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Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients

  • Kim, Shin-Hyuk;Ahn, Byung-Kyu;Nam, Young-Su;Pyo, Joo-Youn;Oh, Young-Ha;Lee, Kang-Hong
    • Journal of Gastric Cancer
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    • v.10 no.4
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    • pp.149-154
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    • 2010
  • Purpose: Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the development of multiple gastric cancers in sporadic gastric cancer patients has not been defined. This study was performed to reveal the association between the clinicopathologic features and MSI in sporadic gastric cancers. Materials and Methods: Between July 2004 and March 2009, the clinicopathologic characteristics, including MSI status, were evaluated in 128 consecutive patients with sporadic gastric cancers. None of the patients had hereditary non-polyposis colorectal cancer of familial gastric cancer. The markers that were recommended by the NCI to determine the MSI status for colorectal cancers were used Results: MSI-H cancers were found in 10.9% of the patients (14/128). Synchronous gastric cancers were shown in 4 patients (3.1%). Synchronous cancers were found in 2 of 14 patients with MSI-H gastric cancer (14.3%) and 2 of 114 patients with MSS gastric cancer (1.8%; P=0.059, Fisher's exact test). Among the patients with synchronous cancer 50% (2/4) had MSI-H cancer, but 9.7% of the patients (12/124) without synchronous cancer had MSI-H cancer. MSI-H (RR, 24.7; 95% CI, 1.5~398.9; P=0.024) was related with to synchronous gastric cancer, but age, gender, family history, histologic type, location, gross morphology, size, and stage were not related to synchronous gastric cancer. Conclusions: MSI is associated with the intestinal-type gastric cancer and the presence of multiple gastric cancers in patients with sporadic gastric cancer. Special attention to the presence of synchronous and the development of metachronous multiple cancer in patients with MSI-H gastric cancer is needed.

Local Heat Transfer Coefficients for Reflux Condensation Experiment in a Vertical Tube in the Presence of Noncondensible Gas

  • Moon, Young-Min;No, Hee-Cheon;Bang, Young-Seok
    • Proceedings of the Korean Nuclear Society Conference
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    • 1999.05a
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    • pp.104-104
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    • 1999
  • The local heat transfer coefficient is experimentally investigated for the reflux condensation in a countercurrent flow between the steam-air mixture and the condensate. A single vertical tube has a geometry which is a length of 2.4m, inner diameter of 16.56mm and outer diameter of 19.05mm and is made of stainless steel. Air is used as a noncondensible gas. The secondary side is installed in the form of coolant block around vertical tube and the heat by primary condensation is transferred to the coolant water. The local temperatures are measured at 15 locations in the vertical direction and each location has 3 measurement points in the radial direction, which are installed at the tube center, at the outer wall and at the coolant side. In three different pressures, the 27 sets of data are obtained in the range of inlet steam flow rate 1.348 -3.282kg/hr, of inlet air mass fraction 11.8 -55.0%. The local heat transfer coefficient increases as the increase of inlet steam flow rate and decreases as the decrease of inlet air mass fraction. As an increase of the system pressure, the active condensing region is contracted and the heat transfer capability in this region is magnified. The empirical correlation is developed represented with the 165 sets of local heat transfer data. As a result, the Jacob number and film Reynolds number are dominant parameters to govern the local heat transfer coefficient. The rms error is 17. 7% between the results by the experiment and by the correlation.

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Merge Control using Reserve Ahead Point in Baggage Handling System (수하물시스템의 사전할당지점을 이용한 병합제어)

  • Kim, Minhee;Shin, Hyunwoo;Chae, Junjae
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.40 no.2
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    • pp.60-67
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    • 2017
  • A baggage handling system (BHS) in airport is an unified system for moving the passengers' baggage in designated time. Input baggage from the check-in counter travels to the baggage claim area or cargo handling terminal through this system. In particular, entryway BHS consists of conveyors, X-ray and sorters such as tilt-tray to send the baggage to departing airplane and it could have various problems for handling certain amount of baggage in restricted time such as baggage jamming at certain merge point. This causes systemic error such as delay of the time, omissions of the baggage and even breakdown of the equipment and inefficiency. Also the increasing maximum time of the baggage passing through the BHS could delay the flight schedule and finally decrease the service level. Thus, the algorithm for controlling the flow of the merge is essential to the system. The window reservation algorithm is the one of the most frequently used methods to control the merge configuration. Above all, the reserve location, so called reserve ahead point, that allocates the window is important for the performance of the algorithm. We propose the modified window reservation algorithm and the best reserve locations by changing the reserve ahead point in the induction conveyors. The effect of various reserve ahead points such as the capacity and utility of the system were analyzed and the most effective reserve ahead point combination was found. The total baggage processing time and the utilization of the tilt-tray are properly considered when choosing the optimal Reserve ahead point combination. In the layout of this study, the configuration of four conveyors merged into one tilt-tray is studied and simulation analysis is done by AutoMod(R), 3D simulation software. Through the simulation, the window reservation algorithm is effectively operated with the best combination of reserve ahead point which reduces the maximum baggage travel time.

