• Journal of Chest Surgery
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• 제30권11호
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• pp.1145-1148
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• 1997

폐탈출증은 근골격으로 구성된 흉곽 밖으로 폐실질이 빠져나와 돌출되는 것으로, 최근까지 문헌으로 보고된 예는 300 례 미만이다. 환자는 늑골 골절을 포함한 외상을 입었던 과거력을 가진 37세와 57세 남자 이며 주소는 전흉부에 무통성의 부드러운 종괴로 호기시나 기침시 그 크기가 증가하였고, 흡기시 혹은 조용한 호흡시에는 감소하였다. 수술은 흉벽 결손에 대한 일차 봉합술을 시행하였으며, 술후 재발은 아직 까지 관찰되지 않았다 저자들은 지금까지 국내 발생보고 예가 없는 후천성 폐탈출증 2례를 수술 치험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제44권6호
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• pp.455-457
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• 2011

A 70-year-old male visited urgent care due to coughing for 1 month and left chest pain. He had no history of trauma. The initial chest computed tomography (CT) showed the 7th left intercostal lung herniation. A follow-up CT showed an intercostal lung herniation combined with a bowl herniation, which had developed due to a Morgagni's hernia. An emergency operation was performed due to the incarceration of the bowl and lung. The primary repair of the diaphragm was performed and the direct approximation of the 7th intercostal space was determined. We concluded that the defect of the diaphragm and the intercostal muscle was a congenital lesion, and the recurrent coughing was the aggravating factor of herniation.

• Journal of Chest Surgery
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• 제50권6호
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• pp.415-423
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• 2017

Background: Recently, many surgeons have chosen sublobar resection for the curative treatment of lung tumors with ground-glass opacity, which is a hallmark of lepidic lung cancer. The purpose of this study was to evaluate the oncological results of sublobar resection for non-lepidic lung cancer in comparison with lobectomy. Methods: We conducted a retrospective chart review of 328 patients with clinical N0 non-small cell lung cancer sized ${\leq}2cm$ who underwent curative surgical resection from January 2009 to December 2014. The patients were classified on the basis of their lesions into non-lepidic and lepidic groups. The survival rates following lobectomy and sublobar resection were compared within each of these 2 groups. Results: The non-lepidic group contained a total of 191 patients. The 5-year recurrence-free survival rate was not significantly different between patients who received sublobar resection or lobectomy in the non-lepidic group (80.1% vs. 79.2%, p=0.822) or in the lepidic group (100% vs. 97.4%, p=0.283). Multivariate analysis indicated that only lymphatic invasion was a significant risk factor for recurrence in the non-lepidic group. Sublobar resection was not a risk factor for recurrence in the non-lepidic group. Conclusion: The oncological outcomes of sublobar resection and lobectomy in small-sized non-small cell lung cancer did not significantly differ according to histological type.

• Journal of Chest Surgery
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• 제43권6호
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• pp.734-738
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• 2010

약 10년전 아이젠멩거 증후군으로 양측 폐이식을 시행받은 43세 여자 환자가 서서히 진행되는 호흡 곤란을 주소로 내원하였다. 환자는 폐이식 후 발생하는 만성거부반응인 폐쇄세기관지염 증후군으로 진단받고 경과 관찰 하였으나 내과적 치료에도 반응이 없이 계속 악화되어 인공 호홉기에 의존하는 상태에서 재폐이식 수술을 시행 받았다. 저자들은 폐이식 후 만성거부반응을 보이는 환자에서 국내 최초로 재폐이식을 시행하였기에 보고하는 바이다.

• Journal of Chest Surgery
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• 제39권6호
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• pp.490-494
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• 2006

말기 폐질환 환자에서 폐이식은 가장 효과적인 치료이나 원발성 이식부전은 아직도 이식 후 합병증과 사망률 증가의 주 요인이 된다. 폐기종으로 진단된 52세 남자 환자가 지속적 호흡기 치료 및 기관절개 상태에서 좌측 폐이식 수술을 시행 받았다. 본 환자는 이식술 후 발생한 원발성 이식부전으로 호흡기 발관이 불가하여 재이식이 결정되었다. 환자는 인공심폐기 하에 순차적으로 양측 폐이식 수술을 시행 받았으며 현재 퇴원하여 건강하게 일상생활을 하고 있다. 폐이식 수술 후에 발생하는 이식부전이 있으면 가급적 빠른 시일 내에 재이식 수술을 시행하는 것이 예후에 중요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4765-4768
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• 2013

