• Journal of Korean Society for Atmospheric Environment
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• v.10 no.E
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• pp.332-342
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• 1994

Hierarchical cluster and factor analyses were used to identify various influences on free tropospheric air samples at Mauna Loa Observatory in Hawaii during MLOPEX. The cluster analysis separated thirteen chemical and meteorological variables into three characteristic groups (1)clean air, (2)anthropogenically influenced air, (3)marine and volcanic influenced air. The cluster analysis results compared well with those of factor analysis. Six independent components were identified in factor analysis. We have related these components to (1)volcano influenced air, (2)stratosphere-like air, (3)boundary-layer air with recent anthropogenic influence, (4)photochemical haze, (5)marine boundary- layer air, and (6)modified marine tropospheric air. Excluding local influence, we could calculate the nighttime free tropospheric values for $O_3$(41$\pm$10 ppbv), HN $O_3$(94$\pm$45 pptv), N $O_3$$^{[-10]}$ (16$\pm$10 ppbv), S $O_4$$^{[-10]}$ (60$\pm$0 pptv), N $H_4$$^{＋}$(71$\pm$6 pptv), N $a^{＋}$(5$\pm$1 pptv), PAN(13$\pm$9 pptv), MeN $O_3$(3.5$\pm$1.5 pptv), 2-butyl N $O_3$(0.6$\pm$0.1 pptv), $H_2O$$_2$(1015$\pm$44 pptv), $C_2$C $l_4$(3.3$\pm$0.1 pptv), condensation nuclei(249$\pm$13c $m^{-3}$), and dew point(-8.5$\pm$5.3$^{\circ}C$) during this experiment..

• Radiation Oncology Journal
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• v.14 no.1
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• pp.17-23
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• 1996

Purpose : To evaluate the role of combination therapy of external radio-therapy and chemotherapy in the management of advanced esophageal cancer as a primary treatment compared with radiation therapy alone. Materials and Methods : A retrospective review of evaluable 55 esophageal cancer patients referred to the Department of Therapeutic Radiology, Paik Hospital for the external radiotherapy between Jul, 1983 and Dec. 1994 was undertaken. Combined therapy patients (A group) were 30 and radiation alone patients (B group) were 25. Median age was 60 years old in A group (ranges : 42-81) and 65 years old in B group (ranges : 50-81). The male patients were 53. The fifty patients had squamous cell carcinomas. Radiation doses of 2520-6480c0y were delivered over a period of 4-7weeks, using 4MV LINAC. Chemotherapy was administered in bolus injection before, after, or during the course of external radiotherapy. The local control rate and patterns of failure according to both treatment modalities and 1, 2 year survival rates according to prognostic factors (stage, tumor length, radiation dose etc.) were analysed. Resuts : Median follow up Period was 7 months (range : 2-73 months). Median survival was 7.5 months (20 days-29 months) in A group and 5 months (20 days-73 months) in B group. The 1, 2 YSRs were $26.7\%$, $8.9\%$ in A group, $12.7\%$, $4.3\%$ in B group (p>0.05), respectively. The 1, 2 YSRs according to stage(II/III), tumor length (5cm more or less). radiation dose (5000cGymore or less) of A and B group were analyzed and the differences of survival rates of both treatments were not statistically significant. But among group B, patients who received 5000cGy or more showed significant survival benefits (p<0.05). The treatment response rates of A and B group were $43.8\%$. $25.0\%$, respectively. Complete response rate of $25.0\%$ in A and $8.3\%$ in B were achieved. The local failure and distant metastsis were $52.4\%$. $23.8\%$ in A group, $64.3\%$, $14.3\%$ in 8 group, respectively. The combination therapy revealed more frequent leukopenia and nausea/vomiting than radiation alone group, but degree of side effects was only mild to moderate. Conclusion : The combined external radiotherapy and chemotherapy for advanced esophageal cancer appears to improve the response rate, local control rate and survival rate, but the improvement was not statistically significant. The side effects of combined modalities were mild to moderate without significant morbidity. Therefore it may be worthwhile to continue the present combined external radiotherapy and chemotherapy in the management of advanced esophageal cancer to confirm our result.

