• Title/Summary/Keyword: M3-competition

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Effect of the Bifunctional Chelate on the Biodistribution of 99mTc-labeled Cyclic RGD Peptide

  • Lee, Dong-Eun;Choi, Kang-Hyuk
    • Journal of Radiation Industry
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    • v.12 no.4
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    • pp.355-363
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    • 2018
  • A novel $N_3S_1$ chelate, Pro-Lys-Cys (PKC) to cyclic RGD to radiolabel with $^{99m}Tc$ was conjugated in an effort to decrease the high intestinal accumulation observed for $^{99m}Tc$-labeled PGC-RGD. The target specificity of the resulting PKC-RGD was similar to that of PGC-RGD as determined by a cell binding assay and a competition binding assay. The $^{99m}Tc$ radiolabeling of PKC-RGD resulted in radiochemical yields of 98% under mild conditions at high specific activities. Biodistribution data in normal mice clearly showed a significant decrease in intestinal uptake at 2 h postinjection for the $^{99m}Tc-PKC-c$ (RGDyK) compared to the $^{99m}Tc-GC-c$ (RGDyK) (from $19.65%ID{\cdot}g^{-1}$ to $7.31%ID{\cdot}g^{-1}$ for the GI tract). The $^{99m}Tc-PKC-c$ (RGDyK) biodistribution was also shown by a higher retention of radioactivity in the whole body, but with kidney accumulation over 8-fold higher than observed with $^{99m}Tc-PGC-c$ (RGDyK) at 2 h ($12.62%ID{\cdot}g^{-1}$ for PKC-RGD and $1.54%ID{\cdot}g^{-1}$ for PGC-RGD, respectively). These results show that the biodistribution may be altered especially concerning lipophilicity resulting in renal rather than hepatobiliary excretion. This comparative study made it possible to explore the effects of lipophilicity on the biodistribution of $^{99m}Tc$-labeled c (RGDyK) through the use of different tripeptide $N_3S_1$ chelators. Therefore, $^{99m}Tc-PKC-c$ (RGDyK) may be an attractive alternative for the in vivo imaging of integrin receptors.

What Happened to Efficiency and Competition after Bank Mergers and Consolidation in Korea? (한국 은행들의 합병, 통합 이후 효율성과 경쟁도는 개선되었는가?)

  • Park, Kang H.
    • KDI Journal of Economic Policy
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    • v.33 no.3
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    • pp.33-55
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    • 2011
  • Market concentration in the Korean banking industry has markedly increased since the financial crisis of 1997-1998 because of M&As, P&As, and consolidation of banks. With this change, there has been a growing concern over market power in the Korean banking sector. We examine the effects of market concentration on bank efficiency and competition for the period of 1992-2006. Three different indicators of bank inefficiency are used in this study, including X-inefficiency that is derived from the directional technology distance function. The level of competition is measured by both the H-statistic of the Panzar-Rosse model and the level of the net interest margin and its standard deviation. Empirical results indicate that market concentration has not improved bank efficiency through scale economies or scope economies. Instead, recent mergers, acquisitions and consolidation of banks resulted in an increase in inefficiency measured by the three different indicators: X-inefficiency, labor inefficiency and asset inefficiency. While an increase in market share of individual banks improved bank efficiency, an increase in the overall market concentration ratio resulted in lower efficiency. Our study also finds that the Korean banking sector has been monopolistically competitive throughout the sample period except for the crisis period according to the H-statistic. Although an increase in market concentration ratio has not changed the overall level of bank competition, it has a positive significant effect on the level of the average interest margin.

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Effect of Number of Sowing Grain on the Rice Growth and Yield in Direct Sowing Culture on Irrigated Paddy Field (벼담수 직파 재배에서 파종 입수가 생육 및 수량에 미치는 영향)

  • Jong-Chul Lee;Chang-Sik Moon;Hae-Yeong Suh;Beom-Yeol Choi
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.14
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    • pp.41-45
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    • 1973
  • This study was carried out in the central part of Korea in 1972 to investigate optimum grain number per square meter and variation of the yield and its components in the direct sowing culture on irrigated paddy field. The results could be summarized as follows; 1. Number of maximum tillerings was directly increased with increase of grain number from 120 to 280 per square meter and it was gradually decreased with increase of number sowing grain. So number of maximum tillerings showed at the plot of 280 grain per square meter. Also it was showed remarkable competition at the plot more than 280 grain per square meter. 2. Percentage of effective tiller was decreased with increase of number of sowing grain from 120 to 280 per square meter and after it was gradually decreased with increase of number of sowing grain. 3. It was not remarkable competition in plot less than 1, 000 tillering per square meter on the number of maximum tillerings. 4. It was remarkable positive correlation between the number of panicle and the number of sowing grain, but it was tendency to negative correlation between the number of panicle and the number of spiklets per panicle, and between the number of panicle and the ripening ratio. 5. Correlation coefficient between the yield and the number of spiklet per square meter of land area was 0.929, r=0.695 in the yield and the number of panicle, r=0.796 in the number of panicles and the number of spiklets per square meter Also in rank correlation, it was showed most highly positive correlation(r=0.954) between the yield and the number of panicles, so number of panicles was most largely dominated on yield among the yield components in direct sowing culture on irrigated paddy field. 6. It was producted highest yield in the plot of 280 grain sowing per square meter.

