.7
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• pp.1295-1305
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• 2000

Status of the contaminated sediments in Lake Paldang was investigated. Sediment samples were taken at 34 points and analyzed in terms of ignition loss, CODer, total P and total N. The contamination level did not show any significant variation with depth of the sediments, which indicated the contaminants were recalcitrant. The type of P in the sediment was analyzed, and the sum of adsorbed P and NAI-P, that can be re-solubilized under the reductive condition, was found to be 20-30% of the total P. From the analysis of the water quality change along with the flowing path, it would be concluded that the effect of the sediments on the water quality is insignificant yet in Lake Paldang. However, long term analysis covering at least four seasons should be continued in order to get a more reliable conclusion. A depth profile map of the sediment in Lake Paldang was provided.