• 한국식품조리과학회지
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• 제20권4호
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• pp.409-417
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• 2004

The purpose of this study was to investigate the quality characteristics of Kugija-Injeulmi by varying the ingredient ratio of Lycii fructus powder (4, 6 and 8%). According to sensory evaluation of Kugija-Injeulmi, as the ratio of Lycii fructus powder was increased, the bitterness, hardness and chewiness all increased. It was found that Kugija-Injeulmi made of glutinous rice was moistened and softened with the addition of more Lycii fructus powder, but it was rougher than Kugija-Injeulmi made of glutinous rice flour. As a result of textural analysis of Kugija-Injeulmi, the hardness, adhesiveness, gumminess and chewiness increased as the amount of Lycii fructus powder increased, whereas the cohesiveness decreased. Kugija-Injeulmi made of glutinous rice was moister than Kugija-Injeulmi made of glutinous rice flour. The overall-acceptability was negatively correlated with coarseness. The overall-acceptability of Kugija-Injeulmi made of glutinous rice was much higher than that made of glutinous rice flour. From the above results, the most advisable mixture ratio of Kugija-Injeulmi is as follows Kugija-Injeulmi add 282g (94%) glutinous rice flour, Lycii fructus powder 18g (6%) and salt 3g. The moisture content was 42.22%.

• 생약학회지
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• 제19권3호
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• pp.193-200
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• 1988

Immunopotentiating activity of water extract of Lycii Fructus, Rubus Fructus, Torilis Fructus, Schizandrae Fructus and Cuscutae Semen were investigated using mouse fed with normal diet and protein deficient diet. Body weight, ratio of spleen or thymus to body weight, number of total peritoneal exudate cell, content of total serum protein and albumin content were decreased in the mouse fed with protein deficient diets as compared to the mouse fed with normal diet. Regardless of the nutritional condition, the supplement of the water extract of Lycii, Rubus Torilis, Schizandrae Fructus or Cuscutae Semen increased the ratio of spleen to body weight. The increment of this ratio was significant by the supplement of water extracts of Lycii and Torilis Fructus in mouse fed with protein deficient diet. The supplement of water extracts of Torilis Fructus to the mouse fed with protein deficient diet increased the content of total serum protein and albumin content significantly. Similar results were obtained with Lycii, Rubus, Schizandrae Fructus and Cuscutae Similar. The electrophorogram shows the difference in the concentration of some serum protein constituents between the mouse fed with normal diet and protein deficient diet.

• 한국조리학회지
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• 제21권6호
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• pp.63-75
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• 2015

본 연구는 당뇨병, 신경마비 증세 등에 효과가 있는 구기자 분말을 10~40%씩 각각 첨가하였다. 스펀지케이크의 반죽의 비중, pH, 부피, 무게, 색도, 조직감을 측정하고 관능검사를 실시하였다. 비중과 무게측정 결과, 대조군의 비중은 0.46, 무게는 139.3 g으로 가장 낮게 나타났다. 구기자의 첨가량이 많아질수록 유의적으로 증가하였다. 높이는 대조군이 5.02 cm, 부피는 340.67 mL, 비용적은 $2.47cm^3/g$으로 가장 높게 나타났으며, 40% 첨가 구까지 유의적으로 감소하는 유의적인 차이를 나타났다. 색도는 L(명도)는 대조군이 78.32로 가장 높게 나타났으며, 40% 첨가군이 35.56로 가장 낮게 나타냈다. b(황색도)는 대조군이 27.38으로 가장 낮게 나타났으며, 40% 첨가군이 38.27로 가장 높은 값을 나타냈다. 구기자 분말 첨가량이 증가할수록 a, b값은 유의적으로 증가하게 나타났다. 조직감인 탄력성(springiness), 응집성(cohesiveness)은 대조군이 높게 나타났으며, 구기자 분말의 첨가량이 증가할수록 감소하는 경향을 보였다. 관능검사는 맛(taste), 종합적인 기호도(Overall acceptability)에서 구기자 분말 10% 첨가군이 가장 우수하게 나타났다. 이와 같이 본 실험을 통해 구기자 분말 10%를 첨가하면 건강 지향적인 측면을 고려한 스펀지케이크 상품으로 개발이 가능한 적절한 배합비로 사료되었다. 또한, 이 실험을 기초로 하여 적당량을 구기자를 첨가한 다양한 실험을 통하여 제과제빵, 식품에 사용 가능한 적합한 배합비를 찾아내 제조 실험을 해야겠다고 판단된다. 그 결과로 더욱 맛있고 질이 좋은 구기자 첨가 제품의 상품화를 추구하는 연구를 계속할 생각이다.

