• BMB Reports
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• v.56 no.5
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• pp.302-307
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• 2023

Lyn, a tyrosine kinase that is activated by double-stranded DNA-damaging agents, is involved in various signaling pathways, such as proliferation, apoptosis, and DNA repair. Ribosomal protein S3 (RpS3) is involved in protein biosynthesis as a component of the ribosome complex and possesses endonuclease activity to repair damaged DNA. Herein, we demonstrated that rpS3 and Lyn interact with each other, and the phosphorylation of rpS3 by Lyn, causing ribosome heterogeneity, upregulates the translation of p-glycoprotein, which is a gene product of multidrug resistance gene 1. In addition, we found that two different regions of the rpS3 protein are associated with the SH1 and SH3 domains of Lyn. An in vitro immunocomplex kinase assay indicated that the rpS3 protein acts as a substrate for Lyn, which phosphorylates the Y167 residue of rpS3. Furthermore, by adding various kinase inhibitors, we confirmed that the phosphorylation status of rpS3 was regulated by both Lyn and doxorubicin, and the phosphorylation of rpS3 by Lyn increased drug resistance in cells by upregulating p-glycoprotein translation.

• Journal of Astronomy and Space Sciences
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• v.16 no.2
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• pp.209-216
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• 1999

Light curves of two near-contact binaries DO Cas and SW Lyn are analyzed to investigate their Roche configurations. We made new BVR observations for DO Cas and employed the published observation data for SW Lyn. Our four night observations for DO Cas were secured over 8 days so that the contamination by the intrinsic light variation is minimized. Based on the WD model, we found that DO Cas could be classified as a near-contact binary, while SW Lyn is better described by semi-detached configuration. Furthermore it is also possible to classify DO Cas as a contact binary. It appears that there are ambiguities in the class of near-contact configuration, and further observations and re-analysis are required to establish the near-contact nature of binary systems.

• Journal of Life Science
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• v.17 no.3 s.83
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• pp.350-355
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• 2007

The rat RBL-2H3 mast cells contain various Src-family kinases. Previous reports with this cell line indicated that Lyn activation is an important initial signaling for the activation of the cells. However, the role and location of other Src-family kinase isoforms which are expressed in the cells are not clear. In this study, we now show that isoforms of Src-family kinases, Lyn, fyn, Fgr, c-Src, and Yes are differentially expressed and located differently in the cells as indicated by RT-PCR, immunoblotting analysis, and confocal microscopy. Lyn and Fgr were located on plasma membrane but on the other hand c-Src and Yes were located on intracellular organelle. All of Src-family kinases were cloned and overexpressed for investigating the roles of the isoforms. Overexpression of Fyn and Fgr, not Lyn and c-Src, stimulated Ag-induced degranulation in the cells. Our findings strongly suggest for the first time that each of Src-family kinase isoform can regulate differentially $Fc{\varepsilon}RI$-mediated signaling in RBL-2H3 mast cells.

• Journal of Astronomy and Space Sciences
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• v.34 no.2
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• pp.75-82
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• 2017

High-resolution spectroscopic observations of the eclipsing binary system RR Lyn were made using the 1.8 m telescope at the Bohuynsan Optical Astronomical Observatory in Korea. The spectral resolving power was R = 82,000, with a signal to noise ratio of S/N > 150. We found the effective temperatures and surface gravities of the primary and secondary components to be equal to $T_{eff}$ = 7,920 & 7,210 K and log(g) = 3.80 & 4.16, respectively. The abundances of 34 and 17 different chemical elements were found in the atmospheric components. Correlations between the derived abundances with condensation temperatures and the second ionization potentials of these elements are discussed. The primary component is a typical metallic line star with the abundances of light and iron group elements close to solar values, while elements with atomic numbers Z > 30 are overabundant by 0.5-1.5 dex with respect to solar values. The secondary component is a ${\lambda}$ Boo type star. In this type of stars, CNO abundances are close to solar values, while the abundance pattern shows a negative correlation with condensation temperatures.

• Journal of Astronomy and Space Sciences
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• v.16 no.1
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• pp.11-20
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• 1999

In this paper all the photoelectric times of minimum for the triple star SW Lyn have been analyzed in terms of light-time effect due to the third-body and secular period decreases induced by mass transfer process. The light-time orbit determined recently by Ogloza et al.(1998) were modified and improved. And it is found that the orbital period of SW Lyn have been decreasing secularly. The third-body revolves around the mass center of triple stars every $5^y.77$ in a highly eccentric elliptical orbit(e=0.61). The third-body with a minimum mass of $1.13M_{odot}$ may be a binary or a white dwarf. The rate of secular period-decrease were obtained as ${Delta}P/P=-12.45{ imes}10^{-11}$, implying the mass-transfer from the massive primary star to the secondary. The mass losing rate from the primary were calculated as about $1.24{ imes}10^{-8}M_{odot}/y$. It is noticed that the mass-transfer in SW Lyn system is opposite in direction to that deduced from it's Roche geometry by previous investigators.

