• Title/Summary/Keyword: M&A effect

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Potential on Hypotriglyceridemic Effect of Chloroform-Methanol Extract of Adlay Diabetic Rats

  • Cho, Youn-Ok;Lee, Mie-Soon
    • Journal of Nutrition and Health
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    • v.31 no.5
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    • pp.921-926
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    • 1998
  • The purpose of this study was to investigate the potential hypolipidemic effect of adlay extract in streptozotocin-induced diabetic rats. Fifty six rats were fed either a control diet or adlay extract diets of : Methanol 1%(Ml%) ; Methanol 2%(M2%) ; Methanol 4%(M4%) ; Chloroform-Methanol 1%(CMl%) ; Chloroform-Methanol 2%(CM2%) ; Chloroform-Methanol 4%(CM4%) for 3 weeks. The amount of extracts added was 1%, 2% or 4% by diet weight respectively. The levels of glucose, total cholesterol(TC), high-density-lipoprotein cholesterol (HDL-C), free-fatty acid(FFA) and triglyceride(TG) in plasma, liver and skeletal muscle were compared. Among diabetic rats, there were no significant differences in the plasma level of glucose and TC regardless of a different extraction procedure or different amount of extracts added. While the plasma 7G level tended to increase with times passed in diabetic control group, was not increased with times passed in CM groups and was significantly lower in CM groups at 3rd week. Compared to the diabetic control group, the levels of FFA tended to be lower in all M groups and were not different in all CM groups. The levels of HDL-cholesterol were not different in all M groups and were significantly lower in all CM groups than diabetic control group. Compared to diabetic control group, liver triglyceride level was lower in M4% group and no significant difference was seen in Ml%, M2% and all CM groups. Muscle triglyceride level tended to be lower in Ml%, M2% and CM2% group and significantly was lower in M4% and CM4% group. Thus, it can be suggested that a CM extract of adllay could have a potential hypotriglyceridemic effect on diabetic subjects. (Korean J Nutrition 31(5) : 921∼926, 1998)

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The Effect of Carbon Monoxide on Contraction, Cytosolic $Ca^{2+}$ Level and Ionic Currents in Guinea Pig Ileal Smooth Muscle

  • Kwon, Seong-Chun;Chung, Seung-Soo;Kim, Yun-Suk;Nam, Taick-Sang
    • The Korean Journal of Physiology and Pharmacology
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    • v.4 no.6
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    • pp.479-486
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    • 2000
  • The aim of this study was to clarify the mechanism of the inhibitory action of carbon monoxide (CO) on contraction, by measuring cytosolic $Ca^{2+}$ level $([Ca^{2+}]_i)$ and ionic currents in guinea-pig ileum. CO (10%) inhibited 40 mM KCl-induced contraction and this effect was blocked by ODQ $(1\;{\mu}M),$ a soluble guanylyl cyclase (sGC) inhibitor. CO inhibited the 40 mM KCl-induced contraction without changing $[Ca^{2+}]_i.$ Cumulative addition of KCl induced a graded increase in $[Ca^{2+}]_i$ and muscle tension. In the presence of CO, cumulative addition of KCl induced smaller contraction than in the absence of CO. On the other hand, the increase in $[Ca^{2+}]_i$ induced by cumulative addition of KCl was only slightly decreased in the presence of CO, and the $[Ca^{2+}]_i-tension$ relationship shifted downwards. Using the patch clamp technique with a holding potential of -60 mV, we found that CO had little effect on the peak Ba currents $(I_{Ba})$ when voltage was stepped from -60 mV to 0 mV. In addition, CO showed no effect on the depolarization-activated outward $K^+$ currents in the all potential ranges. We conclude that CO inhibits smooth muscle contraction mainly by decreasing the $Ca^{2+}$ sensitivity of contractile elements via a cGMP-dependent pathway, not by involving L-type $Ca^{2+}$ and outward-potassium currents in guinea-pig ileum.

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Effects of nitric oxide on the proliferation and differentiation of human periodontal ligament cells (산화질소가 인간 치주인대세포의 증식과 분화에 미치는 영향)

  • Choi, Sun-Young;Cho, Jin-Hyoung;Kang, Kyung-Hwa
    • The korean journal of orthodontics
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    • v.36 no.6
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    • pp.465-473
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    • 2006
  • Objective: This study evaluated the effects of nitric oxide (NO) on the proliferation and differentiation of human periodontal ligament cells involved in orthodontic tooth movement. Methods: A range of concentrations of sodium nitroprusside (SNP), a NO donor, were administered to samples of human periodontal ligament cells, followed by measurement of cell viability, alkaline phosphatase (ALP) activity, and expression of osteonectin and bone sialoprotein. Results: Cell viability, ALP activity and the expression of osteonectin and bone sialoprotein were increased in human periodontal ligament cells treated with SNP concentrations of < 0.2 mM compared with controls, but were decreased with SNP concentrations of > 1.0 mM. Conclusion: NO has a biphasic effect on proliferation and differentiation in human periodontal ligament cells, with a stimulatory effect at low concentrations and an inhibitory effect at high concentrations.

