• 대한의생명과학회지
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• 제23권2호
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• pp.49-56
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• 2017

Fibroblast growth factor (FGF)-2 is one of the most effective growth factors to increase the growth rate of mesenchymal stem cells (MSCs). Previously, we reported that low dose of FGF-2 (1 ng/ml) induced proliferation of bone marrow-derived mesenchymal stem cells (BMSCs) through AKT and ERK activation resulting in reduction of autophagy and senescence, but not at a high dose. In this study, we investigated the effects of high dose FGF-2 (10 ng/ml) on proliferation, autophagy and senescence of BMSCs for long term cultures (i.e., 2 months). FGF-2 increased the growth rate of BMSCs in a dose dependent manner for a short term (3 days), while during long term cultures (2 months), population doubling time was increased and accumulated cell number was lower than control in BMSCs when cultured with 10 ng/ml of FGF-2. 10 ng/ml of FGF-2 induced immediate de-phosphorylation of ERK1/2, expression of LC3-II, and increase of senescence associated ${\beta}$-galactosidase (SA-${\beta}$-Gal, senescence marker) expression. In conclusion, we showed that 10 ng/ml of FGF-2 was inadequate for ex vivo expansion of BMSCs because 10 ng/ml of FGF-2 induced growth retardation via ERK1/2 de-phosphorylation and induction of autophagy and senescence in BMSCs.

• Asian-Australasian Journal of Animal Sciences
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• 제15권6호
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• pp.838-843
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• 2002

The objectives of this study were to examine growth performance and meat quality by three different feeding patterns in Korean native cattle (KNC). In each of 3 years, fifteen KNC were randomly assigned in a (3 feeding management)${\times}$(3 sex) factorial design experiment; thus, in total, there were 5 animals in each of the 9 treatments. The three feeding management treatments were longterm (24 month) restriction feeding (LTFR), long-term restriction feeding-hormone implant (LTFR-tH), and short-term (18 month) nonrestriction feeding (STFNR). Three sexes were bull, steer, and heifer. Concentrate diet was fed restriction-feeding method based on body weight in LTFR and LTFR-tH. However, the diet was fed ad libitum in STFNR. Hormonal implantation was made three times with M-$PO^{TM}$ for bulls and with F-$TO^{TM}$ for heifers at 18, 20, 22 month of age in LTFR-tH. Animal were purchased from the local cattle market and managed in two local farms and at the university research unit. Animals were slaughtered at 24 months for long-term trial and at 18 month for short-term trial. The growth rate was the highest in bulls and the lowest in heifers. However, the differences were diminished in F-$TO^{TM}$ implanted heifers. The average daily gain was high in STFNR due to ad libitum feeding. The carcass grade was similar among the treatments on percentage bases. Hormonal implants improved significantly the meat quality grade in all sexes. Castration increased body fat content and improved meat quality grade by intramuscular fat deposition. In conclusion, long-term feeding and hormone treatment increased meat quality grade more than short-term feeding. However, ADG was higher in the short-term trial although feedefficiency was lower.

• 생물환경조절학회지
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• 제6권2호
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• pp.92-96
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• 1997

단고추의 장기자루식 양액배지에 있어서 분지수가 생육과 수량에 미치는 영향을 구명하고자 1폿트당 4지, 6지, 8지를 유인하여 재배한 결과를 요약하면 다음과 같다. 1 초장, 경경, 엽중, 근중, 경중은 유의성은 없었으나 엽수와 엽면적은 8지유인에 많았다. 2. 과경, 과중은 4지 유인구에서 많았고 유의성은 없었으나 수량도 124.5ton/ha로 8지 유인의 113.4ton/ha보다 9% 많았다. 3. 유인방법별 월별 수량은 초기 5개월은 8지 유인이 4지 유인보다 많았으나 중기이후인 4월부터 수확 종료까지 4지 유인이 수량이 많았으며 유인에 따른 노동력 절감 및 상품율면에서 자루식 장기재배의 경우 4지 유인이 알맞을 것으로 사료되었다.

• 중소기업연구
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• 제42권3호
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• pp.123-144
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• 2020

