• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4607-4611
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• 2012

Objective: Endometrial cancer (EC) is the most common gynecologic malignancy. Identification of potential biomarkers of EC would be helpful for the detection and monitoring of malignancy, improving clinical outcomes. Methods: The Weighted Gene Co-expression Network Analysis method was used to identify prognostic markers for EC in this study. Moreover, underlying molecular mechanisms were characterized by KEGG pathway enrichment and transcriptional regulation analyses. Results: Seven gene co-expression modules were obtained, but only the turquoise module was positively related with EC stage. Among the genes in the turquoise module, COL5A2 (collagen, type V, alpha 2) could be regulated by PBX (pre-B-cell leukemia homeobox 1)1/2 and HOXB1(homeobox B1) transcription factors to be involved in the focal adhesion pathway; CENP-E (centromere protein E, 312kDa) by E2F4 (E2F transcription factor 4, p107/p130-binding); MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived [avian]) by PAX5 (paired box 5); and BCL-2 (B-cell CLL/lymphoma 2) and IGFBP-6 (insulin-like growth factor binding protein 6) by GLI1. They were predicted to be associated with EC progression via Hedgehog signaling and other cancer related-pathways. Conclusions: These data on transcriptional regulation may provide a better understanding of molecular mechanisms and clues to potential therapeutic targets in the treatment of EC.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6533-6535
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• 2013

Background: The purpose of this study was to evaluate a new type of tumor biomarker, eukaryotic elongation factor 2 (eEF2), in serum for the early diagnosis, confirmative diagnosis as well as assessment of treatment of non-small cell lung cancer (NSCLC). Methods: 130 patients with NSCLC and 50 healthy individuals undergoing physical examination in our hospital provided the observation and healthy control groups. An enzyme linked immune sorbent assay (ELISA) method was applied to determine serum eEF2 levels. Serum neuron specific enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group were assessed with an automatic biochemical analyzer. Results: The median levels of eEF2 in the serum of NSCLC patients was found to be significantly higher than the healthy control group (p < 0.01) and it was markedly higher in stages III, IV than stages I, II (p < 0.05). eEF2 was higher with tumor size ${\geq}2$ cm than <2 cm (P< 0.01). Furthermore, two weeks after surgery patients showed a significant trend for eEF2 decrease (p < 0.05). Conclusions: The eukaryotic elongation factor 2 (eEF2) has certain clinical values for early diagnosis, verification, and prognosis as well as classification of lung cancer patients.

• Journal of computational fluids engineering
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• v.4 no.1
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• pp.53-61
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• 1999

Two-dimensional, unsteady, incompressible and compressible Navier-Stokes codes are developed for the computation of the viscous turbulent flow over high-lift airfoils. The compressible code involves a conventional upwind-differenced scheme for the convective terms and LU-SGS scheme for temporal integration. The incompressible code with pseudo-compressibility method also adopts the same schemes as the compressible code. Three two-equation turbulence models are evaluated by computing the flow over single and multi-element airfoils. The compressible and incompressible codes are validated by predicting the flow around the RAE 2822 transonic airfoil and the NACA 4412 airfoil, respectively. In addition, both the incompressible and compressible code are used to compute the flow over the NLR 7301 airfoil with flap to study the compressible effect near the high-loaded leading edge. The grid systems are efficiently generated using Chimera overlapping grid scheme. Overall, the κ-ω SST model shows closer agreement with experiment results, especially in the prediction of adverse pressure gradient region on the suction surfaces of high-lift airfoils.

• Journal of Power Electronics
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• v.18 no.5
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• pp.1479-1488
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• 2018

Power packet (PP) distribution system distributes power to different loads that share the same distribution cable in a packetized form. When compared with conventional power systems, a PP distribution system (PPDS) can reduce standby power, eliminate Point-of-Load (PoL) power conversion, and intelligently control the load demand from the source side. Due to the absence of PoL conversion, when multiple power sources at different voltage levels and conditioning requirements jointly send power to various loads at different voltage ratings, the generated voltage has an irregular shape. A large filter at each of the load sides is required to reduce such a large voltage ripple. In this paper, a single-inductor, multiple-input-single-output converter structure based multiple-energy-source mixer is proposed. It combines PP generation, maximum power point tracking (MPPT) of renewable energy sources (RESs) and filtering at the source side. To demonstrate the possible renewable energy integration, a PV panel is used as a power source together with other constant voltage sources. The PV power is approximately tracked using the constant voltage method and it is used for each of the PP generations. The proposed PP distribution system is experimentally verified and it is shown that a conventional PI controller is sufficient for stable system operation.

