• Radiation Oncology Journal
• /
• 제4권1호
• /
• pp.15-20
• /
• 1986

1979년부터 1984년까지 이식신에 대하여 39회의 국소적 방사선조사가 서울대학교병원 치료방사선과에서 시행되었다. 10회는 예방적으로, 29회는 치료적으로 시행되었고 전체 환자 수는 29명이었다. 방사선조사는 1일 150cGy로 격일간 450cGy를 원칙으로 하였으며 methylprednisolone(Solumedrol)과 동시 병용되었다. 면역억제제로서 prednisone과 Imuran은 이식 후 계속 투여되었다. 방사선조사 시기는 예방목적일 경우에는 이식수술 후 1, 3, 5일에, 치료목적인 경우에는 거부반응의 진단 후 어느정도 시간간격을 두고 시행되었는데, 간격은 개인차이가 있었다. 10예의 예방적조사를 받은 이식신의 8예가 추후 거부반응이 출현하였으며, 이식 후 15개월 후에 기능적 생존을 보인 예는 없어서 예방적조사 효과는 회의적이었다. 치료목적으로 처음 조사받은 21예의 거부반응 회복율은 $71\%$였고, 방사선조사 전 혈청 크레아티닌이 $5.5mg\%$이하일 경우는 $93\%,\; 5.5mg\%$이상일 경우는 $17\%$였다(P<0.01). 극복이 안된 경우 재차 방사선조사에 대한 효과는 초회효과보다 열등하였다. 거부반응이 회복된 경우에 $47\%$가 재차 거부반응이 출현하였다. 거부반응에 대한 처음 방사선조사 후 이식신의 기능적 생존율은 방사선조사 후 6개월, 1년, 2년 및 3년에 각각 $70\%,\;65\%$ 및 $54\%$였고, 방사선조사 전 혈청 크레아티닌 수준, 거부반응 진단 후 방사선조사까지의 경과시간 및 방사선조사후의 반응 등이 이식신의 기능적 생존에 유의한 영향을 미침을 알 수 있었다(P<0.001). 따라서 방사선조사로 효과를 얻기 위하여는 거부반응으로 인한 이식신 파괴가 한계수준을 넘지 않는 범위 내에서 시행함이 필요함을 알 수 있었다. 이 효과는 Solumedrol과 병용된 결과이므로 방사선조사의 상대적 기여도를 밝히는 것은 어려웠다.

• Imaging Science in Dentistry
• /
• 제36권1호
• /
• pp.7-15
• /
• 2006

Purpose : To investigate the caspase-3 expression in the acinar and ductal cells of rat submandibular glands after the irradiation of various doses. Materials and Methods : The male Sprague-Dawley rats weighing approximately 250 gm were used for this study. The experimental group was irradiated with a single absorbed dose of 2, 5, 10, and 15 Gy on the head and neck region. The rats were sacrificed on the 1st, 3rd, 7th, 14th, 21 st, and 28th day after irradiation. The specimens including the submandibular gland were sectioned and observed using histopathological and immunohistochemical methods. Results : The local destruction of the acinar and ductal cells and the karyopyknotic nuclei of the acinar cells were observed in the 2 Gy and 5 Gy irradiation groups later than in the 10 Gy and 15 Gy irradiation groups. And the expression of caspase-3 was prominent only in the ductal cells in the 2 Gy and 5 Gy irradiation groups. Conclusion : This experiment suggests that radiation-induced apoptosis in the ductal cells of rat submandibular glands was induced by a low dose radiation associated with the activation of caspase-3 and radiation-induced necrosis was induced by a high dose radiation.

