• 천문학논총
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• 제12권1호
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• pp.111-143
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• 1997

We have developed a spherical FCT code in order to simulate the interaction of supernova remnants with stellar wind bubbles. We assume that the density profile of the supernova ejecta follows the Chevalier mode1(1982) where the outer portion has a power-law density distribution($\rho{\propto}\gamma^{-n}$) and the SN ejecta has a kinetic energy of $10^{51}$ ergs. The structure of wind bubble has been calculated with the stellar mass loss rate $\dot{M}=5\times10^{-6}M_{\odot}/yr$ and the wind velocity $\upsilon=2\times10^3$ km/s We have simulated seven models with different initial conditions In the first two models we computed the evolution of SNRs with n=7 and n=14 in the uniform medium The numerical results agree with the Chevalier's similarity solution at early times. When all of the power-law portion of the ejecta is swept up by the reverse shock, the evolution slowly converges to the Sedov-Taylor stage. There is not much difference between the two cases with different n's The other five models simulate SNRs produced inside wind bubbles. In model III, we consider the SN ejecta of 1.4 $M_{\odot}$ and the radius of bubble ~2.76 pc so that ratio of the mass $\alpha(=M_{W.S}/M_{ej}$ is 2. We follow the complex hydrodynamic flows produced by the interaction of SN shocks with stellar shocks and with the contact discontinuities, In the model III, the time scale for the SN shock to cross the wind shell $\tau_{cross}$ is similar to the time scale for the reverse shock to sweep the power-law density profile $\tau_{bend}$. Hence the SN shock crosses the wind shell. At late times SN shock produces another shell in the ambient medium so that we have a SNR with double shell structure. From the numerical results of the remaining models, we have found that when $\tau_{cross}/\tau_{bend}\leq2$, or equivalently when $\alpha\leq50$, the SNRs produced inside wind bubbles have double shell structure. Otherwise, either the SN shock does not cross the wind shell or even if it crosses at one time, the reverse shock reflected at the center accelerates the wind shell to merge into the SN shock Our results confirm the conclusion of Tenorio-Tagle et a1(1990).

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2523-2528
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• 2014

In the present study, at first, azo Schiff base ligand of (N,N'-bis(5-phenylazosalicylaldehyde)-ethylenediamine) ($H_2L$) has been synthesized by condensation reaction of 5-phenylazosalicylaldehyde and ethylenediamine in 2:1 molar ratio, respectively. Then, its cobalt complex (CoL) was synthesized by reaction of $Co(OAc)_2{\cdot}4H_2O$ with ligand ($H_2L$) in 1:1 molar ratio in ethanol solvent. This ligand and its cobalt complex containing azo functional groups were characterized using elemental analysis, $^1H$-NMR, UV-vis and IR spectroscopies. Subsequently, the interaction between native calf thymus deoxyribonucleic acid (ct-DNA) and CoL complex was investigated in 10 mM Tris/HCl buffer solution, pH = 7 using UV-vis absorption, thermal denaturation technique and viscosity measurements. From spectrophotometric titration experiments, the binding constant of CoL complex with ct-DNA was found to be $(2.4{\pm}0.2){\times}10^4M^{-1}$. The thermodynamic parameters were calculated by van't Hoff equation.The enthalpy and entropy changes were $5753.94{\pm}172.66kcal/mol$ and $43.93{\pm}1.18cal/mol{\cdot}K$ at $25^{\circ}C$, respectively. Thermal denaturation experiments represent the increasing of melting temperature of ct-DNA (about $0.93^{\circ}C$) due to binding of CoL complex. The results indicate that the process is entropy-driven and suggest that hydrophobic interactions are the main driving force for the complex formation.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 추계학술대회 논문집
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• pp.269-270
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• 2010

• 한국해안해양공학회지
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• 제15권4호
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• pp.232-241
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• 2003

