• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.258-258
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• 2017

We received 73 wheat resources from CIMMYT for analysis of agricultural characteristics and qualities of them. We sowed 73 lines and 4 Korean varieties in fall and spring to compare differences of wheat traits between fall and spring seeding. The heading and maturity date of fall seeding lines has coming faster average 18 days than spring seeding lines. Fall seeding lines have more number of spike per $m^2$ and grain number of spike. Spike and awn length of spring seeding lines were shorter than fall seeding lines and stem length was variable to varieties in both condition. Protein contents of five of 73 lines, Jokyoung and Jopoom varieties decreased but the others increased. The sedimentation values of 34 lines include Jokyoung and falling number (F/N) of 44 lines include two varieties, Keumkang and Jokyoung, decreased but the others increased, respectively. Particle size was presented that most spring seeding lines were bigger. However, when it sowed in fall, the lightness (L) of wheat flour was lighter. Consequently, we confirmed when it was sowed in spring, agricultural traits and qualities of wheat got weak.

• IMMUNE NETWORK
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• 제21권1호
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• pp.8.1-8.17
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• 2021

The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is a novel virus called the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). As of December 2020, there have been 80.2 million confirmed patients, and the mortality rate is known as 2.16% globally. A strategy to protect a host from SARS-CoV-2 is by suppressing intracellular viral replication or preventing viral entry. We focused on the spike glycoprotein that is responsible for the entry of SARS-CoV-2 into the host cell. Recently, the US Food and Drug Administration/EU Medicines Agency authorized a vaccine and antibody to treat COVID-19 patients by emergency use approval in the absence of long-term clinical trials. Both commercial and academic efforts to develop preventive and therapeutic agents continue all over the world. In this review, we present a perspective on current reports about the spike glycoprotein of SARS-CoV-2 as a therapeutic target.

• 한국작물학회지
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• 제24권2호
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• pp.35-41
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• 1979

To observe the effects of temperature and photoperiod on the growth and yield of winter wheat (Triticum aestivum, L) eight varieties including Chang Kwang were tested at various treatments like longday-high temperature (24hrs-20\circ), shortdayhigh temperature (12hrs-20\circ), longday-low temperature (24hrs-14\circ) and shortday-low temperature (12hrs-14\circ). Among the traits measured, days to heading, plant height, spike length, number of spikes per hill and grain yield per hill were generally decreased at high temperature and long day treatment and increased at low temperature and shortday condition. Number of grains per spike was decreased at low temperature and short day condition while increased at longday and high temperature conditions. Grain weight was decreased significantly at high temperature and shortday while increased at low temperature and longday treatment.

• 센서학회지
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• 제27권1호
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• pp.64-67
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• 2018

A new CMOS neuron circuit for implementing bistable synapses with spike-timing-dependent plasticity (STDP) properties has been proposed. In neuromorphic systems using STDP properties, the short-term dynamics of the synaptic efficacies are governed by the relative timing of the pre- and post-synaptic spikes, and the efficacies tend asymptotically to either a potentiated state or to a depressed one on long time scales. The proposed circuit consists of a negative shifter, a current starved inverter and a schmitt trigger designed using 0.18um CMOS technology. The simulation result shows that the proposed circuit can reduce the total size of neurons, and the spike energy of the proposed circuit is much less compared to the conventional circuits.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.100-104
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• 2022

The gene encoding solute carrier family 9 member 6 (SLC9A6) on Xq26.3 is associated with Christianson syndrome (CS) mimicking Angelman syndrome. In CS, developmental and epileptic encephalopathy (DEE) appears in about 20%, and DEE with spike-and-wave activation in sleep (SWAS) is reported only in several cases. A 10-year-old boy with DEE showed multidrug resistant focal seizures from 6 months of age. He had progressive microcephaly, regression, global developmental delay without speech, hyperkinesia, and truncal ataxia; he had a long thin face, esotropia, and happy demeanor. Brain magnetic resonance imaging demonstrated cerebellar atrophy. Electroencephalogram at 7.5 years of age showed nearly continuous diffuse paroxysms in slow wave sleep. The seizures were responsive to corticosteroids for a while. Trio whole exome sequencing exhibited a likely pathogenic variant of SLC9A6 in the proband and his asymptomatic mother: c.1194dup (p.Leu399AlafsTer12). This is a rare case report of CS with DEE-SWAS in a Korean patient.

