• 척추신경추나의학회지
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• 제7권2호
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• pp.63-74
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• 2012

Objectives : The purpose of this study was to evaluate the effect of Oriental medical treatment in patients with Spondylolisthesis and lumbar Herniated Intervertebral Disc(HIVD). Methods : This clinical study was carried out on 39 patients with Spondylolisthesis and lumbar Herniated Intervertebral Disc(HIVD), who had been admitted from Jan. 2012 to Nov. 2012. All of 39 patients were treated with acupuncture, Chuna treatment and herbal medicine during the whole admission period. Verbal numerical rating scale(VNRS) and Oswestry disability index(ODI) were used to evaluated the effectiveness of the Oriental medical treatment. Results : 1. Significant improvement of the symptoms of low back pain and leg pain on 39 patients with Spondylolisthesis and lumbar Herniated Intervertebral Disc(HIVD) was seen when evaluated with VNRS and ODI. 2. There was no significant difference of improvement by herniated type when evaluated with VNRS and ODI.. 3. There was no significant difference of improvement by spondylolisthesis type(degenerative and spondylolytic) when evaluated with VNRS and ODI. Conclusions : These results suggest that in the case of low back pain and lower limb numbness caused by Spondylolisthesis and HIVD, conservative treatments can be considered as one of the options of treating the symptoms beside surgical way.

• Biomolecules & Therapeutics
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• 제26권3호
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• pp.298-305
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• 2018

Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha ($TNF-{\alpha}$) converting enzyme, which is the molecule responsible for the release of $TNF-{\alpha}$. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of $TNF-{\alpha}$ release induced by Rhbdf2 gene KO, collagen-induced arthritis (CIA), which is the representative $TNF-{\alpha}$ related disease, was induced in the Rhbdf2 mutant mouse using chicken collagen type II. The severity of the CIA was measured by traditional clinical scores and histopathological analysis of hind limb joints. A rota-rod test and grip strength test were employed to evaluate the severity of CIA based on losses of physical functions. The results indicated that Rhbdf2 mutant mice showed clear alleviation of the clinical severity of CIA as demonstrated by the significantly lower severity indexes. Moreover, a grip strength test was shown to be useful for the evaluation of physical functional losses by CIA. Overall, the results showed that the Rhbdf2 gene has a significant effect on the induction of CIA, which is related to $TNF-{\alpha}$.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1311-1315
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• 2012

Objectives: Thrombotic risk is increased in patients with cancer and there are important implications for those who suffer a venous thromboembolism (VTE). We undertook this study to determine the frequency, clinical patterns, and outcome of VTE in Saudi patients with cancer. Methods: Cancer (solid tumors and lymphoma) patients who developed VTE from January 2004 to January 2009 were studied retrospectively. Demographics and clinical characteristics related to thrombosis and cancer were evaluated. Results: A total of 701 patients with cancer were seen during the study period. VTE was diagnosed in 47 (6.7%) patients (median age 52, range 18-80 years). Lower limb DVT was the most common type, seen in 47% patients, followed by PE in 19%, and 19% patients had both DVT & PE. Thrombosis was symptomatic in 72% patients while it was an incidental finding on routine workup in 28%. Cancer and VTE were diagnosed at the same time in 38% of patients, and 47% patients developed VTE during the course of disease after the cancer diagnosis. The majority of VTE post cancer diagnoses occurred during the first year (median 4 months, range 1-14). Additional risk factors for VTE were present in 22 (47%) patients and 14 (30%) of these patients were receiving chemotherapy at the time of thrombosis. Only 5 (10.6%) patients were receiving thrombo-prophylaxis at the time of VTE diagnosis. Most common types of tumors associated with thrombosis were breast cancer, non-Hodgkin's lymphoma and lung cancer. The majority of the affected patients (79%) had advanced stage of cancer. After a median follow-up of 13 (range 0.5-60) months, 38 (81%) patients had died. There was no difference in the mortality of patients with symptomatic or asymptomatic thrombosis (82% vs 78.6%). Conclusions: Thrombotic complications can develop in a significant number of patients with cancer, and almost half of the patients have additional risk factors for VTE. Thrombosis is usually associated with advanced disease and can be asymptomatic in more than a quarter of cases. Thromboprophylaxis in cancer patients is under-utilized. Community based studies are needed to accurately define the extent of this problem and to develop effective prophylactic strategies.