3차원 선형포텐셜 이론아래에서 해저면 바닥에 고정된 N개의 투과성 원기둥과 입사파의 상호작용 문제를 살펴보았다. 유체영역을 때의 외부영역과 N개의 내부영역으로 나누고, 각 유체영역에서의 회절포텐셜을 고유함수전개법에 의해 표현하였다(Williams and Li, 2000). 투과성 구조물은 파력과 처올림 파형을 크게 줄일 수 있다는 사실을 해석결과는 보여주고 있다. 개발된 해석모델을 검증하기 위하여 일렬로 배열한 투과성 원기둥들을 가지고 조파수조(30m $\times$ 7m $\times$ 1.5m)에서 체계적인 모형실험을 수행하였다. 해석결과와 모형실험결과는 정성적으로 잘 일치하고 있음을 확인하였다. 투과성 원기둥을 일렬로 배열하여 만든 방파제는 해수교환뿐 아니라 우수한 소파성능을 가지고 있어 미래의 해수교환방파제로써 무한한 잠재력이 있다고 판단된다.

• 한국전자통신학회논문지
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• 제13권3호
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• pp.593-600
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• 2018

효과적인 암호시스템 설계에 셀룰라 오토마타(이하 CA)가 적용되고 있다. CA는 국소적 상호작용에 의해 상태가 동시에 업데이트되는 성질이 있어서 LFSR보다 랜덤성이 우수하다. 이런 CA를 암호 시스템에 적용하기 위해 주어진 다항식에 대응하는 CA를 합성하는 방법에 대한 연구가 진행되었다. 본 논문에서는 90 UCA의 특성다항식과 전이규칙이 <$00{\cdots}001$>인 90/150 CA의 특성다항식의 점화관계를 분석한다. 또한 f(x)=f(x+1)을 만족하는 삼항다항식 $x^{2^n}+x+1$에 대응하는 90/150 CA를 90 UCA 전이규칙 블록과 특별한 전이규칙 블록을 이용하여 합성한다. 또한 $x^{2^n}+x+1$의 기약인수에 관한 성질을 분석한 후 $x^{2^n}+x^{2^m}+1(n{\geq}2,n-m{\geq}2)$에 대응하는 90/150 CA 합성 알고리즘을 제안한다.

• BMB Reports
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• 제31권2호
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• pp.149-155
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• 1998

The N199H variant of the EcoRI endonuclease has about twice the catalytic activity of the wild-type. A comparison of their biochemical characteristics, using synthetic oligonucleotides 5'-dAAAACTTAAGAAAAAAAAAAA-3' (KA) and 5'-dTTTTTGAATTCTTTTTTTTTT-3' (KT), helps to define the cleavage reaction pathway of these enzymes. Both EcoRI and EcoRI variant N199H were found to cleave singlestranded KA or KT about three times faster than the double-stranded forms, although the KT oligonucleotide was more susceptible. Using the ssDNA substrate in kinetic analyses, lower $K_m$ values were obtained for the N199H variant than for the wild-type at low (50 mM), as well as high (200 mM), sodium chloride concentrations. This difference between the endonucleases is attributed to a grealter accessibility for tbe substrate by the variant, and also a higher affinity for the DNA backbone. It also appears that the relative activities of the two enzymes, particularly at high ionic strength, are proportional to their populations in the monomeric enzyme form. That is, according to gel filtration data, half of the N199H molecules exist as monomers in 200 mM NaCl, whereas those of the wild-type are mainly dimeric. Consequently, the Asp199 residue of the EcoRI endonuclease may be implicated in the protein-protein interaction leading to dimerization, as well as in coupling to DNA substrates. In summary, it is proposed that active monomeric endonuclease molecules, derived from the dimeric enzyme, recognize and form a complex with a single stranded form of the DNA substrate, which then undergoes nucleophilic substitution and cleavage.

• Bulletin of the Korean Chemical Society
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• 제33권8호
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• pp.2499-2507
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• 2012

A novel and convenient electrochemical method has been developed for sensitive determination of melamine (MEL) using ascorbic acid (AA) as the recognition element. The working electrode employed in this method was modified with the nanocomposite of hydroxyapatite/carbon nanotubes to enhance the current signal of recognition element. The interaction between MEL and AA was investigated by fourier transform infrared spectroscopy and cyclic voltammetry, and the experimental results indicated that hydrogen bonding was formed between MEL and AA. Because of the existing hydrogen bonding and electrostatic interaction, the anodic peak current of AA was decreased obviously while the non-electroactive MEL added in. It illustrated that the MEL acted as an inhibitor to the oxidation of AA and the decreasing signals can be used to detect MEL. Under the optimal conditions, the decrease in anodic peak current of AA was proportional to the MEL concentrations ranging from 10 to 350 nM, with a detection limit of 1.5 nM. Finally this newly-proposed method was successfully employed to detect MEL in infant formula and milk, and good recovery was achieved.

