• Structural Engineering and Mechanics
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• 제46권2호
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• pp.231-244
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• 2013

An efficient method is proposed here to identify multiple damage cases in structural systems using the concepts of flexibility matrix and strain energy of a structure. The flexibility matrix of the structure is accurately estimated from the first few mode shapes and natural frequencies. Then, the change of strain energy of a structural element, due to damage, evaluated by the columnar coefficients of the flexibility matrix is used to construct a damage indicator. This new indicator is named here as flexibility strain energy based index (FSEBI). In order to assess the performance of the proposed method for structural damage detection, two benchmark structures having a number of damage scenarios are considered. Numerical results demonstrate that the method can accurately locate the structural damage induced. It is also revealed that the magnitudes of the FSEBI depend on the damage severity.

• Journal of Pharmaceutical Investigation
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• 제40권4호
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• pp.201-212
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• 2010

Self-organized nanogels from polysaccharide derivatives offer a promising approach in treatment of cancer due to their flexibility in chemistry and their ability to improve the therapeutic index of a drug by modifying biodistribution by their preferential localization at target sites and lower distribution in normal healthy tissues. These properties have promoted studies of active cancer targeting by self-organized nanogels for even better accumulation in solid tumors. However although many researchers have reported their potential by using cell culture systems and small animal tumor models in cancer therapy, these nanogels need more decoration such as conjugation with targeting moiety and endowment of stimuli-sensitivity for precise targeting of the cancer site. In this review, we summarize the recent efforts in developing novel targeting approaches via active endocytosis and stimuli-sensitive systems responding to hyperthermic or acidic tumor pH conditions.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2001년도 가을 학술발표회 논문집
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• pp.109-116
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• 2001

An integrated damage identification system (IDIS) and system identification (SID) technique using modal information to detect damage in structures is presented. The objective is to detect damages in cracked model plate-girder without baseline modal parameters. The theory of damage localization and system identification is outlined. Experiments on a model plate-girder was described and a baseline model representing the experimental modal characteristics of the model plate-girder is updated using the system identification technique. Finally, damage inflicted in the model plate-girder is predicted using the IDIS software.

• Computers and Concrete
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• 제20권5호
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• pp.563-572
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• 2017

Ordinary reinforced concrete (RC) and prestressed concrete bridges are two popular and typical types of short- and medium-span bridges that accounts for the vast majority of all existing bridges. The cost of maintaining, repairing or replacing degraded existing RC bridges is immense. Detecting the abnormality of RC bridges at an early stage and taking the protective measures in advance are effective ways to improve maintenance practices and reduce the maintenance cost. This study proposes a systematic method from influence line (IL) identification to damage detection with applications to RC bridges. An IL identification method which integrates the cubic B-spline function with Tikhonov regularization is first proposed based on the vehicle information and the corresponding moving vehicle induced bridge response time history. Subsequently, IL change is defined as a damage index for bridge damage detection, and information fusion technique that synthesizes ILs of multiple locations/sensors is used to improve the efficiency and accuracy of damage localization. Finally, the feasibility of the proposed systematic method is verified through experimental tests on a three-span continuous RC beam. The comparison suggests that the identified ILs can well match with the baseline ILs, and it demonstrates that the proposed IL identification method has a high accuracy and a great potential in engineering applications. Results in this case indicate that deflection ILs are superior than strain ILs for damage detection of RC beams, and the performance of damage localization can be significantly improved with the information fusion of multiple ILs.

• 한국전산구조공학회논문집
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• 제25권1호
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• pp.81-89
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• 2012

본 연구에서는 무선 가속도 센서노드를 이용한 강 거더 볼트연결 부재의 진동기반 손상 모니터링 체계를 제안하였다. 이 같은 연구목표를 위해, 다음과 같은 연구를 수행하였다. 먼저, 무선 가속도 센서노드의 하드웨어 구성 및 내장된 작동 소프트웨어를 제시하였다. 다음으로, 강 거더 볼트연결 부재의 진동기반 손상 모니터링 체계를 제시하였다. 손상 모니터링 체계는 가속도 응답특성 분석을 통해 전역적 손상발생 경보 및 손상위치 추정을 수행한다. 전역적 손상발생 경보는 파워스펙트럼밀도의 상관계수를 적용하였다. 손상위치 추정은 고유 진동수기반 손상검색 기법과 모드형상기반 손상검색 기법을 적용하였다. 마지막으로, 모형 강 거더의 볼트연결 부재 손상을 식별하기 위한 진동기반 손상 모니터링 체계의 적용성을 검증하였다.