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Effect of Acalypha australis Occurrence on Soybean Growth and Economic Threshold Level of Acalypha australis (깨풀의 발생이 콩 생육에 미치는 영향 및 경제적 피해 한계수준)

  • Yoo, Ji-Hyock;Moon, Byeong-Chul;Lee, In-Yong;Kim, Doo-Ho
    • Weed & Turfgrass Science
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    • v.1 no.4
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    • pp.13-17
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    • 2012
  • A field experiment was conducted to investigate the effect of Acalypha australis occurrence on the growth and yield of soybean, to predict the reduction rate of soybean yield caused by competing with A. australis and to establish the economic threshold of A. australis for soybean cultivation. As the density of A. australis increase, the height and stem length of soybean were not affected by the competition with A. australis, however, the yield of soybean was decreased as 11~51% as compared with weed-free condition. The relationship between weed density and soybean yield was established as Y=415.5 / (1+0.003356X) and the reduction rate of soybean yield were predicted from this equation. Compared with the weed-free condition, the reduction rate of soybean yield were calculated as 0.3~9%, 17~29%, and 40~46% when the density of A. australis were 1~30, 60~120, and 200~250 plants $m^{-2}$, respectively. The economic threshold level of A. australis for soybean cultivation was established as 6.3 plants $m^{-2}$ from the Cousens' equation.

Inhibition of Biological Perchlorate Reduction by Nitrate and Oxygen (질산염과 산소에 의한 생물학적 퍼클로레이트 환원의 저해)

  • Choi, Hyeok-Sun
    • Journal of Soil and Groundwater Environment
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    • v.14 no.6
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    • pp.29-34
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    • 2009
  • In this study, a chloride ion probe as a direct measurement for perchlorate reduction was used to determine whether biological perchlorate reduction was inhibited by other electron acceptors ($O_2$ and ${NO_3}^-$) and to investigate competition of electron acceptors for using electron donors. Profiles of chloride production (= perchlorate reduction) in flasks containing perchlorate reducing populations were monitored by a chloride ion probe. Biological reduction of 2 mM perchlorate was inhibited by 2 mM nitrate that chloride production rate was decreased by 30% compared to perchlorate used as the only electron acceptor and chloride production rate was decreased by 70% when acetate was limited. Reduction of 2mM perchlorate was completely inhibited by oxygen at 7~8 mg/L, regardless of acetate excess / limitation.

Competition Relation and Forage Yields by Different Sowing Rate in Grass and Legume Mixtures (몇가지 화본과목초(禾本科牧草)와 콩과목초(科牧草)를 혼파(混播)할 경우 파종비율(播種比率)에 따른 목초(牧草)의 생산성(生産性)과 경합관계(競合關係))

  • Cho, Jin Woong;Kim, Choong Soo;Lee, Suk Young
    • Korean Journal of Agricultural Science
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    • v.20 no.2
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    • pp.109-116
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    • 1993
  • This experiment was carried out to investigate the competition in mono-and binary-associations of four forage species; ochardgrass (Dactylis glomerata L. cv. Potomac), tallfescue (Festuca arundinacea Scnreb, cv. Fawn), white clover (Trifolium repns L. cv. California), and red clover (Trifolium pratense L. cv. Kenland) as affected by different sowing rate. Each species was grown in interspecific stands in field. And samplings of shoot were taken at first cliping stages. The interspecific competition was evaluated by calculating traditional methods: aggressivity, relative yield total (RYT), relative crowding coefficient (RCC), and compensation index (CI) with shoot dry matter production and calories of nutrient ingredient of each species in mono-and binary-mixture. Compared mixture with monoculture. RYT based on dry weight was lucrative in mixture except for orchardgrass-redcover (1:0.1,1:1). RYT of calculated calories with produced nutrients was in inlucrative in mixture of orchardgrass-redclover's 1:0.1 mixture by RYT<1.0. Generally, RYT was the highest in mixture of 1:0.5 sowing rate. Aggressivity of grass was poor competition tendency that raised up legume's sowing rate, particularly, with whiteclover. In grasses, tallfescue was stronger competitor than orchardgrass with legume in mixture, RCC of grasses against legume's growth was depressed in higher sowing rate with legume. Grass's growth depression was severer with whiteclover than redclover in mixture.