Glucose Release Induced by 1,2-Dioctanoyl-sn-Glycerol in Perfused Rat Liver (관류 흰쥐 간에서 1,2-Dioctanoyl-sn-Glycerol에 의한 글루코오스의 유리작용)

  • Hwang, Young-Eun;Moon, Eun-Soon;Kim, Mie-Young
    • YAKHAK HOEJI
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    • v.35 no.6
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    • pp.509-514
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    • 1991
  • The effect of diacylglycerol on glucose release was studied by using 1,2-dioctanoyl-sn-glycerol ($diC_8$), a cell permeable diacylglycerol, in perfused rat liver. The glucose release was increased by $diC_8(50\;{\mu}M$), and the effect was depended on calcium ions. The increment of glucose release by $diC_8(50\;{\mu}M$) was inhibited by indomethacin ($50\;{\mu}M$); the amount of glucose release was almost the same with that of control group. Arachidonic acid($200\;{\mu}M$) also increased glucose release and the release was inhibited by indomethacin. There was no synergistic effect on glucose release by the combination of $diC_8(50\;{\mu}M$) and phenylephrine($10\;{\mu}M$).

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Semantic Priming Effect of Korean Lexical Ambiguity: A Comparison of Homonymy and Polysemy (한국어의 어휘적 중의성의 의미점화효과: 동음이의어와 다의어의 비교)

  • Yu, Gi-Soon;Nam, Ki-Chun
    • Phonetics and Speech Sciences
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    • v.1 no.2
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    • pp.63-73
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    • 2009
  • The present study was conducted to explore how the processing of lexical ambiguity between homonymy and polysemy differs from each other, and whether the representation of mental lexicon was separated from each lexical ambiguity by a semantic priming paradigm. Homonymy (M1 means the literal meaning of '사과', i.e. apple and M2 means another literal meaning of '사과', i.e. apologize) was used in Experiment I, and polysemy (M2 means the literal meaning of '바람', i.e. wind and M2 means the figurative meaning of '바람', i.e. wanton) was used in Experiment 2. The results of both experiments showed that a significant semantic priming effect occurs regardless of the type of ambiguities (homonymy and polysemy) and the difference of their semantic processes. However, the semantic priming effect for polysemy was larger than that for homonymy. This result supports the hypothesis that the semantic process of homonymy is different from that of polysemy.

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Micro-PIV Measurements of interfacial electrokinetic effects in a microchannel (마이크로 PTV 기법을 이용한 미세채널 내부 계면의 electrokinetic 효과 해석)

  • Kim Guk-bae;Lee Sang-Joon
    • 한국가시화정보학회:학술대회논문집
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    • 2002.11a
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    • pp.49-50
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    • 2002
  • In micro-channels, the electro-viscous effect is caused by the electrical double layer on pressure-driven liquid flow. Velocity fields of flow inside micro-channels were measured using micro-PIV system for investigating the electro-viscous effect. De-ionized water and aqueous NaCl solutions with four different concentrations were used as working fluid in a PDMS micro-channel of $100{\mu}m$ width and $66{\mu}m$ height. The pressure gradient, dP/dx, was determined from the pre-determined input flow rate Q of syringe pump. The mean velocity $u_m$ used for calculating Reynolds number was obtained from the PIV velocity field data. These are used to plot the pressure gradient as a function of Reynolds numbers. The pressure gradient far lower concentration solution $(10^{-5}\;M)$ was higher than that for the higher concentration solution. The increase of flow resistance was about $30\%\;and\;37.5\%$ at Re=0.02 and 0.06, respectively.

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Antibacterial effect of Zingiberaceae extracts mediated photodynamic therapy on Streptococcus mutans (Streptococcus mutans에 대한 생강과 천연추출물의 광역학 항균효과)

  • Hwang, Hye-Rim;Kang, Si-Mook;Lee, Eun-song;Kim, Baek-Il
    • The Journal of the Korean dental association
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    • v.57 no.10
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    • pp.560-568
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    • 2019
  • Purpose: This study evaluated the antibacterial effects of curcuma, ginger, and finger root extracts in water-soluble powder on planktonic Streptococcus mutans(S.mutans), which is known to cause dental caries, in order to confirm whether these extracts could perform as photosensitizers for the effects of photodynamic therapy (PDT). Methods: This study used the strain of streptococcus mutans ATCC 25175 distributed by the Korean Collection for Type Cultures of the Korea Research Institute of Bioscience & Biotechnology. Commercial edible curcuma, ginger and finger root were used as the natural extracts for the use of photosensitizer. To extract organic solvent, 3 g of each powder was mixed in $30m{\ell}$ of dimethyl sulfoxide (DMSO, VWR, Germany) before extraction. $1.8m{\ell}$ of the photosensitizer solution, manufactured in the concentrations of 5, 0.5, and $0.05mg/m{\ell}$, was mixed with $0.2m{\ell}$ of the S. mutans culture medium that had been cultured for 2 days. To induce the photodynamic reaction, Qraycam (AIOBIO, Seoul, Korea) equipped with 405 nm LED was used to expose light for 5 minutes to irradiate 59 nW energy for 300 seconds. Results: Compared with the case with no light, a higher photodynamic therapeutic effect was confirmed with $0.05mg/m{\ell}$ curcuma powder extract, the concentration of $0.5mg/m{\ell}$ and LED light of 405 nm wavelength (p=0.000, p=0.003). $0.05mg/m{\ell}$ of curcuma powder extract and the concentration of $0.5mg/m{\ell}$ showed 100% antibacterial effect when exposed to light, whereas the concentration of $5mg/m{\ell}$ showed 11.95% antibacterial effect. When exposed to light, $0.05mg/m{\ell}$ of ginger powder extract showed an antibacterial effect which didn't statistically decrease. The concentrations of $0.5mg/m{\ell}$ and $5mg/m{\ell}$ did not show any antibacterial effects. As a result of examining any photodynamic therapeutic effects of finger root powder extract on S. mutans, no statistically significant effect was found. Conclusion: The curcuma powder extract is expected to perform as a photosensitizer. Even though belonging to the same ginger family, ginger powder and finger root powder seem difficult to perform as photosensitizer.