• Radiation Oncology Journal
• /
• 제6권2호
• /
• pp.289-293
• /
• 1988

방사선 치료는 악성 종양의 치료에서 국소 치료의 효과를 높이기 위한 수술 전후의 보조치료로서, 혹은 수술 불가능한 암, 잔여암, 또는 재발암의 치료로서 널리 사용되어 왔으며 외부 방사선 치료, 동위원소를 사용한 자입치료 등에 의한 장기간의 국소 치료효과 및 증상의 호전에 대한보고는 많다. 그러나 수술전후의 방사선 요법과 수술을 병행한 직장암 환자에서의 치료후의 재발은 외과적 치료가 대부분에서 불가능하여 외부 방사선 요법, 화학요법 등이 증상판화의 목적으로 사용되어 왔으나 강내 조사의 보고는 거의 없다. 영남대학교 치료방사선과에서는 수술전 경사에서 수술 불가능으로 판명되어 수술전 방사선 치료를 받은 후 개복 하였으나 절제가 불가능하였던 환자에서 발생한 누도(fistula tract)를 따라 재발된 직장암 환자에서 강내 치료를 실시하여 매우 빠른 증세의 호전을 경험하였기에 문헌 고찰과 함께 보고하는 바이다

• Radiation Oncology Journal
• /
• 제5권2호
• /
• pp.173-176
• /
• 1987

담도암은 서서히 자라며 원격전이가 늦은데 비하여 완전절제가 어렵고 수술 후 재발율이 높아. 생존율은 매우 낮다. 많은 예에서 국소치료의 실패가 치료실패의 요인으로 밝혀짐에 따라 술후 방사선 치료의 중요성이 인정되어 왔다. 외부방사선치료 만으로는 충분한 선량을 조사할 수 없으므로 국소적인 고선량치료법으로서 술중방사선치료, 간질방사선치료 (interstitial irradiation), 경관방사선치료(transcatheter irradiation) 등이 사용되고 있으나 경관방사선치료의 보고는 드물다. 영남대학병원 치료방사선과에서는 진행된 담도암 1예에서 암 종괴의 부분절제 후 삽입된 T-자관을 통하여 고선량 방사선 치료를 실시하였기에 문헌고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권6호
• /
• pp.3747-3750
• /
• 2013

Purpose: To evaluate the efficacy of conservative surgery plus chemo-, radio-therapy in treating patients with early stage breast cancer. Patients and Methods: Eligible patients were treated by postoperative chemotherapy as well as whole-breast irradiation with tumor bed boost. Postoperative radiotherapy consisted of 6 MV whole breast linear accelerator irradiation with two tangential half fields to a total dose of 45~50 Gy, followed by $10{\sim}15MeV{\beta}$ boost irradiation to tumor bed for 10~20Gy, total dose 56~66Gy. Results: Fifty-two patients were enrolled. Overall 1-, 2- and 3 year survival rates were 98.1%, 92.3%, and 90.4%, respectively, with a local recurrence rate of 5.77%. Cosmetic results were evaluated as good by doctors in 90.4% of patients. Conclusions: Breast conservative surgery combined with chemo- radio-therapy could be a treatment option for Chinese patients with early stage breast cancer.

• Radiation Oncology Journal
• /
• 제1권1호
• /
• pp.103-109
• /
• 1983

47 out of 56 cases of intact uterine cervix cancer treated by radiation at the Hanyang University Hospital were followed 18 months or more after treatment. (7 patients died before 18 months, 2 cases lost to follow-up). Age distribution reveal 5 cases in 30's, 18 cases in 40's, 17 cases in 50's, 7 cases in 60's. Histologically, all cases were squamous cell type except one case of adenocarcinoma. 1. 45 cases were treated by combined external Co-60 irradiation and intracavitary irradiation by Cs-137 small sources. 1 case was treated by external irradiation only, and 1 case by intracavitary only. 2. Rectal injuries were observed in 13 cased (27.6%), 4 cases in Grade 1, 8 cased in Grade 2 and 1 cases in Grade 3 which needed surgical management. 3. Average intervals of rectal injury following treatment was 9.2 months varying from 5 to 15 months. 4. Relation between rectal injury and point A dose reveal 6 cases between 7000-7999 rad and 6 cases between 8000-8999 rad and 1 case above 9000 rad. Even though there is no direct relation between point A dose and rectal injury, it is expected that rectal injury increases as point A dose increase. 5. In the normal condition, rectal injury can't be attributed to one major cause. Radiation dose, small source distribution, general condition of patients, local anatomy of the individual patient, history of PID and previous surgery, all play complex roles.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2008년도 제39회 하계학술대회
• /
• pp.625-626
• /
• 2008