• 전자공학회논문지
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• 제52권3호
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• pp.181-189
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• 2015

동력의족은 하지 절단 환자나 다리근력이 부족한 사람들의 보행 보조를 위해 사용된다. 동력의족의 자연스러운 구동을 위해 선 보행단계가 잘 분류되어야 한다. 물리센서를 이용하여 보행단계를 분류하는 기존 연구는 동력의족이 사전에 훈련된 보행속도로만 재현되는 단점이 있다. 따라서 본 논문에서는 물리센서를 사용하지 않고, 근전도 신호만을 이용하여 오르막, 내리막 계단보행을 각각 4단계로 분류하는 방법을 제안한다. 근전도 신호를 RMS, VAR, MAV, SSC, ZC, WAMP 특징으로 산출하여 LDA(Linear Discriminant Analysis) 분류기를 통해 보행단계를 인식한다. 훈련 단계에서는 AHRS센서를 이용하여 무릎각도 변화에 따른 보행단계 범위를 생성한다. 실험 결과, 선행 연구의 경우 오르막 보행에서 평균 58.5%, 내리막 보행에서 35.3%의 정확도를 보인다. 반면, 제안하는 방법은 오르막 보행에서 평균 85.6%, 내리막 보행에서 69.5%의 인식률을 보인다. 또한, 본 연구를 통해 개별 근육 별 보행단계 평균 인식률을 분석하였다.

• 대한기계학회논문집 C: 기술과 교육
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• 제1권2호
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• pp.153-165
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• 2013

기존의 보행분석 연구들은 하지를 하나의 스프링으로 간주하였다. 만약 슬관절 신전을 보조할 수 있는 슬관절 액추에이팅 메커니즘을 개발할 수 있다면 보행에 필요한 탄성-변형률에너지를 혁신적으로 저장-방출할 수 있고, 그 결과 보행 중 하지강성은 더욱 증가할 것이다. 게다가 족관절 액추에이팅 메커니즘까지 추가되어 있다면 슬관절 액추에이터에 의한 과도한 인공하지강성을 능동적이고 적절한 수준으로 보상해주는 기전으로 작동할 것이다. 만약 가속도에 의한 보행속도 증가를 방지하기 위해 인위적 감속통제를 작동시킨다면 불필요한 운동에너지의 방출이 발생되고 하지강성 액추에이터의 실효성은 의심을 받게 된다. 따라서 본 저자는 보행속도를 2개의 세그먼트에 의한 상대 각속도 조절기법을 이용하여 하지강성을 증가시킨다는 기본개념으로 슬-족관절 액추에이터 시스템을 개발하였다. 또한 족관절에 슬관절 액추에이팅에 대한 보상기전이 존재하는 경우, 족관절의 보상기전이 중족지절관절 경사각 및 보행속도 변화에 미치는 상호영향을 연구하였다.

• 국제물리치료학회지
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• 제5권2호
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• pp.743-751
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• 2014

This study aims to identify the effect of home physical therapy on patients who left the hospital after total knee arthroplasty, compared to the Daily living group, when it was applied to them, under the guidance of physical therapists. As research subjects, 20 patients that were scheduled to leave the hospital after unilateral total knee arthroplasty, were chosen, and they were randomly divided into a home physical therapy group(10 patients) and an Daily living group(10 patients) in order to conduct an experiment. During the 4-week research, home physical therapy was offered for 40 mins once for 5 days a week, and muscular strength, gait components were measured. For muscular strength, quadriceps muscle strength, hamstring muscle strength were measured, and as gait components, endurance, speed, step time, single-limb support were analysed. For this experiment, pre- and post-measurement were performed, and collected data were analyzed using SPSS ver. 18.0 statistical program. From the analysis of data, the following study results were obtained. Home physical therapy group and Daily living group both showed significant improvements in quadriceps muscle strength, hamstring muscle strength, and quadriceps muscle strength, hamstring muscle strength of home physical therapy group more significantly improved than Daily living group's. In relation to gait components, gait endurance, gait speed, step time significantly improved in both of home physical therapy group and Daily living group, whereas home physical therapy group only showed significant improvements in single-limp support. According to the comparison between two groups, gait speed, single-limp support and step time improved more significantly in the home physical therapy group than in the Daily living group. In conclusion, positive results were revealed in both home physical therapy group and Daily living group, with regard to muscular recovery of lower limbs of patients discharged from the hospital after total knee arthroplasty and walking, but considering the comparison results between two groups, it seems that applying home physical therapy is more effective than maintaining a daily life.

• 대한방사선기술학회지:방사선기술과학
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• 제42권6호
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• pp.423-428
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• 2019

The Precise measurement of the knee's Congruence angle is required for diagnosis of patella dislocation. The purpose of this study is to consider the distortion diagram and usefulness about the test of the bilateral side and one side through the evaluating congruence angle from Merchant view of patellofemoral joint to central X-ray. We've evaluated the sulcus angle and Congruence angle following central X-ray's changes when we took Merchant view of patellofemoral joint aimed to right lower limb from human whole body phantom. The subject of the evaluation was classified as normal group and varus group, and the varus group has experimented with External rotation of legs as 15° and 30°. When normal groups result as 0, 7.5, 15 cm, it was measured as 17.25 ± 1.34°, 19.60 ± 1.41°, 20.55 ± 1.77° each. The gap between minimal and maximum angle was 3.3°, and the value was shown as getting bigger when it further away from the centeral X-ray. When Congruence angle in 15° varus group was 0, 7.5, 15 cm, it was each 16.45 ± 1.34°, 17.10 ± 0.99°, 17.80 ± 1.13°. And when Congruence angle in 30° varus group was 0, 7.5, 15 cm, it was measured each 18.35 ± 1.63°, 18.95 ± 1.06°, 19.60 ± 1.41°. The difference between minimum and maximum of angle in 15° varus group and 30° varus group was each 1.35° and 1.25°, the angles have shown as increasing the further away from the center. The patellofemoral joint showed that the congruence angle increases as the further away from Central X-ray, and also it is judged that is possible to change the congruence angle by a degree of varus knee. Thus, accurate measurement of the congruence angle is shown to advantage that methods for examining by split each side at two times than methods for examining both sides at a time. Therefore, it is expected to helpful on the diagnostic side of patella dislocation and subluxation.