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A Study on the Effect of Shading on a Photovoltaic Module

  • Baatarbileg, Ankhzaya;Otgongerel, Zulmandakh;Lee, Gae-Myoung
    • New Physics: Sae Mulli
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    • v.68 no.11
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    • pp.1215-1224
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    • 2018
  • Most solar photovoltaic (PV) modules frequently get shadowed, completely or partially, resulting in a reduction of PV generation. This paper presents and compares the results from simulations and experimental measurements of the power output from a single PV module under various shading conditions. The study was carried out with a 90 W PV module and a 250 W PV module. The shaded area was increased from 0 to 100% for both variable and constant irradiances to analyze the effect of fluctuations in the solar irradiance certain shading conditions. The effect of shading for irradiance levels from 100 to $900W/m^2$ was investigated. Results showed that for every $100W/m^2$ decrease in the solar irradiance level, the power output decreased by 9, 0.7 and 1.5 W at 0, 25 and 50% shading, respectively. For solar irradiance levels higher than $500W/m^2$, the temperature increased by 1.6, 2.7 and $1.1^{\circ}C$ at 0, 25 and 50% shading, respectively, for every $100W/m^2$ increase in the irradiance.

A Study of Limitation of Service Area by UWB Transmission Jamming in DMB System (DMB 시스템에서 UWB 전파가 서비스에 미치는 영향에 관한 연구)

  • Kim, Dong-Ok
    • Journal of The Institute of Information and Telecommunication Facilities Engineering
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    • v.4 no.2
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    • pp.1-8
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    • 2005
  • In this paper, n system did research about effect that interference effect with neighborhood single equipment or group equipment gets in DMB service. For this, 2.6425 GHz SDMB(Satellite Digital Multimedia Broadcasting) that a special of electric wave interference is near frequency-band including interference of signal by unnecessary radiation level that is radiated in UWB system, and degree of 3.4125GHz broadcasting relay net that is In-band frequency-band and interference effect that get in service analyzed comparison ud, modulation of broadcasting relay net and interference measurement equipment used Impulse and OFDM methods. Impulse method was $BER=1{\times}10^4$ that broadcasting signal receiption is possible at 1.4m point because interference effect happens from 2m point in SDMB system, and it was $BER=1^{\times}10-4$ that OFDM method receives interference effect from 0.8m point and broadcasting signal receiption is possible at 0.5m point. Also, about gap-filler center frequency, in case of space interval more than 0.01m, there was no interference effect. Therefore, for the electric wave of W system that is small output applies to system without interference effect in DMB service, confirmed that UWB system of OFDM method is less interference effect than UWB system of impulse method.

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A Study of Limitation of Service Area by UWB Transmission Jamming in Broadcasting Communication System (방송통신 시스템에서 UWB 전파가 서비스에 미치는 영향에 관한 연구)

  • Park, No-Jin
    • Journal of The Institute of Information and Telecommunication Facilities Engineering
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    • v.7 no.1
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    • pp.23-31
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    • 2007
  • In this paper, UWB system did research about effect that interference effect with neighborhood single equipment or group equipment gets in broadcasting communication service. For this, 2.6425GHz SDMB(Satellite Digital Multimedia Broadcasting) that a special of electric wave interference is near frequency-band including interference of signal by unnecessary radiation level that is radiated in UWB system, and degree of 3.4125GHz broadcasting relay net that is In-band frequency-band and interference effect that get in service analyzed comparison and, modulation of broadcasting relay net and interference measurement equipment used Impulse and OFDM methods. Impulse method was $BER\;=\;1{\times}\;10^{-4}$ that broadcasting signal receiption is possible at 1.4m point because interference effect happens from 2m point in SDMB system, and it was $BER\;=\;1{\times}\;10^{-4}$ that OFDM method receives interference effect from 0.8m point and broadcasting signal receiption is possible at 0.5m point. Also, about Gap-Filler center frequency, In case of space interval more than 0.01m, there was no interference effect. Therefore, for the electric wave of UWB system that is small output applies to system without interference effect in broadcasting communication service, confirmed that UWB system of OFDM method is less interference effect than UWB system of Impulse method.

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