• 한국통신학회논문지
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• 제35권12C호
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• pp.1044-1051
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• 2010

본 논문에서는 공간다중화 multiple input multiple output (MIMO) 시스템을 위한 효율적인 soft-output 신호검출 기법을 제안한다. 제안된 기법은 ordered successive interference cancellation (OSIC) 알고리즘을 기반으로 하지만, 오류 전파 문제를 크게 줄임으로써 기존 OSIC 알고리즘에 비해 큰 성능 향상을 보인다. 제안된 기법은 다중 순서화 기술을 이용한 enhanced OSIC (ESIC) 알고리즘을 결합한 기법으로 신뢰도 높은 log likelihood ratio(LLR) 값을 매우 적은 후보 심볼 벡터를 이용하여 생성할 수 있다. 본 논문에서는 $4{\times}4$ 16-QAM MIMO 시스템을 위한 OSIC, K-Best 가법과 제안된 신호검출 기법을 $0.13{\mu}m$ CMOS 기술 환경에서 구현하였으며, 모의 시험과 구현 결과를 통해 제안된 신호검출 기법이 성능과 하드웨어 구현 측면에서 매우 효율적임을 확인하였다.

• 한국통신학회논문지
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• 제32권7C호
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• pp.616-626
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• 2007

무선통신 채널에서 높은 전송 속도를 가능하게 하는 공간다중화 MIMO 시스템 수신부에서 다중화된 신호를 검출하는 것은 어려운 작업이며, 최근 다양한 신호검출 기법들이 개발되어졌다. 다양한 신호검출 기법 중 maximum likelihood detection with QR decomposition and M-algorithm (QRM-MLD), sphere decoding (SD)과 같은 기존 기법들은 maximum likelihood (ML)기법과 유사한 성능을 가진 것으로 보고되었다. 본 논문에서는 ML 기법과 거의 동일한 성능을 가지면서 낮은 연산복잡도를 보이는 새로운 신호검출 기법을 제안한다. 모의실험을 통하여 제안된 기법은 ML 기법과 거의 동일한 성능을 보이면서 MMSE-OSIC와 유사한 연산복잡도를 가지는 것을 보인다. 또한 기존의 QRM-MLD, SD 기법들의 경우 hard decision 후 추가적인 연산을 통해 soft decision을 위한 log likelihood ratio(LLR) 값을 생성하는 반면, 제안된 기법에서는 추가적인 연산 없이 LLR 값을 성공적으로 생성할 수 있음을 보인다.

• 한국음향학회지
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• 제36권4호
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• pp.279-284
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• 2017

음원 위치 추정은 여러 방면에서 쓰임이 있는 응용 기술이다. 음원의 위치를 추정하기 위한 기본 기법 중에는 시간 지연 추정 기법이 있다. 이 기법에선 음원의 위치를 추정하기 위해서 두 개 또는 그 이상의 수신기에 들어오는 신호간의 상대적 시간 지연을 알아내야 한다. 시간 지연 추정 기법에는 일반화 된 상호 상관(Generalized Cross-Correlation, GCC) 대표적이지만, 정준형 상관 분석(Canonical Correlation Analysis, CCA)을 이용한 방법도 있다. 본 논문에서는 시간 지연 추정용 정준형 상관 분석의 고유벡터의 희소성을 이용하기 위해 새로운 알고리즘을 제안한다. 이를 위해서 로그-합(log-sum) 정규화를 이용한다. 본 논문에서는 서로 다른 여러 신호 대 잡음비 환경 하에서 비교 모의실험을 하였고, 이 비교 실험을 통하여 얻는 데이터를 통해서 제안한 새 정준형 상관 분석 기반 알고리즘이 이전의 정준형 상관분석 기반 알고리즘이나 기존 GCC보다 더 우수하다는 것을 보인다.

• 오토저널
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• 제14권5호
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• pp.41-53
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• 1992

The main purpose of this study is to investigate the atomizing characteristics of a two phase spray by using a liquid column type coaxial nozzle. The experiments have been carried out to analyze the atomization behavior, the droplet size distributions, and the statistical properties of droplet size distributions. Immersion sampling method and the image processing technique were adapted for the measurements of particles, and the distributions of the droplet sizes were statistically analyzed. In the experiments, the mass ratio defined as Mr= $M_{\sigma}$/ $M_{1}$ has been changed from 1.0 to 3.4 and the measurements have been performed along the axis of the spray. As a result of this experimental study, the distributions of droplet size were satisfied with the Log-Normal distributions and arithmetic mean diameter and deviation of mass ratio. Droplet volume-surface mean diameter was denoted by a exponential function of mass-ratio and the exponent was denoted by linear relation according to the central axis from the nozzle. Dispersions, skewness factors and flatness factors had comparatively constant values regardless of mass ratio and location.