• The Korean Journal of Physiology
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• 제22권2호
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• pp.189-206
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• 1988

The effects of ouabain on the contractile and electrical activities were investigated in the isolated preparations of guinea-pig taenia coli, and compared with those of vanadate. Spontaneous contractions were recorded with force transducer, and electrical activites were measured by use of suction electrode, or single sucrose-gap technique. The contractions were induced by the electrical stimulation for 5 seconds every 1 minute with alternating current (60 Hz, 3.0 V/cm) through the platinum electrodes located in parallel with the long axis of the preparation. All experiments were performed in tris-buffered Tyrode solution which was aerated with $100%{\;}O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) Responses of spontaneous contractions to ouabain were concentration-dependent; $10^{-7}M$ ouabain caused a rise of basal tone. Above the concentration of $10^{-6}M$ ouabain, an initial increase followed by a decrease in tension was observed. 2) A continuous spike discharge was induced by the administration of $10^{-7}M$ ouabain. Above $10^{-6}M$ ouabain, a transient initial increase followed by a decrease in spike frequency and amplitude was produced, and finally membrane potential was sustained at a certain level without a spike discharge. 3) The characteristic response to $10^{-7}M$ ouabain was not blocked by the pretreatment with $10^{-7}M$ atropine. 4) The electrically induced contractions were completely suppressed at the concentration of $2{\times}10^{-7}M$ ouabain. These contractions were blocked more rapidly in paralled with the increase in ouabain concentration. 5) Effects of vanadate on the spontaneous activities were quite different from those of ouabain; $10^{-6}M$ vanadate increased the amplitude of contractions and $10^{-5}M$ vanadate increased slightly both amplitude and frequency of spontaneous contractions. $10^{-4}M$ vanadate showed irregular phasic contractions superimposed on the increased basal tone. 6) $10^{-5}M$ vanadate depolarized the membrane potential and shortened the interval between the bursts of spike discharge, whereas $10^{-4}M$ vanadate induced continuous spike discharge with membrane depolarization. 7) Vanadate caused a characteristic inhibitory response to the contractions induced by electrical stimulation; An initial rapid inhibition of tension development and then gradual recovery to a certain level. From the above results, the following conclusions could be made: 1) The rise of basal tone at $10^{-7}M$ ouabain is due to continuous spike discharge without a silent period. The continuous spike discharge is likely to be associated with a slight membrane depolarization caused by the blockage of Na pump. 2) The biphasic response induced by above $10^{-6}M$ ouabain seems to occur by the different mechanisms. The initial increase in tension is associated with depolarization along with an increase in spike frquency, whereas the subsequent relaxation occurs through a non-electrical mechanism. 3) The characteristic response to $10^{-7}M$ ouabain is resulted not from the action on intrinsic nerve terminal, but from its direct action on the membrane of smooth muscle cells. 4) The phasic contractions superimposed on the increased basal tone at the concentration of $10^{-4}M$ vanadate is resulted from the continuous spike discharge with membrane depolarization, of which mechanism remains unknown. 5) The inhibitory action of ouabain on the electrically induced contractions suggests that the increasein intracellular Na in some way inhibits the electrically induced $Ca^{2+}$ influx. The mechanism of vanadate action on the induced contractions remains unknown.

