• Medical Lasers
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• v.10 no.1
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• pp.15-21
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• 2021

As technology advances at a rapid rate, innovations in regenerative medicine will eventually include the use of energy-based therapeutics, such as low intensity-pulsed ultrasound stimulation (LIPUs), pulsed electromagnetic field stimulation (PMFs), and low-level laser/light therapy (LLLt) or photobiomodulation therapy (PBMt). Among these treatments, LLLt/PBMt attracted significant attention by the turn of the century, as evidenced by the numerous publications compared to LIPUs and PMFs, particularly for augmented bone regeneration (ABR). This is a testament of how the maturation of technology and scientific knowledge leads to latent compounded applications, even when the value of a technique is reliant on empirical data. This article reviews some of the notable investigations using LLLt/PBMt for bone regeneration published in the past decade, focusing on how this type of therapy has been utilized together with the existing regenerative medicine landscape.

• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1589-1595
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• 2010

In order to effective degradation of organic dye both under visible light or ultrasonic irradiation, the MWCNTs (multiwalled carbon nanotube) deposited with Fe and $TiO_2$ were prepared by a modified sol-gel method. The Fe/$TiO_2$-MWCNT catalyst was characterized by surface area of BET, scanning electron microscope (SEM), Transmission Electron Microscope (TEM), X-ray diffraction (XRD), and energy dispersive X-ray (EDX) and ultraviolet-visible (UV-vis) spectroscopy. The low intensity visible light and low power ultrasound was as an irradiation source and the methylene blue (MB) was choose as the model organic dye. Then degradation experiments were carried out in present of undoped $TiO_2$, Fe/$TiO_2$ and Fe/$TiO_2$-MWCNT catalysts. Through the degradation of MB solution, the results showed the feasible and potential use of Fe/$TiO_2$-MWCNT catalyst under visible light and ultrasonic irradiation due to the enhanced formation of reactive radicals as well as the possible visible light and the increase of ultrasound-induced active surface area of the catalyst. After addition of $H_2O_2$, the MB degradation rates have been accelerated, especially with Fe/$TiO_2$-MWCNT catalyst, in case of that the photo-Fenton reaction occurred. The sonophotocatalysis was always faster than the respective individual processes due to the more formation of reactive radicals as well as the increase of the active surface area of Fe/$TiO_2$-MWCNT catalyst.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.32 no.5
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• pp.607-611
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• 1999

Carrageenan are sulfated polymers containing galactose and anhydrogalctose units, and is used for its gelling, thickening, stabilizing, emulsifying, and suspending properties. However, carrageenan is limited to use beyond $0.03\%$ as food additives because of its high degree of gelling and viscosity with low solubility. The use of ultrasound significantly reduced the viscosity of $\lambda$-carrageenan solutions. The optimal parameters of ultrasound for reduction of carrageenan molecular weight were temperature, $10^{\circ}C$ ultrasound intensity, 114.7 $W/cm^2$ ; carrageenan concentration, $2\%$; treatment time, 10 min. The molecular weights of control, ultrasound peak 1, and peak 2 were approximately 250,000, 184,000, and 67,000 daltons, respectively. The lower molecular weight of $\lambda$-carrageenan showed the higher solubility, the lower alcohol precipitation ratio and the lower emulsifying capacity. Browning degree of both control and lower molecular $\lambda$-carrageenans was not significantly different.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.34 no.3
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• pp.163-172
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• 2012

