• Biomolecules & Therapeutics
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• 제10권4호
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• pp.236-239
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• 2002

The goal of this study was to evaluate the antidiarrheal efficacy of $Lacteol^{TM}$-loperamide combination against the mouse model of secretory diarrhea. Secretory dirrhea was induced in mice by p.o. administration of castor oil (0.3 ml). Antidirrheal effects of $Lacteol^{TM}$-loperamide combination were compared with each individual component. $Lacteol^{TM}$-loperamide combination was the most potent among these agents, eliminating diarrhea in 100% of mice at a dose 1360/4 mg/kg (Lacteol/loperamide, respectively). In this study, we also measured changes of bodyweight as another indicator of the dirrhea, based on the assumption that lower bodyweight loss represented reduced fecal passage. The bodyweight loss of $Lacteol^{TM}$-loperamide combination administered group was 4 times lower than that of vehicle control. These findings indicate that $Lacteol^{TM}$-loperamide combination may be more potent than individual component in its antidiarrheal action, so we are going to challenge this combination for further study and clinical evaluation.

• 한국전자통신학회논문지
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• 제17권2호
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• pp.237-244
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• 2022

본 논문에서는 저층 고밀도 교외 환경에서 신호의 클러터 손실(Clutter loss)과 건물 인입 손실(Building entry loss)을 측정 후 분석했다. 선정된 환경에서 BEL, CL, BEL과 CL 결합 등 3가지 전파 모델을 측정하였다. 각 모델 측정 결과 바탕으로 BEL과 CL을 결합하였을 때의 수치를 분석했다. 각각 주파수에서 BEL과 CL 결합 측정값은 27.55dB 와 26.12dB 였으며, 계산값과 차이는 -4.19dB와 5.82dB였다. 측정이 건물 내부에서 이루어졌다는 점을 고려할 때 이러한 차이는 미미해 보인다. 따라서 BEL과 CL의 각각 측정값 합산과 결합 모델의 측정값을 비교하였을 때 -4.19dB와 5.82dB 오차를 도출하였고, 본 결과는 유사한 사례의 전파 모델 분석 시 참고 자료로 활용될 수 있을 것이다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제9권2호
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• pp.61-68
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• 2020

e-sports는 최근 꾸준한 성장을 이루면서 세계적인 인기 스포츠 종목이 되었다. 본 논문에서는 e-sports의 대표적인 게임인 리그오브레전드 경기 시작 단계에서의 승패 예측 모델을 제안한다. 리그오브레전드에서는 챔피언이라고 불리는 게임 상의 유닛을 플레이어가 선택하여 플레이하게 되는데, 각 플레이어의 선택을 통하여 구성된 팀의 챔피언 능력치 조합은 승패에 영향을 미친다. 제안 모델은 별다른 도메인 지식 없이 플레이어 단위 챔피언 능력치를 팀 단위 챔피언 능력치로 임베딩한 Bidirectional LSTM 임베딩 기반 딥러닝 모델이다. 기존 분류 모델들과 비교 결과 팀 단위 챔피언 능력치 조합을 고려한 제안 모델에서 58.07%의 가장 높은 예측 정확도를 보였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 추계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.71-73
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• 2006

AC loss on variation of external magnetic field is a very important factor in development of power applications. In this paper, we measured and compared AC loss of hybrid-multi stacked wire made of the combination of 1G wires and 2G wires and uniform-multi-stacked wire made of one type of wires, 1G wires or 2G wires. Measurement was performed using by the linked-picked coil method. As results, as the number of wires increase, AC loss per unit volume of both stacked wires in low external magnetic field is reduced. Also AC loss of 2G slacked wire is higher than that of 1G wire. AC loss per unit length of 2G stacked wire is less than that of 1G stacked wire. And AC loss of hybrid-multi stacked wire made of the combination of 1G wires and 2G wires was between uniform-multi-stacked wire made of 1G wires and 2G wires.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제49권4호
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• pp.208-213
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• 2023

Objectives: Orthognathic surgery is a corrective intervention for maxillofacial deformities. Bleeding is a major concern for oral and maxillofacial surgeons. Various agents, such as hemocoagulase, tranexamic acid, and aprotinin have been developed to reduce intraoperative bleeding and transfusion requirements. Therefore, in this study we aimed to investigate the effects of hemocoagulase and tranexamic acid, as well as their simultaneous use, to reduce bleeding during orthognathic surgery. Patients and Methods: This retrospective study included patients who had undergone simultaneous orthognathic surgery of the maxilla and mandible between January 2013 and September 2022 and were classified into three groups based on drugs administered: hemocoagulase (Botropase), tranexamic acid, and a combination of both drugs. We recorded patient age, sex, weight, blood loss, and duration of surgery. Red blood cell (RBC), hemoglobin, hematocrit, and platelet levels were measured before, immediately after, and one day after surgery. Results: No statistically significant differences were found in blood loss, RBC, hemoglobin, hematocrit, or platelet levels between any of the groups. There were no differences in the drug effects between Le Fort I and bilateral mandibular sagittal split osteotomies, with or without double genioplasty. However, there were significant reductions in RBC, hemoglobin, hematocrit, and platelet levels during genioplasty. Conclusion: Tranexamic acid, hemocoagulase, and their combination had similar efficacy in patients who underwent Le Fort I and bilateral mandibular sagittal split osteotomies with and without genioplasty.