• Journal of Microbiology and Biotechnology
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• 제15권6호
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• pp.1377-1383
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• 2005

In a cDNA microarray experiment using Cy3 and Cy5 as labeling agents, particularly for the direct design, cDNAs from some genes incorporate one dye more efficiently than the other, which is referred to as the gene-specific dye bias. Dye-swaps, in which two dyes are switched on replicate arrays, are commonly used to control the gene-specific dye bias. We developed a simple procedure to extract the gene-specific dye bias information from a partial dye swap experiment. We detected gene-specific dye bias by identifying outliers in an X-Y plane, where the X axis represents the average log-ratio from two sets of dye swap pairs and the Y axis exhibits the average log ratio of four forward labeled arrays. We used this information for detecting differentially expressed genes, of which the additionally detected genes were validated by real-time RT-PCR.

• Journal of Information Processing Systems
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• 제14권2호
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• pp.552-562
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• 2018

With the advent of the information society, image restoration technology has aroused considerable interest. Guided image filtering is more effective in suppressing noise in homogeneous regions, but its edge-preserving property is poor. As such, the critical part of guided filtering lies in the selection of the guided image. The result of the Expected Patch Log Likelihood (EPLL) method maintains a good structure, but it is easy to produce the ladder effect in homogeneous areas. According to the complementarity of EPLL with guided filtering, we propose a method of coupling EPLL and guided filtering for image de-noising. The EPLL model is adopted to construct the guided image for the guided filtering, which can provide better structural information for the guided filtering. Meanwhile, with the secondary smoothing of guided image filtering in image homogenization areas, we can improve the noise suppression effect in those areas while reducing the ladder effect brought about by the EPLL. The experimental results show that it not only retains the excellent performance of EPLL, but also produces better visual effects and a higher peak signal-to-noise ratio by adopting the proposed method.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.197-203
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• 2007

A bioequivalence study of $Dilast^{TM}$ Capsule (Chong Kun Dang Pharma. Co., Ltd.) to $Ketas^{(R)}$ Capsule (Han Dok Pharma. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty eight healthy male Korean volunteers received each medicine at the ibudilast dose of 20 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of ibudilast were monitored by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) for over a period of 36 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 36 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Dilast^{TM}$ $Capsule/Ketas^{(R)}$ Capsule were $log0.93{\sim}log1.06$ and $log0.93{\sim}log1.11$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Dilast^{TM}$ Capsule and $Ketas^{(R)}$ Capsule with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.303-308
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two talniflumate tablets, SOMALGEN tablet (Kun Wha Pharm. Co., Ltd., Seoul, Korea, reference drug) and FLUTAL tablet (Kukje Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received two tablets at the talniflumate dose of 740 mg in a $2{\pm}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of niflumic acid were monitored by an HPLC-UV for over a period of 14 hr after the administration. $AUC_t$(the area under the plasma concentration-time curve from time zero to 14 hr) was calculated by the linear trapezoidal rule method. $C_{max}$(maximum plasma drug concentration) and $T_{max}$(time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$, ratio and the $C_{max}$ ratio for SOMALGEN/FLUTAL were $log0.8510{\sim}log1.0318$ and $log0.9264{\sim}log1.0607$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Taken together, our study demonstrated the bioequivalence of SOMALGEN and FLUTAL with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.131-136
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• 2006

The purpose of the present study was to evaluate the bioequivalence of two losartan tablets, $Cozaar^{TM}$ tablet (MSD Korea. Co., Ltd., Seoul, Korea, reference drug) and $Losartan^{TM}$ tablet (DaeWon Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received two tablets at the losartan kalium dose of 100 mg in a $2\;{\time}\;2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of losartan were monitored by an LC-MS/MS for over a period of 12 hr after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Cozaar^{TM}/Losartan^{TM}$ were $log\;0.97{\sim}log\;1.12\;and\;log\;0.93{\sim}log\;1.23$, respectively. These values were within the acceptable bioequivalence intervals of $log\;0.80{\sim}log\;1.25$. Taken together, our study demonstrated the bioequivalence of $Cozaar^{TM}$ and $Losartan^TM$ with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제37권4호
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• pp.255-261
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• 2007

A bioequivalence study of $Nimegen^{TM}$ soft capsule (Medica Korea Pharma. Co., Ltd.) to $RoAccutane^{(R)}$ soft capsule (Roche Korea Ind. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Thirty healthy male Korean volunteers received each medicine at the isotretinoin dose of 60 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of isotretinoin were monitored by a high performance liquid chromatography (HPLC) for over a period of 48 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48 hr) was calculated by the linear trapezoidal rule method. $C_{MAX}$ (maximum plasma drug concentration) and $T_{MAX}$ (time to reach $C_{MAX}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{MAX}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{MAX}$ ratio for $Nimegen^{TM}/RoAccutane^{(R)}$ were $log0.860{\sim}log0.98\;and\;log0.85{\sim}log1.00$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Nimegen^{TM}\;and\;RoAccutane^{(R)}$ with respect to the rate and extent of absorption.