• 대한두경부종양학회지
• /
• 제27권1호
• /
• pp.96-98
• /
• 2011

Non-Hodgkin's Lymphoma(NHL) is a malignant tumor that is derived from the lymphatic system. The most common symptoms of NHL are painless lymph node enlargement. However, we should not diagnose NHL by only fragmentary clinical symptom and radiologic finding because of the various lymphoma characters. We have treated a patient with such preoperative findings of Branchial cleft cyst. However, the pathologic diagnosis of the surgical specimen was diffuse large b-cell lymphoma.

• Archives of Plastic Surgery
• /
• 제45권3호
• /
• pp.275-279
• /
• 2018

Chronic lymphedema is caused by an impairment of the lymphatic system due to primary or secondary causes. Vascularized lymph node transplantation (VLNT) is currently the most promising and frequently used technique besides lymphaticovenous anastomosis. However, the vessel anatomy in the lateral thoracic region is sometimes quite variable. Based on our experiences with vascular anatomical inconstancy in the lateral thoracic region, we planned a lateral intercostal artery perforator flap for VLNT in a female patient with chronic stage II lymphedema of both legs after cervical cancer treatment. After surgery, the patient reported significant improvement in limb volume and the accompanying symptoms. The limb circumference was reduced by an average of 19.2% at 6 months postoperatively. Despite having a short pedicle and small vessel caliber, the lateral intercostal artery perforator flap can safely be used for VLNT in lymphedema patients with anatomical variants.

• Journal of Yeungnam Medical Science
• /
• 제6권1호
• /
• pp.165-169
• /
• 1989

본원 산부인과에서 산전 초음파 검사에 의해 거대 태아 경부 낭종으로 진단, 중절시킨 임신 22주 태아의 부검 결과 낭포성 히그로마로 판명되어 이에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
• /
• 제52권1호
• /
• pp.51-54
• /
• 2019

Castleman disease is a relatively rare disease, characterized by well-circumscribed benign lymph-node hyperplasia. The disease may develop anywhere in the lymphatic system, but is most commonly reported as unicentric Castleman disease in the mediastinum along the tracheobronchial tree. It is usually asymptomatic and detected on plain chest radiography as an incidental finding. We report an incidentally detected case of Castleman disease in the paravertebral space that was preoperatively diagnosed as a neurogenic tumor and treated by complete surgical resection.

• Korean Journal of Acupuncture
• /
• 제30권2호
• /
• pp.122-130
• /
• 2013

Objectives : The fact that Primo vessel as a new circulatory system exists in the lymphatic vessels of the rabbits which were treated with sound wave vibration therapy is confirmed with the anatomy of rabbit. Isolated Primo vessel is investigated, particularly focused on morphological features. Methods : Before the anatomy, a rabbit in a cage box was laid on the sound wave vibrating apparatus and then is applied by various frequencies and intensities for 30 min with music that a rabbit likes. Results : Isolation and observation of Primo vessel was easier when the lymphatic circular system was applied at a certain frequency and intensity of 7 Hz and 50. The probability of observation for Primo vessel enhanced to 90%. Conclusions : The sound wave therapy by a vibration apparatus is considered necessary as major process to facilitate the reproducible isolation and observation of Primo vessel.

• Anatomy and Cell Biology
• /
• 제56권1호
• /
• pp.25-31
• /
• 2023

Johannes Nathanael Lieberkühn was a prodigious anatomist whose meticulous experiments and precise detailing helped in comprehending the microscopic anatomy of digestive system during early part of eighteenth century. Notably, his inventions in the field of microscopy aptly complemented his quest for anatomical knowledge at microscopic level. He designed a reflector (Lieberkühn reflector) which enhanced the amount of focussed light leading to bright illumination of tissue specimen. He invented the solar microscope which provided excellent resolution of minute anatomical details. Lieberkühn discovered the digestive juice secreting tubular glands (glands of Lieberkühn) present at the base of intestinal villi producing epithelial invaginations (crypts of Lieberkühn). He also described the intricate juxtaposition of blood vessels in relation to a single intestinal villi. Moreover, through empirically designed experimental set up, Lieberkühn was able to demonstrate the flow of lymph from intestinal villi to collecting lymphatic vessels. Also, his grandiose collection of laboratory specimens involving vascular anatomy are a testimony of his untiring efforts in academia. His contributions were seminal in comprehending the anatomy of digestive system and paved the way for future revelations. His work unveiled the enormous scope of microanatomy in medical science and catalysed the advent of histological staining methods a century later.

• Korean Journal of Acupuncture
• /
• 제28권1호
• /
• pp.125-137
• /
• 2011

Objectives : The Primo system is a hypothesis on the new circulation system. It orginates from Bonghan theory. Bonghan theory is about the anatomical substance of acupuncture point and meridian system. It has been regarded as a misunderstanding of the lymphatic system or as a made-up story for the past 40 years. Since 2002, many studies have been published either to support the theory or to refute the old viewpoint. But there are still difficulties about the proper sampling. The purpose of this study is to find out the discriminative criteria of Organ Surface Primo sytem by reviewing the Kim Bonghan's publications. Methods : Abstract of description about the Organ Surface Primo system in 5 publications of Kim Bonghan are weighted by the reverse order of publication. Results and Conclusions : 6 characters of anatomical structure and 11 characters of histological structure are founded as repeated descriptions. We hope that this summarized characteristics would be a good guide to Primo system experiments.