• Journal of Astronomy and Space Sciences
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• v.12 no.2
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• pp.196-203
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• 1995

The UBV light curves of a close eclipsing binary SW Lyn were obtained with the observations made at the Sobaeksan Astronomy Observatory during 7 nights from September 1983 to March 1987. These light curves show asymmetry to the secondary minimum light and the asymmetry is larger at the shorter wavelength light curve. Assuming that the star sport makes the asymmetry, we employed the WD code to make the B and V light curves solution. We confirmed that SW Lyu has near contact(semi-detached) Roche configuration and has the Case A evolution.

• Bulletin of the Korean Space Science Society
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• 2008.10a
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• pp.22.3-22.3
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• 2008

We present the results of the investigations of high dispersion spectra of two stars. These are the eclipsing binary RR Lyn, and $\rho$ Pup - the prototype of the group of pulsating variables. The spectra were obtained at 1.8 m Bohyuunsan observatory telescope, and 8.2 m VLT. We found the chemical composition. The both components of RR Lyn are Am stars (metallic line stars), but the abundance patterns of the components are not similar - the iron abundance and the abundances of other elements are surely different. For few elements the differences exceeds 1 dex. We found the abundances of 56 chemical elements in the atmosphere of $\rho$ Pup. This is one of the best stellar abundance patterns. It permits to investigate the role of the charge-exchange reactions in stellar atmospheres. These reactions can produce the abundance anomalies in the atmospheres of B-F type stars. These reactions can be one of the sources of galactic cosmic rays, and the reason of the braked rotation of A-F type chemically peculiar stars.

• 비료회보
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• s.492
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• pp.17-26
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• 1998

• Journal of the Korean earth science society
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• v.37 no.7
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• pp.389-397
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• 2016

In order to investigate the light curve difference in visual and infrared wavelength of ${\delta}$ Scuti variable Bo Lyn, observations were performed using BOAO 1.8m reflecting telescope and an infrared detector, KASINICS, with J, H, and Ks filters. Infrared light curves of total 7 nights were obtained between March and April in 2011, and those were compared to the V-filter light curve to examine the differences in period, time of maximum light, amplitude, and shape. From the periodic analysis of infrared light curve, a single frequency of $f_1=10.712cycle/day$, $P=0.09335{\pm}0.00002days$ was obtained, and there was no difference in the period along different wavelengths. In the infrared light curve, a frequency of $2f_1$ was detected. This frequency well explains the asymmetric shape of light curve, one of the characteristics of high-amplitude ${\delta}$ Scuti variables. We compared the locations of the measured infrared maxima and the predicted maxima of V-filter, finding that the times of maxima were delayed about 0.3 phase at infrared wavelengths. Amplitude ratios were adopted to be ${\Delta}J/{\Delta}V=0.328$, ${\Delta}H/{\Delta}V=0.216$, and ${\Delta}Ks/{\Delta}V=0.211$, with the range of variation being smaller at longer wavelengths. It seems that the differences in the times of maxima and amplitude occurred because the changes in brightness of a pulsating variable star are mainly caused by the change in temperature.

• Journal of Chest Surgery
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• v.29 no.11
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• pp.1248-1256
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• 1996

From June 1987 to December 1994, 372 patients underwent operation for resection of esophageal cancer, and 48 patients with metastasis to distant abdominal lymph nodes were analyzed.. The primary tumors were located predominantly in lower thoracic esophagus(n=29). The location of involved lymph nodes were celiac L/N(n=45), common hepatic L/N(n=4), paraaortic L/N(n=l), and retropancreatic L/N(n=l). Most tumors penetrated the esophageal wall(T3,T4, n=43), metastased to regional L/N(N1, n=41), but a few tumors were limited to the esophageal wall(T1,T2, n=5), metastased to distant abdominal L/N without metastasis to regional L/N(NO, n=7). Resectability rate was 87.5%(42/48), and complete resection was possible in 31 patients(64.6%). The most frequent cause of incomplete resection and unresectability was unresectable T4 lesions(n=8), extranodal invasion(n=7). Overall operative mortality and morbidity was 4.2%, 22.9%, and resection mortality was 4.8%. Adjuvant therapy was given to 27 patients, and postoperative follow-up was possible in all patients(median follow-up, 32 months). The 1 year and 3 year survival for resection group was 54.0%, 18.1%(median, 386 days) including operative deaths. Our results suggest that resection of the esophageal cancer with metastasis to distant abdominal lymph nodes(M1LYN) can be done with acceptable mortality and morbidity, and may playa role in long-term survival in carefully selected patients because prognosis is dismal in unresectable esophageal cancer. We recommend that lymph nodes around celiac axis be dissected thoroughly for exact staging and possible prolongation of survival, and multimodality therapy as necessary because most patients with M1(LYN) esophageal cancer do poorly with only primay surgical treatment.