• Journal of Korean Neurosurgical Society
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• 제44권5호
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• pp.327-333
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• 2008

Objective: The purpose of this study is to verify the usefulness of the rabbit model for disc degeneration study. Materials: The L1-L2, L2-L3, L3-L4. or L4-L5 lumbar intervertebral disc (IVD) of 9 mature male New Zealand White rabbits were injured by inserting a 16-gauge needle to a depth of 5 mm in the left anterolateral annulus fibrosus while leaving L5-L6 IVD uninjured. Three other rabbits also received intradiscal injections of rabbit disc cells transfected with adenovirus and bone morphogenetic protein-2 (ad-BMP-2) at L4-L5 in addition to injury by 16-gauge needle at the L1-L2 level. Using digitized radiographs, measurements of IVD height were made and analyzed by using the disc height index (DHI). Magnetic resonance imaging (MRI) scans of the injured discs, injected discs, and uninjured L5-L6 discs were performed at 15 weeks post surgery and compared with preoperative MRI scans. Results: All twelve rabbits showed consistent results of disc degeneration within 15 weeks following annular puncture. DHIs of injured discs were significantly lower than that of the uninjured L5-L6 discs (p<0.05). The mean value of disc degeneration grade of injured discs was significantly higher than that of uninjured discs (p<0.05). The injection of disc cell transfected with ad-BMP-2 did not induce disc regeneration at 15 weeks after injection. Conclusion: This study showed that the injured disc had a significant change in DHI on simple lateral radiograph and disc degeneration grade on MRI scans within 15 weeks in all rabbits. Rabbit annular puncture model can be useful as a disc degeneration model in vivo.

• Journal of Korean Neurosurgical Society
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• 제45권1호
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• pp.24-31
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• 2009

Objective : To investigate the effectiveness of radiographic parameters on segmental instability in the lumbar spine using Kinetic magnetic resonance imaging (MRI). Methods : Segmental motion, defined as excessive (more than 3 mm) translational motion from flexion to extension, was investigated in 309 subjects (927 segments) using Kinetic MRI. Radiographic parameters which can help indicate segmental instability include disc degeneration (DD), facet joint osteoarthritis (FJO), and ligament flavum hypertrophy (LFH). These three radiographic parameters were simultaneously evaluated, and the combinations corresponding to significant segmental instability at each level were determined. Results : The overall incidence of segmental instability was 10.5% at L3-L4, 16.5% at L4-L5, and 7.3% at L5-S1. DD and LFH at L3-L4 and FJO and LFH at L4-L5 were individually associated with segmental instability (p<0.05). At L4-L5, the following combinations had a higher incidence of segmental instability (p<0.05) when compared to other segments : (1) Grade IV DD with grade 3 FJO, (2) Grade 2 or 3 FJO with the presence of LFH, and (3) Grade IV DD with the presence of LFH. At L5-S1, the group with Grade III disc and Grade 3 FJO had a higher incidence of segmental instability than the group with Grade I or II DD and Grade 1 FJO. Conclusion : This study showed that the presences of either Grade IV DD or grade 3 FJO with LFH at L4-L5 were good indicators for segmental instability. Therefore, using these parameters simultaneously in patients with segmental instability would be useful for determining candidacy for surgical treatment.

• 한국언론정보학보
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• 제30권
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• pp.175-201
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• 2005

본 논문은 '다양성'이라는 규범적 가치에 입각해 뉴스 기사 선별 및 취재 경로와 관련한 미 신문의 뉴스 제작 방식에는 어떤 변화가 진행돼 왔는지를 통시적으로 살펴보고 있다. 이에 따라 본고에서는 '뉴스 토픽'과 '정보원' 등 두 가지 분야에서 지난 50년간 뉴욕 타임스와 시카고 트리뷴, 로스앤젤레스 타임스 등 3대 유력 일간지의 1면 기사를 분석, 연대기적인 가치 변화를 추적해 보았다. 데이터 분석 결과, 지난 반세기 동안 미 신문에서 정부 및 정치권에 대한 정보원의 의존도는 지속적으로 줄어들고 있는 반면, 기업/산업체발 정보원의 등장은 점차 빈번해 지고 있는 것으로 나타났다. 이와 함께, 뉴스 주제의 분포에 있어서는 사건, 사고 기사의 감소와 군사, 안보기사의 퇴조 속에, 경제, 건강, 교육 등과 같은 주제가 점차 활발하게 다뤄지고 있는 것으로 조사됐다. 그러나 전통적인 비인기 주제였던 빈곤, 노동, 소수자, 사회 갈등 등과 같은 토픽들은 시대를 거듭해도 제자리를 맴돌거나 오히려 줄어들고 있는 것으로 나타났다.