• 한국구조물진단유지관리공학회 논문집
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• 제14권1호
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• pp.165-174
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• 2010

본 논문에서는 실물 콘크리트 거더 교량의 가속도 응답 신호를 이용하여 구조물의 상태변화를 경보한 후 그 위치 변화를 검색하는 2단계 구조건전성 모니터링 체계를 제시하였다. 먼저, 2경간 연속 콘크리트 거더 교량인 미호천교를 대상교량으로 선정하였으며, 볼링공을 이용한 강제진동 실험으로부터 동특성을 추출하였다. 다음으로, 미호천교의 2단계 구조건전성 모니터링 체계 구축을 위한 손상 발생 경보 및 손상 위치 검색 기법들을 선정하였다. 손상 경보 기법으로는 시간영역 특징을 이용하는 자기회귀모델과 주파수응답함수의 상관계수, 주파수응답비보증지수를 선정하였다. 손상 위치 검색 기법으로는 모드변형에너지기반 손상지수법을 선정하였다. 마지막으로, 덤프트럭을 이용한 정적 재하 실험을 통해 2단계 손상 모니터링 체계의 적합성을 검증하였다.

• Structural Engineering and Mechanics
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• 제86권6호
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• pp.715-730
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• 2023

Broad studies have addressed the issue of structural element damage identification, however, rubber bearing, as a key component of load transmission between the superstructure and substructure, is essential to the operational safety of a bridge, which should be paid more attention to its health condition. However, regarding the limitations of the traditional bearing damage detection methods as well as few studies have been conducted on this topic, in this paper, inspired by the model updating-based structural damage identification, a two-stage bearing damage identification method has been proposed. In the first stage, we deduce a novel bearing damage localization indicator, called element relative MSE, to accurately determine the bearing damage location. In the second one, the prior knowledge of bearing damage localization is combined with sailfish optimization (SFO) to perform the bearing damage estimation. In order to validate the feasibility, a numerical example of a 5-span continuous beam is introduced, also the noise robustness has been investigated. Meanwhile, the effectiveness and engineering applicability are further verified based on an experimental simply supported beam and actual engineering of the I-40 Bridge. The obtained results are good, which indicate that the proposed method is not only suitable for simple structures but also can accurately locate the bearing damage site and identify its severity for complex structure. To summarize, the proposed method provides a good guideline for the issue of bridge bearing detection, which could be used to reduce the difficulty of the traditional bearing failure detection approach, further saving labor costs and economic expenses.

• 한국의류학회지
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• 제34권9호
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• pp.1546-1557
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• 2010

This study analyzes the status of foreign direct investment in Korean textiles and fashion firms and investigates the factors determining their performance. A total of 1,251 cases (including 1,116 manufacturers and 135 of distributors from the 2009/2010 Korean Overseas Business Directory published by KOTRA) were used. The results of this study are as follow: 1) In the case of manufacturers, China was the most heavily invested in country, and the Asian region that included China, Vietnam, Indonesia and Bangladesh consisted of 80% total investment. In cases of distributors, China was also the first ranking country and other countries, that included Vietnam, United States, and Japan are major ones. 2) In terms of the foreign entry mode, wholly-owned subsidiaries represented 90% of total cases. As the index of the degree of localization, the ratio of local employees was very high. 3) Different countries were utilized by year, type of business, and area of process. In manufacturers, Indonesia, China, and Vietnam were the most heavily utilized countries in the 1980s, 1990s, and 2000s, respectively. For distributors, China was the major market ill the 1980s and 1990s but Vietnam has emerged as the biggest market in the 2000s. In terms of area of process, China was for manufacturing fibers and fabrics, Vietnam was for most items, Indonesia was for assembly, knit, accessories, and Bangladesh was for embroidery and accessories. 4) The determining factors of the age of foreign business as the proxy index and performance of foreign business entry, were different by the type of business. For manufacturers, four factors including the dollar amount of investment, number of local employees, the mode of foreign direct investment, and entry to China were significant. On the other hand, only two factors including the dollar amount of investment and entry (other than China) were significant distributors.