• Journal of architectural history
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• v.7 no.3 s.16
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• pp.151-170
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• 1998

This study is about Le Corbusier's early years of loarning and training at La Chaux-de-Fonds. It is an attempt to show how Le Corbusier's groundwork was laid which characterize his work throughout the life. Charles Edouard Jeanneret was trained as a watch engraver and wished to be a painter. C. L'Eplattenier was to play a decisive role in shaping the young introspective boy's future. He encouraged Jeanneret's habit of the close study and observation of nature. Jeanneret was not the product of an established school, but instead made the unusual choice of educating himself. He found two indispensible sources of inspiration in study the past and in contemplating nature. His four years of self-education consisted of extensive reading, summer travels and winter layovers in larger cities-Vienna, Paris, Berlin-while sketching in museums or apprenticing local architects-Pellet, Behrens-. All these impressions then blended together to become part of a comprehensive source book of knowledge and imagination of the later Le Corbusier. A largely self-taught man, he never stopped making notes, drawing and writing, always aspiring to a clearer understanding of the meaning and underlying principles of objects and architecture. Jeanneret's five villas in La Chaux-de-Fonds are barometers which show the sequences of his development and change as an architect. In 1917, being thirty, he uprooted himself from his hometown to get a wider range of opportunities and moved to Paris. By that time Jeanneret was almost ready to blossom into Le Corbusier It was during this formative years of his life that Le Corbusier established the working method, mind-set and philosophical basis that determined the course of an architect in the making.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.583-587
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• 2006

국부세굴의 발생은 일반적으로 흐름조건, 구조물 조건과 하상재료 세 가지의 주 원인으로 구분할 수 있다. 흐름조건의 경우 구조물 영향으로 발생되는 3차원적인 와류가 주요원인이며 하상재료의 경우 여러 요인이 있겠지만 비중이 같은 입자라 가정할 경우 입자의 크기를 주요 변수로 정할 수 있다. 교각 국부세굴에 관한 연구는 1960년대 이후 연구자들에 의해 매우 다양하게 수행되어 졌으며 많은 산정공식도 제시되었다. 하지만 기존 연구는 최대세굴심 조건으로 다양한 하상재료와 시간에 대한 세굴변동(홍수사상 등)에 대한 영향을 고려하는데 어려움이 있다. 특히 국내의 경우 다양한 하상재료와 홍수빈도를 고려할 때 이에 대한 세굴적용은 매우 중요한 인자라 할 수 있다. 따라서 교각세굴에 대한 궁극적인 목적은 다양한 하상재료와 홍수빈도를 고려할 수 있는 세굴평가를 제안하는데 있다. 이를 위해 본 연구에서는 우선적인 연구로 입자의 다양성과 이미지 기법을 이용한 실시간 측정을 통해 보완하여 입자에 따른 시간적 변화를 분석하였다. 현재 4가지의 하상재료의 입경차이에 따른 국부세굴의 시간적 변화와 초기세굴 발생의 수리적 조건을 파악하고 기존연구와 비교분석하였으며, 이를 기초자료로 세굴심$(S,\;S_{max})$, 교량주변 전단력$({\tau}_p,\;{\tau}_{pc})$, 접근수로부 전단력$({\tau}_a)$와 입자한계전단력$({\tau}_c)$에 대한 시간분석 (time effect)을 통해 다양한 하상재료와 홍수빈도를 해석을 위한 초기분석을 수행하는데 목적이 있다. 수리모형실험에 사용된 가변경사수로의 제원은 $0.6m(W){\times}20m(L){\times}2m(H)$이며 모형구조물은 투명한 아크릴로 제작하였다. 실험방법은 교각 내부에 CC카메라를 전 후면 및 상측면에 설치하여 세굴 발생을 실시간으로 촬영한 후 이미지 분석을 통해 분석하였다.

