• Title/Summary/Keyword: M330

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Antimicrobial Activities of Ethosome-Encapsulated Palmitoyl Tripeptide (Ethosome에 캡슐화된 Palmitoyl Tripeptide의 항균효과)

  • Lee, Yeon-Jung;Lee, Yun Sub;Jin, Byung Suk
    • Applied Chemistry for Engineering
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    • v.25 no.6
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    • pp.570-576
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    • 2014
  • Palmitoyl tripeptide (M330) showed higher antimicrobial activities than methyl paraben or phenoxy ethanol through minimum inhibitory concentration (MIC) test. However, when the M330 was added into cosmetic formulation, white precipitates formed due to the electrostatic interaction between M330 and carbopol (carboxy vinyl polymer) as a thickener in cosmetics, and the viscosity of cosmetics decreased sharply. Also, the antimicrobial activities of M330 in cosmetics became lower than those of methyl paraben or phenoxy ethanol. Thus, the encapsulation of M330 in ethosome vesicle was attempted in order to recover the declined antimicrobial activities of M330 in cosmetics and prevent the precipitates from forming. When ethosome-encapsulated M330 was added into cosmetics, the precipitates did not form, and the decrease in the viscosity of cosmetics was not large compared to the addition of unencapsulated M330. Challenge tests showed that antimicrobial activities against gram negative bacteria were improved by the encapsulation of M330, but the encapsulation was not effective against gram positive bacteria and fungus. A combination of M330 with EDTA showed synergistic inhibitory potential against C. albicans. After coencapsulation of M330 and EDTA in ethosome, antimicrobial activities proved to be higher than those of unencapsulated M330 and EDTA.

Comparison of Growth Period and Local Climate for 'Hongro' Apple Orchards Located at Different Altitudes in Jangsu-Gun (장수군의 해발고도별 '홍로' 사과원의 미기상 및 생육기 비교)

  • Song, Ju-Hee;Seo, Byung Sun;Choi, Dong Geun;Choi, In Myung;Kang, In-Kyu;Guak, Sunghee
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.15 no.1
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    • pp.1-8
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    • 2013
  • This study was conducted to compare the local climate conditions and growth periods for the apple (Malus domestica 'Borkh') orchards at different altitudes (330, 500, and 670 m) in Jangsu-Gun, Korea. Observation data for the growth period show that the monthly mean air temperatures at the 'Hongro' apple orchard sites decrease with height at the rate of 1.0 to $3.0^{\circ}C$/100 m. The monthly minimum temperatures in April (blooming period for 'Hongro' apple) were 4.3, 2.9, and $0.4^{\circ}C$ at 330, 500, and 670 m, respectively. The monthly mean temperatures in September (i.e., the coloration and maturation period) were 20.6, 18.7, and $14.5^{\circ}C$, respectively. The annual precipitation range varied from 1,234 to 1,439 mm, which tended to increase with height. The heavy rainfall occurred in summer (June to August) and amounted to 827-933 mm. No significant differences in the duration of sunshine were observed amongst the orchards at three different altitudes. The earliest bud break was observed at the 330 m altitude (18 March 2009), which was 4 and 11 days earlier in comparison to those at 500 and 670 m, respectively. The time of full bloom at 330 m was 12 days ahead of that at 670 m. The optimal maturation of fruit (based on skin redness > 80%) was observed between 7 and 10 September at 330 m, 15 and 18 September at 500 m, and 21 and 23 September at 670 m.

Nutrient Intake, Acid Base Status and Growth Performance of Thalli Lambs Fed Varying Level of Dietary Cation-anion Difference

  • Sarwar, M.;Shahzad, M. Aasif;Nisa, Mahr-un
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.11
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    • pp.1713-1720
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    • 2007
  • Influence of -110, +110, +220 and +330 mEq/kg of dry matter (DM) dietary cation-anion difference (DCAD) on growth performance of Thalli lambs were examined in a randomized complete block design. Four DCAD diets were randomly allotted to four groups, with ten lambs in each group. A linear increase in nutrient intake was recorded with increasing DCAD level. The digestibilities of nutrients were higher in lambs fed -110 DCAD diet than those fed +110, +220 and +330 DCAD diets. Lambs fed +330 DCAD diet had higher nitrogen balance than those fed -110 and +110 DCAD diets. Blood pH and serum $HCO_3$ increased with increasing DCAD level. Serum chloride was higher in lambs fed -110 DCAD diet, while serum (Na+K)-(Cl+S) increased linearly with increasing DCAD level. Serum calcium increased with decreasing DCAD level while serum magnesium and phosphorus remained unaffected. Lambs fed -110 DCAD diet had higher Ca balance than those fed +110, +220 and +330 DCAD diets. Urine pH increased with increasing DCAD level. Lambs fed +220 and +330 DCAD diets gained more weight than those fed -110 and +110 DCAD diets. In conclusion, increased DCAD level not only increased the dry matter intake but also improved the weight gain of growing Thalli lambs.