Purpose: Diabetes mellitus (DM) has been shown to alter the properties of the bone and impair bone healing around a titanium implant. The aim of this study is to investigate whether the low-intensity pulsed ultrasound (LIPUS), which has been known to stimulate the bone healing, improve the osseointegration of the titanium implant in tibia of DM-induced rats. Methods: 16 rats were received streptozotocin (60 mg/kg) for inducing diabetes. A total number of 32 titanium implants were placed bilaterally into both tibiae of these rats. The right tibia of each rat received LIPUS application (10 min/day) during 7 days post-operation, while the left side received no treatment. The study was carried on for six weeks and the rats were sacrificed at 1, 2, 4, and 6 weaks postoperatively (4 rats for each week) for histomorphometric and histologic analysis. Bone-implant contact and bone area were measured. Comparisons between the groups were made using statistical analysis on histomorphometric analysis. Results: The histomorphometry parameters showed that the bone-implant contact and the bone area values have decreased in the late osseointegration periods (4, 6 weeks) compared to the early osseointegration periods (1, 2 weeks) in both two groups. The bone-implant contact values of the LIPUS group were somewhat higher than those of controls at 1, 2 weeks, but the difference was not statistically significant. The bone area values of the LIPUS group were also higher than those of controls at 1, 2 weeks, but the difference was not statistically significant as well. Conclusion: Results of this study indicate that LIPUS may have positive effects on early osseointegration but could not improve the long term stability of dental implants.

• The Journal of the Acoustical Society of Korea
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• v.42 no.1
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• pp.50-56
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• 2023

The hydroxyl radical (·OH) and superoxide anion radical (·O₂^- ) generated by the shock wave generated during ultrasonic cavitation collapse in TiO₂ suspension are highly useful because they can sterilize and disinfect. For practical use as a sterilization method without any chemicals, in this study, we proposed a method for evaluating the generation of radicals generated by high-intensity ultrasound emitted to titanium dioxide suspension. In the proposed method, the sonoluminescence phenomenon, which emits light by ultrasonic cavitation decay energy, was utilized, and the degree of radical generation was evaluated through the amount of light energy by sonoluminescence. As a result, even at a low concentration of titanium dioxide of 0.02 wt%, light energy 5 times higher than in the absence of titanium dioxide was received. After that, as the concentration increased by 0.1 wt%, the luminous intensity of sonoluminescence increased linearly by about 14.8 × 10^-12 lm. Therefore, it was confirmed that the radicals generated by radiating high-intensity ultrasound to the titanium dioxide suspension increased linearly as the concentration of titanium dioxide increased within a given concentration range.

• Journal of Biomedical Engineering Research
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• v.44 no.5
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• pp.336-345
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• 2023

The present study was designed to evaluate changes in neuromuscular properties and the structural and qualitative characteristics of muscles during submaximal isometric contractions at low-to-relatively vigorous target forces and to determine their influence on force steadiness (FS). Thirteen young adult males performed submaximal isometric knee extensions at 10, 20, 50, and 70% of their maximal voluntary isometric contraction using their non-dominant legs. During submaximal contractions, we recorded force, EMG signals from vastus medialis (VM), vastus lateralis (VL), and rectus femoris (RF), and ultrasound images from the distal RF (dRF). Force and EMG standard deviation (SD) and coefficient of variation (CV) values were used to measure FS and EMG steadiness, respectively. Muscle thickness (MT), pennation angle (PA), echo intensity (EI), and texture features were calculated from ultrasound images to assess the structural and qualitative characteristics of the muscle. FS, neuromuscular properties, and texture features showed significant differences across different force levels. Additionally, there were significant differences in EMG_CV among the quadriceps at the 50% and 70% force levels. The results of correlation analysis revealed that FS had a significant relationship with EMG_CV in VM, VL, and RF, as well as with the texture features of dRF. This study's findings demonstrate that EMG steadiness and texture features are influenced by the magnitude of the target force and are closely related to FS, indicating their potential contribution to force output control.