• Journal of Acupuncture Research
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• 제36권4호
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• pp.264-271
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• 2019

Background: The purpose of this study was to redefine the location of acupoints in the lower abdomen by taking actual thoracic and abdominal measurements. Methods: Measurements of the length and height of the thorax, and both the upper and lower abdominal area were compared to standard values defined by the World Health Organization Western Pacific Region (WHO/WPRO), and medical text books such as Miraculous Pivot, and A-B Classic of Acupuncture and Moxibustion. These measurements were used to redefine the standard of 1 cun, and the cun value of the lower abdomen. Results: Of the 60 studies screened, all studies used the cun measurement system. Considerable variation in the localization of acupoints in the lower abdominal area were detected. The average measurement of a typical male lower abdomen was within 6.33 cun to 6.34 cun. From this data, 6.5 cun appears to be more accurate than the current standardized length of 5 cun. The standardized index values of the width of the 4 fingers, and the distance from the lateral prominence from the greater trochanter to the popliteal crease (Fm), appeared to apply to only males, as defined by the WHO/WPRO. Conclusion: Further studies on standardizing the index measurements for the lower abdominal area are necessary. For males, the more accurate standardized length of the lower abdomen was 6.5 cun, whereas for females, the measurement would typically be longer than 6.5 cun.

• 대한임상검사과학회지
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• 제52권1호
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• pp.1-17
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• 2020

조직병리학에서 현미경을 이용한 삼차원적 접근법은, 이차원 단면의 조직 슬라이드에서 박절 과정 중 부차적으로 발생하는 공간정보의 손실로 인하여 확인하기 어려웠던, 조직 내부 분자들의 공간적 배열, 상호결합, 구조적인 형태와 이들의 통합적인 공간적 정보체로서, 조직 내에 복잡하게 얽혀진 다양한 정보를 풀어내는데 있어서 복합적인 데이터를 제시하여 준다. 이광자 현미경(two-photon microscope)과 자동화된 보정환(correction collar)이 탑재된 고성능 대물렌즈의 개발과 같은 광학장비 영역의 발전은 조직투명화 과정을 거치지 않은 두꺼운 시료의 이미징에 있어서 광학적인 이론과 실체 사이에 존재하는 격차를 줄이는데 기여하였다고 할 수 있다. 하지만, 대물렌즈의 길어진 작동범위(working distance)와 최적화된 고강도 레이저의 사용으로 얻게 되는 이점들은 세포 내 각 구성요소의 굴절률(refractive index) 차이로 인하여 증가되는 빛의 분산(light scattering) 현상으로 인해 자연스럽게 감소하게 된다. 조직투명화 기술이 처음 등장하였던 초창기 시도되던 간단한 굴절률 일치화(RI matching) 기법에서부터 현대의 최첨단 통합 조직 투명화 기술에 이르기 까지를 관찰하여 볼 때, 형태학적인 변화없이 조직의 투명도를 높이는 것과, 내재적으로 또는 고정과정 중에 유래되어 혼합된 자가형광 노이즈를 효과적으로 제거하는것이 선명한 이미지를 얻기 위한 주요한 고려대상이라고 할 수 있다. CLARITY는 장비에 기반한 조직투명화 기법으로서 임상 조직병리 실험실에서 처리되는 동결절편과 포르말린에 고정된 검체 모두의 투명화를 위한 실험실 작업흐름(workflow) 통합 및 일상적인 실험절차와 호환이 가능할 것으로 보여진다.