• Title/Summary/Keyword: Loss sensitivity

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Treatment Outcome and Prognostic Factors of Cushing's Disease in Adults (성인 쿠싱병의 치료성적과 예후인자)

  • Park, Chul-Kee;Hwang, Sung Kyun;Gwak, Ho-Shin;Yoo, Heon;Chung, Young Seob;Paek, Sun Ha;Kim, Dong Gyu;Jung, Hee-Won;Kim, Seong Yeon;Hong, Seung Kuan
    • Journal of Korean Neurosurgical Society
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    • v.29 no.10
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    • pp.1316-1321
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    • 2000
  • Objectives : The authors analyzed the surgical series of Cushing's disease to evaluate the proper treatment policy and to verify the possible prognostic factors. Material and Methods : Of 50 patients diagnosed as Cushing's disease and operated at Department of Neurosurgery of our institute between 1988 and 1999, 48 patients with available medical records were analyzed retrospectively. Mean follow-up period was 48 months(3 to 109 months). Preoperative diagnosis was made after evaluating the patients with multiple-stage endocrinological studies and 31 selective patients were evaluated with inferior petrosal sinus sampling(IPSS). Magnetic resonance imaging(MRI) and/or high resolution computerized tomography(CT) was done in all patients. A total of 51 transsphenoidal adenomectomy(TSA) were performed including 3 revision for initial surgical failure cases. Remission was decided on the basis of both endocrinological criteria and clinical status. Radiation and/or ketoconazole therapy were applied to failed cases. For the verification of prognostic factors, the authors evaluated the statistical significance of multiple variables over remission rate by chi-square test. Result : Sensitivity of IPSS for central localization was 93.5% which was better than that of MRI(87.5%). But for lateralization, it was 72.4% for IPSS versus MRI 90.5%. Success rate of TSA was 82%(42/51) and recurrence rate was 9%(4/48). When including adjuvant treatments for surgically failed cases, overall success rate was 89.6% and all of 3 reoperated cases(TSA) due to recurrence were successful. Significant complication occurred in 7.8%(4/51) after TSA including hypopituitarism, diabetes insipidus, and visual loss. Non-existence of tumor in MRI and prolonged symptom duration(>3 years) were significant prognostic factors. Conclusion : TSA can be considered as initial treatment for Cushing's disease. In surgically failed cases, multiple treatment modality may improve the overall outcome and repeated TSA for recurrent cases seem to provide similar success.

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Internal Defection Evaluation of Spot Weld Part and Carbon Composite using the Non-contact Air-coupled Ultrasonic Transducer Method (비접촉 초음파 탐상기법을 이용한 스폿용접부 및 탄소복합체의 내부 결함평가)

  • Kwak, Nam-Su;Lee, Seung-Chul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.11
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    • pp.6432-6439
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    • 2014
  • The NAUT (Non-contact Air coupled Ultrasonic Testing) technique is one of the ultrasonic testing methods that enables non-contact ultrasonic testing by compensating for the energy loss caused by the difference in acoustic impedance of air with an ultrasonic pulser receiver, PRE-AMP and high-sensitivity transducer. As the NAUT is performed in a state of steady ultrasonic transmission and reception, testing can be performed on materials of high or low temperatures or specimens with a rough surface or narrow part, which could not have been tested using the conventional contact-type testing technique. For this study, the internal defects of spot weld, which are often applied to auto parts, and CFRP parts, were tested to determine if it is practical to make the NAUT technique commercial. As the spot welded part had a high ultrasonic transmissivity, the result was shown as red. On the other hand, the part with an internal defect had a layer of air and low transmissivity, which was shown as blue. In addition, depending on the PRF (Pulse Repetition Frequency), an important factor that determines the measurement speed, the color sharpness showed differences. With the images obtained from CFRP specimens or an imaging device, it was possible to identify the shape, size and position of the internal defect within a short period of time. In this paper, it was confirmed in the above-described experiment that both internal defect detection and image processing of the defect could be possible using the NAUT technique. Moreover, it was possible to apply NAUT to the detection of internal defects in the spot welded parts or in CFRP parts, and commercialize its practical application to various fields.