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Solubilization of an Angiotensin II Binding Site from Rat Liver

  • Chung, Sung-Hyun;Ravi Iyengar
    • Archives of Pharmacal Research
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    • v.14 no.3
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    • pp.231-236
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    • 1991
  • The high affinity binding sites for angiotensin II were solubilized from rat liver membranes by treatment with CHAPS. The binding protein was also partially purified by angiotensin III inhibitor-coupled Affi-gel affinity chromatography. Binding to the intact membrances as well as to the solubilized preparation was specific and saturable. According to the Scatchard plot, the membrane preparations exhibited a single class of high affinity binding sites with a Kd OF 0.71 nM. The solubilized preparation also showed the presence of a single class of bindings sites with less affinity (Kd of 14 nM). Meanwhile the competition studies using angiotensin II analogues represented two separate binding sites for angiotensin II and single binding site for antagonist. These latter findings were correlated to the results provided by Garrison's research group. More works are needed to clarify this discrepancy.

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Types of Weed Community in Transplanted Lowland Rice and Relationship between Yield and Weed Weight in Weed Communities (논 잡초의 군락형 종류와 군락형별 잡초발생과 수도수량과의 관계)

  • S. C, Kim;Keith, Moody
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.25 no.3
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    • pp.1-8
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    • 1980
  • Eight different weed community types growing in association with transplanted rice were identified in the experimental fields used in these studies. The Importance Value (LV.) of weed species growing in association with rice changed with time. The I. V. of Echinochloa glabrescens Munro ex Hook f. increased from 40 days after transplanting (DAT) until heading and then, decreased from heading to maturity of rice. However, the LV. of Monochoria vaginalis (Burm.) Pres!. and Echinochloa crus-galli ssp. hispidula (Retz.) Honda increased from 40 DAT to maturity while Scirpus maritimus L. decreased from 40 DAT. There was a high negative correlation between grain yield and weed weight at rice heading in all weed communities. The competitive ability of rice against weeds varied depending upon weed species. The highest yield decrease due to weed competition was obtained from the E. crus-galli ssp. hispidula-S. Maritimus community. Forty-two percent yield reduction was caused by competition of 100g dry weight of weeds per square meter of this community type at rice heading. The yield decrease for the same amount of weeds was 10% for the E. glabrescens community, 15% for the M vaginalis community and the M vaginalis-Scirpus supinus L. community and 21% for the M vaginalis-E. glabrescens-Fimbristylis littoralis Gaud.-S. maritimus community type.

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The Growth and Yield of Soybean as Affected by Competitive Density of Cuscuta pentagona (미국실새삼 발생밀도가 콩 생육 및 수량에 미치는 영향)

  • Song, Seok-Bo;Lee, Jae-Saeng;Kang, Jong-Rae;Ko, Jee-Yeon;Seo, Myung-Chul;Woo, Koan-Sik;Oh, Byeong-Geun;Nam, Min-Hee
    • Korean Journal of Weed Science
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    • v.30 no.4
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    • pp.390-395
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    • 2010
  • This study was conducted to predict reduction of soybean yield as affected by different densities of Cuscuta pentagona. All data were fitted to Cousens' rectangular hyperbola model to estimate parameters for predicting soybean yield loss. The yield of soybean in the various densities (1 to 48 plants $m^{-2}$) of C. pentagona reduced by 80.3 to 99.7%, respectively. Among yield components, number of pods was the most significantly influenced by weed interferences. The prediction model for soybean yield as affected by weed competition was as follows: Y= 274.6783/(1+4.3522X), $r^2$=0.999 in C. pentagona. Economic threshold levels calculated using cousens' equation was 0.004 plants $m^{-2}$ in C. pentagona.

Intra- and Inter-specific Competition of Bulrush(Scirpus juncoides Roxb.) (올챙고랭이(Scirpus juncoides Roxb.)의 종내(種內) 및 종간경합(種間競合)에 관한 연구(硏究))

  • Guh, J.O.;Huh, S.M.
    • Korean Journal of Weed Science
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    • v.9 no.2
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    • pp.168-173
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    • 1989
  • In the characteristics of intra-specific competition according to bulrush density, the intra-specific competition in plant height began at 5 and 15% per pot in mixed culture and bulrush monoculture, respectively. The intra-specific competition in the shoot began at 5 plants per pot in both mixed culture and bulrush monoculture. The competition in dry matter weight began at 15 plants per pot in monoculture, and at 10 plants in mixed culture. On the rice density, the plant height, and numbers of shoot and dry matter weight in rice were rapidly increased up to 2.6, and 2.5 plants per pot, respectively, And then the increments were slow, The critical intra-specific competition of bulrush with rice was 2.5 to 3 plants per pot in their traits of rice, and especially the number of shoots and dry matter weights per pot showed significant decrements. In the different transplanting time in rice, the plant heights in both rice and bulrush elongated longer in mixed culture than in monoculture. The plant height of bulrush became shorter but the height of rice longer with late transplanting. The ratio of shoot number in rice to the number in bulrush was about 1 : 3 in all plots, and shoot numbers became less by late transplanting. The dry matter weight in both species were decreased by late transplanting, and the decrements were more prominent in bulrush than in rice.

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