• 대한의용생체공학회:의공학회지
• /
• 제34권4호
• /
• pp.170-176
• /
• 2013

Lymphedema is a phenomenon in which fluid is accumulated inside tissues due to the damaged lymphatic systems. Lymphedema can cause complications such as lymphangitis, infection, changes in skin texture, fibrosis, and lymphangiosarcoma. In this study, a lymphedema screening system based on the elasticity of the skin is proposed to easily quantify lymphedema. The developed probe consists of touch sensors, a load cell and hall-effect sensors to measure the indentation force on the skin and the return time of the skin. The developed system can be used to estimate the change in the elasticity of the skin to quantify lymphedema. The system was tested with a thyroid phantom and gelatin phantoms of different concentrations and the resulting force and the time were recorded. It was found that the increase in the elasticity leads to a higher indentation force and shorter return time. This shows that the developed system can monitor the change in the skin elasticity by measuring the return time and the indentation force. The feasibility of the system in clinical applications will be evaluated in the future study.

• 대한미생물학회지
• /
• 제13권1호
• /
• pp.55-62
• /
• 1978

항암제(抗癌劑)로 잘 알려진 cyclophosphamide(CY)를 성숙(成熟)한 마우스에 체중(體重) kg당(當) 300mg을 복강내(腹腔內)에 투여(投與)하여 CY가 체중(體重), 비장중량(脾臟重量) 및 말초임파조직(末梢淋巴組織)에 미치는 영향(影響)을 실험(實驗)하였다. CY는 마우스의 체중(體重)을 약간(若干) 감소(減少)시켰으나 체중(體重)은 곧 회복(回復)되었다. CY가 비장중량(脾臟重量)에 미치는 영향(影響)은 현저(顯著)하였는데 초기(初期)엔 비장중량(脾臟重量)은 감소(減少)되었으나 곧 회복(回復)되고 그 후(後) 정상(正常)보다 더 증가(增加)되었는데 그 증가(增加)는 CY투여(投與) 20일(日)이 지나서야 정상(正常)으로 되돌아왔다. 비장(脾臟) 및 임파절(淋巴節)의 조직학적(組織學的) 형태(形態)에 미치는 CY의 영향(影響)은 다양(多樣)하였다. 즉(卽), 흉선의존세포(胸線依存細胞)가 위치(位置)하는 비장(脾臟)의 periarterial lymphatic sheath와 임파절(淋巴節)의 paracortex는 골수유래세포(骨髓由來細胞)가 위치(位置)하는 follicles보다 1일(日) 내지(乃至) 2일(日) 늦게 소실(消失)되었으며 비장(脾臟)의 비대(肥大)가 최고(最高)에 달(達죠)하였을때 비장(脾臟)이나 임파절(淋巴節)의 구조(構造)는 동일(同一)한 임파양세포(淋巴樣細胞)로 구성(構成)된 interstitial tissue로 대치(代置)되어 있었다. 비장(脾臟)의 중량(重量)이 정상화(正常化)되어감에 따라 비장(脾臟)이나 임파절(淋巴節)의 구조(構造)가 정상화(正常化) 되어갔다. 이와 같은 본(本) 실험(實驗)의 소견(所見)은 CY는 골수유래세포(骨髓由來細胞) 뿐만 아니라 흉선의존세포(胸線依存細胞)에도 영향(影響)을 미친다고 사료(思料)된다. 저자(著者)들은 전보(前報)에서 CY에 의(依)한 지연성과민반응(遲延性過敏反應)의 항진(亢進)은 suppressor T cell의 제거(除去)에 기인(基因)한 것이라고 시사(示唆)하였는데 본(本) 실험결과(實驗結果)는 이를 뒷받침해준다고 사료(思料)되었다.

• 생명과학회지
• /
• 제34권2호
• /
• pp.128-137
• /
• 2024

이 리뷰 논문에서는 혈관 투과성, 내피세포 모집, 종양관련 혈관 및 림프관의 유지 등에서 핵심적인 과정인 angiogenesis와 lymphangiogenesis에 있어서 vascular endothelial growth factors (VEGF)가 이행하는 중요한 역할에 대해 재조명하고자 한다. VEGF는 tyrosine-kinase receptor인 VEGFR-1, VEGFR-2, VEGFR-3를 통해 그 역할을 이행하며, 이러한 VEGF-VEGFR 시스템은 암에서뿐만 아니라 비정상적인 혈관 및 림프관 형성으로 인해 야기되는 다른 질병들에 있어서도 핵심적인 요소로 각광받고 있다. 암의 측면에서 보았을 때, VEGF와 그 수용체는 종양관련 혈관 및 림프관을 형성하는 과정에서 필수적이라는 점에서 치료적인 타겟으로 이목을 끌고 있다. 때문에 암세포의 성장을 방해하기 위한 항VEGF 항체, 수용체 길항체, 수용체 기능 억제제 등과 같은 여러 가지 시도들이 있었지만, 아직까지 그 임상효과가 불확실하며 더 많은 연구들이 필요한 실정이다. 이 논문에서는 VEGF의 생리적 역할을 VEGF-A, VEGF-B, VEGF-C, VEGF-D, PLGF에 따라 나누어 설명하면서 VEGF/VEGFR 시스템의 중요성을 강조한다. VEGFR-1과 VEGFR-3은 각각 angiogenesis와 lymphangiogenesis에 핵심적인 인자이며, VEGFR-2의 경우 두 가지 모두를 일으킨다. 전반적으로 이 리뷰는 현재까지 밝혀진 암을 포함한 다양한 질병에서의 VEGF와 VEGFR의 역할에 대해 상세히 설명하고자 하였다. 이를 통해 치료 표적으로서 VEGF와 VEGFR의 활용이 더욱 촉진될 것으로 기대된다.