• Radiation Oncology Journal
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• 제38권2호
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• pp.119-128
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• 2020

Purpose: Colorectal cancer is becoming an increasing concern in the middle-aged population of Iran. This study aimed to compare the preliminary results of short-course and long-course neoadjuvant chemoradiotherapy treatment for rectal cancer patients. Materials and Methods: In this clinical trial we recruited patients with rectal adenocarcinoma located from 5 cm to 15 cm above the anal verge. Patients in group I (short-course) received three-dimensional conformational radiotherapy with a dose of 25 Gy/5 fractions in 1 week plus concurrent XELOX regimen (capecitabine 625 mg/㎡ from day 1-5 twice daily and oxaliplatin 50 mg/㎡ on day 1 once daily). Patients in group II (long-course) received a total dose of 50-50.4 Gy/25-28 fractions for 5 to 5.5 weeks plus capecitabine 825 mg/㎡ twice daily. Both groups underwent consolidation chemotherapy followed by delayed surgery at least 8 weeks after radiotherapy completion. The pathological response was assessed with tumor regression grade. Results: In this preliminary report on complications and pathological response, 66 patients were randomized into two study groups. Mean duration of radiotherapy in the group II (long-course) was 5 ± 1 days (range, 5 to 8 days) and 38 ± 6 days (range, 30 to 58 days). The median follow-up was 18 months. Pathological complete response was achieved in 32.3% and 23.1% of patients in the shortcourse and long-course groups, respectively (p = 0.558). Overall, acute grade 3 or higher treatment-related toxicities occurred in 24.2% and 22.2% of patients in group I and II, respectively (p = 0.551). No acute grade 4 or 5 adverse events were observed in either group except one grade 4 hematologic toxicity that was seen in group II. Within one month of surgery, no significant difference was seen regarding grade ≥3 postoperative complications (p = 0.333). Conclusion: For patients with rectal cancer located at least 5 cm above the anal verge, short-course radiotherapy with concurrent and consolidation chemotherapy and delayed surgery is not different in terms of acute toxicity, postoperative morbidity, complete resection, and pathological response compared to long-course chemoradiotherapy.

• 한국발생생물학회지:발생과생식
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• 제14권1호
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• pp.21-25
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• 2010

Nile tilapia (Oreochromis niloticus) are mouth-brooders so that the females holding eggs in their mouth sacrifice their somatic growth for reproduction. For this reason, artificial control of reproduction for the culture of this species has been of interest. Manipulation of photoperiod is an emerging technique for such purpose, but little information is available to establish appropriate photoperiod regime. To obtain necessary basic information, sexually mature females were individually accommodated to glass aquarium, and the spawning activity of these females were monitored for two years under natural photoperiod regime. Female tilapia spawned most frequently on March, April and May when the day length gradually increased from 11 hours to 14 hours and least frequently on September, October, November and December when the day length gradually decreased from 13 hours to less than 10 hours in the first year. The decrease of spawning frequency as day length decreased was also observed in the second year, although the increase of spawning frequency as day length increased was less clear. Spawning of female tilapia was less active when the night was dark due to the disappearance of moonlight (Dark Phase), compared to the Phase of Getting Lighter, Light Phase and Phase of Getting Darker. Results from this study suggest that long day length, particularly increasing phase, is favoured for active spawning of Nile tilapia, and that this species, as a tropical fish species, may utilize changing lunar phases as a secondary environmental cue for reproduction.

• 한국물환경학회지
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• 제28권2호
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• pp.247-254
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• 2012

Soil and Water Assessment Tool (SWAT) model has been widely used in estimation of flow and water quality at various watersheds worldwide, and it has an auto-calibration tool that could calibrate the flow and water quality data automatically from thousands of simulations. However, only continuous measured day flow/water quality data could be used in the current SWAT auto-calibration tool. Therefore, 8-day interval flow and water quality data measured nationwide by Korean Ministry of Environment (MOE) could not be used in SWAT auto-calibration even though long-term flow and water quality data in the Korean Total Maximum Daily Load (TMDL) watersheds available. In this study, current SWAT auto-calibration was modified to calibrate flow and water quality using 8-day interval flow and water quality data. As a result of this study, the Nash and Sutcliffe Efficiency (NSE) values for flow estimation using auto-calibration are 0.77 (calibration period) and 0.68 (validation period), and NSE value for water quality (T-P load) estimation (using the 8-day interval water quality data) is 0.80. The enhanced SWAT auto-calibration could be used in the estimation of continuous flow and water quality data at the outlet of TMDL watersheds and ungaged point of watersheds. In the next study, the enhanced SWAT auto-calibration will be integrated with Web based Load Duration Curve (LDC) system, and it could be suggested as methods of appraisal of TMDL in South Korea.