• Bulletin of the Korean Chemical Society
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• v.27 no.11
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• pp.1854-1860
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• 2006

Electrochemical behaviors of acetaminophen at a muti-wall carbon nano-tube composite film modified glassy carbon electrode were investigated by cyclic voltammetry, linear sweep voltammetry and chronocoulometry. Compared with that obtained at the unmodified electrode, the peak currents were enhanced significantly, and the oxidation peak shifted towards more negative potential with the reduction peak shifted positively. The peak-to-peak separation turned narrow, and suggested that the reversibility was improved greatly. Experimental parameters, such as scan rate, pH and accumulation conditions were optimized. It was found that a maximum current response can be obtained at pH = 5.0 after accumulation at -0.50 V for 80 s. The oxidation peak current was found to be linearly related to acetaminophen concentration over the range of $5.0{\times}10^{-7}\;\sim\;1.0{\times}10^{-4}$ mol $L^{-1}$ with a detection limit of $5.0{\times}10^{-8} $mol $L^{-1}$. A convenient and sensitive electrochemical method was developed for the determination of acetaminophen in a commercial paracetamol oral solution. Its practical application demonstrated that it has good selectivity and high sensitivity.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.1
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• pp.9-16
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• 2016

Carbon-11 is one of the most sensitive and desirable positron emission tomography radio-isotope, which offers the capacity to be incorporated, through a covalent bond, into biologically active molecules without altering their biological properties. Carbon-11 can be obtained from the cyclotron with two different chemical forms: $[^{11}C]CO_2$ and $[^{11}C]CH_4$. [$^{11}C$]Methyl iodide has been widely used as a highly reactive labelling precursor that can be applied to label carbon-11 with biologically active molecules via alkylation of N-, O-, or S-nucleophiles. A more recent and still challenging labeling method is transition metal mediated $^{11}C$-carbonylation. Advances in organic chemistry, radiochemistry and improved automated techniques greatly encourage researchers to develop more carbon-11 labelled radiotracers for molecular imaging studies. This mini-review will introduce a historical track of carbon-11 chemistry combining with examples and its role in near future.

• Nano
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• v.13 no.10
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• pp.1850121.1-1850121.11
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• 2018

In this study, a series of $LaMnO_3$-diamond composites with varied $LaMnO_3$ mass contents supported on micro-diamond have been synthesized using a sol-gel method. The as-prepared composites were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and the Fourier transform infrared spectra (FTIR). Meanwhile, the photocatalytic performances were also tested by photoluminescence (PL) spectroscopy, ultraviolet-visible diffuse reflection spectra (UV-Vis DRS) and the degradation of weak acid red C-3GN (RC-3GN). Results show that the peak position of $LaMnO_3$ is shifted to low angle after the introduction of diamond, and perovskite particles uniformly distributed on the surface of diamond, forming a network structure, which can increase the active sites and the absorption of dye molecules. When the mass ratio of $LaMnO_3$ and diamond is 1:2 (LMO-Dia-2), the composite shows the most excellent photocatalytic activity. This result offers a sample route to enlarge the range of the application of micro-diamond and provide a new carrier for perovskite photocatalysts.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3213-3228
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• 2023

As an important part of the digital reactor, the pin-by-pin wise fine coupling calculation is a research hotspot in the field of nuclear engineering in recent years. It provides more precise and realistic simulation results for reactor design, operation and safety evaluation. CORCA-K a nodal code is redeveloped as a robust pin-by-pin wise neutronics and thermal-hydraulic coupled calculation code for pressurized water reactor (PWR) core. The nodal green's function method (NGFM) is used to solve the three-dimensional space-time neutron dynamics equation, and the single-phase single channel model and one-dimensional heat conduction model are used to solve the fluid field and fuel temperature field. The mesh scale of reactor core simulation is raised from the nodal-wise to the pin-wise. It is verified by two benchmarks: NEACRP 3D PWR and PWR MOX/UO₂. The results show that: 1) the pin-by-pin wise coupling calculation system has good accuracy and can accurately simulate the key parameters in steady-state and transient coupling conditions, which is in good agreement with the reference results; 2) Compared with the nodal-wise coupling calculation, the pin-by-pin wise coupling calculation improves the fuel peak temperature, the range of power distribution is expanded, and the lower limit is reduced more.

• Nuclear Engineering and Technology
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• v.56 no.10
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• pp.4437-4445
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• 2024

During the process of bilateral teleoperation, operators not only need to perform complex maintenance tasks but also have to constantly monitor the safety of the operation, leading to reduced operational efficiency. Therefore, in this paper, we introduce a shared autonomous scheme that intervenes in the operator's command input when necessary, autonomously ensuring the safe operation of the manipulator by employing a rolling horizon planning controller based on Nonlinear Model Predictive Control (NMPC). This controller considers the motion boundaries and collision avoidance constraints of the manipulator, accompanied by the design of corresponding objective functions. To validate the effectiveness of the proposed method, we conduct tests on collision-free trajectory tracking and comprehensive performance with collision constraints, confirming the feasibility and excellent performance of the approach.

• Natural Product Sciences
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• v.24 no.3
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• pp.159-163
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• 2018

Two new polyketides, chinoketides A and B (1 - 2) with a known compound xylarphthalide A (3), were isolated from the solid medium of the endophytes from the leaves of the relic plant Distylium chinense with the "black-box" co-culture method, and the structures of two new compounds were elucidated by NMR, MS and CD spectra. And the absolute configurations of chinoketides A (1) and B (2) were determined as 2R,3R,8S and 5R,6S by calculating their ECD spectra to compare with the experimental CD spectra. Finally, the antimicrobial activities were evaluated to Erwinia carotovora sub sp. Carotovora (Jones) Bersey et al, and the results showed that compounds 1 - 3 displayed the antimicrobial activities with MIC value at 20.5, 30.4 and $10.2{\mu}g/mL$.