• Journal of Korean Neurosurgical Society
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• 제52권6호
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• pp.517-522
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• 2012

Objective : Meningiomas represent 18-20% of all intracranial tumors and have a 20-50% 10-year recurrence rate, despite aggressive surgery and irradiation. Hydroxyurea, an inhibitor of ribonucleotide reductase, is known to inhibit meningioma cells by induction of apoptosis. We report the long-term follow-up result of hydroxyurea therapy in the patients with recurrent meningiomas. Methods : Thirteen patients with recurrent WHO grade I or II meningioma were treated with hydroxyurea (1000 $mg/m^2/day$ orally divided twice per day) from June 1998 to February 2012. Nine female and 4 male, ranging in age from 32 to 83 years (median age 61.7 years), were included. Follow-up assessment included physical examination, computed tomography, and magnetic resonance imaging (MRI). Standard neuro-oncological response criteria (Macdonald criteria) were used to evaluate the follow-up MRI scans. The treatment was continued until there was objective disease progression or onset of unmanageable toxicity. Results : Ten of the 13 patients (76.9%) showed stable disease after treatment, with time to progression ranging from 8 to 128 months (median 72.4 months; 6 patients still accruing time). However, there was no complete response or partial response in any patients. Three patients had progressive disease after 88, 89, 36 months, respectively. There was no severe (Grade III-IV) blood systemic disorders and no episodes of non-hematological side effects. Conclusion : This study showed that hydroxyurea is a modestly active agent against recurrent meningiomas and can induce long-term stabilization of disease in some patients. We think that hydroxyurea treatment is well tolerated and convenient, and could be considered as an alternative treatment option in patients with recurrent meningiomas prior to reoperation or radiotherapy.

• The Journal of Asian Finance, Economics and Business
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• 제9권2호
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• pp.71-79
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• 2022

The aim of this study is to see how government spending on education, health, and social security affects ratios in Indonesia. The third sector has a critical role to play in reducing the dependency ratio. It also aims to lower unemployment and poverty rates. This study uses the GMM panel data model. This model can determine the dynamic response of the ratio that comes from a number of variables. This study uses data from 33 provinces from 2010 to 2018. The results show that government spending in the education and health sectors has a positive effect on the dependency ratio, both in the short and long term. Social security has a significant effect on the dependency ratio in the long term, but not in the short term. Government spending in the education sector and health sector and social security sector have a positive and significant effect on disease and illness. The study's findings show a high level of poverty with a large standard deviation. The high ratio value is due to the large number of restrictions placed on a number of regions. Each province has made a significant contribution to overcoming these challenges, particularly in terms of the comparative ratio.

• Clinical and Experimental Reproductive Medicine
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• 제41권3호
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• pp.125-131
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• 2014

Objective: Under estrogen deficiency, blastocysts cannot initiate implantation and enter dormancy. Dormant blastocysts live longer in utero than normal blastocysts, and autophagy has been suggested as a mechanism underlying the sustained survival of dormant blastocysts during delayed implantation. Autophagy is a cellular degradation pathway and a central component of the integrated stress response. Reactive oxygen species (ROS) are produced within cells during normal metabolism, but their levels increase dramatically under stressful conditions. We investigated whether heightened autophagy in dormant blastocysts is associated with the increased oxidative stress under the unfavorable condition of delayed implantation. Methods: To visualize ROS production, day 8 (short-term dormancy) and day 20 (long-term dormancy) dormant blastocysts were loaded with $1-{\mu}M$ 5-(and-6)-chloromethyl-2', 7'-dichlorodihydrofluorescein diacetate, acetyl ester (CM-$H_2DCFDA$). To block autophagic activation, 3-methyladenine (3-MA) and wortmannin were used in vivo and in vitro, respectively. Results: We observed that ROS production was not significantly affected by the status of dormancy; in other words, both dormant and activated blastocysts showed high levels of ROS. However, ROS production was higher in the dormant blastocysts of the long-term dormancy group than in those of the short-term group. The addition of wortmannin to dormant blastocysts in vitro and 3-MA injection in vivo significantly increased ROS production in the short-term dormant blastocysts. In the long-term dormant blastocysts, ROS levels were not significantly affected by the treatment of the autophagy inhibitor. Conclusion: During delayed implantation, heightened autophagy in dormant blastocysts may be operative as a potential mechanism to reduce oxidative stress. Further, ROS may be one of the potential causes of compromised developmental competence of long-term dormant blastocysts after implantation.