• Journal of Environmental Health Sciences
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• v.35 no.5
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• pp.393-401
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• 2009

We isolated and identified a microorganism which was excellent for ammonia oxidation in the biological control of ammonia gas in odor producing materials from organic composting. The isolated strain was tested for growth characteristics and ammonia elimination efficiency under various conditions of temperature, pH, carbon concentration and ammonia concentration. The strain was isolated from a culture broth used in a $NO_2$ producing test with Griess-Ilosvay reagent. The results of 16S rRNA sequence from the isolated strain by using BLANST (Basic Local Alignment Search Tool) and confirming RDP (Ribosomal Database Project II) and ERRD (The European Ribosomal RNA Database) indicate that the strain is related to Delftia sp. UV-Spectrophotometer (Shimadzu, UVmini-1240) was used as a microbial growth test by measuring turbidity on OD660nm and ammonia concentration was measured by Spectrophotometer (HACH, DR-4000). The optimum growth culture conditions of the ammonia oxidizer Delftia sp. were $30^{\circ}C$, pH 7, glucose concentration 1.00% and $(NH_4)_2SO_4$ 0.5 g/l. Ammonia elimination efficiency was over 94% under the same conditions.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.6
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• pp.737-742
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• 2004

Garole, a prolific small sized sheep breed of West Bengal, was introduced in the Mutton project of the Institute in 1997 to explore the possibility of incorporating fecundity gene(s) into monotocus Malpura sheep of Rajasthan. Results of reproduction and production traits in respect of Garole${\times}$Malpura (G${\times}$M) half-breds have been obtained. Of 35 lambing obtained so far from the ewes of Garole${\times}$Malpura, 45.71% were twin lambing, whereas, Malpura sheep produced mostly single lamb except 2.55% twin lambing on an average. Other reproduction traits in G${\times}$M ewes such as lambing rate, litter size at birth and weaning were considerably improved over Malpura ewes. Results revealed that the fecundity genes responsible for increasing ovulation rate and litter size have been incorporated in to the G${\times}$M genotype and it might prove a valuable germ plasm towards evolving a new prolific strain of sheep. Interestingly, survivability of G${\times}$M half-breds was almost at par with the local Malpura sheep in harsh climatic conditions of semi-arid tropics. The body weights at different ages of G${\times}$M half-breds were on little lower side compared to contemporary Malpura lambs. Average kilogram of lambs weaned/ewe lambed in Malpura and G${\times}$M genetic group was 11.86 and 11.07 kg respectively. In view of minimizing the differences in body weights and kg of lambs weaned/ewe lambed between the two genetic groups, G${\times}$M ewes has to be backcrossed with Malpura rams to raise the inheritance of latter up to 75% level. However, further research is needed to reach on certain conclusions regarding net returns from such crosses.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.3
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• pp.229-236
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• 2016

Resveratrol (RSV) may provide numerous protective effects against chronic inflammatory diseases. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress, and aldehyde products formed during lipid peroxidation, such as 4-hydroxy-2-hexenal (HHE), might be responsible for tubular injury. This study aimed at investigating the effects of RSV on renal and its signaling mechanisms. While HHE treatment resulted in decreased expression of Sirt1, AQP2, and nuclear factor erythroid 2-related factor 2 (Nrf2), mouse cortical collecting duct cells (M1) cells treated with HHE exhibited increased activation of p38 MAPK, extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and increased expression of NOX4, $p47^{phox}$, Kelch ECH associating protein 1 (Keap1) and COX2. HHE treatment also induced $NF-{\kappa}B$ activation by promoting $I{\kappa}B-{\alpha}$ degradation. Meanwhile, the observed increases in nuclear $NF-{\kappa}B$, NOX4, $p47^{phox}$, and COX2 expression were attenuated by treatment with Bay 117082, N-acetyl-l-cysteine (NAC), or RSV. Our findings indicate that RSV inhibits the expression of inflammatory proteins and the production of reactive oxygen species in M1 cells by inhibiting $NF-{\kappa}B$ activation.