• 대한화학회지
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• 제20권3호
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• pp.198-205
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• 1976

Parr의 Integral Hellmann-Feynman이론을 비대각꼴에 까지 일반화하여 의의를 갖도록 하였으며 그 특징을 논하였다. 그리하여 이 비대각꼴을 결정장론에 미치는 배치작용의 효과를 검토하는데 적용함으로서, 모든 차의 섭동 에너지를 하나의 묶음으로서 도입하였다. 그 결과 ${\Gamma}$, S 및 m로 특징지워지는 상태들에게, 파라미터화 할 수 있는 공통적인 동경적분이 존재하지 않음을 밝혔다. 그러나 만일 각 성분에 변형이 없고 동경성분에게 동등한 변형만이 있는 여기된 배치들의 작용만을 허락한다면, 이는 고전적인 결정장론에서 결정장 파라메터 10 Dq와 Condon-Slater 적분 $F^n$의 척도를 변경시키는 결과를 초래함을 알게 되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제2권3호
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• pp.385-393
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• 1998

Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent manner up to 0.4 mM, but as the concentration increased, the inhibitory effect gradually diminished. Binding of phenylbutazone to the human neutrophil elastase caused strong Raman shifts at 200, 440, and 1194 $cm^{-1}$. The peak at 1194 $cm^{-1}$ might be evidence of the presence $of\;-N=N-{\Phi}$ radical. The core area of the elastase, according to the visual molecular model of human neutrophil elastase, was structurally stable. A deeply situated active center was at the core area surrounded by hydrophobic amino acids. Directly neighboring the active site was one positively charged atom and two atoms carrying a negative charge, which enabled the enzyme and the drug to form a strong interaction. Phenylbutazone may form a binding, similar to a key & lock system to the atoms carrying opposite charges near the active site of the enzyme molecule. Furthermore, the hydrophobicity of the surrounding amino acid near the active site seemed to enhance the binding strength of phenylbutazone. Binding of phenylbutazone near the active site may cause masking of the active site, preventing the substrate from approaching the active site and inhibiting elastase activity.

• 약학회지
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• 제43권5호
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• pp.642-651
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• 1999

Nonsedating antihistamines do net cause sedation in therapeutic doses because these drugs hardly cross the blood-brain barrier. Since most of the peripheral side dffects of conventional antihistamines are related to their muscarinic receptor blocking action, the present study was performed to investigate whether nonsedating antihistamines interact with the muscarinic receptors and discriminate the muscarinic receptor subtypes in the rat cerebral microsomal fraction which containes both $M_1,{\;}M_2,{\;}M_3{\;}and{\;}M_4$ receptors. Five nonsedating antihistamines at high concentrations inhibited [$^3H$]QNB binding to the muscarinic receptor in a dose-dependent manner. The inhibition curves of these drugs except loratadine which showed positive cooperativity (nH=1.55) were steep (nH=1), indicating interaction with a single homogenous population of the binding sites. Astemizole, clemizole and mequitazine increased the $K_D$ value for [$^3H$]QNB without affecting the binding site concentrations, and this increase in the $K_D$ value resulted from the ability of these drugs to slow [$^3H$]QNB-receptor association. The Ki values of astemizole, clemizole and mequitazine for the inhibition for the inhibition of [$^3H$]QNB binding to muscarinic receptor were 0.58, 5.99 and $0.007{\;}{\mu}M$, respectively. However, loratadine and terfenadine inhibited noncompetitively [$^3H$]QNB binding with the normalized $IC_50$ value of about $2{\;}{\mu}M$. These results demonstrate that; 1) astemizole, clemizole and mequitazine interact directly with the muscarinic receptor at high concentrations; 2) muscarinic receptor blocking potency of these drugs varies widely among drugs; 3) these drugs do not discriminate between muscarinic receptor subtypes.