기술 기반 신생기업들은 창업 초기부터 세계화를 추구함으로써 경쟁력을 확보하려는 BGF전략을 추구하는 현상은 기존 국제화 이론으로는 설명하기 어려운 현상으로 태생적 글로벌 기업(BGF 또는 BGV)에 대한 새로운 접근법이 적용되고 있다. 그러나 BGF에 대한 대부분의 연구는 세계화 전략의 선행 요소)에 초점을 맞추고 있어 기업 재무성과에 어떤 영향을 미치는가에 대한 연구는 적으며 기존의 연구 결과의 일관성도 없는 상황이다. 이러한 차이는 BGF에 대한 정의의 문제와 연구 방법과 연구 대상에 의한 결과이며 특히 기업의 재무적 성과에 대한 측정의 타당성 부족에 기인한 것이다. 본 연구는 기존 연구의 한계를 극복하고 신속한 세계화 전략이 BGF의 성과(매출량, 투자수익률, 직원당 순이익, 매출증가율, 종업원당 순이익 증가율)에 어떤 영향을 미치는지 이해하기 위해 KIS-Value의 2차 자료를 활용하여 연구를 시도 하였다. 특히, BGF에 대한 정의를 기업이 설립 후 5년 내에 수출 집중도가 25%, 50%, 75%에 따른 수준별 구분에 따라 분석을 시도하였다. 본 연구의 결과는 첫째, 신속한 국제화 전략은 장·단기적으로 매출 효과는 있는 것으로 검증되었고 특히, 단기적인 효과가 장기적인 효과에 비하여 크게 나타났다. 그러나 BGF의 투자 수익률(ROI)에 대한 영향은 BGF수준이 엄격할수록 ROI에 대한 단기적인 영향은 있지만 장기적인 영향은 사라지는 것으로 나타났다. 셋째, 매출 성장률 성과는 BGF수준에 따라 단기적 효과가 있으나 ROI와 같이 장기적인 효과는 나타나지 않는다. 반면에 순이익 증가율은 BGF전략이 장기적으로는 부정적인(-) 효과가 있는 것으로 나타났다. 특히, 기업의 BGF 수준이 높을수록 순이익 증가율에 미치는 부정적인 영향은 더 크게 나타났다.

• Neonatal Medicine
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• 제16권2호
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• pp.131-136
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• 2009

Preterm infants are frequently discharged from the hospital with growth retardation. Given the potentially lifelong effects of growth impairmnet during a critical time of development, considerable effort should be focused on improving growth after discharge. Growth monitoring must be based on regular measurements of weight, length, and head circumference to identify those preterm infants with poor growth that may need additional nutritional support. Although prior studies vary in design and the intervention used, the evidence supports the use of fortified formulas in formula-fed preterm infants after discharge. The situation for infants fed human milk is much less clear, it seems prudent to concentrate our efforts on the encouragement of breast-feeding in this population. Catch up growth may have many benefits, and may lead to improved development. However, its long-term metabolic consequences are currently unclear. Understanding the optimal means of providing nutrition after discharge is an ongoing process.

• The Journal of Asian Finance, Economics and Business
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• 제3권4호
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• pp.57-66
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• 2016

Foreign Direct Investment (FDI) plays a vital role in economic growth of the countries. The present study analyses the impact of the FDI on economic growth of South Asian Association of Regional Cooperation countries by using the pooled data for the period 1990-2014. Neo-classical production function has been used for analysis and getting stock-to-flow estimation, Taylor series approximation has applied. Fixed Effects Model has been used to investigate the impact of FDI, domestic capital, labour and government expenditures on economic growth. It is the evident from the results that both domestic investment and FDI have been a positive effect on economic growth. The study finds that the contribution of domestic private investment is more trustworthy than the contribution of FDI. Consequently, FDI loses its attraction as an engine of growth if the adverse balance of payment consequence of the resulting profit repatriating is also taken into account. The labour has positive and significant association with GDP. The effect of government expenditure is negligible on economic growth. The findings suggest that growth strategy cannot yield the long term benefits if it neglects investments on human capital.

• Journal of Ecology and Environment
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• 제32권2호
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• pp.87-96
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• 2009

Pinus thunbergii plantations in Pohang-si, Gyeongsangbuk-do, Korea, are of low ecological quality, with arrested succession and a high proportion of ruderal species. To improve the quality of the habitat, we created canopy gaps ($\sim42\;m^2$) and monitored changes in abiotic (light availability, canopy openness) and biotic (survival and growth of seedlings and understory communities) variables in 2007 and 2008 in plots that had received one of five types of treatment: cutting of canopy trees and removal of the understory (CU), cutting of canopy trees only (C), girdling of canopy trees and removal of the understory (GU), girdling of canopy trees (G) or control. Each treatment was applied to three replicate plots. Abiotic variables did not significantly differ among treatments. Survival rates of target species were slightly lower in the CU, G and control conditions. Based on logistic regression analysis, the only significant growth factor affecting survival was height growth. Positive effects of seedling height and leaf area growth on survival were also detected, but did not reach statistical significance. In treatment G, gradual improvement of overstory conditions and mitigation of competition by limitation of disturbance to the understory community were likely to have promoted seedling growth. There were no significant effects of gap treatments on changes in species abundance (cover and richness) and composition of understory between the study years. This result implies that the small gaps created in our study may be below the threshold size to affect understory growth. However, the results of this study are based on a short-term investigation of only two years. Long-term research is strongly recommended to clarify the effects of gap treatment on plant communities in afforested areas.