• The Journal of Bigdata
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• v.4 no.2
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• pp.115-126
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• 2019

There have been many discussions on export indices in trade exports, but there is no definite trade export index which can be explained by objective indicators. Korea International Trade Association (KITA), Korea Trade-Investment Promotion Agency (KOTRA), etc., but we are currently in the process of thinking about ways to express the capabilities of exporting companies. In this study, we constructed the AI data sets by setting the activity indicators such as the size of the company and the credit score, the number of transaction customers, the number of transactions, the number of items, the transaction volume, and the transaction period as features, Lightgbm. Using the Graph Neural Network as an industrial cluster classification model, the export live index which expresses the exportable capacity among companies, items, and business groups was calculated. This includes the past activity of the company from the current calculating index Objectivity.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.12
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• pp.1701-1704
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• 2003

Melatonin regulates circadian rhythms and reproduction changes in seasonally reproductive mammals through binding to high-affinity, G-protein-coupled receptors. Small Tail Han sheep that has significant characteristics of high prolificacy and nonseasonal ovulatory activity is an excellent local sheep breed in P. R. China. The exon 2 of the ovine melatonin receptor 1a (MTNR1A) gene was amplified and a uniform fragment of 824 bp was obtained in 150 ewes of Small Tail Han sheep. The 824 bp PCR product was digested with restriction endonucleases Mnl I and Rsa I, and genetic polymorphism was detected by PCR-RFLP. Polymorphic Mnl I site was detected at base position 605 of the exon 2 of the MTNR1A gene. There were two kinds of genotypes in Small Tail Han sheep, AB (303 bp, 236 bp/67 bp) and BB (236 bp/67 bp, 236 bp/67 bp). The results indicated that genotype AA (303 bp, 303 bp) at Mnl I-RFLP site did not exist in non-seasonal estrous Small Tail Han sheep, which suggested that there was an association between genotype AA (303 bp, 303 bp) and reproductive seasonality in sheep. Polymorphic Rsa I site was detected at base position 604 of the exon 2 of the MTNR1A gene. Three kinds of genotypes were found in Small Tail Han sheep, AA (290 bp, 290 bp), AB (290 bp, 267 bp/23 bp) and BB (267 bp/23 bp, 267 bp/23 bp). Least squares means of litter size in the first parity and the second parity for genotype AA (290 bp, 290 bp) at Rsa I-RFLP site were 0.43 and 1.06 more than those for genotype AB (290 bp, 267 bp/23 bp) in Small Tail Han sheep.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.3
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• pp.314-319
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• 2008

Duck (Anas platyrhynchos) is one of the most important domestic avian species in the world. In the present research, fifteen polymorphic microsatellite markers were used to evaluate the diversity and population structure of 26 Chinese indigenous duck breeds across the country. The Chinese breeds showed high variation with the observed heterozygosity (Ho) ranging from 0.401 (Jinding) to 0.615 (Enshi), and the expected heterozygosity (He) ranging from 0.498 (Jinding) to 0.707 (Jingjiang). In all of the breeds, the values of Ho were significantly lower than those of He, suggesting high selection pressure on these local breeds. AMOVA and Bayesian clustering analysis showed that some breeds had mixed together. The FST value for all breeds was 0.155, indicating medium differentiation of the Chinese indigenous breeds. The FST value also indicated the short domestication history of most of Chinese indigenous ducks and the admixture of these breeds after domestication. Understanding the genetic relationship and structure of these breeds will provide valuable information for further conservation and utilization of the genetic resources in ducks.