• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.1
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• pp.63-79
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• 2008

Background: The consequences of disordered breathing patterns are not only distressing to the patient but also expensive to our health care systems if they are not diagnosed and treated. So we performed this study to investigate clinical significants trough gigong, yoga and hyperventilation in oriental medicine and westen medicine Method: Voluntary control of respiration is one of the main methods of physical and mental training such as meditation, qigong meditation or Yoga. So, this study focuses on breathing in qigong and yoga. This study appreciates a role that a control of respiration has in physical, mental aspects and searches side-effects in qigong and yoga Conclusions: A control of respiration has a function that manages Jung(精), Qi(氣), Shin(神) in Oriental Medicine. It manages Autonomic Nerve system, Endocrine system and induces natural awareness. So Briging the body and mind work through a control of breathing. Breathing pattern disorder has Damum and Qiher pattern in Oriental Medicine pattern. This disease pattern concearnes ATP metabolism. Qiher is concearned with a mitochondria disorder and Damum is concearned with a products of lactate. we guess that Lactate analysis may be utilized as a diagonostic criteria of Breathing pattern disorder. After this, It needs a study that Lactate analysis is concearned with Breathing pattern disorder as Damum pattern. Result: A control of respiration is related not only breathing but also spiritual and physical state. Joo-hwa-ip-ma as Breathing pattern disorder is smiliar to hyperventilation. HVS is patternated Damum and Qi-Weakness pattern in oriental medicine. Lactate is an important complement that diagonates HVS and will be concearned with Damum.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.1
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• pp.282-304
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• 2014

Each cloud service has numerous owners and tenants, so it is necessary to construct a privacy preserving identity management and access control mechanism for cloud computing. On one hand, cloud service providers (CSP) depend on tenant's identity information to enforce appropriate access control so that cloud resources are only accessed by the authorized tenants who are willing to pay. On the other hand, tenants wish to protect their personalized service access patterns, identity privacy information and accessing newfangled cloud services by on-demand ways within the scope of their permissions. There are many identity authentication and access control schemes to address these challenges to some degree, however, there are still some limitations. In this paper, we propose a new comprehensive approach, called Privacy pReserving Identity and Access Management scheme, referred to as PRIAM, which is able to satisfy all the desirable security requirements in cloud computing. The main contributions of the proposed PRIAM scheme are threefold. First, it leverages blind signature and hash chain to protect tenant's identity privacy and implement secure mutual authentication. Second, it employs the service-level agreements to provide flexible and on-demand access control for both tenants and cloud services. Third, it makes use of the BAN logic to formally verify the correctness of the proposed protocols. As a result, our proposed PRIAM scheme is suitable to cloud computing thanks to its simplicity, correctness, low overhead, and efficiency.

• Journal of Microbiology and Biotechnology
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• v.25 no.7
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• pp.1093-1100
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• 2015

Acetate and lactate in growth media are detrimental to the production of Thermus maltogenic amylase (ThMA), a heterologous protein, as well as to the growth of recombinant Escherichia coli. Only 50 mM of acetate or 10 mM of lactate reduced 90% of specific ThMA activity. In this study, mutant E. coli strains blocked in the ackA-pta or ackA-pta and ldh pathways were created, characterized, and assessed for their culture performace in 300 L-scale fermentation. The ackApta and ldh double-mutant strain formed significantly less lactate and acetate, and produced a concomitant increase in the excretion of pyruvate (17.8 mM) under anaerobic conditions. The ackA-pta mutant strain accumulated significant acetate but had an approximately 2-fold increase in the formation of lactate. The ackA-pta and ldh double-mutant strain had superior overall performance in large-scale culture under suboptimal conditions, giving 67% higher cell density and 66% higher ThMA activity compared with those of the control strain. The doublemutant strain also achieved a 179% improvement in volumetric ThMA production.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.1
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• pp.91-97
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• 2017

Hyperglycemia is associated with an increased risk of cardiovascular diseases. It has been demonstrated that chronic exposure to high glucose impaired endothelial functions. However, specific effects of short-term exposure to high glucose on vascular reactivity are controversial. Moreover, the combined effects of other metabolic substrates such as free fatty acids (FFA) on vascular reactivity remain poorly understood. Here we investigate the effects of short-term exposure to high glucose with or without other metabolic substrates including FFAs termed "nutrition full" (NF) solution, on mesenteric (MA) and deep femoral arteries (DFA) of rats. Arterial ring segments were mounted in a double-wire myograph. Contraction in response to phenylephrine (PhE) was determined in control (5 mM) and high glucose (23 mM, HG) environments over a 30 min period. In both arteries, PhE-inducedvasocontraction was enhanced by pre-incubation of HG solution. A combined incubation with HG and palmitic acid ($100{\mu}M$) induced similar sensitization of PhE-contractions in both arteries. In contrast, high $K^+$-induced contractions were not affected by HG. Interestingly, pre-incubation with NF solution decreased PhE-induced contraction in MA but increased the contraction in DFA. In NF solution, the HG-induced facilitation of PhE-contraction was not observed in MA. Furthermore, the PhE-induced contraction of DFA was attenuated by HG in NF solution. Our results demonstrate that the sensitization of PhE-induced arterial contraction by HG is differentially affected by other metabolic substrates. The conversation of skeletal arterial contractility by HG in NF solution requires careful interpretation of the previous in vitro studies where only glucose is included in physiological salt solutions. Further studies are required to elucidate the mechanism underlying the inconsistent effect of NF solution on MA and DFA.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.26 no.2
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• pp.53-60
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• 2020