• Asian-Australasian Journal of Animal Sciences
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• 제21권6호
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• pp.868-872
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• 2008

This experiment was conducted to evaluate the long term effects of dehulled soybean meal (DHSM) as fish meal (FM) replacer in the diet for olive flounder, Paralichthys olivaceus, for 42 wk at a commercial fish farm. The four experimental diets were MP (moist pellet based on raw fish), $DHSM_0$ (fish meal based dry pellet), $DHSM_{30}$ (30% fish meal was replaced by DHSM) and COMD (commercial dry pellet). Fish were fed one of the four diets containing 50% crude protein and 16.7 kJ available energy/kg diet for 42 wk. Fish averaging $3.20{\pm}0.04g$ ($mean{\pm}SD$) were initially distributed to each tank as a group of 6,000 fish reared in a flow-through system. At the end of the experiment, average body weight of fish was $315{\pm}9.3g$ ($mean{\pm}SD$) ). Weight gain (WG) and feed efficiency (FE) of fish fed MP, DHSM0 and DHSM30 showed no significant difference among the diet treatments. However, WG and FE of fish fed MP were significantly higher than those of fish fed COMD (p<0.05). Specific growth rate (SGR), protein efficiency ratio (PER) and survival of fish fed all diets were not significantly different among the dietary treatments. Therefore, these results indicate that DHSM could replace up to 30% white fish meal with amino acid supplementation in olive flounder diets for long-term feeding practice at the commercial farm.

• 통상정보연구
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• 제15권3호
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• pp.41-62
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• 2013

본 논문은 외환보유고 축적이 신흥경제권의 금융시스템에 중 장기적으로 어떠한 영향이 미치는지에 대해서 고찰하였다. 외환보유고의 축적은 신흥경제권에 있어서 금융위기의 재발방지라는 관점에서 매우 유효한 수단이며 금융위기의 리스크를 줄이기 위한 수단이기도 하다. 외환보유고의 과도한 축적이 경제적으로 대외채무, 국내소비, 국내투자 및 경제성장에 각각 어떠한 영향을 미치는지 중 장기적인 관점에서 보면 외환보유고의 축적이 국내소비를 감소시키는 한편 수출증가에 의한 무역재 산업의 확대를 가져온다. 즉 무역재 산업의 확대는 무역재 산업이 자본집약적인 경우에 국내투자의 확대를 통해서 경제성장에 긍정적인 영향을 준다. 그러나 중국은 국내투자를 대폭적으로 확대하는 정책을 실시하고 있지만 그 외의 국가에서는 과도한 외환보유고의 축적으로 인해서 국내투자가 정체되고 있다. 이러한 사실은 중국을 제외하고 과도한 외환보유고의 축적이 비무역재 산업의 축소를 통해 중 장기적으로 경제성장을 침체시킴으로서 잠재적인 리스크가 높아진다는 것을 의미한다.

• Asian-Australasian Journal of Animal Sciences
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• 제10권4호
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• pp.335-356
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• 1997

Injection of bovine growth hormone (bGH) to lactating dairy cows increases milk yield and yields of milk components including fat. It is generally believed that most of the anabolic effects derived from bGH in animal tissues are primarily mediated by IGF-1. IGF-1 is a strong anabolic peptide in the plasma of animals and exerts mitogenic and metabolic effects on target cells. Contrary to most protein hormones, the majority of IGF-1 in circulation is bound to the binding proteins (IGFBPs) which are known to be responsible for modifying the biological actions of IGF-1, thus making determinations of IGF-1 actions more difficult. On the other hand, fat is a major milk component and the greatest energy source in milk. Currently, the fat content of milk is one of the major criteria used in determining milk prices. It has been known that flavor and texture of dairy products are mainly affected by milk fat and its composition. Acetyl-CoA carboxylase (ACC) is the rate limiting enzyme which catalyzes the conversion of acetyl-CoA to malonyl-CoA for fatty acid synthesis in 1ipogenic tissues of animals including bovine lactating mammary glands. In addition to the short-tenn hormonal regulation of ACC by changes in the catalytic efficiency per enzyme molecule brought about by phosphorylation and dephosphorylation of the enzyme, the long-term hormonal regulation of ACC by changes in the number of enzyme molecules plays an essential role in control of ACC and lipogenesis. Insulin, at supraphysiological concentrations, binds to IGF-1 receptors, thereby mimicking the biological effects of IGF-1. The receptors for insulin and IGF-1 share structural and functional homology. Furthermore, epidermal growth factor increased ACC activity in rat hepatocytes and adipocytes. Therefore, it can be assumed that IGF-1 mediating bGH action may increase milk fat production by stimulation ACC with phosphorylation (short term) and/or increasing amounts of the enzyme proteins (long term). Consequently, the main purpose of this paper is to give the readers not only the galactopoietic effects of bGH, but also the insight of bGH action with regard to stimulating milk fat synthesis from the whole body to the molecular levels.