• Journal of Ginseng Research
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• v.48 no.3
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• pp.276-285
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• 2024

Diabetes mellitus (DM) is a systemic disorder of energy metabolism characterized by a sustained elevation of blood glucose in conjunction with impaired insulin action in multiple peripheral tissues (i.e., insulin resistance). Although extensive research has been conducted to identify therapeutic targets for the treatment of DM, its global prevalence and associated mortailty rates are still increasing, possibly because of challenges related to long-term adherence, limited efficacy, and undesirable side effects of currently available medications, implying an urgent need to develop effective and safe pharmacotherapies for DM. Phytochemicals have recently drawn attention as novel pharmacotherapies for DM based on their clinical relevance, therapeutic efficacy, and safety. Ginsenosides, pharmacologically active ingredients primarily found in ginseng, have long been used as adjuvants to traditional medications in Asian countries and have been reported to exert promising therapeutic efficacy in various metabolic diseases, including hyperglycemia and diabetes. This review summarizes the current pharmacological effects of ginsenosides and their mechanistic insights for the treatment of insulin resistance and DM, providing comprehensive perspectives for the development of novel strategies to treat DM and related metabolic complications.

• Korean Circulation Journal
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• v.53 no.3
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• pp.168-169
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• 2023

• Korean Circulation Journal
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• v.53 no.6
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• pp.404-405
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• 2023

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08a
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• pp.239-244
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• 2007

Highly efficient and stable white PIN OLED structures have been developed with a focus on possible AM display applications. Due to the use of the novel air-stable Novaled n-dopant material NDN26, the mass production compatibility of the PIN approach is improved. With both a conventional n-dopant, NDN1, and a novel air-stable n-dopant, NDN26, similar performance in efficiency and lifetime are reached. Based on highly a stable red fluorescent emitter system, the Novaled PIN approach allows for reaching ultra-long lifetimes of 1,000,000 hours at a brightness of $1,000\;cd/m^2$, both for top and for bottom emission layouts. Furthermore, inverted PIN structures for a possible use in a-Si backplane applications for AM displays are shown. With a phosphorescent green emitter system it could be demonstrated that for bottom and inverted as well as non-inverted top emission, a brightness of $1,000\;cd/m^2$ can be reached at below 3 V. In addition to low operating voltages and long lifetimes, PIN OLEDs also enable for device structures with extremely low operating voltage drifts, a feature of increasing importance for future AM display developments.

• Steel and Composite Structures
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• v.6 no.3
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• pp.237-255
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• 2006

This paper presents a novel analytical formulation for the analysis of composite beams with partial shear interaction stiffened by a bolted longitudinal plate accounting for time effects, such as creep and shrinkage. The model is derived by means of the principle of virtual work using a displacement-based formulation. The particularity of this approach is that the partial interaction behaviour is assumed to exist between the top slab and the joist as well as between the joist and the bolted longitudinal stiffening plate, therefore leading to a three-layered structural representation. For this purpose, a novel finite element is derived and presented. Its accuracy is validated based on short-and long-term analyses for the particular cases of full shear interaction and partial shear interaction of two layers for which solutions in closed form are available in the literature. A parametric study is carried out considering different stiffening arrangements to investigate the influence on the short-and long-term behaviour of the composite beam of the shear connection stiffness between the concrete slab and the steel joist, the stiffness of the plate-to-beam connection, the properties of the longitudinal plate and the concrete properties. The values of the deflection obtained from the finite element simulations are compared against those calculated using the effective flexural rigidity in accordance with EC5 guidelines for the behaviour of elastic multi-layered beams with flexible connection and it is shown how the latter well predicts the structural response. The proposed numerical examples highlight the ease of use of the proposed approach in determining the effectiveness of different retrofitting solutions at service conditions.

• International Journal of Computer Science & Network Security
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• v.21 no.2
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• pp.77-87
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• 2021

In this study, a novel improved second order Radial Basis Function Neural Network based method with excellent scheduling capabilities is used for the dynamic prediction of short and long-term energy required applications. The effectiveness and the reliability of the algorithm are evaluated using training operations with New England-ISO database. The dynamic prediction algorithm is implemented in Matlab and the computation of mean absolute error and mean absolute percent error, and training time for the forecasted load, are determined. The results show the impact of temperature and other input parameters on the accuracy of solar Photovoltaic load forecasting. The mean absolute percent error is found to be between 1% to 3% and the training time is evaluated from 3s to 10s. The results are also compared with the previous studies, which show that this new method predicts short and long-term load better than sigmoidal neural network and bagged regression trees. The forecasted energy is found to be the nearest to the correct values as given by England ISO database, which shows that the method can be used reliably for short and long-term load forecasting of any electrical system.