• 한국수자원학회논문집
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• 제49권1호
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• pp.41-49
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• 2016

본 연구에서는 일강수량의 누적 패턴을 고려하여 새로운 가뭄지수(RADI)를 개발하였다. RADI는 누적 강수량의 장기간의 평균과 특정 기간에 관측된 누적 강수량을 비교하여 일단위로 가뭄지수를 간단히 산정할 수 있도록 개발되었다. 우리나라의 대표적인 가뭄기간 동안의 RADI의 시 공간적 변동성과 재현 주기를 살펴봄으로써 장 단기 가뭄의 감시에 대한 RADI의 적용성을 평가하였다. SPI의 경우, 장 단기 가뭄을 표현하기 위해서는 여러 가지 지속기간을 가지는 SPI를 사용해야 하지만, RADI는 하나의 지수로 단기 및 장기가뭄을 표현하고 모니터링 할 수 있다. RADI의 전국 평균값을 살펴본 결과, 우리나라에서 20년 주기로 가뭄이 발생하고 있다는 사실을 확인하였다. 또한 RADI의 발생확률 및 통계 분석을 통해 5단계의 가뭄 등급을 제안하였으며, 이는 가뭄 예보와 대응을 위한 기준으로 활용될 수 있을 것으로 판단된다.

• 해양환경안전학회지
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• 제29권5호
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• pp.505-511
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• 2023

본 논문에서는 소형어선의 운동 응답을 예측하기 위해 딥러닝 모델을 구축하였다. 크기가 다른 두 소형어선을 대상으로 유체동역학 성능을 평가하여 데이터세트를 확보하였다. 딥러닝 모델은 순환 신경망 기법의 하나인 장단기 메모리 기법(LSTM, Long Short-Term Memory)을 사용하였다. 딥러닝 모델의 입력 데이터는 6 자유도 운동 및 파고의 시계열 데이터를 사용하였으며, 출력 라벨로는 6 자유도 운동의 시계열 데이터로 선정하였다. 최적 LSTM 모델 구축을 위해 hyperparameter 및 입력창 길이의 영향을 평가하였다. 구축된 LSTM 모델을 통해 입사파 방향에 따른 시계열 운동 응답을 예측하였다. 예측된 시계열 운동 응답은 해석 결과와 전반적으로 잘 일치함을 확인할 수 있었다. 시계열의 길이가 길어짐에 따라서 예측값과 해석 결과의 차이가 발생하는데, 이는 장기 데이터에 따른 훈련 영향도가 감소 됨에 따라 나타난 것으로 확인할 수 있다. 전체 예측 데이터의 오차는 약 85% 이상의 데이터가 10% 이내의 오차를 보였으며, 소형어선의 시계열 운동 응답을 잘 예측함을 확인하였다. 구축된 LSTM 모델은 소형어선의 모니터링 및 경보 시스템에 활용될 수 있을 것으로 기대한다.

• Journal of Korea Trade
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• 제23권5호
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• pp.87-101
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• 2019

Purpose - This paper examines the effectiveness of the foreign exchange risk insurance system in the promotion of SME exports in Korea. The purpose of this study is to analyze the short-term and long-term responses of SME exports to foreign exchange risk insurance support policies. Based on these empirical studies, we would like to present some operational improvements to the operation of the foreign exchange risk insurance system. Design/methodology - In order to analyze the effect of exchange risk insurance on the exports of SMEs, a VAR model consisting of foreign exchange risk insurance underwriting values, export relative price, and domestic demand pressure, including export volume, was established. The study began with tests of the stationarity of time series data. The unit root tests showed that all concerned variables were non-stationary. Accordingly, the results of the cointegration test showed that the tested variables are not cointegrated. Finally, an impulse response function and variance decomposition analysis were conducted to analyze the impulse of foreign exchange risk insurance on exports of SMEs. Findings - As a result of estimating the VAR (1) model, foreign exchange risk insurance was found to be significant at a 1% significance level for SME' export promotion. In the impulse response analysis, SMEs' export response to the impulse of foreign exchange risk insurance showed that exports gradually increased until the third quarter, and then slowed down. However, the impulse did not disappear, and appeared continuously. Originality/value - This study analyzed the effect of foreign exchange insurance on exports of SMEs by applying the VAR model. In particular, this study is the first to analyze the short-term and long-term effects of foreign exchange risk insurance on exports of SMEs. The empirical evidence in the current study have a policy implication for the policy authority to support and promote the foreign exchange risk insurance in the effect of exchange rate volatility on Korea' export SMEs.