A concept of household container to create and keep the modified atmosphere (MA) beneficial for fresh produce mix was devised and tested under typical chilled storage conditions of 3℃. The container system containing mixed products is initialized by applying weak hypobaric condition (0.9 atm) and subsequently injecting CO₂ gas at an appropriate low level (0.03 atm). The passive atmosphere modification by produce respiration is then induced to reach a target until gas diffusion tube of proper dimension starts to open. The design was made to attain quasi-steady state mass balance of O₂, CO₂ and N₂ to maintain the desired MA through the storage. Interrupted opening for taking out or placing some products was to reinitialize the loop of control logic. The developed concept was tested by the container which held commodities of spinach, pak choi, oyster mushroom, peeled onion, strawberry and cut carrot. The target optimum MA of 11% O₂ and 10% CO₂ (0.11 and 0.10 atm, respectively) was set to avoid injurious range of O₂ and CO₂ concentrations for any commodities. The developed container system could work to reach and maintain beneficial MA of 0.10-0.12 atm O₂ and 0.07-0.10 atm CO₂ close to the target during the storage contributing to quality retention of products measured in weight loss, chlorophyll content of spinach, ascorbic acid content of pak choi, color of onion, texture of oyster mushroom, bacterial count of strawberry and carotenoids of carrot. The container system shows potential to improve current preservation practice of fresh produce mix on consumers' level.

• Journal of Pharmaceutical Investigation
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• v.26 no.4
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• pp.309-314
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• 1996

The purpose of this study is to explain the relationship between the pharmacological mechanism of levamisole and the cellular activity of cellular alkaline phosphatase (ALPase) in kidney cells. The results of our investigation were as follows. 1. Cellular ALPase activity in Macacus rhesus monkey kidney cells (MA 104 cells) and primary cultured rabbit kidney proximal tubular cells treated with levamisole was increased about two or three times than control. However, 50% of ALPase activity in cultured medium was inhibited by levamisole itself. 2. The proliferation of MA 104 and cultured rabbit kidney proximal tubular cells was linearly decreased in paralleled with increase of levamisole concentration $(50\;and\;500\;{mu}M)$ with MTT test. 3. In the heat stability tests, the inhibition of ALPase activity with and without levamisole at $56^{\circ}C$ in MA 104 cells showed different $IC_{50}$ values. 4. HPLC analysis of levamisole metabolites produced by cultured MA 104 cells suggested that the formation of a metabolite, that may be associated with its increase of cellular ALPase activity. Based on these results, we assumed that the increase of cellular ALPase activity by levamisole was evoked by modification of the ALPase catalytic sites.

• Journal of Power System Engineering
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• v.15 no.2
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• pp.69-77
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• 2011

In this paper, an optimal PID sliding mode controller is proposed for the position control of electro-hydrostatic actuator(ERA) systems with system uncertainties and saturation in the motor. An ERA prototype is developed and system modeling and parameter identification are executed. Then, optimal PID and optimal anti-windup PID controller are designed based on identified system model by using optimization toolbox in MA TLAB/Simulink and the performance of the two control systems are compared by experiment. It was found that the optimal anti-windup PID control system has better performance than the optimal anti-windup PID control system.

• Herbal Formula Science
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• v.15 no.2
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• pp.113-117
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• 2007

Objectives: Samul-tang(Siwu-tang) has been traditionally prescribed a medicine as a restorative. Methods: In this study, we investigated the acute toxicity about water-extracted Samul-tang(Siwu-tang). Twenty-five mice completed 14 days of oral Samul-tang(Siwu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. Results: We observed survival rates, general toxicity, change of body weight, and autopsy. Conclusions: Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). $LD_{50}$ of Samul-tang(Siwu-tang) was over 5000mg/kg and it is very safe to ICR mice.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.55-58
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• 1997

In this paper we reviewed and stated the present state of our team's research of the moving-actuator type total artificial heart (MA-TAH). Especially, this paper showed new direction of researches. The integrated research of battery, telemetry, TET is required. And the real-time supervisory of the state of hemodynamic variables and MA-TAH is also needed. These requirement made us to think the supervisory control system (SCS). As functional abilities of the SCS require very high computational cost, the digital signal processor is an appropriate choice for our need.

• Preventive Nutrition and Food Science
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• v.19 no.2
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• pp.69-74
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• 2014

The present study investigated the anti-obesity effects of Mycoleptodonoides aitchisonii (MA) in mice fed a high-fat (HF) diet. Two groups were fed either a normal control diet or an HF (45% kcal fat) diet for 12 weeks and three groups were fed an HF diet supplemented with powdered MA (MAP, 1%, 3%, and 5%) for 12 weeks. The anti-obesity effects of MAP supplementation on body weight, fat mass development, and lipid-related markers were assessed. Consumption of an HF diet resulted in increased body weight, serum lipids, relative adipose tissues weight, and liver fat accumulation. However, administration of MAP significantly decreased body weight gain, food intake, food efficiency ratio, hepatic cholesterol level, and adipose tissue weight in a dose-dependent manner. In addition, treatment with MAP significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited an HF diet-induced increase in adipocyte size. These results suggest that dietary supplementation with MAP exerts anti-obesity effects and indicate that MAP could be used as a functional food to control obesity.