• 한국안전학회지
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• 제15권4호
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• pp.119-122
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• 2000

The truss bridge is composed of numerous steel beams. In long span bridges the size of beams is getting larger, so the number of plate girders is increasing instead of rolled beams. This plate girder has long welding lines at the intersection of steel plates. The improper welding at the intersection line causes the steel bridge to be structurally unsafe. In this paper the loss of member section from improper welding was measured and the experimental testing was performed to get the S-N curve from testing models with sectional losses. The improper welding resulted in the lowering of structural safety and the shortening of life cycle.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.5.1-5.14
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• 2023

Background: Perfluoroalkyl substances (PFAS) are chemicals widely used in various products in everyday life. Due to its unique strong binding force, the half-life of PFAS is very long, so bioaccumulation and toxicity to the human body are long-standing concerns. In particular, effects on kidney function have recently emerged and there are no studies on the effect of PFAS on kidney function through epidemiological investigations in Korea. From 2018 to 2020, the Korean National Environmental Health Survey (KoNEHS) cycle 4, conducted an epidemiological investigation on the blood concentration of PFAS for the first time in Korea. Based on this data, the relationship between PFAS blood concentration and kidney function was analyzed for adolescents. Methods: We investigated 5 types of PFAS and their total blood concentration in 811 middle and high school students, living in Korea and included in KoNEHS cycle 4, and tried to find changes in kidney function in relation to PFAS concentration. After dividing the concentration of each of the 5 PFAS and the total concentration into quartiles, multivariable linear regression was performed to assess the correlation with kidney function. The bedside Schwartz equation was used as an indicator of kidney function. Results: As a result of multivariable linear regression, when observing a change in kidney function according to the increase in the concentration of each of the 5 PFAS and their total, a significant decrease in kidney function was confirmed in some or all quartiles. Conclusions: In this cross-sectional study of Korean adolescents based on KoNEHS data, a negative correlation between serum PFAS concentration and kidney function was found. A well-designed longitudinal study and continuous follow-up are necessary.

• 한국안전학회지
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• 제27권4호
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• pp.115-120
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• 2012

In order to establish preventive maintenance standards through analysis & reliability prediction of about 60,000pcs of 20kindsof relays and contractors used for Seoul subway trains, several life prediction methodologies were applied. Firstly, Occurrence, Severity, Detection were defined and predicted by applying operation characteristic of EMU to the number of actions of relays & contactors which the manufacturers generally offer as the life cycle data. Secondly, failure distribution and average life of parts were analyzed through interpretation of field data based on a lot of experience which had built up in the field for a long time. Finally, using the 217PLUS standard as a reliability prediction program, comparative analysis of use reliability and inherent reliability was done through reliability prediction at the part level and system level.

• 한국CDE학회논문집
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• 제17권4호
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• pp.234-245
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• 2012

This paper proposes a multi-level product modeling framework for long-term lifecycle products. The framework can help engineers to define product models and relate them to physical instances. The framework is defined in three levels; data, design model, modeling language. The data level represents real-world products, The model level describes design models of real-world products. The modeling language level defines concepts and relationships to describe product design models. The concepts and relationships in the modeling language level enable engineers to express the semantics of product models in an engineering-friendly way. The interactions between these three levels are explained to show how the framework can manage long-term lifecycle product information. A prototype system is provided for further understanding of the framework.

• 대한토목학회논문집
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• 제32권4D호
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• pp.345-356
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• 2012