• 한국식품위생안전성학회지
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• 제14권4호
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• pp.333-338
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• 1999

호도에 4。Bx의 영지, 녹차 및 구기자물 추출물을 첨가하여 저장 안전성을 조사 비교한 결과는 다음과 같다. 1. 4。Bx로 제조한 천연 첨가물의 종류가 호도의 AV와 POV에 미치는 영향은 구기자가 가장 효과적이었으며, 영지<녹차의 순으로 나타났으나 저장기간 2개월까지 첨가물에 의한 영향은 거의 없었다. 저장기간이 증가함에 따라 첨가물에 의한 항산화효과가 증가되는 것으로 나타나 영지 첨가 시 2개월, 녹차 첨가 시 4개월, 구기자 첨가 시 8개월 연장하여 권장유통기간을 설정하여도 안전성을 기대할 수 있을 것으로 나타났다. 2. 4。Bx의 구기자는 가장 우수한 항산화력이 있어 호도의 저장 안전성을 높일 수 있는 것으로 생각되었으며 새로운 천연 항산화제로서의 응용이 가능함을 알 수 있었다.

• 생약학회지
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• 제28권3호
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• pp.138-142
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• 1997

To elucidate antidiabetic activity of Lycii Fructus. The extract of the Lycii Fructus was subjected to bioactivity-guided fractionation. The extract of the Lycii Fructus was partitioned suceesively with hexane, dichloromethane, ethylacetate and butanol. The butanol fraction, which is most abundant in the Lycii Fructus was subjected to silica gel column chromatography and resulted in seven fractions namely Fr. I - Fr. VII. Among tested several subfractions, Fr IV. Showed the highest antidiabetic activity in the streptozotocin-induced model rat.

• 한방안이비인후피부과학회지
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• 제31권2호
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• pp.1-10
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• 2018

Objectives : To present rough guide for the proper use of Lycii Fructus and Chrysanthemum indicum on ophthalmic patients. Methods : Traditional medical classics(本草綱目, 銀海精微, 秘傳眼科龍木論, 東醫寶鑑) and recent studies for Lycii Fructus and Chrysanthemum indicum were reviewed. Results : The results are as follows. 1. According to traditional medical classics, the efficacy of Lycii Fructus and Chrysanthemum indicum is removing nebula(退?) and improving acuity of vision(明目). 2. According to contemporary studies, Lycii Fructus has strong antioxidant, neuroprotective and anti-inflammatory effect. Chrysanthemum indicum has strong anti-inflammatory effect. Results and Conclusions : The Lycii Fructus is proper to macula or neuro-ophthalmology disease. Chrysanthemum indicum is proper to cornea or conjunctiva disease. Absolutely, It may be changed according to the individual condition. However, this may be a rough guide for usage in Korean medicine ophthalmology.

• 대한한의학회지
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• 제29권1호
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• pp.47-59
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• 2008

Objective : Anti-inflammatory effects of the extract of Lycii Fructus on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells were investigated. Method : In order to assess the cytotoxic effect of Lycii Fructus on the raw 264.7 macrophages 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was performed. Reverse transcription-polymerase chain reaction(RT-PCR) analysis of the mRNA levels of tumor necrosis factor-$\alpha$(TNF-$\alpha$) and inducible nitric oxide synthase(iNOS) was performed in order to provide an estimate of the relative level of expression of these genes. The protein level of the inhibitor of nuclear factor-${\kappa}B(I{\kappa}B)$ and nuclear factor-${\kappa}B$(NF-${\kappa}B$) activity was investigated by Western blot assay. NO production was investigated by NO detection. Result : Lycii Fructus suppressed NO production by inhibiting the LPS-induced expressions of iNOS and TNF-$^-\alpha$ mRNA and iNOS protein in RAW 264.7 macrophage cells. Also, Lycii Fructus suppressed activation of NF-${\kappa}B$ in the nucleus. Conclusion : These results show that the extract of Lycii Fructus has anti-inflammatory effect probably by suppressing iNOS expressions through the down-regulation of NF-${\kappa}B$ binding activity.

