• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.21-21
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• 2011

A series of Quasi-Elastic Neutron Scattering (QENS) experiments helps us to understand the single-particle (hydrogen atom) dynamics of a globular protein and its hydration water and strong coupling between them. We also performed Molecular Dynamics (MD) simulations on a realistic model of the hydrated hen-egg Lysozyme powder having two proteins in the periodic box. We found the existence of a Fragile-to-Strong dynamic Crossover (FSC) phenomenon in hydration water around a protein occurring at TL=$225{\pm}5K$ by analyzing Intermediate Scattering Function (ISF). On lowering of the temperature toward FSC, the structure of hydration water makes a transition from predominantly the High Density Liquid (HDL) form, a more fluid state, to predominantly the Low Density Liquid (LDL) form, a less fluid state, derived from the existence of a liquid?liquid critical point at an elevated pressure. We showed experimentally and confirmed theoretically that this sudden switch in the mobility of the hydration water around a protein triggers the dynamic transition (so-called glass transition) of the protein, at a temperature TD=220 K. Mean Square Displacement (MSD) is the important factor to show that the FSC is the key to the strong coupling between a protein and its hydration water by suggesting TL${\fallingdotseq}$TD. MD simulations with TIP4P force field for water were performed to understand hydration level dependency of the FSC temperature. We added water molecules to increase hydration level of the protein hydration water, from 0.30, 0.45, 0.60 and 1.00 (1.00 is the bulk water). These confirm the existence of the FSC and the hydration level dependence of the FSC temperature: FSC temperature is decreased upon increasing hydration level. We compared the hydration water around Lysozyme, B-DNA and RNA. Similarity among those suggests that the FSC and this coupling be universal for globular proteins, biopolymers.

• 한국수자원학회논문집
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• 제54권3호
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• pp.203-215
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• 2021

본 연구에서는 유역내 댐 건설과 하천내 식생성장으로 육역화 현상이 진행되는 내성천 환경 변화의 원인을 파악하기 위해 내성천 유역에 위치한 3개 관측소를 대상으로 2010년부터 2019년까지 관측된 수문자료와 항공사진 및 지형자료를 수집하여 수문특성에 따른 수위-유량관계 변화 및 횡단면의 침식·퇴적 변화율을 분석하였다. 또한 상류 지류인 월호교 관측소에서 인위적인 유량 조절 유무에 따른 영향을 비교하였다. 분석결과, 내청천에서는 2013년부터 2015년까지 지속적인 가뭄에 의해 홍수터에서는 식생활착 및 식생사주 면적 증가로 육역화가 진행되었고, 저수위에서는 흐름부 축소, 유속 및 하상소류력 증가로 지속적인 하상침식이 발생한 것으로 판단되었다.

• 에너지공학
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• 제16권3호
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• pp.103-112
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• 2007

국내 1970년대에 설계 및 건설된 원자력발전소에 대해 침수분석을 수행한 결과 기기냉각수펌프 및 열교환기 건물, 주/보조건물, 중간건물 주증기 헤더 격실, 중간건물 주급수관 지역 및 하부층 등이 침수사고에 매우 취약하며 발전소 안전정지능력을 저해할 정도로 침수 영향이 심각한 것으로 판명되었다. 이들 지역에서의 침수원은 주급수관 파단이다. 현재 원자력발전소 내환경기기검증에서 주급수관 파단 방출량 계산은 수계산(Hand calculation)방법으로 Henry-Fauske 임계유량 모델 사용하고 있다. 이 방법은 배관파단 위치에서의 차압으로 계산되며, 실제 원자력발전소의 각종 제어로직에 의한 격리신호를 반영하지 못하므로 지나치게 보수적으로 파단 방출유량이 계산된다. 이러한 문제점을 개선하기 위해 원자력발전소 열수력계통 해석 전산코드인 RETRAN을 사용하여 원자력발전소 일/이차측 계통과 제어로직을 모사하고, 주급수관 파단 방출량 분석을 위한 입력가정과 해석방법을 개발하였다. 침수위 분석은 웨스팅하우스형 원자력발전소 격납건물 외부 하부격실에 대해 적용하였다. 전산코드 해석에서 각종 제어계통과 로직을 고려하였으며, 가장 제한적 사고조건을 계산하기 위해 노심출력, 파단형태, 면적, 위치 등의 조합으로 구성된 18개 사고 사례를 분석하였다. 그 결과 가장 제한적 사례 분석에서는 기존 수계산 분석에서보다 파단 방출유량이 크게 줄었고, 하부격실의 침수위도 상당히 낮아졌다.