도로포장은 충족되어야 하는 서비스 수준을 유지하기 위해 반복적인 유지보수를 필요로 한다. 그러나 노후화된 하부구조와 반복적인 유지보수는 포장의 파손속도를 가속화시키기도 하며, 이는 한정된 예산의 효율성을 저해하는 요소가 될 수 있다. 따라서 본래의 기능을 유지하기 위해 도로의 재포장이 주기적으로 요구된다. 특히, 국도는 그 건설수요가 한계점에 다다랐으며, 노후로 인해 재포장 및 유지관리의 필요가 점점 증가하고 있는 시점이다. 그러나 도로관리자들은 예산의 한계로 이러한 노후포장에 대해 재포장 및 효율적인 유지관리를 시행하기에 많은 어려움을 겪고 있다. 이는 의사결정에 필요한 장기적인 유지보수 전략의 부재 때문이라 할 수 있다. 이에 본 논문은 반복적인 유지보수로 인한 포장의 상태변화를 고려한 유지보수 전략을 도출하여 관리자들의 의사결정에 도움을 주고자 하였다. 분석을 위해 포장관리시스템(PMS)이 도입된 1986년부터 장기간 누적된 국도의 유지보수 이력데이터를 활용하였으며, 방법론으로는 유지보수 횟수에 따른 수명분포 도출 및 위험률(hazard) 함수의 변화과정을 분석한 후, 이 결과를 근거로 다양한 유지보수 대안들에 대해 중장기 유지보수비용을 산정하였다. 이를 위해 포장파손과정의 불확실성을 고려하고, 도로관리자들에게 보다 실용적인 정보를 제공하기 위해 확률론적 방법(몬테카를로기법)을 추가로 도입하였다. 또한, 신뢰성 이론을 활용하여 유지보수에 대한 품질보증과 관련된 정보도 도출하고자 하였다. 이러한 정보는 장기유지보수전략 수립에 중요한 정보로 활용할 수 있다.

• 환경생물
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• 제35권2호
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• pp.160-168
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• 2017

비단털쥐 (Tscherskia triton)는 중국 북부와 한국, 극동러시아 지역 등 국한된 지역에 분포하며, 번식, 성장과 발달 및 분포에 관한 정보는 알려져 있으나 발정주기와 생식기관에 관한 번식생물학적 연구는 거의 연구된 바 없다. 이에 본 연구는 제주도에서 포획된 개체를 사육하면서 광주기에 따른 암컷 비단털쥐의 생식주기 및 생식기관의 특징을 밝혀 비단털쥐의 번식생물학적 정보를 제공하고자 진행하였다. 연구결과, 평소 사육환경(16L : 8D)에서의 비단털쥐 발정주기는 4~5일이었고, 발정 단계는 발정전기, 발정기, 발정후기, 발정휴지기의 4단계로 구분되었다. 광주기 8L : 16D 환경에서 비단털쥐의 발정주기는 6~12일째부터 발정휴지기 상태가 계속 유지되었다. 광주기에 따른 비단털쥐 생식기관의 조직도 차이를 보였다. 16L : 8D 경우에는 발달된 난소 내에 다수의 성숙 난포와 황체가 관찰되었고, 자궁내막도 두껍고 분비샘도 잘 발달되어 있었으나 8L : 16D 조건에서는 원시난포와 제2차, 3차 난모세포가 관찰되고 얇은 자궁내막과 발달되지 않는 자궁분비샘을 확인하였다. 이에 따라 광주기에 따른 비단털쥐의 생식주기 변화와 난소와 자궁의 조직학적 차이를 확인하였다. 이 결과는 비단털쥐의 번식생물학적 측면에서 매우 중요한 단서가 되는 자료이기에 생물종 다양성 유지를 위한 자료로 널리 활용될 것이라 판단된다.

• 여성건강간호학회지
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• 제12권1호
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• pp.53-60
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• 2006

Purpose: This study aimed to explore changes in symptom distress and functional status in gynecologic cancer patients during the entire treatment cycles of chemotherapy. Methods: A prospective and longitudinal study with repeated measures was designed. Symptom Distress Scale and Karnofsky Performance Status Index were included in a daily log developed for self-administration. A total of 39 patients with a mean age of 48.4 years participated. Results: The levels of symptom distress and functional status changed significantly over the six cycles. Symptom distress kept increasing until its peak at the fourth cycle, while the functional status scored lowest at the first cycle, then it improved as the cycle repeated. In each cycle, symptom distress was marked higher during the first 6 days accompanying poor functional status. However, both changes did not recover completely until the end of each cycle. Conclusion: Nursing assessment and intervention need to be provided based on these changing patterns to help cancer patients cope and adjust successfully during the long treatment period. Further studies are needed to examine the impact of the major symptoms on psychological responses, quality of life, and outcomes of the cancer treatments.