• 대한한방내과학회지
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• 제10권1호
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• pp.81-91
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• 1989

It has been known for a long time that Palmiwon water extract can be prescribed for the treatment of deficiency of Yang in oriental medicine. But the exact mechanism of it has not been Known yet. In the present experiments, it was attempted to explain the effect of Palmiwon water extract on the serum Hormone level in rabbits and the antifatigue in mice. Palmiwon water extract oral intake showed a increase of serum hormone level in rabbits and the effects of the antifatigue in mice. The results obtained were as follows. 1. The administration of this medicine was observed to cause continuously a significant increase of the testosterone content in the serum from the 7th day to the 21th day. 2. The estradiol centent in the serum, as compared with the control experiment, was seen to increase significantly by the administration of this medicine from the 7th day to the 21th day. 3. The LH and FSH content in the serum, as compared with the control experiment, indicated a tendency toward an increase by the administration of this medicine from the 7th day to the 21 th day, but with no significant difference. 4. In the effect to Palniwon on the antifatigue in mice, swimming time was prolonged in both sample A, B groups than control group, and significance revealed in both sample A, B groups. These data suggest that Palmiwon water extract can increase serum hormone level and that it can have therapeutic effectiveness to the antifatigue.

• 대한간호학회지
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• 제7권1호
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• pp.55-62
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• 1977

Varieties of literatures were reviewed in regard to the fundamental concept of day hospital, historical trends, the recipient of its care, facilities and personnel, therapeutic programmes and the follow-up care plans. Through the research the advantages of day hospital were highlighted in order to provide the reference for those who consider planning such health care institution. Since the introduction of the concept of day hospital and its implementation in 1930, many psychiatric patients world over are treated and cared. Patients with specific health problems ; alcoholism, acute or serious psychiatric disease, tendencies of humidor suicidal attempts, and with serious physical problems were excluded from the general recipient. Day hospital were annexed to the psychiatric hospitals in most in instances ; facilities, personnel, except nursing personnel, were shared. All therapeutic care were planned in daley, weekly programmes, and were focussed on socialization. The follow-up care were provided for those participating post- therapy club activities which were planned and introduced ahead. Many advantages of day-hospital care in contrast to the traditional hospitalization care were found: 1. The abrupt discontinuity of his family and other social role is prevented. 2. Therapeutic progress is faster. 3. Lessened economic burden to the family. 4. Behavioral regression is lessened and the lessened fear of hospitalization. 5. Less injury to the patients, self- respect, through lessened anxiety of hospitalization. 6. Incidents of secondary crisis believed to be existing in long term cases are decreased. 7. Therapeutic care implemented in freer atmosphere, better Patient-personnel relationships are created. 8. Varieties of group activities are Induced which enable faster recovery. 9. Patients could engage himself with social activities including getting job on part-time basis. 10. Rehabilitation of patient could be implemented.

• 한국환경보건학회지
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• 제47권5호
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• pp.446-453
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• 2021