• 디지털융복합연구
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• 제15권4호
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• pp.65-71
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• 2017

과학 기술의 발달과 더불어 학습자들에게 맞는 맞춘 교수 방법을 찾기 위한 연구를 부단히 노력해 오고 있다. 그러한 교수법 중의 하나로써 많은 연구자들은 플립드 러닝 방식을 제시하고 있다. 이 논문의 목적은 플립드 러닝방식이 i) 전통적 교육방식 수업에 비해 학업 성취도 면에서 유용한지 ii) 학생들의 영어성적에 상관없이 모든 영어레벨의 학생에게 적용되어 질수 있는지 iii) 학습자들의 학습에 대한 동기유발을 일으키는데 도움이 되는 교수법인지를 알아보고자 한다. 학업성취에 있어서 플립드 러닝 수업을 받은 학생 그룹 중 가장 성적이 좋은 그룹 학생들은 학업에 있어 많은 향상을 보인 반면 학업 성적이 가장 낮은 그룹 학생들은 오히려 성적이 낮아지는 결과로 나타났다. 플립드 러닝 교수법으로 수업을 진행할 시에는 학습자들의 수준에 따른 콘텐츠를 교수자가 개발해야한다고 본다. 학습자들의 수준에 맞는 맞춤형 콘테츠 개발이 학습자들의 학습 성취도를 높일 것으로 본다.

• 한국체육학회지인문사회과학편
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• 제58권4호
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• pp.447-459
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• 2019

이 연구는 비활동 여성 30명을 대상으로 중강도 지속 운동(moderate-intensity continuous exercise; MICE)과 고강도 인터벌 운동(high-intensity interval exercise; HIIE) 시 감정적 반응과 신경전달물질의 차이를 규명하기 위해 실시되었다. 두 집단 모두 설계된 일회성 트레드밀 운동을 실시하였고, 동일한 운동을 1주일 간격으로 총 3회 반복 실시하였다. MICE는 환기역치(VT) 50% 수준에서 5분간 준비운동 후 90%VT 수준에서 25분간 지속운동을 실시하였고 다시 50%VT 수준에서 5분간 정리운동을 실시하였다. HIIE는 115%VT 수준에서 2분간 6회 반복하였고, 중간의 운동성 회복은 85%VT 수준에서 2분간 4회 반복하였다. 통계분석결과 MICE는 첫 번째 실험에서 운동 중 감정반응과 운동 후 즐거움에 대해 긍정적으로 나타났지만 세 번째 실험에서는 부정적으로 나타났다. 반대로 HIIE는 첫 번째 실험에서 운동 중 감정반응과 운동후 즐거움에 대해 부정적으로 나타났지만 세 번째 실험에서는 긍정적으로 나타났다. 신경전달물질의 경우 3번의 실험에서 두 집단 모두 운동전에 비해 운동 10분 후 유의하게 증가한 것으로 나타났다. 종합해볼 때 비활동 여성에게 HIIE 운동이 운동순응을 높이는 전략이 될 수 있다고 판단된다.