• 한국산학기술학회논문지
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• 제21권4호
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• pp.311-316
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• 2020

무기체계발 및 운영 간 지속적으로 발생하는 부품단종 문제를 해소하고, 비용대비 가장 효과적인 부품단종 대응방안을 선정하기 위해, 총수명주기 비용분석을 통해 정량적 성능개량 시점판단 기준을 제시한다. 이를 위해 국내외 비용분석 방안을 조사하고, 본 연구를 검증하기 위해 국내 운영장비 1종에 시범적용 하였다. 부품단종(DMSMS)이 발생하는 가장 큰 원인은 긴 수명주기를 갖는 무기체계에 비해 과학의 발전에 따라 부품의 빠른 교체주기와 짧은 수명주기 때문이다. 특히 군수품 양산 및 전력화단계 이후 운영유지 단계 시에는 이러한 부품수급문제가 더욱더 심화된다. 부품의 수명주기 초기 단계에는 신기술과 기능으로 인해 부품의 수정이 빈번하며 사용도는 낮은 반면 비용은 고가이다. 성숙 단계에서는 사용도는 최고이나 비용은 최저가 되며 이후 부품의 쇠퇴 단계를 거쳐 단종에 가까워지면 가격은 다시 상승하는 경향을 나타낸다. 또한 운용유지단계 장비의 경우 부품단종에 대한 소극적인 대응(재고확보 위주)으로 인해 소요군 장비유지 필수품목의 조달이 제한되고 있는 실정이다. 본 연구에서는 부품단종관리를 위한 수명주기비용 분석을 통해 정량적 성능개량 시점 판단기준을 수립하여 부품단종 문제에 대응하고 군수품의 총수명주기 소요비용 절감에 기여하고자 한다.

• BMB Reports
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• 제49권6호
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• pp.325-330
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• 2016

T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as a novel TCP10L-interacting protein. The interaction depends on the leucine zipper domain of both TCP10L and MAD1. TCP10L, but not the interaction-deficient TCP10L mutant, synergizes with MAD1 in transcriptional repression, cell cycle G1 arrest and cell growth suppression. Mechanistic exploration further revealed that TCP10L is able to stabilize intracellular MAD1 protein level. Consistently, the MAD1-interaction-deficient TCP10L mutant exerts no effect on stabilizing the MAD1 protein. Taken together, our results strongly indicate that TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.

• 종양간호연구
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• 제1권1호
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• pp.32-43
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• 2001

High risk breast cancer patients receive aggressive treatments such as APBSCT in order to prevent the recurrence. These treatments take a long time and decrease the quality of life of patients as a result. The purpose of this study is to examine when the changes of quality of life are dramatic in general and in specific dimension. This is a time series study of two types of treatment groups, in which 15 patients were treated by chemotherapy only and nine patients by auto-peripheral blood stem cell transplantation. Subjects were in this study were stage III and above of breast cancer. Data were collected from April 1999 to April 2000 with the 3 month-interval starting after 3rd cycle of chemotherapy. Data were collected 3 times ; treatment period, treatment finishing period and 3 months later after the treatment. Ferrell's QOL instrument was used which had been developed for the breast cancer patients in 1989. Repeated Measure ANOVA was used to examine differences of quality of life at 3 points of time respectively. As a result, average age was 43.29 years (4.38yrs) and the number of married person was 22(91.7%). Scores of quality of life were 5.45 at 1st period after 3rd cycle of chemotherapy, 5.17 after treatment, 5.10 at 3 months later after treatment and difference of quality of life was decreased according to period of treatment (P=.085). Only the psychological dimension of the quality of life showed the significant difference (P=.045). Two different treatment groups showed a difference of quality of life at 3 month later after treatment. In conclusions, high risk breast cancer patients showed the decreased quality of life related to treatment up to 3 months later of treatment. Subjects who received APBSCT returned to the normal quality of life more rapidly than those who received chemotherapy. Psychological nursing intervention was needed during the whole period of treatment.