Effect of Mesh Size of Net on Biomass Estimation of Acartia steueri (Copepoda: Calanoida) (네트 망목 크기가 Acartia steueri (Copepoda: Calanoida)의 생체량 추정에 미치는 영향)

  • Kang Hyung Ku;Kang Yong Joo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.35 no.4
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    • pp.445-450
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    • 2002
  • A series of 29 sampling with a 330 ${\mu}$m and a 64 ${\mu}$m mesh size of nets was conducted at a fixed station in Ilkwang Bay, southeast cost of Korea, from Oct, 2, 1991 to Oct. 10, 1992, to investigate the effects of mesh size of nets on biomass estimation of copepod Acartia steueri. The catch of copepodite and nauplius stages of A. steueli taken by two nets with different mesh size was different, showing that all developmental stages of A. steueri were retained on the 64 ${\mu}$m mesh net, but only $\geq$stage 4 copepodite were caught by the 330 ${\mu}$m mesh net. Abundance and biomass in each developmental stage estimated with the 64 ${\mu}$m mesh net were significantly higher than those of the 330 ${\mu}$m mesh net, except for adult female and stage 5 copepodite in female. The body length as well as the body width is likely to affect the catch of the nets. The mean biomass of A. steueli estimated with the traditional 330 ${\mu}$m net was 2.8 times lower than the value obtained with the 64 ${\mu}$m mesh net. However, the seasonal patterns of the biomass were comparable. These results suggest that accurate sampling strategr of the entire copepods assemblage including nauplii and copepodites are essential when estimating the abundance and biomass of copepods for the better understanding of the role of copepods in marine ecosystem.

Effect of Channel Length on Electrical Characteristics of a Bendable a-Si:H TFTs (밴더블 a-Si:H 박막트랜지스터의 전기적 특성에 미치는 채널 길이의 영향)

  • Oh, Hyungon;Cho, Kyoungah;Kim, Sangsig
    • Journal of IKEEE
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    • v.20 no.3
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    • pp.330-332
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    • 2016
  • In this study, we investigate the influence of channel length of bendable a-Si:H thin film transistors (TFTs) on their electrical characteristics as a function of bending strain. Under a tensile strain of 1.69%, $8{\mu}m$-channel-length TFT has the threshold voltage shift up to 5.25 V, while $100{\mu}m$-channel-length TFT operates stably.

Synthesis of Quantum Dot-Tagged Submicrometer Polystyrene Particles by Miniemulsion Polymerization

  • Joumaa, Nancy;Lansalot, M.;Theretz, A.;Elaissari, A.;Sukhanova, A.;Artemyev, M.;Nabiev, I.;Cohen, J.H.M.
    • Proceedings of the Polymer Society of Korea Conference
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    • 2006.10a
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    • pp.330-330
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    • 2006
  • The elaboration of fluorescent submicronic polymer particles exhibiting narrow particle size distribution as well as good photostability is of particular interest in various biomedical applications. In the frame of this work, labeled polystyrene latexes have been synthesized by miniemulsion polymerization using luminescent semiconductor nanoparticles (quantum dots, QD). The influence of incorporation of QDs on the polymerization kinetics as well as on the optical properties of the obtained latexes will be discussed.

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A Study on the Integrated Electronic Medical Record System Using QR Code (QR코드를 활용한 통합전자의무기록 시스템에 관한 연구)

  • Yun Hwan Oh;Deok Gyu Lee
    • Proceedings of the Korea Information Processing Society Conference
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    • 2023.05a
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    • pp.330-331
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    • 2023
  • 의료정보의 클라우드화는 허용되었지만 정작 의료현장에서의 영향력은 매우 낮은 상황이다. 이에 따라 통합전자의무기록 시스템을 제안해 전자의무기록의 클라우드화와 QR코드를 활용해 주민등록증의 노출 및 위변조 될 우려를 낮출 수 있으며 사용자의 중복검사를 막아 비용과 시간을 절약할 수 있다.

The toxicity of Aceporol 460 as a novel high loading capacity solubilizer of paclitaxel

  • Kim, Yeo-Woon;Kim, Ja-Young;Cho, Min-Jung;Song, Hye-Weon;Lee, Min-Jae;Kim, Jong-Jae;Lee, Mi-Suk;Sheen, Yhun-Yhong
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 2002.10a
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    • pp.172-172
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    • 2002
  • Previously, we reported a novel polymeric micellar solubilizer, Aceporol 330, that showed relatively low toxic effects when it was compared with that of Cremophor EL which is currently being used for paclitaxel. In this study, we have developed a new micellar solubilizer, Aceporol 460, that has 3-4 times higher loding capacity for paclitaxel than Aceporol 330. The single-dose and the repeated-dose toxicity of Aceporol 460 were evaluated in ICR mice. For single dose toxicity test, male and female mice were randomly assigned to one of five study groups to receive, and injected intravenously with dosages of 0, 3, 4mL Cremophor EL/kgbody weight, and 3, 4mL Aceporol 460/kg body weight, respectively. In both male and female mice, LD50 for Aceporol 460 can not he determined even at the maximal administrable dosage, 4mL/kg due to the high viscosity of chemical and there was no significant change in body weight, hematological and serum biochemical analysis, organ weight, and histopathological examination compared with that of Cremophor EL. For the repeated dose toxicity test, male and female mice were given the dosage of 0, 1.6mL Cremophor EL/kgbody weight/day, and 1.6mL Aceporol 460/kg body weight/day for 2 weeks. Results of repeated dose toxicity tests for 2 weeks suggested that Aceporol 460 treated group show no significant toxicological findings with body weight, hematological and serum biochemical analysis, organ weight, urinalysis, and ophthalmoscopic and histopathological examination compared with that of Cremophor EL. These results indicate that Aceporol 460 have higher paclitaxeL-loading capacity than Aceporol 330 and less toxic effects than Cremophor EL in male and female mice.

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