• 정보보호학회논문지
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• 제12권4호
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• pp.67-76
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• 2002

분산 네트워크 환경에서 커버로스는 사용자와 응용 서버 사이에 인증을 위해서 대칭키를 사용하고 있으며 다른 영역의 시스템을 신뢰할 것을 가정하고 있다. 본 논문에서는 기존의 커버로스에 공개키/개인키를 적용하여 효율적이고 강력한 인증 메커니즘을 설계하였다. 제안하고 있는 메커니즘에서는 사용자 인증을 위해 미리 정해진 long-term 키와 공개키를 통해 교환한 랜덤 수에 MAC 알고리즘을 적용하여 암호화에 사용하는 세션키 값을 매번 바꾸어주기 때문에 안전성을 높였다. 또한, 영역간의 신뢰성을 높이기 위해 전자 서명 기반의 시도-응답(challenge-response) 기법을 통한 상호 인증 방법을 사용하고 있으며, 인증 절차를 간소화하여 사용하는 키의 수를 줄였다.

• 한국해양공학회지
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• 제36권5호
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• pp.295-302
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• 2022

The initial response to a marine accident can play a key role to minimize the accident. Therefore, various decision support systems have been developed using sensors, simulations, and active response equipment. In this study, we developed an algorithm to predict damage locations using ship motion data with bidirectional long short-term memory (BiLSTM), a type of recurrent neural network. To reflect the low frequency ship motion characteristics, 200 time-series data collected for 100 s were considered as input values. Heave, roll, and pitch were used as features for the prediction model. The F1-score of the BiLSTM model was 0.92; this was an improvement over the F1-score of 0.90 of a prior model. Furthermore, 53 of 75 locations of damage had an F1-score above 0.90. The model predicted the damage location with high accuracy, allowing for a quick initial response even if the ship did not have flood sensors. The model can be used as input data with high accuracy for a real-time progressive flooding simulator on board.

• 한국지진공학회논문집
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• 제27권6호
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• pp.231-236
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• 2023

The importance of Structural Health Monitoring (SHM) in the industry is increasing due to various loads, such as earthquakes and wind, having a significant impact on the performance of structures and equipment. Estimating responses is crucial for the effective health management of these assets. However, using numerous sensors in facilities and equipment for response estimation causes economic challenges. Additionally, it could require a response from locations where sensors cannot be attached. Digital twin technology has garnered significant attention in the industry to address these challenges. This paper constructs a digital twin system utilizing the Long Short-Term Memory (LSTM) model to estimate responses in a pipe system under simultaneous seismic load and arbitrary loads. The performance of the data-driven digital twin system was verified through a comparative analysis of experimental data, demonstrating that the constructed digital twin system successfully estimated the responses.

• Asian-Australasian Journal of Animal Sciences
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• 제21권11호
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• pp.1559-1571
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• 2008

A rule was developed to constrain the annual rate of inbreeding to a predefined value in a population with different lifetimes between sires and dams, and to maximize the selection response over generations. This rule considers that the animals in a population should be divided into sex-age classes based on the theory of gene flow, and restricts the increase of average inbreeding coefficient for new offspring by limiting the increase of the mean additive genetic relationship for parents selected. The optimization problem of this rule was formulated as a quadratic programming problem. Inputs for the rule were the BLUP estimated breeding values, the additive genetic relationship matrix of all animals, and the long-term contributions of sex-age classes. Outputs were optimal number and contributions of selected animals. In addition, this rule was combined with the optimization of emphasis given to QTL, and further increased the genetic gain over the planning horizon. Stochastic simulations of closed nucleus schemes for pigs were used to investigate the potential advantages obtained from this rule by combining the standard QTL selection, optimal QTL selection and conventional BLUP selection. Results showed that the predefined rates of inbreeding were actually achieved by this rule in three selection strategies. The rule obtained up to 9.23% extra genetic gain over truncation selection at the same rates of inbreeding. The combination of the extended rule and the optimization of emphasis given to QTL allowed substantial increases in selection response at a fixed annual rate of inbreeding, and solved substantially the conflict between short-term and long-term selection response in QTL-assisted selection schemes.