• Annals of Rehabilitation Medicine
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• v.42 no.6
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• pp.846-853
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• 2018

Objective To compare the effects of low intensity ultrasound (LIUS), traditional exercise therapy (TET), low level laser therapy (LLLT) and TET on temporomandibular joint (TMJ) pain and trismus following recovery from head and neck cancer (HNC). Methods Sixty participants following, who had experienced HNC, were randomly allocated to three groups of 20 people each. Each group received different therapy. Group A received LIUS and TET; group B received LLLT and TET; while group C received TET. All 60 participants were evaluated under the visual analog scale (VAS), the University of Washington Quality of Life questionnaire (UW-QOL) and the Vernier caliper scale (VCS) at the beginning of the therapies and after 4 weeks. Results ANOVA test revealed significant improvements across all three groups with outcomes of p<0.05. The results of the UW-QOL questionnaire showed a significant difference between groups A, B and C in favor of group A (p<0.05). The VAS results showed a more improvement in group A as compared to group B (p<0.05), while there was no statistical difference between groups B and C (p>0.05). The VCS results showed more improvement for the individuals in group B as compared to those in group C (p<0.05), while there was minimal difference between groups A and B (p>0.05). Conclusion The LIUS and TET are more effective than LLLT and/or TET in reducing TMJ pain and trismus following HNC.

• Physical Therapy Korea
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• v.6 no.4
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• pp.1-7
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• 1999

이 연구에서는 24마리의 Japanese White 토끼를 대상으로 양쪽 비골을 인위적으로 골절시킨 후 초음파치료가 골절의 치유에 효과가 있는지를 알아보았다. 초음파 치료 후 대조군의 비골과 실험군의 비골에서의 골소주 비율은 차이가 없었으며 초음파 주파수를 0.875 MHz로 하였을 때와 3 MHz로 하였을 때의 골소주 비율도 차이가 없었다. 따라서 초음파 치료는 토끼의 비골 골절의 치유 효과가 없었다. 그러나 다양한 주파수와 초음파 전달양식을 변화시켰을 때 골절치유 효과가 있는지에 대해서는 지속적인 연구가 필요하다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.38 no.4
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• pp.195-203
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• 2012

Dental implants using titanium have greatly advanced through the improvement of designs and surface treatments. Nonetheless, the anatomical limits and physiological changes of the patient are still regarded as obstacles in increasing the success rate of implants further, even with the enhancement of implant products. So there have been many efforts to overcome these limits. The intrinsic potential for bone regeneration can be stimulated through adjuvant treatments with the continuous improvement of implant properties, and this can play an important role in achieving optimum osseointegration toward peripheral bone tissue and securing ultimate long-term implant stability in standard surgical procedures. For this purpose, various chemical, biological, or biophysical measures were developed such as bone grafts, materials, pharmacological agents, growth factors, and bone formation proteins. The biophysical stimulation of bone union includes non-invasive and safe methods. In the beginning, it was developed as a method to enhance the healing of fractures, but later evolved into Pulsed Electromagnetic Field, Low-Intensity Pulsed Ultrasound, and Low-Level Laser Therapy. Their beneficial effects were confirmed in many studies. This study sought to examine bone-implant union and its latest trend as well as the biophysical stimulation method to enhance the union. In particular, this study suggested the enhancement of the function of cells and tissues under a disadvantageous bone metabolism environment through such adjunctive stimulation. This study is expected to serve as a treatment guideline for implant-bone union under unfavorable circumstances caused by systemic diseases hampering bone metabolism or the host environment.

• Journal of Wetlands Research
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• v.16 no.2
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• pp.205-212
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• 2014

Ultrasound technology can be applied in various fields including environmental, energy, and material engineering processes. In this study the effect of liquid height/volume on calorimetric energy and sonochemical oxidation was investigated as one of the basic steps for the design of water/wastereater treatment sonoreactors. The liquid height was increased from 0 to $4{\lambda}$ by $1/4{\lambda}$ and it was found that both calorimetric energy and sonochemical oxidation were significantly increased at relatively high liquid height/volume where the power density was relatively low. The sonochemiluminescence (SCL) images for the visualization of the activity of cavitation also showed that larger and more stable active zone was formed with high SCL intensity at high liquid height/volume. Therefore, it was revealed that sonoreactors for water/wasterwater treatment could be significantly effective in terms of removal efficiency and energy consumption.