• 천문학회보
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• 제30권2호
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• pp.52.1-52.1
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• 2005

• Archives of Plastic Surgery
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• 제43권5호
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• pp.481-482
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• 2016

• 보험의학회지
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• 제31권1호
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• pp.19-28
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• 2012

Nowadays, Rheumatic diseases are increasing more and more. So, it's important knowing the pathophysiology and extra-risk of each rheumatic disease so as to do sound underwriting. Here is brief review and long-term prognosis of some rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sj$\ddot{o}$gren syndrome, antiphospholipid syndrome, systemic sclerosis, ankylosing spondylitis, Takayasu's arteritis, and Behcet syndrome.

• Childhood Kidney Diseases
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• 제26권1호
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• pp.18-24
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• 2022

Pediatric rheumatologic diseases are rare systemic diseases that can involve various organs, including the kidneys. Each rheumatologic disease can exhibit characteristic renal involvement, which requires proper treatment and diagnosis. In this review, we discuss renal involvement in classic rheumatologic diseases, including juvenile idiopathic arthritis, Sjogren's syndrome, systemic sclerosis, and juvenile dermatomyositis. Reviews addressing lupus nephritis and antineutrophil cytoplasmic antibody-associated renal disease are complex and tend to cover a wide array of topics, and thus were excluded from this review.

• 대한한의학회지
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• 제29권1호
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• pp.67-84
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• 2008

Objective : The main purpose of this study was to evaluate the effect of Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) on MRL/MpJ-Ipr/Ipr mouse model with systemic lupus erythematosus. Methods: The effect of JWT on MRL/MpJ-Ipr/Ipr mice that have autoimmune disease similar to SLE in humans was evaluated after JWT per oral in the present study. Mice were administered with Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) (80 or 400mg/kg) or distilled water for control group from experimental week 10 for 22 weeks. Results : The amount of erythematosus skin lesion and proteinuria were significantly decreased. The size and weight of cervical lymph nodes and spleen were significantly reduced. The ratio between activated $CD3^+CD69^+$ T-cells and undifferentiated $CD3^+CD4^-CD8^-$ T-cells in lymph nodes, spleen and kidney was effectively reduced. The gene expression of TGF-$\beta$ in spleen and kidney was increased. The amount of anti-dsDNA IgG in blood was decreased. The gene expression of TGF-$\beta$ in normal mouse spleen cells was increased depending on concentration by treatment of with T cell stimulating agent. In the histological examination of skin and kidney, the amount of infiltration of immune cells involved in the inflammatory response was decreased. Conclusions : According to the above results, JWT should be considered as an applicable therapeutic agent to SLE in clinical practice. Further research is required to investigate other efficacies of JWT on SLE.

• 천문학회보
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• 제35권2호
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• pp.67.2-67.2
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• 2010

We present results of searching for the Very Low Luminosity Objects (VeLLOs; internal luminosity : $L_{int}$ < $0.1(d/140pc)^2\;L\odot$) in the Gould's Belt clouds using observations from 3.6 to 70 micron by the Spitzer Space Telescope. The clouds are California, Chamaeleon I, III, Musca, Lupus V, VI, Scorpius, Serpens, Corona Australis, Cepheus, and IC 5146 having the properties of active low-mass star-forming such as the Taurus cloud. The observing sensitivity of the Spitzer data is estimated to be about $L_{int}\;\geq\;5\times10^{-3}(d/140pc)^2\;L\odot$, a factor of 20 better than that of the Infrared Astronomical Satellite (IRAS). The observing data were processed by the c2d Legacy pipeline. As the criteria to select the VeLLOs, we slightly modified previous ones by Dunham et al. The most important criterion is a flux density at 70 micron that is directly converted to the internal luminosity. Also, we used additional criteria to remove the contamination of evolved stars and extragalaxies which have colors or SEDs very similar to YSOs. We identified a total of 64 new embedded VeLLO candidates with $L_{int}$ < $0.1(d/140pc)^2\;L\odot$, consisting of 8 in California, 15 in Chamaeleon-Musca, 13 in Scorpius-Lupus, 20 in Serpens, 3 in Corona Australis, 3 in Cepheus, and 2 in IC 5146. The classification of the spectral index (${\alpha}$) fitted to the shape of the Ks-24 micron SEDs shows most of VeLLO candidates (89%) are in types of Class I and Flat spectrum. We plot various diagrams based on their 2MASS-Spitzer bands colors and magnitudes to discuss properties of the VeLLOs. This search will lead us new adventure toward a future systematic study of the VeLLOs.