The magnetic domain-refining techniques such as ball scratching, laser irradiation and plasma have been developed to reduce the domain wall spacing and thus iron losses in Fe-3%Si grain-oriented silicon steels. In view point of magnetic properties, it was supposed that the locally residual stresses change the magnetoelastic energy of the material and thus the spacing between $180^{\circ}$ domain walls decreases in order to reduce the magnetostatic energy. The effect of laser irradiation on iron loss and magnetostriction reduction for Fe-3%Si grain-oriented steel were investigated. Since the local tensile stresses were induced at the surface of Fe-3%Si steel by the laser irradiation, the minimum iron loss caused by reducing eddy current loss was obtained in spiete of the decrease of permeability by hindering eddy current loss was obtained in spite of the decrease of permeability by hindering the domain wall movement around the induced stress field. Furthermore, the laser treated 3%Si steel has lower magnetostriction as compared to non laser-treated steel and is less sensitive to applying pre-stresses due to the volume reduction of $90^{\circ}$ domain in materials.

• 한국레이저가공학회지
• /
• 제4권2호
• /
• pp.21-28
• /
• 2001

The laser strengthening of 35kgf/㎟ and 60kgf/㎟ grade steel sheets is investigated by using CO$_2$ laser beam irradiation. The increase of tensile strength is dominated by the number of fully penetrated melting line. Also. the optimal laser input energy(hardness) and the number of melting line (melting width) are important variables for laser strengthening. Local strengthening by laser beam may be effective for the weight reduction of components where the tailored welded blank can not be applied.

• Radiation Oncology Journal
• /
• 제37권1호
• /
• pp.1-12
• /
• 2019

Despite recent innovation in treatment techniques and subsequently improved outcomes, the majority of glioblastoma (GBL) have relapses, especially in locoregional areas. Local re-irradiation (re-RT) has been established as a feasible option for recurrent GBL of all ages with safety, tolerability, and effectiveness both in survival and quality of life regardless of fractionation schedule. To keep adverse effects under acceptable range, cumulative dose limit in equivalent dose at 2 Gy fractions by the linear-quadratic model at α/β = 2 for normal brain tissue (EQD2) with narrow margin should be observed and single/hypofractionated re-RT should be undertaken very carefully to recurrent tumor with large volume or adjacent to the brainstem. Promising outcome of re-operation (re-Op) plus re-RT (re-Op/RT) need to be validated and result from re-RT with temozolomide/bevacizumab (TMZ/BV) or new strategy is expected. Development of new-concept prognostic scoring or risk group is required to select patients properly and make use of predictive biomarkers such as O(6)-methylguanine-DNA methyltransferase (MGMT) promotor methylation that influence outcomes of re-RT, re-Op/RT, or re-RT with TMZ/BV.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.1
• /
• pp.271-275
• /
• 2004

A fast switching thyristor with a superior trade-off property between the on-state voltage drop and the turn-off time could be fabricated by the proton irradiation method. After fabricating symmetric thyristor dies with a voltage rating of 1,600V from $350{\mu}m$ thickness of $60{\Omega}cm$ NTD-Si wafer and $200{\mu}m$ width of N-base drift layer, the local carrier lifetime control by the proton irradiation was performed with help of the HI-13 tandem accelerator in China. The thyristor samples irradiated with 4.7MeV proton beam showed a superior trade-off relationship of $V_{TM}=1.55V\;and\;t_q=15{\mu}s$ attributed to a very narrow layer of short carrier lifetime(${\sim}1{\mu}s$) in the middle of its N-base drift region. To explain the small increase of $V_{TM}$, we will introduce the effect of carrier compensation by the diffusion current at the low carrier lifetime region.