Vulnerability Assessment of Soil Loss in Farm area to Climate Change Adaption (기후변화 적응 농경지 토양유실 취약성 평가)

  • Oh, Young-Ju;Kim, Myung-Hyun;Na, Young-Eun;Hong, Sun-Hee;Paik, Woen-Ki;Yoon, Seong-Tak
    • Korean Journal of Soil Science and Fertilizer
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    • v.45 no.5
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    • pp.711-716
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    • 2012
  • Due to the climate change in South Korea the annual total precipitation will increase by 17 percent by 2100. Rainfall is concentrated during the summer in South Korea and the landslide of farmland by heavy rain is expected to increase. Because regional torrential rains accompanied by a storm continue to cause the damage in farmland urgent establishment of adaptation plant for minimizing the damage is in need. In this study we assessed vulnerability of landslide of farmland by heavy rain for local governments. Temporal resolution is 2000 year and the future 2020 year, 2050 year, 2100 year via A1B scenario. Vulnerability of local government were evaluated by three indices such as climate exposure, sensitivity, adaptive capacity and each index is calculated by selected alternative variable. Collected data was normalized and then multiplied by weight value that was elicited in delphi investigation. Current vulnerability is concentrated in Jeju island and Gyeongsangnam-do, however, it is postulated that Kangwon-do will be vulnerable in the future. Through this study, local governments can use the data to establish adaptation plans for farmland landslide by climate change.

Value of FDG PET/Contrast-Enhanced CT in Initial Staging of Colorectal Cancer - Comparison with Contrast-Enhanced CT

  • Kunawudhi, Anchisa;Sereeborwornthanasak, Karun;Promteangtrong, Chetsadaporn;Siripongpreeda, Bunchorn;Vanprom, Saiphet;Chotipanich, Chanisa
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.8
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    • pp.4071-4075
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    • 2016
  • Background: FDG PET/CT is at an equivocal stage to recommend for staging of colorectal cancer as compared to contrast-enhanced CT (ceCT). This study was intended to evaluate the value of FDG PET/ceCT in colorectal cancer staging as compared to ceCT alone. Materials and Methods: PET/ceCT was performed for 61 colorectal cancer patients who were prospectively enrolled in the study. Three patients were excluded due to loss to follow-up. PET/ceCT findings and ceCT results alone were read separately. The treatment planning was then determined by tumor board consensus. The criteria for T staging were determined by the findings of ceCT. Nodal positive by PET/ceCT imaging was determined by visual analysis of FDG uptake greater than regional background blood pool activity. The diagnostic accuracy of T and N staging was determined only in patients who received surgery without any neoadjuvant treatment. Results: Of 58 patients, there were 40 with colon cancers including sigmoid cancers and 18 with rectal cancers. PET/ceCT in pre-operative staging detected bone metastasis and metastatic inguinal lymph nodes (M1a) that were undepicted on CT in 2 patients (3%), clearly defined 19 equivocal lesions on ceCT in 18 patients (31%) and excluded 6 metastatic lesions diagnosed by ceCT in 6 patients (10%). These resulted in alteration of management plan in 15 out of the 58 cases (26%) i.e. changing from chemotherapy to surgery (4), changing extent of surgery (9) and avoidance of futile surgery (2). Forty four patients underwent surgery within 45 days after PET/CT. The diagnostic accuracy for N staging with PET/ceCT and ceCT alone was 66% and 48% with false positive rates of 24% (6/25) and 76% (19/25) and false negative rates of 47% (9/19) and 21% (4/19), respectively. All of the false negative lymph nodes from PET/ceCT were less than a centimeter in size and located in peri-lesional regions. The diagnostic accuracy for T staging was 82%. The sensitivity of the peri-lesional fat stranding sign in determining T3 stage was 94% and the specificity was 54%. Conclusions: Our study suggested promising roles of PET/ceCT in initial staging of colorectal cancer with better diagnostic accuracy facilitating management planning.