• Toxicological Research
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• 제33권3호
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• pp.205-209
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• 2017

Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM39A seems to be involved in systemic lupus erythematosus and multiple sclerosis in numerous of populations. All of these works stop at insufficient information by using gene functioning methods such as: Genome-wide association studies (GWASs) and/or follow-up study. It is the fact that the less understood of TMEM39A actually is the attraction to the scientist in near future. In this review the current knowledge about TMEM39A and its possible roles in cell biology, physiology and pathology will be described.

• 한국보건간호학회지
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• 제16권1호
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• pp.105-114
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• 2002

This study was to investigate the level of fatigue and its associated variables in patients with systemic lupus erythematosus(SLE) in Korea. From March to June, 2001, 100 patients, registered at one university hospital rheumatology clinic in Seoul, were accepted as subjects for this study. The sampling method was adopted a non-probability, purposive technique. The instruments used for this study were The Multidimensional Assessment Fatigue scale developed by Tack and Beck Depression Instrument develped by Beck. The collected data were analyzed by SAS program using t-test, ANOVA with Scheffe-test, Pearson correlation coefficients and stepwise multiple regression. The results were as follows: 1. Total scores of fatigue of the subjects averaged $24.46(\pm10.85)$, degree of fatigue was $5.08(\pm2.29)$, and influence of fatigue was $3.52(\pm2.12)$. 2. Regarding characteristics, more depressive(p=.0001) and more painfuI(p=.0122) patients revealed more fatigue. Also, the subjects with spouse(p=.0337) and having poor quality of sleep(p=.0445) revealed more fatigue. 3. The subjects' total fatigue score, depression, pain and age was correlated positively(r=.53; r=.48; r=.24), and total fatigue score, and exercise time, quality of sleep was correlated negatively(r=-.45; r=-.21). 4. The main influencing factors on the fatigue were depression$(52.92\%)$ and quality of sleep $(8.10\%)$. These two main variables made it possible to explain $61.02\%$ of the varience in fatigue. In conclusion, this study revealed depression and quality of sleep is an important factor that can improve quality of life in patients with SLE. It is recommended that nursing intervention for SLE patients would be focused to decrease depression and to enhance quality of sleep.

• 한국임상수의학회지
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• 제36권4호
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• pp.190-195
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• 2019

We aimed to identify genomic variations as well as the marker genes related with chronic mitral valve disease (CMVD) in Canis lupus familiaris using whole genome resequencing, which provides valuable resources for further study. Two ten-year old female Canis lupus familiaris English cocker spaniels were used for this study, one control and one who had been diagnosed as CMVD. For the whole genome resequencing, muscles from the left ventricular wall were collected from each dog. With the HiSeq DNA Shotgun library and $HiSeq^{TM}$ 2000 platform, whole genome resequencing was performed. From the results, we identified 5 million and 6 million variants in gene expression in the control and CMVD-diagnosed subject, respectively. We then selected the top 1,000 genes from the SNP, INS, and DEL mutation and 675 genes among them were overlapped for every mutation between the control and CMVD-diagnosed patient. Interestingly, in both groups, the intron variant (91.16 and 91.18%) and upstream variant (3.10 and 3.08%) are most highly related. Among the overlapped 675 genes, gene ontology for intracellular signal transduction is highly counted in INS, and DEL, and SNPs (35, 33, 31, respectively). In this study, we found that the COL and CDH gene families could be key molecules in identifying the difference in gene expression between control and CMVD-diagnosed dogs. We believe further studies will prove the importance of variants in key molecule expression and that these data will serve as a valuable foundation stone the study of canine CMVD.

• 천문학논총
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• 제32권1호
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• pp.117-121
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• 2017

We show Akari data, Herschel data and data from the SCUBA2 camera on JCMT, of molecular clouds. We focus on pre-stellar cores within the clouds. We present Akari data of the L1147-1157 ring in Cepheus and show how the data indicate that the cores are being externally heated. We present SCUBA2 and Herschel data of the Ophiuchus region and show how the environment is also affecting core evolution in this region. We discuss the effects of the magnetic field in the Lupus I region, and how this lends support to a model for the formation and evolution of cores in filamentary molecular clouds.