Background: Plastic particles less than 5 mm in diameter (microplastics) are well-known for causing various toxicities such as lung inflammation, oxidative stress, genotoxicity, and reproductive toxicity. As microplastics become smaller, they can move across cell membranes, the placenta, and the blood-brain barrier. Objectives: We evaluated the toxicities of polyethylene microplastics (PE-PMs) in dams and neonates through intragastric intubation of pregnant ICR mice. Methods: Low concentrations (0.01 mg/mouse/day) and high concentrations (0.1 mg/mouse/day) of polyethylene microplastics were administered from the ninth day of pregnancy to postnatal day seven. The control group was administered with distilled water. On the day of sacrifice, the weight of dams and neonates and the organ weight of neonates was measured. Further, acetylcholinesterase levels and glutathione peroxidase levels were evaluated by using a blood sample obtained on the sacrifice day. Results: No significant difference in the number of neonates was found, but the body weight gain of dams was seen to be lower in the low-dose group. On the other hand, we observed a consecutively declining trend in the weight gain and organ weight of neonates among the high-, control, and low-dose groups. Meanwhile, the serum acetylcholinesterase and glutathione peroxidase level were higher in the low-dose group compared to the control group. Further, the dose-dependent accumulation of microplastics in the organs of neonates revealed the transport of plastic particles from dams to their offspring. Conclusions: Although the exact mechanism of toxicity caused by microplastics could not be confirmed, it was validated that exposure to microplastics during pregnancy and lactation causes its migration between generations and accumulation throughout the body. Hence, it is necessary to evaluate the systemic toxicity of microplastics and assessment of co-morbidities such as second-generation toxicity, neurotoxicity, and depression following long-term exposure.

• 한국환경보건학회지
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• 제48권2호
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• pp.106-115
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• 2022

Background: Current research suggests that humans are exposed to microplastics through consumption of foods and beverages, the airway route, and a variety of other means. Objectives: We evaluated oxidative stress and inflammation from polyethylene microplastics (PE-MPs) in the neonatal liver through intragastric administration or intratracheal instillation in pregnant mice. Methods: PE-MPs were administered from gestational day 9 to postnatal day 7. The intragastric administration group (0.01 mg/mouse/day or 0.1 mg/mouse/day) and intratracheal instillation group (6 ㎍/mouse/day or 60 ㎍/mouse/day) of PE-MPs were administered. After sacrifice, the oxidative stress and inflammation of the neonatal livers were measured. Results: As a result of the oxidative stress caused by PE-MPs in the neonatal livers, glutathione peroxidase decreased in a concentration-dependent manner in the intragastric administration group compared to the control group and intratracheal instillation decreased in high concentration PE-MPs. The catalase level increased at high concentrations of intragastric administration and intratracheal instillation. To confirm the level of inflammation caused by PE-MPs, monocyte chemoattractant protein-1 and tumor necrosis factoralpha were increased compared to the control group except for intratracheal intilation-high concentration PEMPs. The C-reactive protein level was decreased by intragastric administration compared to the control group and intratracheal instillation was increased compared to the control group. Conclusions: Despite the difficulty in comparing the toxic intensity between intragastric administration and intratracheal instillation of PE-MPs, our study revealed that oxidative stress and inflammation were induced in the neonatal liver. However, it is necessary to evaluate the toxic effects of microplastics on various organs as well. Overall, the present study indicates that the evaluation of toxic effects of long-term microplastic exposure, potential of microplastic toxicity on next-generation offspring and toxicity mechanism in human should be considered for further investigations.

• 한국임상수의학회지
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• 제18권2호
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• pp.139-145
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• 2001