• 유통과학연구
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• 제17권1호
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• pp.105-115
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• 2019

Purpose - Previous research has shown that a very high level and a very low level of job scope can both be more stressful than intermediate levels of job scope. This study investigates the potential positive and negative effects of the number of accounts handled by sales personnel. The primary objective of this paper is to examine how the number of accounts salespeople handle affects their stress and performance. Research design, data, and methodology - This research conducted the data collection using a survey of salespeople in the pharmaceutical industry. I sent the survey to 420 salespeople, and received 318 usable responses. To assess measurement reliability and validity, I ran an exploratory and confirmatory factor analysis. I also employed structural equation modeling (SEM) to test all hypothesized effects in AMOS and also measured the interaction variable using Ping's (1996) approach. Results - These results show that there are linear and non-linear effects of the number of accounts handled by the salesperson on both role ambiguity and role conflict. First, the number of accounts handled by a salesperson is positively related to role ambiguity and role conflict. Second, the effect of the number of accounts handled on role ambiguity and role conflict decreases as the number of accounts handled by the salesperson increases. Third, as accounts increase from a low level, role stress increases; when the number of accounts reaches an optimal level, role stress decreases; and when the number of accounts increases to a high level, it can be detrimental to the salesperson's role stress. Fourth, while product complexity is positively related to role ambiguity, brand strength is negatively related to both role ambiguity and role conflict. Fifth, the greater the brand strength, the weaker the relationship will be between the number of accounts handled and salesperson role ambiguity. Finally, role ambiguity is positively related to salesperson performance. Conclusion - Too much and too little accounts increase the role ambiguity and role conflict of salespersons. Managers should identify the complex effect of the number of accounts handled by salespeople. Also, when products are complex, managers should provide training to eliminate any complex processes and complex information. These results suggest ways to decrease salespersons' role stress by ensuring an optimal level of the number of accounts and brand strength.

• 대한간호학회지
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• 제27권4호
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• pp.787-795
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• 1997

This descriptive study was conducted to ascertain whether the needs of patients with cancer, their caregivers and their nurses changed according to the illness phases and if the perceived needs of the three groups were different for three categories of nursing needs. At two hospitals in Seoul and Choongnam, three groups of subjects, -patients with cancer(79), caregivers(92), and nurses(72) - responded to a questionnaire consisting of items on educational need(11 items), physical need(8 items), emotional need(9 items) using a 4-point Likert scale. The patients and caregivers were selected according to the phase of the cancer (initial, intermediate or recurred, terminal phases). Finding revealed that the level of perception and degree of satisfaction of the needs were low, just around two points in patients and caregivers. Of the three categories of needs, physical needs were received the highest score and the degree of satisfaction of physical needs was also the highest. There was no significant difference between the level of perception and satisfaction of needs in patients and caregivers according to the phases of the illness and the degree of per reception and the satisfaction of the patients were not significantly different and caregivers showed the same result. There was a significant difference in the level of importance of the needs of nurses according to the phases of the cancer. They perceived emotional needs were the most important in first phase and second phase, physical needs in third phase and the educational needs were more important in the first phase than in any other phase. The degree of importance of needs was significantly lower than the degree to which needs were addressed, according to the nurses response. In a comparison of patient and caregiver's perceived degrees of need, and need satisfaction, and nurse's perceived degree of need provision, patient and caregiver scores were lower than the nurses.

• Asian-Australasian Journal of Animal Sciences
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• 제22권6호
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• pp.803-811
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• 2009