Range-free localization algorithm between sensor nodes based on the Radical Line for Sensor Networks (센서 네트워크를 위한 Radical line을 기반으로 한 센서 노드간의 Range-free 지역화 알고리즘)

  • Shin, Bong Hi;Jeon, Hye Kyoung
    • Journal of Digital Convergence
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    • v.14 no.8
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    • pp.261-267
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    • 2016
  • In this paper, we studied the range-free localization algorithm between sensor nodes based on the Radical Line for sensor networks. Routing in wireless sensor networks should reduce the overall energy consumption of the sensor network, or induce equivalent energy consumption of all the sensor nodes. In particular, when the amount of data to send more data, the energy consumption becomes worse. New methods have been proposed to address this. So as to allow evenly control the overall energy consumption. For this, the paper covers designing a localization algorithm that can obtain the location information of the peripheral nodes with fewer operations. For the operation of the algorithm is applicable Radical Line. The experimental environment is windows 7, the Visual C ++ 2010, MSSQL 2008. The experimental results could be localized to perform an error rate of 0.1837.

Utilization of Syllabic Nuclei Location in Korean Speech Segmentation into Phonemic Units (음절핵의 위치정보를 이용한 우리말의 음소경계 추출)

  • 신옥근
    • The Journal of the Acoustical Society of Korea
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    • v.19 no.5
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    • pp.13-19
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    • 2000
  • The blind segmentation method, which segments input speech data into recognition unit without any prior knowledge, plays an important role in continuous speech recognition system and corpus generation. As no prior knowledge is required, this method is rather simple to implement, but in general, it suffers from bad performance when compared to the knowledge-based segmentation method. In this paper, we introduce a method to improve the performance of a blind segmentation of Korean continuous speech by postprocessing the segment boundaries obtained from the blind segmentation. In the preprocessing stage, the candidate boundaries are extracted by a clustering technique based on the GLR(generalized likelihood ratio) distance measure. In the postprocessing stage, the final phoneme boundaries are selected from the candidates by utilizing a simple a priori knowledge on the syllabic structure of Korean, i.e., the maximum number of phonemes between any consecutive nuclei is limited. The experimental result was rather promising : the proposed method yields 25% reduction of insertion error rate compared that of the blind segmentation alone.

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A study on the transformation of cadastral map using Geo-Spatial Information System (지형공간정보체계를 활용한 지적도의 변환에 관한 연구)

  • Kim, Jung-Sik
    • Journal of Korean Society for Geospatial Information Science
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    • v.8 no.1 s.15
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    • pp.111-120
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    • 2000
  • A cadastral map that is base map on Land Information System is divided by two categories, graphical and digital cadastre. And digital cadastre can be displayed with location coordinates of nodes that depict parcel boundary on digital cadastral records. The transformation of digital cadastral records means that imported text data of node coordinate would be transformed into system data. This study was implemented to search reasons of errors resulted from transformation of graphic data and then to analyze the accuracy in terms of Position and area. For this, checking of software used in Geo-Spatial Information System was implemented at first and it was found that the accuracy is up by using double precision in coordinate transformation. On the position accuracy the errors at nodes was erased during making topology and the errors did not effect other nodes. On the area may the area errors because of being in error limit of allowable area had no problems in using of system.

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Availability Evaluation of Network DGPS Positioning for Various Facilities Management In Dense Housing Area (주택가 밀집지역에서의 각종 시설물 관리를 위한 네트워크 DGPS 측위의 가용성 평가)

  • Kim, In-Seup
    • Journal of Korean Society for Geospatial Information Science
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    • v.18 no.4
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    • pp.93-99
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    • 2010
  • Since the facility management for various facilities in urban area are conducted by general managers who have poor knowledge for surveying technology, it is not easy to trace the exact location of the facility in a short time with the GIS map only by themselves in the field. In order to improve it, VRS-RTK or SBAS DGPS system integrated with UMPC and PDA which is uploaded GIS field software are being used recently however lot of difficulties are still existed with the GPS positioning in urban area due to the lack of visible satellites, no reception of correction data and multipath error by the interruption of the high buildings and houses etc. Therefore, in this study, we applied with Network DGPS system which allows better reception of satellite signal and correction data even in dense housing areas with the use of GNSS receiver and CDMA mobile phone. Based on the analysis of field data, it was confirmed that standard deviations of the Network DGPS positioning are 0.3 to 0.84m with a very high positioning rate even in dense housing areas. Therefore, it was concluded that the Network DGPS system could be used widely to fast and accurate positioning for various facilities management works in dense housing areas in the future.