• 한방비만학회지
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• 제18권1호
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• pp.1-9
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• 2018

Objectives: The objective of this study was to assess the safety of 'Gamitaeeumjowee-tang' by analyzing adverse events in weight loss program in combination with 'Gamitaeeumjowee-tang' and low-calorie diet. Methods: A retrospective review of adverse events in weight loss program in combination with 'Gamitaeeumjowee-tang' and low-calorie diet from the electronic medical chart (n=124) between June 2015 and December 2016 was conducted. Three Korean Medicine Doctors (KMDs) reviewed adverse events for two times, during week 2 to 4 and at week 10, after starting weight loss program. Adverse events were evaluated in terms of causality, severity and system-organ classes. Also, agreement among the three KMDs was made through further discussion in case of disagreement after independent review. Results: The overall rate of adverse events was 37.1% during week 2 to 4 and 16.9% at week 10. For causality of adverse events using the World Health Organization-Uppsala Monitoring Centre causality categories, 52.2% were evaluated 'possible' at week 2-4 and 57.1% were evaluated 'unlikely' at week 10. All symptoms were evaluated as 'mild' by LDS scale. Nausea (15, 12.1%) was the most frequent adverse event at week 2-4 and dizziness (6, 4.8%) was the most common at week 10. Conclusions: Adverse events decreased over time. There were no serious adverse events and none of the subjects were dropped due to adverse events. Continuous study is needed to prove the safety of 'Gamitaeeumjowee-tang' for treating obesity.

• 한국음향학회지
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• 제41권1호
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• pp.38-44
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• 2022

잡음에 오염된 음성의 명료도와 음질을 향상시키고자 음성 향상을 수행한다. 본 연구에서는 복소값 스펙트럼을 이용한 마스크기반 음성 향상에서 시간 영역 손실함수와 주파수 영역 손실함수에 따른 학습 결과를 비교하였다. 시간 영역의 음성 파형과 주파수 영역의 스펙트럼의 세부정보를 고려해 두 영역의 장점을 활용할 수 있도록 손실함수 조합에 관해 연구를 진행하였다. 시간 영역 손실함수는 Scale Invariant-Source to Noise Ratio(SI-SNR)을 이용해 계산하고, 주파수 영역 손실함수는 복소값 스펙트럼과 크기 스펙트럼을 Mean Squared Error(MSE)로 계산하여 사용하였고, sin 함수를 이용해 위상에 대한 손실함수를 계산하였다. 손실함수 조합은 시간 영역 손실함수인 SI-SNR과 각 주파수 영역 손실함수를 조합하였다. 또한 크기 값과 위상 값을 모두 고려할 수 있도록 SI-SNR과 크기 스펙트럼, 위상에 관련된 손실함수들도 조합하여 실험을 진행하였다. 음성 향상 결과는 Source-to-Distortion Ratio(SDR), Perceptual Evaluation of Speech Quality(PESQ), Short-Time Objective Intelligibility(STOI)를이용해 성능 비교 평가를 진행하였다. 음성 향상 결과를 확인해보기 위해 스펙트럼 상에서 비교를 진행하였다. TIMIT 데이터베이스를 이용한 실험 결과, 시간 영역 또는 주파수 영역 손실함수보다 SI-SNR과 크기 스펙트럼을 조합한 손실함수를 사용하여 음성 향상을 학습했을 때 가장 높은 성능을 보였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 C
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• pp.1076-1078
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• 1998

This paper proposes a new approach for calculating frequency and duration by using the moment matching technique. Two separate expressions are derived, one for the loss of load expectation(LOLE) and the other for the loss of load frequency(LOLF). These expressions are combination of exponentials and are therefore easily integrable and can be readily evaluated. The proposed approach is quite comparable of with the other methods at the aspect of accuracy and efficiency.

• 대한한의학방제학회지
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• 제18권2호
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• pp.167-182
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• 2010

Cervi parvum cornu (Deer Antler) and Carthami tinctorii fructus (Also known as Carthami seed) are widely used for treating osteoporosis and rheumatoid arthritis. In this study, We found out that the water extract of Cervi parvum cornu(WECPC), Carthami tinctorii fructus(WECTF) and their combination have effects of suppressing the RANKL-induced osteoclast differentiation. We assayed mRNA expression levels of NFATc1, c-Fos, TRAP and GAPDHS from bone marrow macrophages(BMMs) by means of RT-PCR. Similarly, the protein expression levels of NFATc1, c-Fos, MAPKs and $\beta$-actin in cell lysates were analyzed by means of Western blotting. then we determined the anti-osteoporotic effects of WECPC, WECTF and their combination using Lipopolysaccharide (LPS)-induced bone-loss mouse. WECPC, WECTF and their combination showed remarkable inhibition on RANKL-treated osteoclast differentiation without cytotoxicity. WECPC suppressed degradation of I-${\kappa}B$. WECPC, WECTF and their combination down-regulated the induction of c-Fos and NFATc1 by RANKL. Lastly, in vivo data showed that WECPC, WECTF and their combination rescued the bone erosion by LPS treatment. Thus, these results demonstrate that WECPC, WECTF and their combination can be efficacious remedies for bone-loss diseases such as osteoporosis and rheumatoid arthritis.

• 전기학회논문지
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• 제62권9호
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• pp.1228-1233
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• 2013

In this paper, design of Wound Rotor Synchronous Motor(WRSM) for Integrated Starter and Generator(ISG) is performed based on Finite Element Analysis(FEA). WRSM can control not only magnitude and phase of armature current, but also field current. Thus, various control methods can be considered. Since driving characteristic of WRSM depends greatly on the control method, characteristic analysis accoding to possible driving current combination is reguired. Especially in high speed region, the control method that reduces unnecessary d-axis current by reducing field current is possible, which is similar to field weakening control. By the current combination reducing field and d-axis current, the design minimizing copper loss to increase efficiency on identical driving point is possible. In this paper, high efficient WRSM is designed applying the current combination which can minimize copper loss on each driving point.