• Journal of Biosystems Engineering
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• 제35권4호
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• pp.250-256
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• 2010

This study is conducted to analyze the drying characteristics of domestically produced Lycii Fructus for improving drying conditions which was dependant on the shape and materials of drying plate. The materials of the drying plates were steel, aluminum and ABS resin, and each plate was shaped semicircle, quadrangular pyramid, and triangle pyramid. Also, mesh plate, the most general type was included. In other words, 10 kinds of plates were made and tested. The test was conducted at $45^{\circ}C$, for 24 hours and moisture content was measured every 4 hours. The quality of tested Lycii Fructus was measured by colorimeter after drying. The experimental results show that regardless of species of Lycii Fructus, the drying rate of the aluminium plate shaped quadrangular pyramid was fastest, 3.11%w.b./h. Except the mesh plate, the drying rate of most plates was about over 2.52%w.b./h. The quality of Lycii Fructus dried on the aluminium plate shaped quadrangular pyramid was the highest, and it was easiest to separate the dried Lycii Fructus from the aluminum plate shaped quadrangular pyramid.

• 생약학회지
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• 제40권2호
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• pp.128-136
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• 2009

This study was carried out to investigate the antidiabetic and antioxidative effect of Lycii fructus in the Streptozotocin(STZ)-induced diabetic rats. The effective fractions were prepared as a form of organic solvents of $CH_{3}(CH_{2})_{4}CH_{3}$ $CHCI_{3}$, EtOAc, BuOH and $H_{2}O$ fractions prepared from the EtOH extract of Lycii fructus and The diabetes were induced by an tail-intravenous injection of STZ with a dose of 45 mg/kg dissolved in citrate buffer. The various fractions of Lycii fructus were orally administrated once a day for 7 days. The contents of serum glucose, and triglyceride in the $CHCI_{3}$ fraction and hepatic lipid peroxidation in the EtOAc, BuOH and $H_{2}O$ fractions treated rats were significantly decreased when compared to those of the STZ-control group In addition, an activity of hepatic GST in the BuOH fraction treated rats was significantly increased compared to that of the STZ-control group. whereas, activities of hepatic catalase, GSH-Px in the BuOH fraction treated rats were significantly decreased compared to those of the STZ-control group. Meanwhile, The content of hepatic glycogen and avtivity of hepatic glucokinase in $CHCI_{3}$ fraction treated rats were significantly increased, but activity of glucose-6-pase was significantly decreased in the $CHCI_{3}$ fraction treated rats. In conclusion, these results indicated that the BuOH fraction of Lycii fructus was effective for the antioxidation, and also the $CHCI_{3}$ fraction of Lycii fructus was effective for the antidiabetes in the STZ-induced diabetic rats.

• 한국식품영양과학회지
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• 제26권4호
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• pp.625-631
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• 1997

구기자 추출물이 S. cerevisiae D7l과 L. casei KC-TC3165, 그리고 E. coli DH5균의 생육에 미치는 영향을 검토하였다. 그 결과 구기자 추출물은 S. cerevisiae D7l과 L. casei KCTC 3165의 생육을 증가시켰으며 E. coli DH5에 대하여는 약간의 생육저해가 있었다. 구기자methanol 추출물을 첨가하여 미생물의 생육을 측정하였을 때 L. casei KCTC 3165와 S. cerevisiae D7l는 각각 1.0%와 1.5% 첨가구에서 가장 높은 생육 촉진 효과를 보였다. 즉 구기자 추출물은 대장균의 생육은 저해하였으나, 인체에 유익한 균으로 알려진 젖산균에 대하여는 생육을 촉진하는 특성이 있었다. 한편, E. coli DH5는 구기자즙 10%, 그리고 methanol, chloroform 추출물 각각 1.0%첨가시 형태적 이상을 일으켜 길이가 8배 이상이 길어졌다. 구기자의 methanol추출물 중 회분성분이 E. coli DH5균에 이상현상의 원인이 되었음을 확인 하였다. 또한 이들 중 $Na^{+}$, $K^{+}$ 및 $Na^{+}$와 $K^{+}$ 혼합물이 0.135% 이상에서 균의 형태가 길어지는 이상 현상이 있었다.