• Journal of Microbiology and Biotechnology
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• v.32 no.8
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• pp.1026-1033
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• 2022

This study presents a novel DNA part characterization technique that increases throughput by combinatorial DNA part assembly, solid plate-based quantitative fluorescence assay for phenotyping, and barcode tagging-based long-read sequencing for genotyping. We confirmed that the fluorescence intensities of colonies on plates were comparable to fluorescence at the single-cell level from a high-end, flow-cytometry device and developed a high-throughput image analysis pipeline. The barcode tagging-based long-read sequencing technique enabled rapid identification of all DNA parts and their combinations with a single sequencing experiment. Using our techniques, forty-four DNA parts (21 promoters and 23 RBSs) were successfully characterized in 72 h without any automated equipment. We anticipate that this high-throughput and easy-to-use part characterization technique will contribute to increasing part diversity and be useful for building genetic circuits and metabolic pathways in synthetic biology.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.62.5-62
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• 2001

In this paper, we present a novel control method for the plant with an integral mode and long time delay. In a constant time delay problem, one can independently adjust the set response and the disturbance response by the proposed DTC without any additional control variables. To verify the effectiveness of the proposed DTC, it is compared with Matausek´s DTC and Normey-rico´s DTC which were recently proposed. Simulation results are given and the superior performance of the proposed scheme over the conventional schemes are successfully verified.

• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1443-1454
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• 2011

Methods to prepare novel second-order nonlinear optical (2O-NLO) materials composed of all-silica zeolite (silicalite-1) and a series of 2O-NLO molecules having high second order hyperpolarizability constants (${\beta}$ values) are reviewed. These methods include the development of novel methods to incorporate a series of hemicyanine (HC) molecules into the channels of silicaite-1 films in uniform orientations. The first method is to incorporate HC molecules tethered with long alkyl chains (octadecyl or longer) into the silicalite-1 channels with the long alkyl chain side first through the hydrophobic-hydrophobic interaction between the long alky chains and the silicalite-1 channels. The second method is to incorporate the HC molecule tethered with a medium length alkyl chain (nonyl) into the silicalite-1 channels with the medium length alkyl chain side first through hydrophobic-hydrophobic interaction between the medium length alky chain in the photoexcited state and the silicalite-1 channels. The third method is to incorporate the HC molecule tethered with propionic acid into the silicalite-1 channels with the propionic acid side last mediated by a tetrabultylammonium cation ion-paired to the propionate unit. A method to prepare a novel third-order nonlinear optical (3O-NLO) material composed of zeolite-Y and PbS or PbSe quantum dots is also reviewed. This Account thus describes a promising new direction to which the search for highly sensitive 2O-NLO and 3O-NLO materials has to be conducted and a new direction to which zeolite research and applications have to be expanded.

• Wind and Structures
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• v.31 no.1
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• pp.21-29
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• 2020

The wind field measurement of severe winds such as hurricanes (or typhoons), thunderstorm downbursts and other gales is important issue in wind engineering community, both for the construction and health monitoring of the wind-sensitive structures. Although several wireless data transmission systems have been available for the wind field measurement, most of them are not specially designed for the wind data measurement in structural wind engineering. Therefore, the field collection is still dominant in the field of structural wind engineering at present, especially for the measurement of the long-term and high-frequency wind speed data. In this study, for remote wind field measurement, a novel wireless long-term and high-frequency wind data acquisition system with the functions such as remote control and data compression is developed. The system structure and the collector are firstly presented. Subsequently, main functions of the collector are introduced. Also novel functions of the system and the comparison with existing systems are presented. Furthermore, the performance of this system is evaluated. In addition to as the wireless transmission for wind data and hardware integration for the collector, the developed system possesses a few novel features, such as the modification of wind data collection parameters by the remote control, the remarkable data compression before the data wireless transmission and monitoring the data collection by the cell phone application. It can be expected that this system would have wide applications in wind, meteorological and other communities.