A Study on Scheme to Support QoS using Differentiated Services in MPLS Network (MPLS 망에서 Differentiated Services를 이용한 QoS 지원 방안에 관한 연구)

  • Park, Chun-Kwan;Jeon, Byung-Chun
    • Journal of IKEEE
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    • v.5 no.2 s.9
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    • pp.136-145
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    • 2001
  • As with appearing new applications that requires QoS guarantee such as VoIP, VPN in Internet, problems of IP QoS has been one of most important issues in next-generation Internet. IETF has proposed integrated services model(Int-Serv) and differentiated service(Diff-Serv) to supply IP QoS in Internet. Int-Serv model uses the state information of each IP flow, so satisfies QoS according to traffic characteristics, but increases the amount of flow state information with increasing flow number. Diff-Serv model uses PHP(Per Hop Behavior), and there are well-defined classes to provide differentiated traffics with different services according to delay and loss sensitivity. Diff-Serv model can provide diverse services in Internet because of having no the state and signal information of each flow. As MPLS uses the packet forwarding technique based-on label, it implements the traffic engineering in the networks easily. The MPLS can set up the path with different traffic parameters, and assign each path to particular Class of Services. Therefore it is possible to support the Diff-Serv model with well-defined classes. In this paper we investigate the performance improvement of Diff-Serv function in the MPLS network to guarantee class of services in Internet.

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Preliminary Design of the NISS onboard NEXTSat-1

  • Jeong, Woong-Seob;Park, Sung-Joon;Moon, Bongkon;Lee, Dae-Hee;Park, Won-Kee;Lee, Duk-Hang;Ko, Kyeongyeon;Pyo, Jeonghyun;Kim, Il-Joong;Park, Youngsik;Nam, Ukwon;Park, Chan;Im, Myungshin;Lee, Hyung Mok;Lee, Jeong-Eun;Shin, Goo-Hwan;Chae, Jangsoo;Matsumoto, Toshio
    • The Bulletin of The Korean Astronomical Society
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    • v.39 no.2
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    • pp.102-102
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    • 2014
  • The NISS (Near-infrared Imaging Spectrometer for Star formation history) onboard NEXTSat-1 is the near-infrared instrument onboard NEXTSat-1 which is being developed by KASI. The main scientific targets are nearby galaxies, galaxy clusters, star-forming regions and low background regions in order to study the cosmic star formation history in local and distant universe. After the Preliminary Design Review, we have fixed major specifications of the NISS. The off-axis optical design with 15cm apertureis optimized to obtain a wide field of view ($2deg.{\times}2deg.$), while minimizing the sensitivity loss. The opto-mechanical structure of the NISS was designed to be safe enough to endure in the launching condition as well as the space environment. The tolerance analysis was performed to cover the wide wavelength range from 0.95 to $3.8{\mu}m$ and to reduce the degradation of optical performance due to thermal variation at the target temperature, 200K. The $1k{\times}1k$ infrared sensor is operated in the dewar at 80K stage. We confirmed that the NISS can be cooled down to below 200K in the nominal orbit through a radiative cooling. Here, we report the preliminary design of the NISS.

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Evaluation of bone quality in alveolar crest obscured by dental implants ; A pilot study by densitometric digital analysis in mandibular bone specimen (치과 임플란트 주변 협설측 치조골의 변화분석 - 하악골 시편에서의 디지털 농도분석법을 이용한 실험적 고찰 -)

  • Kwon, Kung-Rock
    • The Journal of Korean Academy of Prosthodontics
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    • v.36 no.6
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    • pp.900-913
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    • 1998
  • Despite of technical difficulties, the combination of occlusal projection and densitometric digital analysis may ultimately provide a means of detection of subtle bone loss at the facial and lingual side of dental implant (Oblique occlusal view is more useful for $ITI^{(R)}$ dental implant due to its contour of shoulder as like tulip flower). In this study, conventional periapical projections of x-ray beam had shown more high sensitivity to detect the bony defects than oblique occlusal projections in alveolar crest obscured by dental implants or not, even if the difference was not statistically significant. Unlike conventional periapical projections. occusal projections combined with densitometric digital analysis technique may provide a means for detection of subtle bone change at the all around of implants without obscuring effect by implant itself. Although the results from this in vitro study were performed under limited circumstances, these results might afford more possibility and versatile modality of diagnosis options to clinician in the implant practice.