UAV Aerial Photogrammetry for Cross Sectional Extraction and Slope Stability Analysis in Forest Area (UAV 항공사진을 이용한 산림지 횡단면도 추출 및 사면안정성 평가)

  • Kim, Taejin;Son, Younghwan;Park, Jaesung;Kim, Donggeun
    • Journal of The Korean Society of Agricultural Engineers
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    • v.60 no.1
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    • pp.67-77
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    • 2018
  • The objective of this study is to extract the shape of the slope from the images acquired using UAV and evaluate its suitability and reliability when applied to slope stability analysis. UAV is relatively inexpensive and simple, and it is possible to make terrain survey by generating point clouds. However, the image acquired from UAV can not be directly photographed by the forest canopy due to the influence of trees, resulting in severe distortion of the terrain. In this study, therefore, the effects of forest canopy were verified and the slope stability analysis was performed. Images acquired in winter and summer were used, because summer images are heavily influenced by the forest canopy and winter images are not. As a result of the study, the winter image is suitable for the extraction of slope shape, but severe terrain distortion occurs in the summer image. Therefore, slope stability analysis using slope shape extracted from summer image is impossible, so it should be modified for slope stability analysis. The modified slope did not completely eliminate the distortion of the terrain, but it could express the approximate shape of the slope. As a result of the slope stability analysis, the location and shape of the failure surface are the same, and the error of the safety factor is less than 0.2, which is close to the actual slope.

Auto-detection of Halo CME Parameters as the Initial Condition of Solar Wind Propagation

  • Choi, Kyu-Cheol;Park, Mi-Young;Kim, Jae-Hun
    • Journal of Astronomy and Space Sciences
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    • v.34 no.4
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    • pp.315-330
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    • 2017
  • Halo coronal mass ejections (CMEs) originating from solar activities give rise to geomagnetic storms when they reach the Earth. Variations in the geomagnetic field during a geomagnetic storm can damage satellites, communication systems, electrical power grids, and power systems, and induce currents. Therefore, automated techniques for detecting and analyzing halo CMEs have been eliciting increasing attention for the monitoring and prediction of the space weather environment. In this study, we developed an algorithm to sense and detect halo CMEs using large angle and spectrometric coronagraph (LASCO) C3 coronagraph images from the solar and heliospheric observatory (SOHO) satellite. In addition, we developed an image processing technique to derive the morphological and dynamical characteristics of halo CMEs, namely, the source location, width, actual CME speed, and arrival time at a 21.5 solar radius. The proposed halo CME automatic analysis model was validated using a model of the past three halo CME events. As a result, a solar event that occurred at 03:38 UT on Mar. 23, 2014 was predicted to arrive at Earth at 23:00 UT on Mar. 25, whereas the actual arrival time was at 04:30 UT on Mar. 26, which is a difference of 5 hr and 30 min. In addition, a solar event that occurred at 12:55 UT on Apr. 18, 2014 was estimated to arrive at Earth at 16:00 UT on Apr. 20, which is 4 hr ahead of the actual arrival time of 20:00 UT on the same day. However, the estimation error was reduced significantly compared to the ENLIL model. As a further study, the model will be applied to many more events for validation and testing, and after such tests are completed, on-line service will be provided at the Korean Space Weather Center to detect halo CMEs and derive the model parameters.

Fast Axis Estimation from 3D Axially-Symmetric Object's Fragment (3차원 회전축 대칭 물체 조각의 축 추정 방법)

  • Li, Liang;Han, Dong-Jin;Hahn, Hern-Soo
    • Journal of the Korean Institute of Intelligent Systems
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    • v.20 no.6
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    • pp.748-754
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    • 2010
  • To reduce the computational cost required for assembling vessel fragments using surface geometry, this paper proposes a fast axis estimation method. Using circular constraint of pottery and local planar patch assumption, it finds the axis of the symmetry. First, the circular constraint on each cylinder is used. A circular symmetric pot can be thought of unions of many cylinders with different radii. It selects one arbitrary point on the pot fragment surface and searches a path where a circumference exists on that point. The variance of curvature will be calculated along the path and the path with the minimum variance will be selected. The symmetric axis will pass through the center of that circle. Second, the planar patch assumption and profile curve is used. The surface of fragment is divided into small patches and each patch is assumed as plane. The surface normal of each patch will intersects the axis in 3D space since each planar patch faces the center of the pot. A histogram method and minimization of the profile curve error are utilized to find the probability distribution of the axis location. Experimental results demonstrate the improvement in speed and robustness of the algorithms.