• Parasites, Hosts and Diseases
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• 제52권1호
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• pp.89-92
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• 2014

Myiasis is usually caused by flies of the Calliphoridae family, and Cochliomyia hominivorax is the etiological agent most frequently found in myiasis. The first case of myiasis in a diabetic foot of a 54-year-old male patient in Argentina is reported. The patient attended the hospital of the capital city of Tucum$\acute{a} $n Province for a consultation concerning an ulcer in his right foot, where the larval specimens were found. The identification of the immature larvae was based on their morphological characters, such as the cylindrical, segmented, white yellow-coloured body and tracheas with strong pigmentation. The larvae were removed, and the patient was treated with antibiotics. The larvae were reared until the adults were obtained. The adults were identified by the setose basal vein in the upper surface of the wing, denuded lower surface of the wing, short and reduced palps, and parafrontalia with black hairs outside the front row of setae. The main factor that favoured the development of myiasis is due to diabetes, which caused a loss of sensibility in the limb that resulted in late consultation. Moreover, the poor personal hygiene attracted the flies, and the foul-smelling discharge from the wound favoured the female's oviposition. There is a need to implement a program for prevention of myiasis, in which the population is made aware not only of the importance of good personal hygiene and home sanitation but also of the degree of implication of flies in the occurrence and development of this disease.

• 대한기계학회논문집A
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• 제38권5호
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• pp.497-503
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• 2014

골절 치료에서 최소 침습 수술 방법은 그 효용성이 입증 되었지만, 의료진이 골편을 직접 볼 수 없기 때문에 방사선 투시영상장치(C-armed fluoroscopy)에 의존하여 수술을 진행하게 된다. 최소침습 수술은 환자에게는 감염이 적고 회복이 빠르다는 장점이 있지만 의료진에게는 과도한 방사선 피폭과 부정확한 골절정복 가능성이 높아지는 문제점이 발생할 수 있다. 본 연구에서는 이와 같은 문제를 해결하기 위해 수술 항법장치와 수술 지원로봇을 활용하는 방법을 제안한다. 골편의 3D CT 모델을 실제 골편과 특징점을 이용해서 정합하는 오픈 소스 기반으로 구성된 수술 항법 장치와 2D 투시 영상에서 골편간의 회전 변위를 정상측 투시 영상과 비교하여 확인 할 수 있는 방법을 제안하였고, 모델 뼈를 이용한 실험으로 제안한 방법의 임상적 타당성을 확인하였다. 그 결과 3D CT-기반 수술 항법 장치의 모델 뼈와 영상정합 정확도는 약 2mm 로 정형외과 수술에서 요구되는 사양을 만족했으며, 2D 투시 영상에서는 ${\pm}15^{\circ}$범위의 골편간의 회전에서 $2.5^{\circ}$이하의 변별력을 나타내었다.

• Reproductive and Developmental Biology
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• 제34권2호
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• pp.89-94
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• 2010

Melatonin is induced by light information through the retina and leads to growth factor activation. Thus, we investigated the effects of melatonin by controlling the photoperiod of growing young rats. Male Sprague-Dawley rats (n=6; 4 weeks old) were divided into two experimental groups: the L/D group (normal photoperiod; light/dark: 12/12 h; lights on at 9:00 a.m.) and the L/L group (light/light: 24 h). Rat body weight and food consumption were measured daily for 8 weeks. After 8 weeks, the rats were anesthetized with a mixture of ketamine (50 mg/kg) and xylazine (10 mg/kg) and sacrificed. Tissue was then collected for RNA isolation (from brain, heart, liver, kidney, adrenal gland, testis, tibia, hind limb muscles). Also, serum was isolated from blood using a centrifugal separation. The L/L group had significantly lower body weight than the L/D group from 4 to 6 weeks (p<0.05). The L/D group had increased tissue mass, compared with the L/L group, but the difference was not statistically significant. The L/D group had a significantly higher melatonin concentration than the L/L group between the hours of midnight and 2:00 a.m (p<0.01). These results indicate that photoperiod length may affect the secretion of melatonin from the pineal gland. Also, the reduction of nocturnal melatonin secretion may retard the development of growing young rats. In future studies, we plan to compare exogenous melatonin administration with endogenous melatonin concentration induced by photoperiod control. Moreover, we will confirm whether the effects seen in pathological animal models can be reversed by controlling the photoperiod.