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Age- and Gender- Specific Reference Levels for Hearing Thresholds of Normal Aging in Korean (한국인의 정상적인 노화에 의한 성별 연령별 순음청력에 의한 기준청력)

  • Kim Sung Hee;Shin Jong Heon;Yeo Chang Ki;Han Young Kyung;Lee Jung Ki;Jarng Soon Suck
    • The Journal of the Acoustical Society of Korea
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    • v.24 no.6
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    • pp.353-357
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    • 2005
  • Declining auditory performance with advanced age is a well known and common problem that is becoming more Prevalent due to the increasing number of elderly people in our society. We introduce a novel ARCISM (Audiogram Result Computer Input. Save & Management software) data management program which enables the assessment of the risk of past history of hearing impairment on the basis of known risk factors. This study investigates the reference levels of pure tone hearing threshold of normal aging in Korean and the difference between fenders. The subjects were carefully selected by questionnaire and absence of any history of otologic infection, noise exposure. and ototoxic drug among 1603 subjects. who visited Health Promotion Center in Daegu Fatima Hospital for one year. The results show (1) hearing sensitivity declines with age. (2) higher frequency shows steeper slope of hearing declines than lower frequency. and (3) there were more hearing loss at 4 and 8 kHz in men than in women. Due to the ARCISM program. it was possible to manage huge data of hearing results and to obtain the reference level of a9e-related hearing declines. Furthermore, we expect that the results of this study can be the fundamental data for hearing rehabilitation for the elderly and for developing suitable hearing aids for Korean.

Design and Fabrication of APD-FET Module for 2.5 Gbps Optical Communicating System (광통신용 APD-FET 광수신모듈 설계 및 제작)

  • 강승구;송민규;윤형진;박경현;박찬용;박형무;윤태열;이창희;심창섭
    • Korean Journal of Optics and Photonics
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    • v.5 no.1
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    • pp.166-172
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    • 1994
  • The fiber optic receiver, ETRI APD-FET 1.0, is developed for the application of optical communication. This fiber optic receiver includes PD sub-module and pre-amplifier case. A single lens system is introduced for the PD sub-module. The sub-module consists of the avalenche photodiode(APD), GRIN rod lens, and a single mode fiber. The above components are enclosed into the stainless steel 304L housings. By bevelling the fiber end, the single mode fiber provides less than ~ 28 dB of optical return loss. The area of image focus is controlled by adjusting the length of spacer located in-between the fiber and the GRIN rod lens. The laser welding technique is applied to achieve the maximum coupling efficiency for the joining of each housing. In the pre-amplifier case, GaAs FET pre-amplifier workes for photocurrent amplification and the thermister is mounted to control the APD bias. The performance of ETRI APD-FET1.0 shows the sensitivity of - 30.3 dBm at $10^{-10}$ BER(bit error rate) and 2.5 Gbps optical random signal of $2^{23}-1$ word length. The fiber optic receiver is one of the essensial parts of the transmission module for B-ISDN. Also, the above optical packaging technology will be adapted for the developement of 10 Gbps transmission application 2.5 Gbps 5 Gbps

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Study on the Filter Collection Methods of Ammonia and Ammonium Salts in the Atomosphere (대기중의 암모니아 및 암모늄염의 필터포집법에 관한 연구)

  • Hui Kang Kim;橋本芳一;Yong Keun Lee
    • Journal of the Korean Chemical Society
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    • v.26 no.1
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    • pp.36-42
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    • 1982
  • Filters were evaluated to use in the collection of ammonia and ammonium salts in the atmosphere. Ammonia from standard gas generator was collected on a glass fiber filter impregnated with a mixture of 3% boric acid and 25% glycerin. The collection efficiency by the impregnated filter was 96.4${\pm}$2.15% in pH control method and 97.4${\pm}$1.06% in the atmosphere for five measurements, respectively. Adsorption and desorption of gaseous ammonia were compared using three commercially available filters; glass fiber, quartz fiber and polycarbonate filters. Both glass and quartz fiber filters indicated some loss of ammonium salts and adsorption of ammonia, respectively. However, polycarbonate filter was found to be satisfactory for the collection of ammonium salts in the atmosphere. The minimum measurable concentration of ammonia was 0.83ppb (ca. 0.63${\mu}g$/$m^3$) by spectrophotometry of the indophenol method for the sample collected by 47mm${\phi}$ filter(20l/min, 60min). The sensitivity of the present method is about 20 folds higher than that of conventional method of bubbler collection followed by spectrophotometry, so that this method makes it possible to measure thevariation of ammoniacal concentrations in the atmosphere for a short time period of about 60 min.

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