The chemical composition and water extractable dry matter (DM) of foliages from Erythrina (Erythrina variegata), Fig (Ficus racemosa), Jackfruit (Artocarpus heterophyllus), Jujube (Ziziphus jujuba Mill), Kapok (Ceiba pentandra) and Mango (Mangifera indica) and the feed intake, digestibility and N retention when feeding these foliages were studied in two experiments. In Experiment 1, 12 male goats, 3.5 months old and weighing 14.6 kg, were randomly allocated to a diet consisting of one of the foliages in a change-over design with three periods. The foliages were offered ad libitum at the level of 130% of the average daily feed intake. The Erythrina foliage had a low content of DM and condensed tannins (CT) and a high concentration of crude protein (CP) in leaves plus petioles (193 g/kg DM) and stem, while the Mango foliage had a low CP (69 g/kg DM) and high DM content. The other foliages were intermediate. High content of CT was found in the leaves plus petioles of Jackfruit foliage and in the stem of Fig and Mango foliage. There was a difference in feed intake, nutrient intake, apparent digestibility and N retention between the foliages, with Erythrina, Jackfruit and Kapok foliage being significantly higher in these parameters than Fig, Jujube and Mango foliage. The water extractable DM could be used to estimate N retention, but not DM digestibility in this study. In Experiment 2, 4 male goats weighing 13.4 kg and 6 months old were allocated to a 4${\times}$4 Latin square design. The treatments were: water spinach ad libitum and Fig, Jujube or Mango foliage ad libitum +0.5% of BW as water spinach DM. Feed intake, apparent digestibility and N retention were not significantly different among the foliage diets, but higher than for water spinach alone (p<0.05). Supplementation with water spinach to a diet consisting of low quality foliages such as Fig, Jujube and Mango, increased DM and CP intake, apparent digestibility and N retention, compared to feeding these foliages as sole feeds.

• The Plant Pathology Journal
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• 제36권6호
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• pp.600-607
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• 2020

Phytophthora capsici Leonian is a major pathogen of pepper worldwide and few resistance sources to this pathogen have been identified so far. The goals of this study were to identify new sources of resistance against P. capsici in Capsicum landraces and analyze the relationship between the resistance indicator of plant symptoms and some plant phenotype parameters of plant height, stem width, leaf length and leaf width. Thirty-two landraces of pepper were collected from fourteen states in Mexico. From each population, 36 plants were inoculated with 10,000 zoospores of P. capsici under controlled conditions. This experiment was repeated twice. Out of the 32 landraces, six showed high level of resistance, four showed intermediate resistance and five showed low level of resistance when compared with the susceptible control 'Bravo' and the resistant control 'CM334', indicating that these landraces are promising novel sources of resistance to P. capsici. There was no correlation between the symptoms and plant phenotype parameters. However, these parameters were not affected in the group classified as highly resistant, indicating that P. capsici does not affect the growing of these resistant pepper landraces. The other resistant groups were significantly affected in a differently manner regarding their phenotype, indicating that this pathogen reduce their growth in different ways. This study reports novel resistance sources with great potential that could be used in breeding programs to develop new pepper cultivars with durable resistance to P. capsici.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4353-4358
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• 2013

Introduction: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, lymph node metastasis, ER, PR and HER2neu status. Methods: A total of 194 cases of newly diagnosed breast cancer were included in the study. Immunohistochemical staining for ER, PR, HER2neu and Ki67 was performed by the DAKO envision method. Associations of the Ki67 index with other prognostic factors were evaluated both as continuous and categorical variables. Results: Mean age of the patients was 51.7 years (24-90). Mean Ki67 index was 26.9% (1-90). ER, PR, HER2neu positivity was noted in 90/194 cases (46.4%), 74/194 cases (38.1%) and 110/194 cases (56.70%) respectively. Significant association was found between Ki67 and tumor grade, PR, HER2neu positivity and lymph node status, but no link was apparent with ER positivity and tumor size. There wasan inverse relation between Ki67 index and PR positivity, whereas a direct correlation was seen with HER2neu positivity. However, high Ki67 (>30%) was associated with decreased HER2neu positivity as compared to intermediate Ki67 (16-30%). The same trend was established with lymph node metastasis. Conclusion: Our study indicates that with high grade tumors, clinical utility of ki67 is greater in combination with other prognostic markers because we found that tumors with Ki67 higher than 30% have better prognostic profile compared to tumors with intermediate Ki67 level, as reflected by slightly lower frequency of lymph node metastasis and HER2neu expression. Therefore we suggest that Ki67 index should be categorized into high, intermediate and low groups when considering adjuvant chemotherapy and prognostic stratification.