Aims: This study was conducted to evaluate the levels of TNF-${\alpha}$, IL-6, IL-8 and VEGF in serum of patients with non- small cell lung cancer, for assessing their possible diagnostic and prognostic roles. Methods: We enrolled 48 patients newly diagnosed with non-small cell lung cancer and 40 healthy controls. TNF- ${\alpha}$, IL-6 and IL-8 levels were measured in the serum of all the subjects with specific radioimmunoassay kits, while EGF was analyzed by sandwich enzyme immunoassay techniques. Results: A statistically significant difference was observed between lung cancer patients and the control group regarding the values of TNF-${\alpha}$, IL-6, IL-8 and VEGF in serum. Moreover, TNF-${\alpha}$, IL-8 and VEGF levels were higher in patients with advanced stages compared to early stages. In addition, higher serum levels of TNF-${\alpha}$, IL-6, IL-8 and VEGF were found in smokers than in non-smokers, both in patients and controls. Conclusion: Serum levels of TNF-${\alpha}$, IL-6, IL-8 and VEGF were all elevated in lung cancer patients, suggesting that inflammatory cytokines could be jointly used as a screening tool. Though TNF-${\alpha}$, IL-8 and VEGF levels were related to advanced disease, long-term survival studies of NSCLC patients should be performed to confirm whether they can act as biomarkers of advanced disease. In addition, smoking would be an important contributor to the processes of inflammation and lung cancer.

• Journal of Chest Surgery
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• 제47권2호
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• pp.185-188
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• 2014

Lobectomy with mediastinal node dissection has been standard treatment for non-small cell lung cancer (NSCLC). Nowadays, video-assisted thoracoscopic surgery (VATS) is gaining acceptance as an alternative treatment option, given the quality-of-life benefits that it confers. For the VATS procedure, most surgeons create two or three ports with a utility incision of 3 to 5 cm. However, with acquired skill and instrumentation advances, single-incision thoracoscopic surgery has emerged over time. Here, we report the case of an 86-year-old female with NSCLC treated by single-incision segmentectomy.

• Journal of Chest Surgery
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• 제50권4호
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• pp.300-304
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• 2017

A 42-year-old man was diagnosed with cancer of the right lower lung lobe with a posteparterial type of tracheal bronchus, in which the posterior segmental bronchus of the right upper lobe arose from the distal bronchus intermedius. A mass involved the distal bronchus intermedius, requiring a right lower bilobectomy with an additional posterior segmental resection of the right upper lung lobe. Thus, we performed a right lower bilobectomy and sleeve anastomosis of the posterior segmental bronchus of the right upper lobe to the proximal bronchus intermedius, sparing the pulmonary parenchyma of the same lobe.

• Journal of Chest Surgery
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• 제41권6호
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• pp.791-794
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• 2008

Bleomycin에 의한 폐독성은 잘 알려져 있으나, Bleomycin 유도 폐독성 후에 기흉 없이 발생한 자연성 종격동 기종은 드문 것으로 알려져 있다. 따라서, Bleomycin 항암 치료를 받은 환자에서 호흡 곤란의 악화 원인으로 자연성 종격동 기종도 고려해야 할 필요가 있다. 저자들은 생식 세포종으로 Bleomycin 항암치료를 받은 후 심한 호흡곤란을 호소하는 두 명의 환자에서 기흉이 없는 자연성 종격동 기종을 진단하고 치료 하였기에 보고하는 바이다.

• Journal of Chest Surgery
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• 제45권2호
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• pp.101-109
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• 2012

Background: A better understanding of the histopathology and molecular biology of lung cancer might improve our capability to predict the outcome for any individual patient. The purpose of this study was to evaluate several histopathologic and molecular markers in order to assess their prognostic value in stage I non-small cell lung cancer. Materials and Methods: One hundred ten patients at the Kyungpook National University Hospital were enrolled in the study. Histopathologic factors and molecular markers were selected. Results: Univariate analysis showed that the T stage, differentiation, visceral pleural invasion, and survivin expression were significantly associated with recurrence. Multivariate analysis demonstrated that differentiation and survivin overexpression emerged as independent prognostic factors of recurrence. Conclusion: In resected stage I non-small cell lung cancer, poor differentiation and survivin overexpression have been identified as independent predictors of poor disease-free survival.