This study was undertaken to determine the normal serial ultrasonographic appearance of the postpartum uterine involution in small pet dogs (Yorkshire terrier and Maltese). Postpartum changes in uterine shape, architecture, echogenicity and diameter were monitored by ultrasonography in 12 small pet dogs. Serial ultrasonographic examinations were done daily during the first week, 3 days interval from 8 to 30 days, and weekly from 31 to 100 days postpartum. The excretory period of vaginal discharge in 12 normal bitches of uterine involution was finished completely within 3 weeks postpartum. The short axis shape of the uterus was initially often flaccid-appearing. It varied from circular to polygonal. This lasted until 15.75$\pm$3.84 days postpartum, during which time the short axis uterine shape gradually changed to circular. Also, the long axis shape of the uterus was a beaded appearance until 30.89$\pm$4.25 days postpartum. After 30 days, it was appeared as tubular shape between placental and interplacental sites. The ultrasonographic image of the postpartum uterus consisted of four echogenicity distinct layers. Uterine wall was represented as very hyperechoic serosa, hypoechoic myometrium, hyperechoic endometrium and anechoic structures of fluid in the uterine cavity until 7 days postpartum. The individual uterine layers were most prominent during the first week postpartum, and they became progressively less distinct throughout the course of uterine involution. The thickness of myometrium was decreased rapidly in the placental sites from 4.47$\pm$1.42 mm at 1 day to 1.92$\pm$0.26 mm at 16 day, and in the interplacental sites from 3.19$\pm$0.61 mm at 1 day to 1.39$\pm$0.61 mm at 16 day. And it was decreased slowly until 94 day and was been minimum thickness at 94 day. The thickness of endometrium was also decreased like that of myometrium. The uterine diameter in the placental sites was decreased from 22.28$\pm$3.01 mm at 1 day to 16.11$\pm$1.46 mm at 7 day, and in the interplacental sites was decreased from 13.65$\pm$2.34 mm at 1 day to 9.41$\pm$1.59 mm at 7 day postpartum. From 7 day to 93 day, the change of diameter was more and more slow. At 94 days postpartum, the uterine diameter was 5~6 mm both placental and interplacental sites, and the uterine horns were uniform hypoechoic, tubular structures without enlargement. Therefore, complete involution of the uterus occurred at 94 days. It was concluded that normal post partum uterine involution in small pet dogs appeared to be completed 94 days postpartum by gross findings such as vaginal discharges, and by ultrasonographic findings, uterine shape and echogenicity.

• 한국농공학회지
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• 제14권3호
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• pp.2703-2715
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• 1972

본 실험 연구는 흙수로내에서의 용수손실에 관한 연구로서 물을 필요로 하는 논과 밭까지 필요한 시기에 필요한 양만큼을 보급해 주어야 하는 관개계획을 수립함에 있어 매년 높아져 가는 사수위에 늘어가는 필요 수량과의 함수관계를 해결하는 지표를 주는데 목표을 두었다. 시험은 용수계통인 간선, 지선, 분선수로로 구분하여 간선수로에서는 1,000m 구간을 잡아 유속계측정 방법으로 지선수로에서는 500m 구간을 잡아 상 하류에 파야샬후륨을 설치하여 측정하였으며 분선수로에서는 200m 구간을 상 하류에 사각예언웨어를 설치하여 손실을 측정하였으며 기타손실에 영향을 주는 제요인들도 조사하여 다음 결과를 얻었다. (1) 1,000m 구간의 간선수로에서는 9.64%의 통수손실을 보였으며, 500m 구간의 지선수로에서는 15.55%. 200m 구간의 분선수로에서는 12.34%의 통수손실율을 보였다. (2) 삼투량조사는 지선수로를 40m 간격으로 3번 반복조사에서 2.08cm/day 또 200m 간격의 지선수로에서는 1일 평균 3.37cm/day의 삼투량을 얻었다. (3) 단 1회의 결과치를 객관성 있게 취급은 곤난하며 종래에 사용해 온 결과치보다는 손실과 삼투가 공히 상당히 큰 값을 보여주고 있어 좀 더 자세한 연구가 필요하다.

• 한국환경과학회지
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• 제12권7호
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• pp.697-704
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• 2003

Through data analysis using the meteorological data during 40 years(1961∼2000) for 2 stations(Daegu and Chupungnyong), we studied the present condition and long-term trends in urban climatic environments of Daegu. It was found that there was about 1.5$^{\circ}C$ rise in annual mean temperature of Daegu from 1961 to 2000. On the other hand, that of Chupungnyung was not more than 0.4$^{\circ}C$ for the same period. The regional disparity in temperature changes has been caused by the difference of urban effects on climate between two regions. In particular, the urban warming appears more significant in winter season. There was about 3$^{\circ}C$ rise in annual mean daily minimum temperature of winter season(Dec.∼Feb.) in Daegu. As the result, the number of winter days continuously decreased from 115 days(1961) to 75 days(2000). The long-term trends of relative humidity were also studied to exame the effects of urbanization on climate in Daegu. It was found that there was about 7% decrease in relative humidity of Daegu during past 40 years(1961∼2000). On the other side, the decrease of Chupungnyung was not more than 2% for the same period. The long-term trends of the other climatic factors(fog days, tropical night days, etc) were also studied in this study.