• 대한한의진단학회지
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• 제14권1호
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• pp.44-56
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• 2010

Objective : To characterize Five Woons of Asian women who live at Los Angeles area in U.S.A Methods : A set of physical tests and diagnostic questions were given to 242 Asian female subjects who were treated for their symptoms at a clinic of Asian medicine near Los Angeles in USA. The participants were given their constitutions, one of the Five Woons based on their birthdays. The physical tests included a body composition via Inbody 4.0 and an autonomic bioelectric response record via ABR2000. The oneway analysis of variance was applied to compare the means of the Five Woons and the physical test results. The Cross tabulation analysis was also applied to look for the effectiveness of Five Woons on the symptoms. Results : 1. In the body composition items, the LSD(least significant difference) showed that there were significant differences between the Soil Woon and the other Four Woons which are Water, Metal, Fire and Wood Woons in weight, fat, body fat %, BMI (p<0.2). 2. Based on the LSD, significant differences were observed among the Five Woons in R5, R6 and R7(p<0.2). 3. The cross tabulation analysis showed the significant effectiveness of the Five Woons on the five symptoms including dizziness, hot and cold, lower body edema, fatigue and to take a medication for high blood pressure out of 24 diagnostic questions (p<0.2). Conclusions : Further clinical research is necessary to develop a more delicate questionnaire and look for ways of characterizing the Five Woons. The diagnosis and corresponding treatment based on the Five Woons should be further studied in view of the Oriental medicine.

• 대한한의진단학회지
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• 제14권2호
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• pp.110-120
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• 2010

Objective: To relate with significant relationship between symptoms and Five Zhang(五臟)symptoms in Five Woon Constitutions and to characterize Five Woons of Asian women who live at Los Angeles area in U.S.A. Methods: 19 diagnostic questions were given to 286 Asian females subjects who were treated for their symptoms at an Asian medical clinic near Los Angeles in USA. The participants were given their constitutions, one of the Five Woons based on their birthdays. The Cross tabulation analysis was also applied to look for the effectiveness of Five Woons on the symptoms. Results: 1. The cross tabulation analysis showed the significant effectiveness of the Five Woons on the five symptoms including dizziness, hot and cold, lower body edema and face fever(p<0.1). 2. The dizziness and the hot and cold were related with Liver diseases, the lower body edema was related with Kidney diseases and the face fever was related to Heart diseases. Conclusions: This study can explain the relationship between the significant symptoms of Five Woons and Five Zhang(五臟)symptoms with reference which is the book by Yoon, ChoChang who lived 1700 years. Further clinical research is necessary to develop more delicate questionnaires and look for ways of characterizing the Five Woons. The diagnosis and corresponding treatment based on the Five Woons should be further studied in view of the Asian medicine.

• 한국구조물진단유지관리공학회 논문집
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• 제8권1호
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• pp.203-210
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• 2004

1994년 Northridge 지진 이후 내진보강한 콘크리트 교량의 손상도 곡선을 유도하였고, 이 곡선을 사용하여 교각과 신축이음장치에 설치한 강재 재킷과 구속부재의 내진보강 효과를 고찰하였다. 손상도 곡선을 2변수(중간값과 대수 표준편차) 대수정규분포함수의 형태로 가정하였고, 최대지반가속도의 함수로 나타냈다. 여기서 Maximum likelihood 방법을 사용하여 대수정규분포함수의 2변수를 구하였고, FEMA SAC 프로젝트의 60개 Los Angeles 지진 시간이력을 지진해석에 사용하였다. 교각의 강재 재킷은 교량의 전반적 손상등급에서 내진보강 효과를 나타냈고, 구속부재는 낙교 등 교량의 심한 손상등급에서 효과적이었다. 여기서, 교각은 Dutta & Handel이 제시한 5개 손상등급으로 손상을 정의하였고, 신축이음장치에서는 구속부재의 파괴 및 낙교를 교량의 심각한 손상으로 규정하였다.