• 한국의학물리학회지:의학물리
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• 제18권2호
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• pp.73-80
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• 2007

제주 해안에서 잡은 60여 개의 군소를 대상으로 한 실험 데이터 중에서 5개의 세포에 대한 실험 결과를 분석해 보니 주목할 만한 결과들이 나왔다. 이들 5개의 세포들 중에 3개의 세포에서는 $32^{\circ}C$에서 $10^{\circ}C$까지 온도를 내리는 동안에 이완된 진동 상태, 연속발화상태 사이의 과분극 기간이 짧은 버스팅, 혼돈 양상의 버스팅, 주기 배가 양상, 연속발화 기간은 길고 휴지 기간은 짧은 버스팅, 일정하게 반복되는 비팅 상태이거나 타원형 버스팅, 휴지상태가 차례차례로 나타났으며, $10^{\circ}C$에서 $32^{\circ}C$까지 온도를 올리는 동안에는 그 반대 순서로 발화 형태가 변화하였다. 같은 온도 범위에서 80분 정도의 주기로 계속해서 열변화 자극을 줄 때마다 이러한 발화 형태 변화는 일정하게 나타났다. 그러나 나머지 두 세포의 경우에는 이와는 다른 발화 형태의 온도에 따른 변화를 보였다. 이들 경우에 이러한 열변화 자극을 24시간 이상 지속하였으나 발화 진폭은 크게 줄어들지 않았다. 그리고 평균발화 진동수, 버스팅 신호 사이의 평균 과분극상태 지속시간, 활동전위 진폭과 활동전위의 최저값 등을 $C^{++}$로 짠 프로그램을 실행시켜서 비교 분석 가능하였다. 온도에 따른 발화 진동수의 분포는 저온과 고온에서는 낮으나 중간 영역에서는 높은 종 모양의 형태를 보였는데, 온도를 내리는 동안에는 온도를 올리는 동안 보다 발화 진동수가 높았다.

• 천문학회보
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• 제41권2호
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• pp.52.1-52.1
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• 2016

The Gamma-Ray Bursts (GRBs) are classified into the long GRBs (LGRBs) and the short GRBs (SGRBs). Their progenitors are expected to be different because they have its own distinct characteristics. Occasionally, the SGRBs having faint extended emission (EGRBs) are observed. The EGRBs exhibit the analogous properties that the SGRBs have, but observed T90 of the EGRBs is longer than two seconds as the LGRBs. Because the EGRBs have characteristics of the LGRBs and the SGRBs, study of the EGRBs is important to understand origins of the GRBs. In this study, we obtain the luminosity relations of the EGRBs observed by Swift/BAT. We compare these results with luminosity relations on the LGRBs and SGRBs. In addition, we examine the spectral lag relations of spike and extended emission component of the EGRBs detected by CGRO/BATSE, Konus/WIND, Swift/BAT, Fermi/GBM and compare to each other. We find that the luminosity relations of the EGRBs present different results with the LGRBs and the SGRBs. In the spectral lag relations, extended emission component expresses opposite results compared with spike component. Furthermore, the spectral lag relations from the four instruments came up with different outcomes to each other.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 A
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• pp.701-703
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• 2004

Although the electricity market structure worldwide may be different in kinds, there generally exists long-term forward market and short-term spot market. Particularly, the bilateral contract in long-term forward market fixes the price between a genco and a customer so that the customer can avoid risks due to price-spike in spot market. The genco also can make an efficient risk-hedge strategy through this bilateral contract. In this paper, we propose a new mechanism for evaluating the optimal bilateral contract price using game theory. This mechanism makes a customer reveal his/her own willingness to purchase electricity so that a fair bilateral contract price can be derived.

• 전기학회논문지P
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• 제59권3호
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• pp.263-267
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• 2010

Although electricity market structures may be different from each country, they have a long-term forward market and a short-term spot market in general. Particularly, a bilateral contract transacted at a long-term forward market fixes the electricity price between a genco and a customer so that the customer can avoid risk due to price-spike in the spot market. The genco also can make an efficient risk-hedging strategy through the bilateral contract. In this paper, we propose a new mechanism for deriving the optimal bilateral contract price using game theory. This mechanism can make the customer reveal his true willingness to purchase so that an adequate bilateral contract price is derived.