• Journal of Microbiology and Biotechnology
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• 제28권12호
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• pp.2079-2094
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• 2018

Sunflower trypsin inhibitor (SFTI) is a 14-amino-acid bicyclic peptide that contains a single internal disulfide bond. We initially constructed chimeras of SFTI with N-terminal secretion signals from the Escherichia coli OmpA and Pseudomonas aeruginosa ToxA, but only detected small amounts of protease inhibition resulting from these constructs. A substantially higher degree of protease inhibition was detected from a C-terminal SFTI fusion with E. coli YebF, which radiated more than a centimeter from an individual colony of E. coli using a culture-based inhibitor assay. Inhibitory activity was further improved in YebF-SFTI fusions by the addition of a trypsin cleavage signal immediately upstream of SFTI, and resulted in production of a 14-amino-acid, disulfide-bonded SFTI free in the culture supernatant. To assess the potential of the secreted SFTI to protect the ability of a cytotoxic protein to kill tumor cells, we utilized a tumor-selective form of the Pseudomonas ToxA (OTG-PE38K) alone and expressed as a polycistronic construct with YebF-SFTI in the tumor-targeted Salmonella VNP20009. When we assessed the ability of toxin-containing culture supernatants to kill MDA-MB-468 breast cancer cells, the untreated OTG-PE38K was able to eliminate all detectable tumor cells, while pretreatment with trypsin resulted in the complete loss of anticancer cytotoxicity. However, when OTG-PE38K was co-expressed with YebF-SFTI, cytotoxicity was completely retained in the presence of trypsin. These data demonstrate SFTI chimeras are secreted in a functional form and that co-expression of protease inhibitors with therapeutic proteins by tumor-targeted bacteria has the potential to enhance the activity of therapeutic proteins by suppressing their degradation within a proteolytic environment.

• 대한원격탐사학회지
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• 제30권6호
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• pp.755-767
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• 2014

본 연구에서는 LARIAC2 GIS 자료와 전산 유체 역학(CFD) 모델을 이용하여 미국 캘리포니아 주 Los Angeles의 두 지역(Wilshire blvd. & Carondelet and Broadway & $7^{th}$ St.)을 대상으로 수치 실험을 수행하였다. 두 지역의 상세 도시 대기 흐름의 특성을 조사하기 위해 건물 자료 구축 알고리즘을 통해 벡터 형식으로 제공되는 LARIAC2 GIS 자료로부터 건물 도메인 자료를 추출하였다. 추출한 자료를 CFD 모델 입력 자료로 사용하여, 각 지역의 오전과 오후의 주 풍향과 풍속에 대해 수치 실험을 수행하였다. 도시 지역 내에서는 건물에 의해 국소적인 2차 흐름이 발생하면서 유입류와 비교하였을 때, 풍향과 풍속의 차이가 두드러졌다. 유입류와 평행한 방향으로 형성된 도시 협곡에서는 채널링 효과가 나타나면서 풍속이 국지적으로 증가하였고, 수직인 방향으로 형성된 도시 협곡에서는 연직 방향으로 잘 발달한 소용돌이가 형성되었다. 도시 협곡을 이루지 않은 건물의 풍상측에서는 말편자 소용돌이가 지면 근처에서 형성되었고, 풍하측에서는 재순환 영역이 형성되었다. 이와 같은 2차 순환(도시 협곡 소용돌이, 말편자 소용돌이, 재순환 영역)이 형성된 구역에서는 지면 근처의 풍속이 크게 증가하였다. 평균 풍속과 풍향 변화율을 조사한 결과, 대체적으로 풍속 증가율이 높은 곳에서 풍향 변화율이 비교적 낮았고 풍속 감소율이 높은 곳에서는 풍향 변화율이 높게 나타났다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1126-1130
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• 2004

This paper describes the design, development, and performance testing of an autonomous ground vehicle that was developed to participate in the DARPA Grand Challenge that was held in March 2004. The authors of this paper are members of Team CIMAR which was one of twenty five teams selected by DARPA to participate in a competition to develop an autonomous vehicle that can navigate from near Los Angeles to near Las Vegas at speeds averaging twenty miles per hour. Most of the event was held on open terrain and trails in a rocky desert environment. This paper describes the overall system design and the performance of the system at the event.

• Journal of Contemporary Eastern Asia
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• 제12권2호
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• pp.19-34
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• 2013

Previous research assessed media reporting on nuclear accidents and risks, whilst studies about the Fukushima accident focused on the impact of the Internet on coverage of the incident. However, little research has addressed news framing or comparisons of the perceptions of journalists in relation to reporting nuclear accidents. The aim of this study is to apply framing analysis to news content in The New York Times, the Los Angeles Times, and USA Today about the Fukushima accident. It explores the question of how journalists view reporting on complex events. Content analysis of these three newspapers shows that conflict, responsibility, and economic consequences were the most frequently used frames. According to the journalists interviewed, the biggest problem was the inability to assess information due to contrary positions held by experts. It is argued that the Fukushima accident was framed as a conflict of experts and officials' opinions, utility and government officials' responsibility, and economic consequences for the United States. Adherence to professional norms of objectivity and impartiality was signified as the best approaches to risk reporting.